Insights into the epidemiological analysis of subarachnoid hemorrhage burden and trends in middle-aged and elderly populations: a global perspective from the Global Burden of Disease Study 2021.

Background: Subarachnoid hemorrhage (SAH) represents a critical neurological emergency with substantial morbidity and mortality, particularly affecting middle-aged and elderly populations. While previous studies have documented SAH epidemiology, the relationship between health workforce distribution and SAH burden remains largely unexplored globally. This study analyzed global epidemiological patterns, temporal trends, and novel associations between health workforce categories and SAH burden among adults aged ≥ 45 years from 1990 to 2021.

A persistent high-chlorophyll turbid zone off the west coast of Hainan Island, China.

Chlorophyll-a (Chl-a) and total suspended sediments (TSS) are globally critical tracers in marine biogeochemistry, decoding ecological health, carbon dynamics, and planetary-scale material fluxes. This study investigates the persistent high-chlorophyll turbid zone off the west coast of Hainan Island, China, integrating satellite observations and high-resolution numerical modeling. Results reveal a year-round high Chl-a (1.

Global, Regional, and National Burden of Smoking-Related Diseases and Associations With Health Workforce Distribution, 1990-2021: Analysis From the Global Burden of Disease Study 2021.

Objectives: To analyze global trends in smoking-related disease burden from 1990-2021 and examine associations with health workforce distribution across countries.

Methods: We analyzed smoking-related deaths and disability-adjusted life years using Global Burden of Disease 2021 data for 204 countries. Age-standardized rates were calculated for 27 geographic regions.

[Current status of acupuncture education and reflections on future reforms].

Education is a crucial element in the development of acupuncture as a discipline, providing essential talent support for its future advancement. A structured interview was conducted with renowned acupuncture expert Professor , focusing on key topics such as the core of acupuncture education, the connotation and development of acupuncture textbooks, and acupuncture teaching models. Through in-depth discussion, the current problems in acupuncture education were analyzed, and possible solutions were explored, aiming to offer ideas for the innovative development of acupuncture education.

Correction: TAK1 inhibition by natural cyclopeptide RA-V promotes apoptosis and inhibits protective autophagy in Kras-dependent non-small-cell lung carcinoma cells.

[This corrects the article DOI: 10.1039/C8RA04241A.].

M1 Macrophage-Derived Extracellular Vesicles Loaded with CX3CR1 siRNA for the Treatment of Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) remains a highly fatal malignancy, with inadequate therapeutic strategies and an adverse prognosis. Gene therapy raises a prospective option to overcome the challenges posed by conventional therapeutic strategies. The CX3CL1-CX3CR1 axis plays a critical role in promoting tumor cell proliferation, migration, and metastasis in PDAC.

Correction: Is the single-ion conductor cubic LiLaZrO a binary ionic electrolyte?

Correction for 'Is the single-ion conductor cubic LiLaZrO a binary ionic electrolyte?' by Peng Bai, , 2025, https://doi.org/10.1039/d5mh00069f.

Identification of CWH43 as a novel prognostic biomarker and therapeutic target in clear cell renal cell carcinoma by a multi-omics approach and correlation with autophagy progression.

Background: Clear cell renal cell carcinoma (ccRCC) poses significant challenges due to its asymptomatic nature and poor prognosis at advanced stages. Identifying novel biomarkers is essential for enhancing prognostic accuracy and therapeutic strategies. This study explores the CWH43 gene, utilizing multi-omics data to determine its role in ccRCC.

Current-Dependent Morphologies of Insulating Electrodeposits in Li-O Batteries Controlled by Coupled Ion-Electron Transfer Kinetics.

Lithium-oxygen batteries (Li-O) present a compelling prospect for the next generation of batteries owing to their exceptionally high theoretical energy density. However, the performance of Li-O batteries remains limited by the formation of insulating oxides covering the gas electrode, leading to low capacity or even unexpected sudden death. Existing mathematical models using Butler-Volmer kinetics exhibit uncertainties and inaccuracies in predicting the voltage responses and the morphological evolution of the insulating oxides.

