Sexual experiences of female partners of Chinese prostate cancer survivors: A qualitative study.

Objective: This qualitative study aims to explore the sexual experiences of female partners of Chinese prostate cancer (PCa) survivors, with a focus on understanding how cultural norms, knowledge gaps, and psychological burdens shape their intimate relationships post-treatment.

Methods: This qualitative descriptive study utilized semi-structured interviews to explore the sexual experiences of 16 female partners of Chinese PCa survivors. Participants were purposively recruited from Peking University First Hospital between December 2021 and June 2022.

Ultra-broadband spectra of 20 amino acids from terahertz to mid-infrared regime.

An ultra-broadband absorption spectral database encompassing 20 solid-state amino acids is meticulously constructed, spanning an unprecedented frequency range of 0.2-120 THz (6.7-4000 cm).

Yak (Bos grunniens) excreta further facilitate the positive effects of soil fauna on litter decomposition in alpine meadow ecosystems.

The influence of grazing activity, specifically excreta deposition, on the positive contributions of soil fauna to litter decomposition was not comprehensively examined. We conducted a 660-day field experiment to test the interactive effects of yak excreta and soil fauna on litter decomposition and underlying driving mechanisms. We found adding yak excreta further increased the positive effect of soil fauna on litter decomposition.

Unraveling the complex role of tumor-associated neutrophils within solid tumors.

Neutrophils are integral to the frontline defense against pathogenic bacterial and fungal invasions. Beyond their traditional roles, these cells are increasingly recognized for their dualistic contributions to the pathology of autoimmune and inflammatory diseases, as well as their complex involvement in cancer progression. Neutrophils interact with different disease states, highlighting their potential as therapeutic targets.

Development and validation of a radiologically-based nomogram for preoperative prediction of difficult laparoscopic cholecystectomy.

Background: Preoperative prediction of difficult laparoscopic cholecystectomy (DLC) remains challenging, as intraoperative anatomical complexity significantly increases complication risks. Current studies have not reached consensus on definitive risk factors for DLC.

Materials And Methods: This retrospective study aimed to identify DLC risk factors and develop a predictive model.

Drug development for chronic hepatitis B functional cure: Recent progress.

Chronic hepatitis B virus (HBV) infection affects approximately 254 million individuals globally, contributing to significant morbidity and mortality due to HBV-related liver failure and cirrhosis, which result in millions of fatalities each year. Although approved antiviral nucleos(t)ide analogues can effectively suppress HBV replication, their ability to reduce hepatitis B surface antigen (HBsAg) levels in plasma remains limited. The clinical application of the immunomodulator interferon-alpha is restricted by concerns regarding its safety and the severity of associated adverse reactions, rendering long-term administration challenging.

Prognostic impact of early versus delayed loop diuretic administration in sepsis: a propensity score-matched analysis using the MIMIC-IV database.

Background: Fluid resuscitation is a standard intervention for patients with sepsis, however, the ideal timing for initiating fluid deresuscitation has not been well established. This study examines the prognostic impact of early versus delayed initiation of loop diuretics in patients with sepsis.

Methods: Data for this analysis were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation.

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of nerve cells in the spinal cord and brain. We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient with ALS due to SOD1 Mutation. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.

Collaborative Governance Strategies for Fever Clinics: A Multi-Scenario Evolutionary Game Analysis.

Purpose: China's fever clinics succeeded during the Coronavirus Disease 2019 pandemic but revealed operational deficiencies. This study explores multiparty coordination mechanisms in fever clinics to improve collaborative management and efficiency in epidemic control.

Patients And Methods: A tripartite evolutionary game model was constructed, involving "primary healthcare institutions-non-primary healthcare institutions-government" to analyze the evolutionary stable strategies among these entities in different scenarios.

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi008-A) from a patient with Spinocerebellar Ataxia Type 3.

Abnormal trinucleotide CAG repeat expansions in exon 10 of the ataxin-3 (ATXN3) gene has been identified as the cause of Spinocerebellar Ataxia Type 3 (SCA3). We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient with genetically confirmed SCA3. The pluripotency of these iPSCs was verified by the expression of several undifferentiated hPSCs markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.

Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel.

Terahertz (THz) waves, positioned between microwave and infrared in the electromagnetic spectrum, have promising applications in medical imaging and biomedicine. In this study, terahertz irradiation at 2.52 THz (100 mW/cm2) did not alter the proliferation of human umbilical vein endothelial cells (HUVECs), but significantly enhanced their angiogenic capacity.

Core capabilities of Chinese centers for disease control and prevention public health personnel: a network analysis from Northeast China.

