Reciprocal Predictions Between Reading Achievement and Cognitive Flexibility Development in Children and the Mediating Roles of the Left Middle Frontal Gyrus.

The development of reading skills and cognitive flexibility is crucial for success in childhood and adulthood. Although previous studies demonstrate the existing links between the development of cognitive flexibility and the reading acquisition in children, it remains unclear how baseline reading achievement influences later cognitive flexibility, or vice versa, particularly in relation to the underlying brain development. Therefore, in this prospective longitudinal study, we investigated the reciprocal prediction between reading achievement and cognitive flexibility, along with the underlying brain development that potentially mediated this relationship in school-aged children.

Safety of fruquintinib in Chinese patients with colorectal cancer: an age subgroup analysis from a phase IV real-world clinical practice study.

Background: Colorectal cancer (CRC) is increasingly prevalent among young adults (<50 years) in China, a demographic that has been historically underrepresented in clinical studies. While most patients with CRC are aged ⩾65 years, this age group is also underrepresented in trials, highlighting the need for a better understanding of treatment outcomes in both younger and older populations. A recent phase IV trial evaluating the safety of fruquintinib in Chinese patients with metastatic CRC (mCRC) showed a manageable profile.

Whole genome resequencing reveals genetic markers for plumage colour in Jingyuan Chicken.

In order to investigate the basic genetic structure of plumage colour in Jingyuan chicken and to explore the genetic markers for plumage colour development, the present study was carried out to investigate the candidate key SNPs and candidate genes regulating black, linen and white plumage and plumage traits of Jingyuan chicken by using selection signal analysis and genome-wide association analysis. Selection signal analyses showed that including 30, 40 and 18 overlapping genes were associated with black, linen and white plumage colours in Jingyuan chicken. Meanwhile, integrative genomic analyses identified BCAT1, LMO3, and PIK3C2G as primary candidates for black plumage, and IL1RAPL1 for white plumage, with all genes showing convergent support across multiple complementary approaches.

Genome-Wide Identification and Comprehensive Analysis of Gene Family in Under Abiotic Stress.

The (APETALA2/ethylene-responsive element binding factor) family represents one of the largest transcription factor families in plants, playing pivotal roles in abiotic stress responses and hormone signaling pathways. Through genome-wide analysis, we identified 163 genes in . Transcriptome data revealed that 12 genes were significantly upregulated under either drought or flooding stress, with 8 genes responding to both conditions.

Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial.

Background: Elevated systolic blood pressure (SBP) accounts for one-half of the population attributable fraction for stroke, so lowering SBP is the most important treatment for preventing stroke.

Objective: In this study, the authors sought to assess the effects of intensive treatment targeting SBP <120 mm Hg on stroke compared with standard treatment targeting SBP <140 mm Hg.

Methods: In the ESPRIT trial, hypertensive patients with high cardiovascular risk were randomly assigned to intensive treatment or standard treatment and followed for 3.

Clinical features, treatment and prognosis analysis of distant metastatic esophageal cancer.

Esophageal cancer (EC) is one of the most common malignant tumors in China. EC is characterized by a poor clinical prognosis, with many patients being diagnosed at advanced stages. This study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database.

Enhanced production of sabinene by engineered Saccharomyces cerevisiae from corn hydrolysates.

Sabinene is a type of monoterpene that is widely used in flavors, fragrances and pharmaceuticals. Though sabinene biosynthesis has been investigated in a variety of microorganisms, application of sabinene is still limited due to its high production cost and lesser yielding strains. The baker's yeast Saccharomyces cerevisiae, which is generally recognized as safe (GRAS), is a suitable cell factory for the food and beverage industries.

Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report.

Propofol is a commonly used sedative for the induction of clinical anesthesia and sedation maintenance in intensive care unit patients. However, in a minority of patients, prolonged infusion of propofol may cause metabolic acidosis, electrocardiographic abnormalities, arrhythmias, and rhabdomyolysis, a condition known as propofol-related infusion syndrome. If not promptly identified and managed, propofol-related infusion syndrome can be fatal.

