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In this study, the development of novel pH-responsive and dual thermo- and pH-responsive filter materials is described. The dual-responsive system combines poly(N-isopropylacrylamide) (PNIPAM) for temperature sensitivity and poly(acrylic acid) (PAA) for pH responsiveness, which offers dynamic filtration capabilities tailored to environmental changes. PNIPAM is a thermo-responsive polymer that undergoes significant conformational changes in response to temperature variations. The present work integrates PNIPAM's temperature sensitivity with the pH-responsive properties of PAA, a versatile polymer widely recognized for its ability to change its conformation in response to pH variations. The dual materials developed here undergo conformational changes at specific temperatures and pH levels, modifying their hydrophilicity, pore size, and permeability. In particular, when exposed to higher temperatures, PNIPAM transitions from a hydrated, expanded state to a dehydrated, collapsed state, directly influencing the flow rate and selectivity of the filter medium that comprises it. On the other hand, PAA responds to pH changes by ionizing or deprotonating, causing swelling or shrinkage that alters the filtration performance of the media with embedded PAA. This dual responsiveness allows for the development of advanced filtration systems that can adapt to varying environmental conditions, optimize the capture of specific contaminants, and reduce fouling.
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http://dx.doi.org/10.1002/marc.202400861 | DOI Listing |
Int J Pharm
September 2025
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China; Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology, Ningbo Cixi Instit
Smart hydrogels have advanced rapidly in recent years. However, systems responsive to a single stimulus are typically triggered by specific cues, limiting their adaptability in complex and dynamic biological environments. To overcome this limitation, this study developed a dual-responsive hydrogel sensitive to both temperature and mechanical stress.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Biomedical Engineering, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, 210023, China.
Heat shock protein 70 (HSP70) represents a critical barrier to effective mild-temperature photothermal therapy (MPTT), limiting its clinical utility in aggressive cancers like triple-negative breast cancer (TNBC). While small interfering RNA (siRNA)-mediated HSP70 suppression offers a promising solution, optimal timing for this therapeutic combination remains unexplored. Here, it is demonstrated that precisely timed administration significantly enhances MPTT efficacy through systematic temporal characterization of HSP70 expression dynamics.
View Article and Find Full Text PDFStereotact Funct Neurosurg
September 2025
Introduction: Stereoelectroencephalography-guided radio-frequency thermo coagulation (SEEG-RFTC) is a minimally invasive technique whereby radiofrequency-thermocoagulation is performed using SEEG electrodes, following recording and stimulation. It helps to disconnect/disrupt or ablate the epileptogenic networks, and provides both therapeutic and diagnostic abilities.
Methods: Retrospective study (2016-2024).
Biosens Bioelectron
December 2025
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Province Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China; Wuhan Resea
Currently most conventional reporters in CRISPR/Cas system, including fluorophore-quencher (FQ) and magnetic bead (MB)-based reporters, encounter limitations in terms of sensitivity and compatibility. To overcome these challenges, we developed novel reporters for CRISPR/Cas systems based on thermo-responsive poly(N-isopropylacrylamide) (PNIPAM). Below the lower critical solution temperature (LCST), PNIPAM-based reporters exhibited a liquid state and can be cleaved by Cas proteins in a homogeneous reaction, preserving function and structure of Cas proteins while effectively accelerating the reaction kinetics.
View Article and Find Full Text PDFMicromachines (Basel)
July 2025
Department of Industrial, Electronic and Mechanical Engineering, Roma Tre University, Via Vito Volterra 62, 00146 Rome, Italy.
Titanium is widely recognized as an interesting material for electrodes due to its excellent corrosion resistance, mechanical strength, and biocompatibility. However, further functionalization is often necessary to impart advanced interfacial properties, such as selective ion transport or stimuli responsiveness. In this context, the integration of smart polymers, such as poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA)-noted for its dual pH- and thermo-responsive behavior-has emerged as a promising approach to tailor surface properties for next-generation devices.
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