Robot-Assisted Boari-flap after Orthotopic Neobladder Using the KangDuo Surgical Robot-01 System.

Purpose: Benign ureteroenteric anastomosis stricture (BUES) is a well-recognized long-term complication following urinary diversion (1). While endourological interventions are often first-line, their success rates are limited (2, 3). Open uretero-ileal reimplantation remains the gold standard but is technically challenging and carries high complication risks (2).

Metallothionein 1X is a tumor suppressor gene and inhibits oxidative stress and metastasis in renal cell carcinoma.

Metallothioneins 1X (MT1X) is expressed at low levels in renal cell carcinoma (RCC) and correlates with tumor progression, stage, grade and prognosis, but the mechanism of MT1X's role in renal cell carcinoma is not fully understood at present, and the aim of this study was to investigate the molecular mechanism of MT1X's role in renal cell carcinoma. We used immunofluorescence and flow cytometry to detect intracellular reactive oxygen species (ROS) levels and immunoblotting to detect the expression levels of key proteins of the epithelial-mesenchymal transition (EMT) signaling pathway, transwell assay to assess the cell migration and invasion capacity. It was found that MT1X knockdown significantly upregulated HO-induced intracellular ROS, activated the EMT pathway, and ultimately promoted cell migration and invasion whereas Trolox inhibited cell migration and invasion by suppressing the elevated ROS induced by MT1X knockdown.

Dental trauma in children: monitoring, management, and challenges-a narrative review.

Background And Objective: Traumatic dental injuries (TDIs) in children pose a significant public health challenge, with a global prevalence of 20-30%. These injuries predominantly affect preschool-aged children (1-3 years) due to underdeveloped motor coordination, while school-aged children face risks from sports and accidents. Maxillary central incisors are most commonly involved, often leading to complications such as pulp necrosis, root resorption, and malocclusion, which impair long-term oral function and aesthetics.

Does ureteral stent drainage prior to radical nephroureterectomy increase the risk of intravesical tumor recurrence?

Purpose: To investigate whether ureteral stent drainage (USD) increases the risk of intravesical recurrence in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).

Methods: This retrospective study was conducted involving 2,756 upper tract urothelial carcinoma (UTUC) patients treated with RNU between 2000 and 2022, of whom 77 had a history of USD. The primary endpoint was to assess the association between USD and post-RNU bladder recurrence-free survival (BRFS).

Global polynomial synchronization of neural networks with bidirectional proportional delays via adaptive pinning control and its application in image encryption.

This paper investigates the adaptive global polynomial synchronization (GPS) of neural networks (NNs) with bidirectional proportional delays. By designing an adaptive controller for all node and constructing novel Lyapunov functional, a GPS criterion is derived. To further increase energy efficiency, an adaptive pinning control is also designed and a corresponding GPS criterion is provided.

Sexual experiences of female partners of Chinese prostate cancer survivors: A qualitative study.

Objective: This qualitative study aims to explore the sexual experiences of female partners of Chinese prostate cancer (PCa) survivors, with a focus on understanding how cultural norms, knowledge gaps, and psychological burdens shape their intimate relationships post-treatment.

Methods: This qualitative descriptive study utilized semi-structured interviews to explore the sexual experiences of 16 female partners of Chinese PCa survivors. Participants were purposively recruited from Peking University First Hospital between December 2021 and June 2022.

Long-term impact of synchronous and metachronous bladder cancer on prognosis after radical nephroureterectomy for upper urinary tract urothelial carcinoma: results from a large population-based cohort in China.

Purpose: This study aimed to evaluate the prognostic significance of synchronous and metachronous bladder cancer (BCa) in Chinese patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU).

Materials And Methods: We retrospectively analyzed clinicopathological data from 2921 consecutive nonmetastatic UTUC patients who underwent RNU between 2000 and 2022. Kaplan-Meier survival analysis and Cox proportional hazards regression models were employed to assess the impact of synchronous or metachronous BCa on clinical outcomes.

Should follow-up cystoscopy be performed in upper-tract urothelial carcinoma patients managed with radical nephroureterectomy after a five-year bladder tumor-free period?