Damage to survival, development, and growth of Japanese flounder (Paralichthys olivaceus) at early developmental stages by Ulva prolifera decay.

Large-scale Ulva prolifera green tides decay in the Southern Yellow Sea has affected coastal ecological environment and caused substantial economic losses. This decay period overlaps with the critical early developmental stages of numerous marine fishes. However, research on the impacts and underlying mechanisms of U.

Lactylation-mediated miRNA regulation in cancer therapy resistance.

Therapeutic resistance in cancer is increasingly understood as a dynamic outcome of the interplay among tumour metabolism, epigenetic regulation, and immune modulation, rather than a consequence of genetic mutations alone. At this intersection, lactylation-a recently discovered lactate-derived post-translational modification (PTM)-acts as a molecular bridge linking metabolic rewiring to transcriptional and post-transcriptional control. Meanwhile, microRNAs (miRNAs) have emerged as essential regulators of metabolic adaptation and epigenetic plasticity.

Safety and efficacy of transcatheter aortic valve replacement using Sapien 3 balloon-expandable valve in type 0 bicuspid aortic valve stenosis patients.

Background: Data regarding the safety and efficacy of balloon expandable valves (BEVs) for transcatheter aortic valve replacement (TAVR) in patients with Sievers type 0 bicuspid aortic valve (BAV) stenosis remain limited.

Aims: This study aims to evaluate the clinical outcomes of BEVs implantation in patients with Sievers type 0 BAV.

Methods: We conducted a multicenter, retrospective study across 28 centers in China between October 2020 and March 2023.

Clinical significance of a machine learning model based on short-term changes in NT-proBNP after TAVR.

Objectives: The purpose of this study was to investigate the short-term dynamic changes in NT-proBNP after transcatheter aortic valve replacement and to evaluate its availability in prognostic assessment based on machine learning.

Methods: The differences in the NT-proBNP ratio between baseline, 30-day, and 6-month follow-up of patients in the internal derivation cohort (n = 1115) were recorded as D and D; the difference ratio of the NT-proBNP ratio (D/D) was recorded as DR. According to the DR-based range, patients were divided into the DR-1 (DR ≥ 1), DR-2 (0 ≤ DR < 1), DR-3 (-0.

Injectable HMME-Loading Emulsion Hydrogel for Ultrasound-Triggered Release and Enhanced Sonodynamic Immunotherapy.

Immune checkpoint blockade (ICB) therapies, such as targeting programmed death-1 (PD-1) and programmed cell death protein ligand-1 (PD-L1), are often ineffective in low-immunogenic tumors, limiting their widespread use. In this study, an emulsion hydrogel is developed to encapsulate the sonosensitizer hematoporphyrin monomethyl ether (HMME), aimed at enhancing sonodynamic immunotherapy for low-immunogenic cancers. The water-in-oil emulsion hydrogel, characterized by its shear-thinning rheological properties, demonstrates excellent ultrasound (US)-triggered and lipase-triggered release, followed by sustained release.

Immunotherapy in EGFR-mutant NSCLC after TKI resistance: role of mutation subtypes and progression patterns.

Background: Patients withEGFR-sensitizing mutations in non-small cell lung cancer (NSCLC) predominantly receive first-line tyrosine kinase inhibitors (TKIs). Subsequent TKI resistance manifests through heterogeneous clinicopathological features, including distinct resistance subtypes (primary vs. acquired),PD-L1expression levels, and molecular profiles from re-biopsies.

Advances and challenges in bioproduction of microbial exopolysaccharides: Synthesis mechanisms, engineering strategies, and future perspectives.

Concerns over environmental sustainability, climate change, and energy crisis have significantly increased attention to chemicals and polymers produced by microorganisms. Microbial exopolysaccharides (EPS) are high molecular-weight polysaccharides with diverse structures secreted by bacteria, fungi, and algae. A broad variety of EPS have been reported and attracted wide interest, especially in the industrial, medical, packaging, and agricultural sectors.

