Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts.

In the realm of regenerative medicine, despite the various techniques available for inducing the differentiation of induced pluripotent stem (iPS) cells into cardiomyocytes, there remains a need to enhance the maturation of the cardiomyocytes. This study aimed to improve the differentiation and subsequent maturation of iPS-derived cardiomyocytes (iPS-CMs) by incorporating mechanical stretching. Human iPS cells were co-cultured with human gingival fibroblasts (HGF) on a polydimethylsiloxane (PDMS) stretch chamber, where mechanical stretching stimulation was applied during the induction of cardiomyocyte differentiation.

Correlation between hyperuricemia and coronary in-stent restenosis in patients with unstable angina: A retrospective study.

This study investigates the correlation between hyperuricemia and the development of in-stent restenosis (ISR) following percutaneous coronary intervention (PCI) in patients with unstable angina. We analyzed clinical data from 128 patients diagnosed with unstable angina who underwent PCI. Patients were categorized into 2 groups: hyperuricemia group (34 cases) and non-hyperuricemia group (94 cases), based on the presence or absence of hyperuricemia.

Predicting the therapeutic efficacy of uterine artery embolization for adenomyosis using a combined model based on MRI radiomics and clinical characteristics.

Objective: Prediction of the therapeutic efficacy of uterine artery embolization (UAE) for adenomyosis (AM) using an MRI-based radiomics model combined with clinical characteristics.

Methods: A retrospective analysis was conducted on 126 patients with AM who underwent UAE at the Interventional Radiology Department of the Second Affiliated Hospital of Soochow University. Radiomics features were extracted from uterine lesions using axial T-weighted imaging with fat suppression (TWI-FS) sequences obtained prior to treatment.

Expression of immunogenic cell death-related genes is correlated with the immune microenvironment and predicts prognosis in lung adenocarcinoma.

Immunogenic cell death (ICD) is a type of regulated cell death that is sufficient to prime adaptive immune responses. Mounting evidence has demonstrated that ICD has the potential to modify the tumor immune microenvironment through the release of numerous damage-associated molecular patterns (DAMPs), which may contribute to the effects of immunotherapy. We aimed to explore the expression profile of ICD-associated biomarkers in lung adenocarcinoma (LUAD) and construct a prognostic signature based on these genes.

Advances and challenges in bioproduction of microbial exopolysaccharides: Synthesis mechanisms, engineering strategies, and future perspectives.

Concerns over environmental sustainability, climate change, and energy crisis have significantly increased attention to chemicals and polymers produced by microorganisms. Microbial exopolysaccharides (EPS) are high molecular-weight polysaccharides with diverse structures secreted by bacteria, fungi, and algae. A broad variety of EPS have been reported and attracted wide interest, especially in the industrial, medical, packaging, and agricultural sectors.

A GLIM-defined malnutrition-based model for predicting prognosis of cirrhotic patients with portal hypertension following TIPS procedure.

Background & Aims: Malnutrition detrimentally impacts the prognosis of patients with cirrhotic portal hypertension (CPH). This study aimed to determine the prevalence of malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria, and its effect on post-transjugular intrahepatic portosystemic shunt (TIPS) hepatic encephalopathy (HE) occurrence and mortality in patients with CPH.

Methods: This study incorporated 330 CPH patients who underwent TIPS between December 2015 and March 2022.

Dietary microRNAs in aging: sources, mechanisms, translational potential, and future directions.

In recent years, the intensifying global aging trend has made anti-aging research a critical area of scientific interest, with dietary interventions playing an essential role. Among dietary components, food-derived microRNAs (miRNAs), emerging as biologically active nutrients, have attracted increasing attention. Accumulating evidence indicates that dietary miRNAs may exert anti-aging effects by modulating gene expression and influencing key signaling pathways related to antioxidant defense, inflammation resolution, and metabolic homeostasis.

Association of quantitative flow ratio with in-stent restenosis in patients with unstable angina undergoing percutaneous coronary intervention.

Objective: To investigate the association of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) with in-stent restenosis (ISR) in patients with unstable angina.

Materials And Methods: Patients treated with PCI and follow-up for ISR were divided into a poor QFR group (QFR < 0.91) and a good QFR group with (QFR ≥ 0.

Effects of exercise on aerobic capacity in people with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.

Objective: This study aimed to evaluate the effects of exercise on aerobic capacity in type 2 diabetes mellitus (T2DM) patients through a systematic review and meta-analysis of randomized controlled trials.