Global trends and hotspots in research for sudden hearing loss over the past two decades: a bibliometric and visualization analyses.

Objective: This study aims to examine and visually map the characteristics, research hotspots, and emerging trends in sudden hearing loss research over the past two decades.

Methods: A systematic search was conducted for English-language articles and reviews on sudden hearing loss published between 2004 and 2023 in the Web of Science Core Collection. Using Citespace, VOSviewer, and Bibliometrix, we performed a comprehensive analysis and visualization of publications, countries, institutions, authors, journals, and keywords.

Is the single-ion conductor cubic LiLaZrO a binary ionic electrolyte?

Garnet-type cubic LiLaZrO (c-LLZO) is a single-ion conductor, but the dynamics of lithium dendrite during one-way plating in Li|c-LLZO|Li symmetric cells demonstrate several trends that all resemble the dendrite initiation mechanisms found in binary liquid electrolytes. This Opinion article provides an analysis of the possible charge carriers and discusses the four species that coexist in c-LLZO when continued electrochemical reactions take place at the opposite interfaces of the ceramic electrolyte. The new understanding explains the possibility of significant concentration polarization before the onset of dendrites in c-LLZO, without violating commonly accepted rules and physical laws.

The mystery of the missing P waves: a case report.

Background: This case highlights the diagnostic challenges of atrial flutter with concealed atrial activity on surface electrocardiograms, emphasizing the necessity of invasive electrophysiological study to avoid unnecessary pacemaker implantation in patients with structural heart disease-a scenario rarely documented in current literature.

Case Presentation: A 60-year-old ​Chinese woman with rheumatic mitral stenosis and prior maze procedure presented with fatigue and bradycardia (heart rate, 47 beats per minute). Surface electrocardiograms (including modified Lewis leads) revealed no discernible P waves, while echocardiography demonstrated atrial mechanical silence.

A narrative review on the effectiveness of PPSV23 vaccination in adults in China.

Pneumococcal Polysaccharide Vaccine (PPSV23) is available for free in some Chinese cities for elderly patients and those with comorbidities. However, there is a lack of studies summarizing its preventive effect specifically in Chinese adults. This review aims to discuss the epidemiology of pneumococcal disease, coverage and effectiveness of PPSV23 vaccination, elderly individuals and patients with comorbidities, coadministration of PPSV23 vaccine with other vaccines, and future directions for its use in China.

Identification of a ligand-binding site on tubulin mediating the tubulin-RB3 interaction.

For decades, microtubules-composed of αβ-tubulin dimers-have been primary targets for cancer chemotherapy. While eight binding sites on the tubulin dimer have been structurally characterized, this study reveals a ninth. We found that the tubulin inhibitor Tumabulin-1 (TM1, a BML284 derivative) binds simultaneously to the well-known colchicine site and a previously unknown site, designated as Tumabulin site.

Rhynchophylline promotes microglia phenotypic transformation and repair of cerebral ischaemic injury through the JAK2/STAT3 pathway.

Background: Rhynchophylline (RIN) is an alkaloid known for its ability to effectively block signal transduction related to various neurodegenerative diseases. However, the specific mechanism by which RIN regulates microglial activation and cerebral ischemia remains unexplored. This study aims to investigate the function and molecular pathways through which RIN activates the JAK2/STAT3 signaling cascade, promoting the transformation of microglial phenotypes that contribute to recovery from cerebral ischemic injury.

Tailoring Crystal Growth Regulation and Dual Passivation for Air-Processed Efficient Perovskite Solar Cells.

