Synergistic Engineering of NiCoFe Layered Hydroxides for Enhanced Energy Storage and Electrocatalytic Water Splitting.

The rational design of electrode materials with outstanding energy and power density for supercapacitors (SCc) and high-performance electrocatalysts in alkaline media plays an indispensable role in the application of energy storage and overall water splitting. In this paper, we prepared NiCoFe layered ternary hydroxides (LTH) using a hydrothermal synthesis method. The sample with a Ni/Co/Fe ratio of 1:2:0.

sp. nov., isolated from the upper respiratory tract of duck.

Five bacterial strains, designated as RCAD1438, RCAD1439, RCAD1670, RCAD1671 and RCAD1672, were isolated from the upper respiratory tract of ducks in Anhui, Shaanxi and Sichuan, China. All strains are Gram-stain-negative, rod-shaped, non-motile, non-spore-forming, aerobic and capsulated. They grow optimally at 37 °C and pH 7.

Research progress of connexin 43 in cardiovascular diseases.

Gap junctions (GJs) are critical structures for cardiac electrical signal conduction and synchronized contraction. Their fundamental components are transmembrane proteins from the connexin (Cx) family, which assemble into hexameric channels to form intercellular ion-permeable pathways, ensuring efficient electrical transmission and coordinated contraction between cardiac cells. Connexin 43 (Cx43), the most abundant connexin in the heart, serves as the primary constituent of ventricular gap junctions.

Duck plague virus ICP27 protein suppresses IFN-β production by dual targeting of DNA- and RNA-sensing pathways.

Duck plague virus (DPV), an alphaherpesvirus causing severe economic losses in global waterfowl industries, adopts sophisticated strategies to subvert host antiviral immunity. Here, we identify DPV ICP27 as a pivotal immune evasion protein that concurrently inhibits both DNA (cGAS-STING) and RNA (RIG-I/MDA5-MAVS) innate immune sensing pathways-a novel function unreported in avian herpesviruses. Through co-transfection and infection assays in duck embryo fibroblasts (DEFs), we demonstrate that ICP27 suppresses key immune sensors' transcriptional and protein expression levels (STING, RIG-I) and the transcription factor IRF7.

Roles of SPI-2 T3SS effectors in virulence of Choleraesuis and Construction of a triple-gene mutant vaccine strain.

Effector protein functions of Type III secretion system (T3SS) encoded by pathogenicity islands 2 (SPI-2) have not been fully characterized in serovar Choleraesuis. This study characterized 21 effectors of SPI-2 T3SS of in terms of macrophage survival and virulence in mice via construction of various gene mutant strains. Eight effector genes including , , and contributed to bacterial survival in macrophage cell line RAW264.

The Effects of Microencapsulation Technology on the Flavor Quality of Oil Based on E-Nose, GC-IMS, and GC-MS.

To investigate the impact of microencapsulation on the volatile organic compounds (VOCs) in oil, this study compared unencapsulated Zanthoxylum oil (ZO) with microencapsulated Zanthoxylum oil (MZO) using physicochemical analysis, sensory evaluation, and molecular sensory analysis. Sensory evaluation revealed significant differences in aroma attributes between ZO and MZO, whereas no notable differences were observed in numbing intensity or overall acceptability. Colorimetric analysis indicated significant distinctions between the two samples.

Telitacicept Inhibits the Maturation and Differentiation of B Lymphocytes in NMOSD.

Telitacicept, a novel recombinant fusion protein comprising the ligand-binding domain of the TACI receptor and the Fc component of human IgG, has rarely been studied for the treatment of neuromyelitis optica spectrum disorders (NMOSD). This study aimed to explore the effects of telitacicept in NMOSD mice. An NMOSD mouse model was constructed.

Optimizing plant-based meat alternatives: Effects of soy protein incorporation methods and freeze-thaw processing on microstructure and quality.

This study evaluated three soy protein isolate (SPI) incorporation methods-dry blending (DB), hydration (HD), and emulsification (EM)-combined with freeze-thaw (F) or normal temperature (N) treatment for plant-based meat alternatives (PB-MAs). Emulsification with normal temperature (EMN) achieved optimal performance: cooking loss reduced to 3.93 % (vs.

