The effect of cognition on the association between cerebral small vessel disease burden and motor function: a cross-sectional study.

Objective: Cerebral small vessel disease (CSVD) is a common condition among the elderly population. In patients with CSVD, imaging markers, motor function, and cognition are closely interrelated. This study aimed to analyze the effect of cognition on the association between CSVD burden and motor function.

Development of a carbon nanoparticle-guided nomogram for predicting lateral cervical lymph node metastasis in clinically node-negative papillary thyroid carcinoma.

Objective: To develop and validate a carbon nanoparticle-enhanced nomogram for predicting lateral lymph node (LLN) metastasis in patients with clinically node-negative (cN0) papillary thyroid carcinoma (PTC).

Methods: A retrospective analysis was conducted on 421 cN0 PTC patients treated between 2014 and 2020. Patients were randomly divided into training (n=316) and internal validation (n=105) cohorts.

The past, present, and future of ALK-targeted drug discovery.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor superfamily, which plays an essential role in the development of the nervous system and is aberrantly activated in various cancers through gene rearrangements, point mutations, or amplifications. Oncogenic ALK alterations are particularly prominent in non-small cell lung cancer (NSCLC), anaplastic large cell lymphoma (ALCL), and neuroblastoma, where they contribute to tumorigenesis, proliferation, and therapeutic resistance. The clinical success of first-generation ALK inhibitors has spurred the development of more potent second- and third-generation agents designed to overcome resistance mutations and improve central nervous system (CNS) penetration.

Recent advances of the mechanistic target of rapamycin (mTOR) inhibitors for drug discovery.

The mechanistic target of rapamycin (mTOR), a serine/threonine kinase, serves as a central regulator of cellular growth, proliferation, metabolism, and survival through its two distinct multiprotein complexes, mTORC1 and mTORC2. Aberrant activation of the mTOR signaling pathway is frequently implicated in a wide range of human cancers and is closely associated with tumor progression, therapeutic resistance, and poor clinical outcomes. Accordingly, pharmacological inhibition of mTOR has emerged as a compelling strategy in the development of anticancer therapeutics.

Discovery of Highly Potent, Selective, and Liver-Targeted THR-β Agonists for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.

With the improvement of living standards, metabolic-disorder-associated steatohepatitis (MASH) has posed a serious threat to public health. In 2024, THR-β agonist was approved by the FDA as the first market drug for the treatment of MASH. In this work, we discovered a new class of THR-β agonists through structure-based rational design.

Composition and distribution characteristics of acetic acid-related bacteria during the fermentation process of strong-flavor baijiu.

Ethyl acetate (EA) has an important impact on the quality of Strong-flavor Baijiu (SFB) and is synthesized from acetic acid (AA) and ethanol by microorganisms during the fermentation process. However, the composition and distribution characteristics of AA-related microorganisms are unclear in the SFB production process. In this study the changes of bacterial community and concentration of AA during the fermentation process (7-67d) and different season fermentation (spring and summer) was investigated, and the composition of AA-related bacteria was analyzed to reveal the distributional characteristics of AA-related bacteria in brewing environment (Daqu, raw materials, pit mud, ground and tools).

The neutrophil percentage-to-albumin ratio mediates the association between depression and all-cause mortality in U.S. adults: Evidence from NHANES 2009-2018.

Background: Depression significaantly reduces the quality of life for hundreds of millions of people globally. Evidence suggests associations among depression, the neutrophil percentage-to-albumin ratio (NPAR), and all-cause mortality (ACM). However, the interrelationship was not elucidated.

Identification of CWH43 as a novel prognostic biomarker and therapeutic target in clear cell renal cell carcinoma by a multi-omics approach and correlation with autophagy progression.

Background: Clear cell renal cell carcinoma (ccRCC) poses significant challenges due to its asymptomatic nature and poor prognosis at advanced stages. Identifying novel biomarkers is essential for enhancing prognostic accuracy and therapeutic strategies. This study explores the CWH43 gene, utilizing multi-omics data to determine its role in ccRCC.

STK32C promotes colon tumor progression through activating c-MYC signaling.

Serine/threonine kinase 32C (STK32C) is a member of the AGC kinase family and has been identified as a potential promoter of cancer progression, though its role remains largely uncharacterized. This study explores the impact of STK32C on colorectal cancer (CRC) progression, particularly focusing on its influence on the MYC signaling pathway. Analysis of CRC samples and in vitro experiments revealed that STK32C expression is significantly elevated in cancerous tissues and associated with poor prognosis.

Baseline factors associated with post-stenting intracranial pressure in patients with idiopathic intracranial hypertension with venous sinus stenosis.

Background: Venous sinus stenting is an effective treatment for idiopathic intracranial hypertension (IIH) with venous sinus stenosis (VSS), which can reduce intracranial pressure (ICP) and alleviate symptoms. The present study aimed to investigate the associations between baseline characteristics and 6-month post-stenting ICP (hereinafter referred to as ICP6M).

Methods: Data from a prospective cohort of patients with IIH + VSS who received venous sinus stenting and a 6-month follow-up at a tertiary medical institution in China between January 2017 and June 2023 were analyzed.

Can coenzyme Q10 supplementation reduce exercise-induced muscle damage and oxidative stress in athletes? A systematic review and meta-analysis.

Background And Purpose: Coenzyme Q10 (CoQ10) has been widely recognized for its potential antioxidative and cytoprotective properties. Oxidative stress and muscle damage can impair recovery in athletes. This meta-analysis evaluates the impact of CoQ10 supplementation on oxidative stress and muscle damage biomarkers in athletes.

