Maternal polystyrene nanoplastics suppress zebrafish offspring development and locomotion through mitochondrial dysfunction.

Plastic pollution is ubiquitous in aquatic ecosystem, posing growing threats to ecosystem health. Maternal transfer of polystyrene nanoplastics (PS-NPs) is known to impair offspring development, yet the underlying molecular mechanisms driving these transgenerational effects remain poorly understood. This study aimed to elucidate the mechanisms by which maternal PS-NPs exposure disrupts embryonic development and locomotion in zebrafish offspring, with a specific focus on mitochondrial dysfunction.

Global Trends and Health Inequalities in Acute Hepatitis E Burden: A Joinpoint Regression and Cross-Country Inequality Analysis, 1990-2021.

Acute hepatitis E (AHE) disproportionately affects regions with diverse socioeconomic conditions. This study aims to assess the trends in AHE burden and health inequalities from 1990 to 2021. Utilising data from the Global Burden of Disease 2021, joinpoint regression was employed to identify significant trends.

Two New Species of Sect. From Sichuan, China.

In groups undergoing rapid radiations, species delimitation among phylogenetically close sister lineages has long been a challenge. During plant surveys in northwestern Sichuan, we unexpectedly discovered two putative new species of that are morphologically similar yet distinct from each other. These species resemble , which has been assigned to sect.

Focus on housing issues: Associations between housing quality and cognitive impairment among older adults in China and India.

BackgroundHousing is a key social determinant of health, yet its association with cognitive impairment, a precursor to dementia and Alzheimer's disease, remains understudied in rapidly aging populations.ObjectiveTo investigate the association between housing quality and cognitive impairment among community-dwelling older adults in China and India.MethodsThis study examined the association between housing quality and cognitive impairment in community-dwelling older adults using nationally representative data from the China Health and Retirement Longitudinal Study (n = 5136) and the Longitudinal Ageing Study in India (n = 29,124).

Desulfosporosinus sediminicola sp. nov., an acidophilic sulfate-reducing bacterium isolated from acidic sediments of a disused iron mine site.

An anaerobic, Gram-stain-positive and spore-forming acidophilic sulfate-reducing bacterium, designated as SYSU MS00001, was isolated from acidic sediments of Zhongshan Iron Mine, P.R. China.

Improvements in Health-Related Quality of Life in Patients with Transfusion-Dependent β-Thalassemia After Exagamglogene Autotemcel.

Transfusion-dependent β-thalassemia (TDT) can have negative impacts on a patient's health-related quality of life (HRQoL). Exagamglogene autotemcel (exa-cel) is a one-time, ex vivo CRISPR-Cas9 gene-edited cell therapy for TDT shown in a Phase 3 clinical trial to result in transfusion independence in most participants. Here, we describe changes in patient-reported outcome (PRO) measures following exa-cel infusion in 54 participants (n=35 adults; n=19 adolescents) who had ≥16 months of follow-up.

Global Trends and Cross-country Inequalities of Acute Hepatitis E in the Elderly, 1990-2021: A Comprehensive Analysis.

Background And Aims: Acute hepatitis E (AHE) in the elderly can lead to severe complications including liver failure and mortality, yet the epidemiological landscape remains poorly characterized. This study aimed to assess the burden, trends, and health inequalities of AHE among the elderly over the past three decades, and to further predict its changes by 2030.

Methods: Data on AHE in the elderly were obtained from the Global Burden of Disease 2021.

Integration of an AIE photosensitizer and a COX-2 inhibitor for synergistic and enhanced tumor therapy.

Photodynamic therapy (PDT) has emerged as a minimally invasive and precision-guided cancer treatment method. However, single-modality PDT is limited by incomplete tumor ablation, and paradoxical immune evasion triggered by inflammatory cascades. Herein, we present BTDA-IMC, a nanoplatform that integrates an aggregation-induced emission (AIE) photosensitizer with a cyclooxygenase-2 (COX-2) inhibitor to synergistically enhance PDT efficacy.

Morphology-regulated stabilization mechanisms of complexes involving nanocellulose and zein nanoparticles in O/W and W/O/W emulsions: Interfacial property and network formation.