The past, present, and future of ALK-targeted drug discovery.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor superfamily, which plays an essential role in the development of the nervous system and is aberrantly activated in various cancers through gene rearrangements, point mutations, or amplifications. Oncogenic ALK alterations are particularly prominent in non-small cell lung cancer (NSCLC), anaplastic large cell lymphoma (ALCL), and neuroblastoma, where they contribute to tumorigenesis, proliferation, and therapeutic resistance. The clinical success of first-generation ALK inhibitors has spurred the development of more potent second- and third-generation agents designed to overcome resistance mutations and improve central nervous system (CNS) penetration.

Two receptor-targeting mechanisms of lambda-like siphophage Gifsy-1 of Salmonella Typhimurium.

The receptor-targeting mechanisms by which λ-like siphophages establish infection in gram-negative bacteria remain poorly characterized. This study demonstrated that the λ-like phage Gifsy-1, which exhibits broad lytic activity in Salmonella enterica, employs two receptor-targeting mechanisms mediated by the side tail fiber Stf and central tail tip J dependent on O-polysaccharide (OPS) production. In rough (OPS-deficient LPS) Salmonella Typhimurium strains, Gifsy-1 employs multiple receptor-targeting: the J protein binds OmpC, OmpX, and BtuB, while the Stf protein targets galactose II (Gal II) of the lipopolysaccharide (LPS) core oligosaccharide.

ASAP1 Promotes Epithelial to Mesenchymal Transition by Activating the TGFβ Pathway in Papillary Thyroid Cancer.

Background: Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy. While the prognosis of PTC is generally favorable, some cases exhibit aggressive behavior, leading to metastasis and recurrence. ASAP1 (ArfGAP with SH3, ankyrin repeats, and PH domain 1), an ADP-ribosylation factor GTPase-activating protein, has been implicated in tumor metastasis.

Hyperammonemia heightens anesthetic sensitivity in male rats with acute hepatic encephalopathy via affecting brain areas represented by the cerebellum.

Background: Precise anesthesia is essential to ensure perioperative safety in patients with hepatic encephalopathy (HE) due to severe liver injuries. Hyperammonemia has been implicated as a possible trigger for HE. However, anesthetic sensitivity in HE and the role of hyperammonemia, in the context of anesthetic sensitivity of HE both remain uncertain.

Inhibition of starch on the formation of free and protein-bound heterocyclic aromatic amines in roasted beef patties and the underlying mechanism.

This study examined how starch influences the formation of free and bound heterocyclic aromatic amines (HAAs) in roasted beef patties and chemical model systems. Corn, potato, and cassava starch increased glucose, creatine, creatinine, and total free amino acid levels in the roasted beef patties while reducing serine content (P < 0.05).

General and versatile electrochemical α-C(sp)-H amidation for -Mannich base synthesis.

A green and versatile electrochemical method for the synthesis of -Mannich bases through oxidative dehydrogenative cross-coupling is reported. A wide range of primary amides, lactams and phthalimides serve as effective amidation reagents, enabling the α-functionalization of both aromatic and aliphatic tertiary amines with excellent regioselectivity and high efficiency under mild, metal-/oxidant-free conditions. This sustainable approach is characterized by its operational-simplicity, broad substrate compatibility, and exceptional functional group tolerance.

The chaperone DnaK promotes the emergence and accumulation of antibiotic-resistant clones through its ATPase activity in Riemerella anatipestifer.

The rapid emergence of antibiotic-resistant bacteria has become a global concern. In particular, the overuse of antibiotics in the breeding industry has accelerated the emergence of antibiotic-resistant bacteria, but the mechanisms driving this phenomenon are not fully understood. Here, using the multidrug-resistant bacterium R.

Electrochemically Chemoselective N-C(O) Bond Activation for Amide Esterification.

The activation of the N-C(O) bond in amides posed a significant challenge in organic synthesis due to resonance stability. Herein, we present an electrochemical method for the direct esterification of primary amides with -based nucleophiles facilitated by TBAB. This sustainable protocol operates under mild, open-to-air conditions, exhibits excellent functional group tolerance, and is effective for the late-stage modification of complex molecules.

Effect of lard-derived diacylglycerol on the physicochemical properties and quality of frankfurters.