Dehydrotrametenolic acid methyl ester, a triterpenoid of Poria cocos, alleviates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation via targeting Caspase-1 in mice.

Non-alcoholic steatohepatitis (NASH) has emerged as a prevalent chronic liver disease with a huge unmet clinical need. A few studies have reported the beneficial effects of Poria cocos Wolf (P. cocos) extract on NASH mice, but the active components were still unknown.

Efects of Y-6 Sblingual Tablets for Paients with Acte Ischemic Stok (FUTURE): a phase II, randomised, double-blind, double-dummy, placebo-controlled, parallel trial.

Background: Acute ischaemic stroke, due to its high mortality and disability rates, imposes a significant economic and social burden worldwide. Typically, endovascular treatment within the therapeutic window is provided to salvage the ischaemic penumbra; however, even when recanalisation is successful during endovascular treatment, the clinical outcomes may still be disappointing. This highlights the necessity of further research, so as to discover better solutions to futile recanalisation and improve patient outcomes.

A deep learning model based on self-supervised learning for identifying subtypes of proliferative hepatocellular carcinoma from dynamic contrast-enhanced MRI.

Objectives: This study employs dynamic contrast-enhanced MRI (DCE-MRI) to noninvasively predict the proliferative subtype of hepatocellular carcinoma (HCC). This subtype is marked by high tumor proliferation and aggressive clinical behavior. We developed a deep learning prediction model that employs a dynamic radiomics workflow and self-supervised learning (SSL).

Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation.

Salt-inducible kinase 1 (SIK1) participates in various physiological processes, yet its involvement in regulating skeletal muscle glucose uptake remains unclear. Previously, we showed that phanginin A, a natural compound isolated from Caesalpinia sappan Linn, activated SIK1 to suppress gluconeogenesis in hepatocytes. Here, we aimed to elucidate the effects of SIK1 on skeletal muscle glucose uptake by using phanginin A.

Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS).

Background: Inflammation and blood-brain barrier disruption may contribute to the pathogenesis of ischaemic stroke. Minocycline was shown to exert anti-inflammatory effects by attenuating microglial activation and protecting blood-brain barrier in preclinical studies. Previous small-scale clinical studies have suggested that minocycline may have a potential beneficial effect on prognosis in acute ischaemic stroke.

Replication factor C4, which is regulated by insulin-like growth factor 2 mRNA binding protein 2, enhances the radioresistance of breast cancer by promoting the stemness of tumor cells.

Radiotherapy resistance, is usually caused by enhanced tumor stemness and poses a significant challenge in treating breast cancer (BRCA). In this study, we investigated the molecular regulatory mechanism of radiotherapy sensitivity in BRCA associated with replication factor C4 (RFC4) and insulin-like growth factor 2 mRNA binding protein 2 mRNA Binding Protein 2 (IGF2BP2). RFC4 expression was increased in BRCA cell lines and tissues, and high RFC4 expression in BRCA patients predicted the occurrence of lymphatic metastasis.

Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells.

Cholestatic liver diseases are characterized by excessive bile acid accumulation in the liver. Endothelial cells (ECs) shape the local microenvironment in both normal conditions and liver injury, yet their role in cholestasis is unclear. Through a comparative analysis of single-cell RNA sequencing data from various murine models of liver injury, we identify distinctive Myc activation within ECs during obstructive cholestasis resulting from bile duct ligation (BDL).

Psychometric Properties of Self-Reported Financial Toxicity Measures in Cancer Survivors: An Overview of Systematic Reviews.

Aim(s): To assess the methodological quality and psychometric properties of self-reported financial toxicity measures for cancer survivors, to offer evidence-based guidance for the selection of these measures in clinical practice, and to supply methodological references for the enhancement and development of related measures in the future.

Design: An overview of systematic reviews.

Methods: Four academic databases were searched to conduct an overview of systematic reviews published from inception to August 2024.

PRMT6 promotes colorectal cancer progress via activating MYC signaling.

Colorectal cancer (CRC) remains a major global health challenge, with high rates of incidence and mortality. This study investigates the role of protein arginine methyltransferase 6 (PRMT6) as an oncogene in CRC and its mechanistic involvement in tumor progression. We found that PRMT6 is significantly overexpressed in CRC tissues compared to adjacent normal tissues and is associated with poorer patient survival.

Advancements in the treatment of cerebral ischemia-reperfusion injury: Acupuncture combined with mesenchymal stem cells transplantation.

Cerebral ischemia-reperfusion injury (CIRI) constitutes a significant etiology of exacerbated cerebral tissue damage subsequent to intravenous thrombolysis and endovascular mechanical thrombectomy in patients diagnosed with acute ischemic stroke. The treatment of CIRI has been extensively investigated through a multitude of clinical studies. Acupuncture has been demonstrated to be effective in treating CIRI.

Digital Interventions for Promoting Skin Self-Examination Behaviors of Melanoma Survivors: A Systematic Review.

Background: Regular and thorough skin self-examination (SSE) is an important strategy to reduce mortality among melanoma survivors. However, less than a quarter of melanoma survivors participate in skin self-examination.

Objective: The aim of this study was to systematically review the effectiveness of digital interventions on SSE-related practices in melanoma survivors.

BD-StableNet: a deep stable learning model with an automatic lesion area detection function for predicting malignancy in BI-RADS category 3-4A lesions.

The latest developments combining deep learning technology and medical image data have attracted wide attention and provide efficient noninvasive methods for the early diagnosis of breast cancer. The success of this task often depends on a large amount of data annotated by medical experts, which is time-consuming and may not always be feasible in the biomedical field. The lack of interpretability has greatly hindered the application of deep learning in the medical field.