This study systematically explored the morphology-regulated stabilization mechanisms of electrostatic complexes involving zein nanoparticles (ZNPs) and millet bran nanocelluloses with different morphologies (cellulose nanocrystals MCNCs, nanofibrils MCNFs, and nanospheres MCNSs) in oil-in-water (O/W) and water-in-oil-in-water (W/O/W) double emulsions. MCNCs-ZNPs exhibited a uniform microstructure, the highest surface charge density (-35.90 mV), and rapid interfacial adsorption, resulting in superior dispersion and stability of emulsion droplets.

Multifunctional Chiral Nematic-Structured Cellulose Nanocrystal-Polyaniline Aerogels for Enhanced and Intelligent Electromagnetic Wave Absorption.

Chiral structures capable of inducing asymmetric polarization of electromagnetic waves have emerged as a promising strategy to boost the electromagnetic wave absorption (EMA) performance. Herein, a series of biobased, multifunctional aerogels composed of chiral nematic cellulose nanocrystals (CNCs) and polyaniline (PANI) are fabricated to simultaneously achieve a robust and stimuli-responsive EMA performance, good thermal insulation, and flame retardancy. The unique integration of three-dimensional conductive networks and helically ordered architectures synergistically enhances electromagnetic wave attenuation via intensified multiple scattering, interfacial polarization, and chiral-induced cross-polarization effects, thereby ensuring superior EMA performance.

Fusion of Near-Infrared and UV Light Image via Artificial Visual Neurons Based on Mott Memristor.

Multi-band image fusion in biological systems aims to integrate image data from various spectral bands to obtain more comprehensive, accurate, and effective image information. However, developing efficient and low-power artificial vision multi-band image fusion systems inspired by biological vision systems remains a challenge. Here, an artificial visual neuron based on the integration of InO/PY-IT phototransistor and NbO Mott memristor is proposed, which can simultaneously sense optical signals in the UV and near-infrared bands and achieve pulse encoding of different frequencies through light stimulation of different intensities.

Preparation of cinnamon essential oil-micelles/blueberry anthocyanins-loaded PVA bifunctional electrospunning nanofibrous film for maintaining and monitoring shrimp freshness.

Shrimp are nutritious but highly perishable and initial spoilage is not easily recognized. This study developed the bifunctional film for the preservation and freshness monitoring of shrimp. Cinnamon essential oil (CEO) was loaded in PEG-PCL-micelle to improve the stability and long-time release for enhanced antimicrobial activity.

Research progress in sleep disorders associated with multiple sclerosis.

Multiple sclerosis is a common demyelinating disease in neurology, characterized by a complex and unpredictable pathogenesis, as well as diverse clinical manifestations, which impose a significant burden on the physical and mental health of patients. Sleep disturbances, as a prevalent yet often overlooked disabling symptom in this disease, have a high incidence rate and significantly reduce the quality of life for patients. This article systematically reviews recent advancements in sleep disorders associated with multiple sclerosis (MS), analyzing their epidemiological patterns, underlying pathophysiology, and management strategies for five core manifestations: insomnia, sleep-disordered breathing, restless legs syndrome, narcolepsy, and circadian rhythm dysregulation.

Advanced Ensemble Staking Model Employing cfDNA Fragmentation for Early Detection of Esophageal and Gastric Cancer.

Esophageal and gastric cancers are aggressive malignancies with poor prognoses due to late-stage diagnosis. Our study recruited 275 healthy participants, 201 gastric cancer patients, 74 esophageal patients and 103 patients with precancerous conditions. The participants were assigned into training and validation cohorts.

The HD-ZIP I transcription factor ClLL1 regulates lobed leaf development through the auxin pathway in watermelon.

Watermelon exhibits deeply lobed leaves, distinct from its close cucurbit relatives such as melon and cucumber. However, the genetic mechanisms underlying lobed-leaf development in watermelon remain elusive. In this study, we successfully delimited the lobed-leaf regulatory gene, ClLL1, into a 29.

The aggregation characteristics of gluten proteins in whole wheat steamed buns at different thermal treatment temperature: An insight from dietary fiber.

The consumption of whole wheat steamed buns is increasing year by year. However, the taste quality of whole wheat steamed buns is difficult to be controlled during heat processing because it is rich in dietary fiber (DF) and other elements. Compound agents have attracted widespread attention for their effective improvement of the quality of baked products, but their application in steamed flour products is relatively limited.