Universal Electrode Based on Ferredoxin-NADP Oxidoreductase Enables Enzymatic Biofuel Cells With Broad Substrate Spectrum.

Enzymatic biofuel cells face substrate limitations due to enzyme specificity of the electrode. A universal electrode was designed by immobilizing ferredoxin-NADP oxidoreductase (FNR) with bacterial cellulose (BC), carbon nanotubes (CNTs), and silver nanowires (AgNWs). The electrode coupled with NADPH-dependent malic enzyme or glucose dehydrogenase generated electricity using malic acid and glucose, respectively.

The E420K mutation in myosin5 confers field resistance to phenamacril in Fusarium asiaticum.

Fusarium head blight (FHB), primarily caused by the Fusarium graminearum species complex (FGSC), is a devastating fungal disease that threatens global wheat production and endangers worldwide food security. Phenamacril, a myosin5 inhibitor, is widely recognized as an effective fungicide against FGSC. Since 2007, phenamacril has been registered in China for the control of FHB.

Genome-Wide Identification of the Gene Family in and Its Responses to Abiotic Stress.

Background: The () gene family plays a critical role in abiotic stress tolerance during plant growth and development. Myricaria laxiflora, as a key pioneer species in the extreme hydrological fluctuation zone of the Yangtze River, has evolved unique adaptation mechanisms potentially linked to gene family evolution. However, the molecular mechanisms underlying how the gene family responds to alternating flooding-drought cycles remain unclear.

Comparative Evaluation of Lipopolysaccharide Administration Methods to Induce Acute Lung Injury in Murine Models: Efficacy, Consistency, and Technical Considerations.

Context: Direct preclinical lipopolysaccharide acute lung injury (ALI) models are commonly used to study acute respiratory distress syndrome. Differences in lipopolysaccharide delivery methods may impact lung injury severity and reproducibility.

Hypothesis: We hypothesized that the severity and variability of ALI outcomes in mice would differ depending on the technique of lipopolysaccharide administration.

Dissecting human cortical similarity networks across the lifespan.

The human cortex exhibits remarkable morphometric similarity between regions; however, the form and extent of lifespan network remodeling remain unknown. Here, we show the spatiotemporal maturation of morphometric brain networks, using multimodal neuroimaging data from 33,937 healthy participants aged 0-80 years. Global architecture matures from birth to early adulthood through enhanced modularity and small worldness.

Dupilumab-induced Eosinophilic Granulomatosis with Polyangiitis Complicated by Peripheral Neuropathic Pain: a Case Report and Literature Review.

Purpose: Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare vasculitis characterized by increased eosinophils in human tissues and peripheral blood. In this case, we present a 53-year-old female patient with EGPA. By this case and literature review, we want to explain the early manifestations, diagnosis, and management of EGPA, which will help clinicians to understand the disease and attach importance to the possibility of dupilumab-induced EGPA, to improve the early diagnosis rate of EGPA, and reduce misdiagnosis and missed diagnosis.

Detection of gastric cancer with implantation metastasis to the inguinal region via F-FAPI PET/CT: a case report.

Implantation metastasis of gastric cancer to the inguinal area is rarely reported, and a clear diagnosis of such metastasis is hard to make, especially when these cancers are invisible on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging. However, certain types of cancers, such as signet-ring cell carcinoma, are particularly sensitive to fibroblast activation protein inhibitor (FAPI) PET/CT. In this case, a patient with a history of gastric cancer and a gastrectomy 2 years previously suddenly developed serious edema in his right lower limb.

Knockdown of PVT1 inhibits cell proliferation in luminal and basal-like breast cancer subtypes by activating LATS2/Hippo signaling pathway.

Background: Breast cancer (BC) is a malignant tumor seriously threatening women's health, while current approaches to BC treatment are challenged by the existence of drug resistance. Combination strategies of targeted therapy have been successfully applied in clinical BC treatment. However, whether there exist critical long non-coding RNAs (lncRNAs) responsible for BC pathogenesis and representing promising candidates for combined targeted therapy remains an issue.