Background: The COVID-19 pandemic has highlighted the continued inadequacy of the capability of Center for Disease Control and Prevention (CDC) public health personnel to respond effectively to emerging infectious disease outbreaks, as well as the urgent need for specific tools to assess the capability needed by CDC public health personnel in the post-pandemic era. Using network analysis, we aimed to analyze the comprehensive capacities of CDC public health staff and the relationships between these capacities. We also examined the impact of standardized public health training on their capacities and provided actionable recommendations for improving their training and overall capability.

Carbon information disclosure and corporate financial performance-Empirical evidence based on heavily polluting industries in China.

Global climate change has become one of the most large-scale, widespread, and far-reaching challenges facing mankind. Against this background, China has proposed a "dual-carbon" target in 2020, which greatly demonstrates China's determination and commitment to carbon emission reduction, and the burden of realizing the "dual-carbon" target is mainly borne by heavy polluters. The burden of achieving the "dual-carbon" goal is mainly borne by the heavily polluting firms.

Study on the repair function of radiation-induced salivary gland injury using human amniotic mesenchymal stem cells pre treated with hypoxia.

Objective: To investigate the reparative effect of hypoxia pretreated hAMSCs on radiation-induced damage to salivary gland function in mice.

Methods: hAMSCs were separated from human amniotic tissues by mechanical and enzymatic digestion methods and a 15 Gy electron beam was used to locally irradiate the neck of mouse to create a salivary gland injury model. The mouse models were randomly divided into four groups: control group, IR+PBS group, IR+Nor group and IR+HP group.

Molecular characterization of avian pathogenic Escherichia coli strains in Jiangxi Province, China, and development of polyvalent inactivated vaccines.

Avian pathogen Escherichia coli (APEC) poses a significant threat to poultry farming, causing colibacillosis in various hosts, including chickens, ducks, geese, and pigeons. This study aimed to investigate the molecular epidemiology of APEC in Jiangxi Province, China, to inform prevention and control strategies. Between 2020 and 2024, 186 APEC strains were isolated and identified, with 88.

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease.

Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.

Surface Microstructure Enhanced Cryogenic Infrared Light Emitting Diodes for Semiconductor Broadband Upconversion.

Broadband upconversion has various applications in solar photovoltaic, infrared and terahertz detection imaging, and biomedicine. The low efficiency of the light-emitting diodes (LEDs) limits the broadband upconversion performance. In this paper, we propose to use surface microstructures to enhance the electroluminescence efficiency (ELE) of LEDs.

PROGNOSTIC IMPLICATIONS OF CHANGES IN PLATELET TRAJECTORIES IN PATIENTS WITH SEPSIS: A RETROSPECTIVE ANALYSIS USING THE MEDICAL INFORMATION MART FOR INTENSIVE CARE IV DATABASE.

Objective: Patients with sepsis often experience reductions or increases in platelet counts, but the implications of these temporal patterns on prognosis remain unclear. The aim of this study was to investigate the impact of changes in platelet trajectories on the clinical prognosis of sepsis. Methods: This study was a retrospective analysis using data from the Medical Information Mart for Intensive Care IV database.

Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial.

Importance: Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking.

Objective: To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation, expressed as complete spontaneous bowel movements (CSBMs).

An Immunomodulator-Boosted Lactococcus Lactis Platform For Enhanced In Situ Tumor Vaccine.

In situ vaccination is an attractive type of cancer immunotherapy, and methods of persistently dispersing immune agonists throughout the entire tumor are crucial for maximizing their therapeutic efficacy. Based on the probiotics usually used for dietary supplements, an immunomodulator-boosted Lactococcus lactis (IBL) strategy is developed to enhance the effectiveness of in situ vaccination with the immunomodulators. The intratumoral delivery of OX40 agonist and resiquimod-modified Lactococcus lactis (OR@Lac) facilitates local retention and persistent dispersion of immunomodulators, and dramatically modulates the key components of anti-tumor immune response.

[Functions and mechanisms of testicular descent in based on transcriptomics and metabolomics].

This study aims to explore the functions and mechanisms of testicular descent in , and analyze the changes in genes and metabolite levels in this process. Illumina NovaSeq and liquid chromatography-mass spectrometry were used for the transcriptomic analysis and metabolomic analysis, respectively, of the normal and descending testis of . .

Joint association of cardiovascular health and frailty with all-cause and cause-specific mortality: a prospective study.

Background: Poor cardiovascular health (CVH) and physical frailty were reported to increase mortality risk, but their joint effects have not been fully elucidated.

Objectives: We aimed to explore the separate and joint effects of CVH and frailty on mortality based on two perspectives of Life's Essential 8 (LE8) and Framingham Risk Score (FRS).

Methods: 21 062 participants in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 were involved in this study.