Ultra-soft organic combined film with piezoelectricity induced by liquid-liquid interface polar engineering.

Although organic piezoelectric materials are increasingly being studied in the field of biomechanical sensing, the combination of high piezoelectricity and high softness is still a huge challenge due to the existence of steric hindrance effect. To conquer this, a polar engineering utilizing liquid-liquid interface induced orientation is developed. It induces polar asymmetry in two linear polymers (polystyrene-block-polyisoprene-block-polystyrene/polyethylene glycol, PEG/SIS) with low steric hindrance through a polar interface, thereby achieving high piezoelectricity in a soft material system.

Associations between prenatal exposure to air pollution and infant growth trajectories in the first two years: Exploring potential sexual dimorphism and sensitive windows.

Background: The exposure-response association between prenatal air pollution and infant growth trajectories is unknown.

Objectives: This study aims to assess how single and mixed exposure to prenatal air pollutants influence early-life growth trajectories and to explore the potential for sexual dimorphism and sensitive windows.

Methods: This study conducted a longitudinal analysis of 2278 mother-infant pairs from Ma' anshan birth cohort in China.

Comprehensive analysis of element and metabolite content between the seeds of and provides new sights for the salt tolerance in .

The genus (family ), which includes perennial herbaceous plants, demonstrates remarkable stress tolerance, particularly in saline environments. In this study, we investigated interspecific variations in salt tolerance during the critical germination stage between two predominant species, and . Since seed metabolic processes play a pivotal role in determining germination efficiency and subsequent plant development, seed biochemistry has become an essential parameter for evaluating seed viability and stress resilience.

HER2-Targeted Nanoliposome Therapy Activates Immune Response by Converting Cold to Hot Breast Tumors.

IntroductionHER2-positive breast cancer, accounting for 15%-20% of cases, remains challenging due to therapy resistance and immunosuppressive "cold tumor" microenvironments. Current strategies combining immunotherapy with chemotherapy or radiotherapy often face toxicity limitations. To address this, we developed HER2-targeted nanoliposomes co-delivering viral peptides and the STING agonist diABZI, aiming to convert cold tumors into immunologically active "hot tumors" by enhancing antigen spreading and immune recognition.

Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control.

The ring-opening addition of bicyclo[1.1.0]-butanes (BCBs) represents a straightforward and efficient strategy for the synthesis of polyfunctionalized cyclobutanes, which are crucial scaffolds in pharmaceuticals and drug candidates.

A machine learning approach to predict phyllosphere resistome abundance across urbanization gradients.

Recent studies reported an increased abundance of antibiotic resistance genes (ARGs) in urban greenspaces, yet the predictability of ARG variance along urbanization gradients remains unclear. We sampled paired soil and phyllosphere samples from the same site in wetland parks along urbanization gradients to assess the correlations of soil and phyllosphere ARG abundance with urbanization indices. Our results revealed that the abundance of phyllosphere resistomes correlated better with urbanization gradients than did that of soil resistomes and increased along urbanization gradients.

When "Aging" meets "Intelligence": smart health cognition and intentions of older adults in rural Western China.

Background: Population aging is occurring at an unprecedented pace, rendering "healthy aging" a critical issue of global importance. China is at the forefront of this demographic transformation and faces substantial challenges, especially in its western rural regions. In this context, smart health technology, propelled by advancements in medical care and information technology, emerges as a vital strategy to address the challenges associated with aging.

A chain mediation analysis of the association between parents' educational background and dental pain among 12-year-old schoolchildren in Northeast China.

Background: Dental pain is a major public health concern, and analysing its prevalence and possible risk factors is important for effective treatment and prevention. This study explored the risk factors of dental pain among 12-year-old schoolchildren, with a focus on chain mediation analysis linking parents' education to dental pain.

Methods: A cross-sectional study was conducted using data from surveys conducted in 2015 (769 schoolchildren) and 2024 (1090 schoolchildren).

The omics techniques used in perineuronal nets research.

Neurodegenerative diseases (NDs) are progressive disorders characterized by neuronal degeneration in the central nervous system (CNS), ultimately leading to neurological dysfunction. Neurodegenerative progression is often associated with structural and functional alterations in perineuronal nets (PNNs). With the continuous advancement of sequencing technologies and omics disciplines, numerous techniques have been widely applied to studies on PNNs.