The omics techniques used in perineuronal nets research.

Neurodegenerative diseases (NDs) are progressive disorders characterized by neuronal degeneration in the central nervous system (CNS), ultimately leading to neurological dysfunction. Neurodegenerative progression is often associated with structural and functional alterations in perineuronal nets (PNNs). With the continuous advancement of sequencing technologies and omics disciplines, numerous techniques have been widely applied to studies on PNNs. Research on PNNs is beneficial for understanding the pathogenesis and clinical diagnosis of NDs and finding new drug treatment targets. In this review, we paid attention to these omics technologies used in PNNs and also summarized some alterations in PNNs in NDs.