Hybrid metal halide perovskite solar cells (PSCs) are emerging as highly competitive next-generation photovoltaics due to their excellent performance and low production cost. However, the construction of high-efficiency PSCs typically requires an inert nitrogen environment within a glove box, inadvertently increasing manufacturing costs and hindering the transition from lab-scale to industrial-scale production. In this work, an air ambient fabrication of pure α-phase FAPbI PSCs with high-efficiency and stability, utilizing a dual-functional engineering strategy assisted by 3-Guanidinopropionicacid (3-GuA) is reported.

Design of a CrZrO-CuMnO@NaWO catalyst-oxygen carrier system for efficient chemical looping oxidative dehydrogenation of propane.

In the utilisation of most oxide-based propane dehydrogenation (PDH) catalysts, each reaction-regeneration cycle necessitates both coke combustion and hydrogen reduction to achieve complete regeneration of the catalyst. However, the need for hydrogen reduction makes it difficult to use such catalysts in chemical looping oxidative dehydrogenation (CL-ODH) processes. This study prepared a series of CrZrO catalysts with Cr/Zr atomic ratios ranging from 0.

Influential publications in sudden hearing loss: a bibliometric and visual synopsis of the top 100 cited articles.

Background: Sudden hearing loss (SHL) is a prevalent emergency in otolaryngology. Despite its frequency, there is a lack of econometric analysis and visualisation of the most significant SHL research literature. This study aims to provide a comprehensive overview and explore the characteristics of the 100 most cited articles in SHL through bibliometric analysis.

Evaluation of contralateral arterial flow compensation using transcranial Doppler in acute internal carotid artery occlusion and implications for neurological outcome.

Acute internal carotid artery occlusion (AICAO) can result in malignant cerebral edema and unfavorable patient outcomes. This study evaluated the utility of transcranial Doppler (TCD) in assessing contralateral flow compensation and predicting outcomes in patients with AICAO. We enrolled 51 patients within 6 h of symptom onset and conducted TCD examinations to evaluate collateral circulation.

Association between chest pain and risk of depression in patients with or without coronary heart disease.

Background: Research on the relationship between chest pain and depression risk in patients with or without coronary heart disease (CHD) is limited.

Methods: This cross-sectional study includes adults in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. The diagnoses of chest pain and CHD were based on self-reports from participants, while depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9).

Exogenous ALA applied on different plant parts promotes tomato fruit quality and GABA synthesis.

Introduction: Tomato fruit are rich in -aminobutyric acid (GABA), which lowers blood pressure and improves sleep. An increase in GABA content is important for enhancing the nutritional quality of tomato fruit.

Methods: To investigate the effects of 5-aminolevulinic acid (ALA) on fruit quality and GABA synthesis in greenhouse tomatoes, the tomato cultivar ( cv.

Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance.

Selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitors not only exhibit antitumor efficacy but also offer the potential to mitigate the toxicities typically associated with broader PARP inhibition. In this study, we designed and synthesized a series of small molecules targeting highly selective PARP1 inhibitors. Among these, demonstrated excellent selectivity to PARP1 along with the capability to effectively cross the blood-brain barrier (BBB).

Modeling ethanol/water adsorption in all-silica zeolites using the real adsorbed solution theory.

A comprehensive set of single-component and binary isotherms were collected for ethanol/water adsorption into the siliceous forms of 185 known zeolites using grand-canonical Monte Carlo simulations. Using these data, a systematic analysis of ideal/real adsorbed-solution theory (IAST/RAST) was conducted and activity coefficients were derived for ethanol/water mixtures adsorbed in different zeolites based on RAST. It was found that activity coefficients of ethanol are close to unity while activity coefficients of water are larger in most zeolites, indicating a positive excess free energy of the mixture.

Surface Microstructure Enhanced Cryogenic Infrared Light Emitting Diodes for Semiconductor Broadband Upconversion.

Broadband upconversion has various applications in solar photovoltaic, infrared and terahertz detection imaging, and biomedicine. The low efficiency of the light-emitting diodes (LEDs) limits the broadband upconversion performance. In this paper, we propose to use surface microstructures to enhance the electroluminescence efficiency (ELE) of LEDs.