There is a lack of consensus regarding the follow-up schedule for patients with upper-tract urothelial carcinoma (UTUC) who remain bladder recurrence-free for 5 years after radical nephroureterectomy (RNU). In this study, we aimed to identify the risk factors for late recurrence in UTUC patients who remained bladder recurrence-free for at least 5 years post-RNU. Data from a large single-center Chinese institution were retrospectively analyzed.

Single-Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling.

Bone metastasis is the second most common site of distant metastatic spread in renal cell carcinoma (RCC) patients, significantly contributing to cancer-related mortality. The metastatic process is driven by both intrinsic tumor cell properties, such as cancer stem cell-like characteristics, and the bone microenvironment. Understanding the complex interactions between cancer cells and their niche is crucial for identifying therapeutic targets to eliminate metastasis-initiating cells and prevent overt metastasis.

Non-contrast cine magnetic resonance urography in evaluating and monitoring of primary obstructive megaureter: a case series study.

Objective: To evaluate the feasibility and usefulness of cine magnetic resonance urography (MRU) as a novel examination for primary obstructive megaureter (POM).

Material And Methods: The study was conducted on 44 patients with POM who underwent cine MRU from May 2020 to October 2022. Referring to the international system of vesicoureteral reflux, patients were divided into the low-risk (grade I-IV) and the high-risk (grade V) groups.

First-in-human Study of a Dual-modality Prostate-specific Membrane Antigen-targeted Probe for Preoperative Positron Emission Tomography/Computed Tomography Imaging and Intraoperative Fluorescence Imaging in Prostate Cancer.

Background And Objective: Accurately distinguishing between cancerous and noncancerous tissues during robot-assisted radical prostatectomy (RARP) is a challenge that can increase the risk of residual disease. This study aimed to evaluate the safety, optimal dose and accuracy of a dual-modality prostate-specific membrane antigen (PSMA)-targeted probe (Ga-P3) for preoperative positron emission tomography (PET)/computed tomography (CT) imaging and intraoperative fluorescence imaging in prostate cancer.

Methods And Surgical Procedure: Each participant received an intravenous chemical dose of Ga-P3 (10, 20, and 40 μg/kg), with radioactivity of 3.

Pattern and risk factors of local recurrence and intravesical recurrence after segmental ureterectomy for upper tract urothelial carcinoma.

Objective: To investigate the pattern and risk factors of local recurrence and intravesical recurrence of ureteral upper tract urothelial carcinoma (UTUC) following segmental ureterectomy (SU).

Methods: From February 2012 to August 2021, a retrospective analysis was conducted on patients following SU. Univariate and multivariate Cox regression analysis were used to evaluate the risk factors.

Fixed-time synchronization of proportional delay memristive complex-valued competitive neural networks.

The fixed-time synchronization (FXS) is considered for memristive complex-valued competitive neural networks (MCVCNNs) with proportional delays. Two less conservative criteria supporting the FXS of MCVCNNs are founded by involving Lyapunov method and inequality techniques. Suitable switch controllers are designed by defining different norms of complex numbers instead of treating complex-valued neural networks as two real-valued systems.

Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering.

The pleiotropic effects of human disease and the complex nature of gene-interaction networks require knock-in mice allowing for multiplexed gene perturbations. Here we describe a series of knock-in mice with a C57BL/6 background and with the conditional or constitutive expression of LbCas12a or of high-fidelity enhanced AsCas12a, which were inserted at the Rosa26 locus. The constitutive expression of Cas12a in the mice did not lead to discernible pathology and enabled efficient multiplexed genome engineering.

Exploring the Potential of tsRNA as Biomarkers for Diagnosis and Treatment of Neurogenetic Disorders.

tRNA-derived small RNA (tsRNA) is a recently discovered small non-coding RNA (ncRNA) molecule that widely exists in prokaryotic and eukaryotic transcriptomes and is produced by specific cleavage of mature tRNA or precursor tRNA. In recent years, with the development of high-throughput sequencing technology, tsRNA has been found to have a variety of biological functions, including gene expression regulation, stress signal activation, etc. In addition, it has been found that these molecules are abnormally expressed in various diseases and participate in various pathological processes, which play an important role.

