AIE functionality ratiometric fluorescent probe based on quinoline-malononitrile for detection of ONOO and its application in bioimaging.

Peroxynitrite (ONOO), a highly reactive endogenous reactive oxygen species (ROS), plays pivotal roles in diverse physiological and pathological processes, the development of sensitive and reliable strategy for efficiently detecting ONOO is helpful to understand its biological functions in biological systems. Here, a novel AIEgen fluorescent probe QM-NP was developed by utilizing quinoline-malononitrile fluorophore as the light-emitting core and aryl borate moiety as the specific ONOO recognition group. Upon reaction with ONOO, QM-NP exhibits remarkable ratiometric fluorescence response with a distinct emission shift from red (630 nm) to green (540 nm), with higher specificity for ONOO compared to other analytes (ROS and RNS), rapid response (<10 s) and high sensitivity (LOD = 1.

AI4HealthyCities: a protocol for a mixed-method ethnographic study on the social determinants of cardiovascular health in New York City.

Introduction: Cardiovascular disease is a leading cause of morbidity and mortality globally and in New York City. Significant disparities in prevalence and risk factors persist across city neighbourhoods and among populations of varying socio-economic status, racial and ethnic backgrounds. These disparities are shaped and sustained by the complex interplay of social determinants of health, including housing, employment, access to healthcare and structural inequities.

Hydrogen Atom Transfer-Mediated -Heterocycles Dehydrogenation Coupled with the CO Photoreduction to Syngas.

Homogeneous photocatalytic organic oxidation coupled with CO reduction remains challenging due to the susceptibility to a back electron transfer scenario. Herein, a pyridinethiol iron-catalyzed system is developed to achieve -heterocycles dehydrogenation coupled with CO photoreduction to syngas. The system is comprised of 2,4,5,6-tetrakis(diphenylamino)isophthalonitrile (4DPAIPN) photoredox catalysts, earth-abundant iron catalysts, and pyridinethiol organocatalysts, and the employment of pyridinethiol both as a hydrogen atom transfer (HAT) catalyst to promote -heterocycles dehydrogenation and as an effective ligand for CO reduction is the key to realizing the coupled redox reaction.

Perspectives of Hospice Medical Directors on Challenges and Solutions for Improving Care for Persons Living With Dementias (PLWD) and Their Caregivers.

BackgroundPersons living with dementia (PLWD) on hospice care face unique end-of-life (EoL) care challenges. A larger proportion of PLWD outlive the 6-month hospice eligibility requirement compared to other terminally ill patients, which leads to high rates of hospice live discharge. Hospice medical directors (HMDs) are physicians with unique insights into both the clinical aspects of care and the administrative and regulatory guidelines of hospice care delivery.

Clinicians Who Practice Primarily in Nursing Homes and the Quality of Care for Residents With Alzheimer Disease and Related Dementias.

Importance: The number of physicians and advanced practitioners (APs) whose care is concentrated in nursing homes (often referred to as nursing home or skilled nursing facility specialists [SNFists]) has increased rapidly. Therefore, whether these clinicians provide better care is important.

Objective: To examine the association between SNFist care and outcomes of long-stay nursing home (NH) residents with Alzheimer disease and related dementias (ADRD).

Effect of Plate Thickness on Residual Stress Distribution of GH3039 Superalloy Subjected to Laser Shock Peening.

To accurately assess the effect of different plate thicknesses on the residual stress field of laser shock peened GH3039 superalloy, residual stress measurements were performed on GH3039 alloy plates with thicknesses of 2 mm and 5 mm after laser shock peening (LSP) treatment. Both quasi-static and high strain rate mechanical tests of GH3039 were conducted, and the Johnson-Cook (J-C) constitutive equation for GH3039 alloy at specific strain rates was fitted based on the experimental results. To obtain the parameter in the J-C constitutive equation of GH3039 alloy under ultra-high strain rates, a modified method was proposed based on LSP experiment and finite element simulation results.

Polyphyllin H inhibits malignant progression of ovarian cancer in patient-derived xenograft mouse models by regulating CGN/RhoA/Rock2 axis: an experimental research.

Background: Discovering new and effective drugs is a top priority for treating ovarian cancer.,a gynecological tumor with a high mortality rate. As a major active ingredient isolated from Paris polyphylla, Polyphyllin H exhibits antitumor effect.

Global polynomial synchronization of neural networks with bidirectional proportional delays via adaptive pinning control and its application in image encryption.

This paper investigates the adaptive global polynomial synchronization (GPS) of neural networks (NNs) with bidirectional proportional delays. By designing an adaptive controller for all node and constructing novel Lyapunov functional, a GPS criterion is derived. To further increase energy efficiency, an adaptive pinning control is also designed and a corresponding GPS criterion is provided.

Quercetin combined with shTERT induces apoptosis in ovarian cancer via the P53/Bax pathway, and RGD-MSN/QR/shTERT nanoparticles enhance the therapeutic efficacy.

Background: Ovarian cancer (OC) is a highly malignant gynecological tumor with poor current treatment effects. Telomerase reverse transcriptase (TERT) is an important component of telomerase and plays an important role in the progression of ovarian cancer. Quercetin(QR) has been shown to inhibit the cell cycle and induce the apoptosis in various types of tumors.

Giant Flexoelectric-Like Response via Macroscopic Symmetry Design.

Flexoelectricity is enabled by symmetry in all materials. However, flexoelectric material application is limited by the normally low charge density produced in bulk materials. In this study, a universal strategy involving a macroscopic symmetry design is proposed to enhance the flexoelectricity.

Next-generation probiotics and engineered BEVs for precision therapeutics in osteoporosis.