Background: Traditional emulsified meat products are high in animal fat, which is associated with good quality (texture, taste, flavor and palatability), but excessive fat intake has adverse effects on human health and has been linked to chronic diseases such as obesity and cardiovascular disease. The present study aimed to evaluate the use of lard-derived diacylglycerol (DG) with health benefits on the physicochemical and sensory properties of frankfurters. Frankfurters were prepared by substituting lard with purified lard-derived diacylglycerol (PDG) at different levels (0%, 25%, 50% and 100%).

Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems.

Retinal diseases, such as age-related macular degeneration and diabetic macular edema, are significant contributors to vision loss. While injection of anti-vascular endothelial growth factors is the current gold standard treatment, their invasive nature reduces patient compliance and treatment outcomes and increases the risk of complications. In this review, we explore the recent advancements in drug delivery systems designed to overcome ocular barriers to effectively deliver drugs to the retina.

Homotransplantation of Engineered Macrophages with Surface-Modified Nanomedicines for Mitigating Myocardial Ischemia-Reperfusion Injury.

Immune disorders are intimately involved in the pathological progression of myocardial ischemia-reperfusion injury (MIRI) and exacerbate cardiac cell damage and mitochondria-related metabolic abnormalities. However, low-immunogenic therapeutic strategies targeting the compromised immune-metabolic microenvironment remain a major challenge. Here, we developed a syngenic reparative macrophage system for the selective delivery of nanoscale drugs by modifying liposomes loaded with nano-Pt/Se and c176 onto the surface of M2 macrophages (PS-c@M).

NIS-Mediated Hofmann-Type Rearrangement to Acyl Isocyanates: A Novel Approach for -Acylurea Synthesis.

A green and efficient method for the assembly of -acylureas through an NIS-promoted Hofmann-type rearrangement has been described. The advantages of this protocol include mild, metal-free conditions, operational simplicity, broad substrate scope, good functional group tolerance, and high chemoselectivity. The potential practicability and synthetic utility were demonstrated by its easy scalability and application in the concise synthesis of commercial pesticides and drugs.

Construction and application of infectious cDNA clone, subgenomic replicon and packaging system for Zika virus and Dengue virus.

Flaviviruses pose a significant global health threat due to their rapid spread and potential to cause severe clinical manifestations. Comprehending the mechanisms of replication of these pathogens and developing effective antiviral strategies are essential for combating these pathogens. In the present study, full-length infectious cDNA clones were generated for Zika virus (ZIKV) and Dengue virus (DENV), respectively.

Cooperative nuclear import of duck plague virus DNA polymerase subunits: pUL42 NLS Enhances pUL30 nuclear import and viral replication, with VP22 as a compensatory factor.

Duck plague (DP), caused by duck plague virus (DPV), is an acute, febrile, and septic disease fatal to geese, ducks, and other wild waterfowl. The DPV UL42 gene product, pUL42, an accessory subunit of the viral DNA polymerase, whose nuclear import is critical for viral replication; however, the underlying mechanism remains unclear. In this study, we identified a 33-amino acids region at the C-terminus of pUL42, containing its nuclear localization signal (NLS).

High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China.

Currently, five types of duck hepatitis viruses have been documented, and they are all associated with liver disorders. However, the prevalence of their coinfections involving these viruses remains largely uncertain. Herein, we screened the prevalence of the five types of hepatitis viruses from A to E in 143 samples of diseased duck livers during 2019-2021 in Southwest China.

Non-volatile optical switch based on SbSe-loaded three-mode interference.

In this Letter, we propose a non-volatile switch based on multimode interference in an SbSe-loaded waveguide. By implementing low-loss phase control within a multimode interference coupler, this design effectively manages the self-imaging phase shift length during a single phase change cycle. The fabricated multiplexed optical switch exhibits impressive performance characteristics, including a low insertion loss of ∼ 1.

Loss of LAPTM4A inhibits M2 polarization of tumor-associated macrophages in glioblastoma, promoting immune activation and enhancing anti-PD1 therapy.

Glioma is a highly aggressive central nervous system tumor with limited treatment options, presenting a significant challenge for effective therapy. Despite advancements, the role of tumor-associated macrophages (TAMs) in glioma remains poorly understood, especially regarding their polarization and its impact on the immune response. This study investigates the effects of Lysosomal-associated protein transmembrane 4 A (LAPTM4A) deficiency on the polarization of TAMs and its role in modulating anti-tumor immunity.