 (Fabaceae), a new species from riparian meadows of Yangtze River basin, China.

(Fabaceae), from Yangtze River basin, China, is described and illustrated as a new species. It is a dwarf shrublet occurring in the riparian meadows along the banks of rivers and lakes. It is morphologically similar to , , and , but differs by its prostrate or decumbent habit, angulate but not furrowed stems, and small stipules (ca.

Tumor-derived exosomal KPNA2 activates fibroblasts and interacts with KIFC1 to promote bladder cancer progression, a process inhibited by miR-26b-5p.

Background: Recent studies have illuminated the complexities of treating advanced bladder cancer (BCa), underscoring the importance of comprehending its molecular mechanisms for creating novel therapies. While the role of Karyopherin a2 (KPNA2) in promoting BCa growth is established, the precise mechanism remains elusive.

Methods: To investigate the regulatory role of KPNA2 in BCa, we employed a comprehensive approach integrating clinical case data and bioinformatics analysis to evaluate the expression of KPNA2 in BCa tissues.

Innovative logic "AND" gate gene circuits for bladder cancer treatment: preclinical study.

In the evolving field of precision oncology, the synthesis of gene circuits that specifically target cancer cells while preserving normal tissue marks a significant breakthrough. However, traditional approaches typically concentrate on single-gene targets, lacking the directed recognition and control among the intricate networks of signaling pathways. Our study presents a synthetic gene circuit, the Logic "AND" Gate Dual-Target Genetic Circuit (LAG-DTGC), which integrates multiple signals to achieve comprehensive reprogramming of various signaling pathways in bladder cancer (BC) cells.

Segmental Resection with Ureteral Reimplantation Radical Nephroureterectomy with Bladder Cuff Removal for Urothelial Carcinoma of Distal Ureter: A Propensity Score Matching Study in a Large Chinese Center.

We aim to compare the clinical outcomes of radical nephroureterectomy with bladder cuff removal (RNU) and segmental resection with ureteral reimplantation (RR) in Chinese patients with distal ureteral urothelial carcinoma. A retrospective analysis of medical records was performed for 922 patients found to have distal ureteral cancer, defined as below the level of the iliac vessels, with 747 patients who underwent RNU and 175 who underwent RR included in the final analysis. The primary endpoints included clinical outcomes and changes in the estimated glomerular filtration rate (eGFR).

Weak acid and pepsin reflux induce laryngopharyngeal mucosal barrier injury: A rabbit-model-based study.

Objective: Using rabbit models, this study simulated the laryngopharynx's response to the synergistic effects of various acidic reflux environments and pepsin to investigate the response mechanism underlying weak acid reflux and pepsin in the mucosal barrier injury of laryngopharyngeal reflux.

Methods: The rabbits were divided into six groups, and the original larynx was recorded for each group. During the study period, rabbits were sprayed with different doses of acid and pepsin solutions and monitored for hypopharyngeal mucosal transient impedance before and after modeling.

Robot-Assisted Radical Prostatectomy Using the KangDuo Surgical Robot-1500: A Prospective, Multicenter, Single-Arm Clinical Study.

The KangDuo Surgical Robot-1500 (KD-SR-1500) is a newly developed surgical robot. We aim to evaluate the feasibility and efficiency of the KD-SR-1500 system for robot-assisted radical prostatectomy (RARP). This prospective, multicenter, single-arm clinical study was conducted among 18-75-year-old patients with suspected T1-2N0M0 prostate cancer scheduled for RARP.

NRP1 overexpression potentially enhances osimertinib resistance in NSCLC via activation of the PI3K/AKT signaling pathway.

Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is the main cause of mortality in lung cancer. This study aimed to investigate the roles of neuropilin 1 (NRP1) in non-small cell lung cancer (NSCLC). NRP1 expression was assessed in tumor tissues from patients with osimertinib-resistant (OR) NSCLC and osimertinib-responsive NSCLC as well as in patients with paracancerous NSCLC tissues who did not undergo radiotherapy or chemotherapy.