Osteoporosis, characterized by reduced bone density and increased fracture risk, faces limitations with conventional therapies due to adverse effects and poor gut microbiota modulation. Emerging strategies leveraging probiotics and bacterial extracellular vesicles (BEVs) offer novel therapeutic potential by targeting the gut-bone axis. Engineered probiotics and next-generation formulations enhance osteoprotection via immunomodulation, metabolite production (e.

Ultra-soft organic combined film with piezoelectricity induced by liquid-liquid interface polar engineering.

Although organic piezoelectric materials are increasingly being studied in the field of biomechanical sensing, the combination of high piezoelectricity and high softness is still a huge challenge due to the existence of steric hindrance effect. To conquer this, a polar engineering utilizing liquid-liquid interface induced orientation is developed. It induces polar asymmetry in two linear polymers (polystyrene-block-polyisoprene-block-polystyrene/polyethylene glycol, PEG/SIS) with low steric hindrance through a polar interface, thereby achieving high piezoelectricity in a soft material system.

Ventricular Arrhythmias and Myocardial Infarction: Electrophysiological and Neuroimmune Mechanisms.

Ventricular arrhythmias (VAs) after myocardial infarction (MI) are still one of the most important causes of cardiovascular death, though patients receive timely vascular recanalization and drug treatment. And it requires further exploring the mechanism and new therapeutics of VAs induced by MI. Here, we review the electrophysiological and neuroimmune mechanisms of VAs induced by MI.

Molecular engineering and channel structure modulation for single-atom iron-embedded high-porosity carbon fibers with enhanced oxygen reduction reaction and zinc-air battery performance.

Iron-based electrocatalysts, owing to their unique electronic structures and abundant resource availability, exhibit significant potential as alternatives to precious metal materials in the oxygen reduction reaction (ORR) catalytic systems of zinc-air batteries. In particular, FeN single-atom catalysts (SACs), with their atomically dispersed active sites and well-defined FeN coordination structure, have further broken through the performance bottlenecks of traditional catalysts. However, the precise and controllable synthesis of the coordination configuration of FeN SACs still faces multiple scientific challenges.

Heterogeneous effects of sodium-glucose cotransporter-2 inhibitors compared to dipeptidyl peptidase-4 inhibitors on nephrolithiasis in older adults with type 2 diabetes.

Background: Type 2 diabetes (T2D) is associated with an increased risk of nephrolithiasis. Emerging evidence suggests that sodium-glucose cotransporter 2 inhibitors (SGLT2i) may reduce this risk; however, data remain inconclusive.

Objective: To examine the risk of nephrolithiasis among users of SGLT2i compared to dipeptidyl peptidase-4 inhibitors (DPP4i) in a real-world population of older adults with T2D.

Evaluation of Digital Transformation Strategies Through Dynamic Business Modeling and Scenario Analysis.

With the continuous advancement of digital technology, traditional manufacturing and service industries are facing dynamic changes with diversified demand and business models. Digital transformation (DT) and dynamic business modeling have become increasingly necessary for companies to evaluate and prioritize better opportunities to improve strategic planning and productivity. This study demonstrates that the system dynamics modeling process, based on the principles of sustainable system development, can fully reflect the comprehensiveness of systems thinking and avoid the drawbacks of linear thinking failing to integrate various departments.

Improved estimation of forage nitrogen in alpine grassland by integrating Sentinel-2 and SIF data.

Nitrogen is an essential element for the growth and reproduction of vegetation in alpine grasslands and plays a vital role in determining the nutrient-carrying capacity of plants and maintaining the balance of forage nutrition supply and demand. In recent years, the widespread application of high-resolution multispectral satellites (i.e.

Supramolecular Structure Enabled Photo-Responsive Charge Transport in Porphyrin-Based Junctions.

Supramolecular electronics offers a valuable opportunity to fabricate functional devices with tunable charge transport (CT) behaviors. Their diverse and non-covalent structures allow for precise modulation of CT with external stimuli. Despite their potential, achieving effective CT modulation in supramolecules through external stimuli remains challenging due to a lack of rigid systems with a predictable response to such stimuli.

Interface Regulated Solid-State Rectification of Peptide via Quantum Dots Self-Assembly Monolayer.

Peptides have been demonstrated as promising candidates for constructing bioelectronic devices. The charge transport through peptides can be effectively modulated via intrinsic composition, structure, and, most notably, interfacial engineering. However, achieving specific electrical properties, such as solid-state rectification, remains a challenge in peptide-based bioelectronics.

Integrated widely targeted metabolomics and flavoromics reveal processing-driven dynamic changes in functional metabolites of leaf tea.

This study employed a widely targeted metabolomics approach combined with flavoromics evaluation to systematically analyze dynamic metabolic variations under four processing techniques: fresh EUL (XY), traditionally dried EUL (HG), green tea processed EUL (GT), and black tea processed EUL (BT). A total of 1839 non-volatile metabolites and 289 volatile metabolites were identified. Key affected metabolites included amino acids (e.

New Rolling Circle Transcription Based on Allosteric Transcription Factors (aTFs) for Trace Detection of Water Contaminants.

Antibiotic and heavy metal contamination in water poses a severe global public health risk, yet conventional detection methods remain constrained by reliance on complex laboratory instrumentation. Although cell-free biosensors utilizing allosteric transcription factors (aTFs) offer promising alternatives, their limited sensitivity impedes reliable detection of small-molecule contaminants. To address this limitation, we developed allosteric transcription factors (aTFs)-regulated rolling circle transcription assay (ARCTA) for ultrasensitive detection of water contaminants.