Methods: A comprehensive search was conducted in Web of Science, PubMed, Embase, Cochrane, and Scopus from inception to September 8, 2024. The Cochrane risk assessment tool was used to assess the methodological quality of the included literature.

The impact of embolization endpoints on the efficacy of uterine artery embolization for adenomyosis.

Background: This study aimed to assess how embolization endpoints affect the efficacy of uterine artery embolization (UAE) for adenomyosis.

Methods: In this single-center retrospective cohort study, patients treated with UAE from 2014-2018 received the standard embolization endpoint (SEE), while those from 2019-2022 received the delayed embolization endpoint (DEE). Clinical outcomes, including embolic microsphere volume, uterine volume, CA125 levels, hemoglobin, menstrual flow, dysmenorrhea, and postoperative complications, were compared between the groups.

An unmanned intelligent inspection technology based on improved reinforcement learning algorithm for power large-area multi-scene inspection.

Patrol path planning, as the basis of unmanned intelligent patrol, significantly influences the efficiency and quality of power system surveillance. Consequently, this study investigates a multi scene unmanned intelligent patrol technology for power large area, based on an improved reinforcement learning algorithm. The unmanned intelligent patrol model is designed according to the patrol UAVs, wireless charging piles distributed in appropriate locations, and the targets to be patrolled (i.

Clinical Application of Traditional Chinese Medicine Nursing Care in Cardiovascular Patients.

Background: This study aimed to probe the clinical effect of traditional Chinese medicine (TCM) nursing care in cardiovascular patients.

Methods: A total of 120 patients with cardiovascular disease were randomized into a control group (n = 60) as well as a research group (n = 60). Patients in the control group received routine nursing care.

Primary hepatic neuroendocrine carcinoma coexisting with atypical lung adenocarcinoma.

Not required for Clinical Vignette.

Effects of Exercise on Balance Function in People with Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

: This study sought to evaluate the impact of exercise on balance function in individuals with knee osteoarthritis (KOA) and determine the most effective exercise protocols for balance enhancement. : A systematic literature search was performed across five major electronic databases (PubMed, Web of Science, EBSCO, Cochrane, Scopus) until 13 September 2024. Statistical synthesis was conducted using weighted mean differences (WMDs) with 95% confidence intervals under a random-effects model.

A Case Report and Literature Review of Hemophagocytic Syndrome Secondary to Garcin-Guillain Syndrome.

Background: This article reports on a case of hemophagocytic syndrome (HPS) secondary to multiple myeloma (MM) with extramedullary lesions presenting as the initial symptom. MM with extramedullary lesions, also referred to as Garcin-Guillain syndrome, is extremely rare, occurring in only 4.6% of MM patients.

Comparing efficacy of different scoring models to predict hepatic encephalopathy after TIPS in cirrhotic patients.

Background: Assessing hepatic encephalopathy (HE) risk post-transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients is crucial. This study compares the predictive performance of Child-Pugh and Model for End-Stage Liver Disease (MELD), CLIFC-AD and Freiburg index of post-TIPS survival (FIPS) scores for overt and severe HE. To compare the predictive value of Child-Pugh, MELD, CLIFC-AD and FIPS scores for overt and severe HE post-TIPS in cirrhotic patients.

Copper(I)-catalyzed asymmetric addition of diarylphosphine sulfides to aldimines.

Herein, we report a copper(I)-catalyzed enantioselective addition of diarylphosphine sulfides to -thiophosphinoyl aldimines. The reaction offers some advantages, such as mild conditions, an easy protocol, and high enantioselectivity. Control experiments indicate that the "soft-soft" interactions between the copper(I) catalyst and the sulfur atoms in both diarylphosphine sulfides and -thiophosphinoyl aldimines facilitate the addition.

Chronic BPAF exposure differentially enhances fat deposition in mice fed normal or high-fat diets via lipid metabolism dysregulation.

Background: Bisphenol AF (BPAF), an alternative to Bisphenol A (BPA), is increasingly utilized in various industrial applications, yet its toxicological profile remains incompletely understood. This study aims to investigate the impact of BPAF exposure on obesity and lipid metabolism in male mice subjected to either a normal chow diet (ND) or a high-fat diet (HFD).

Methods: Mice were exposed to BPAF at a concentration of 100 μg/kg every other day for five months under different dietary conditions, and body weight, rectal temperature, and food intake were monitored regularly.

Activation of Rab7-mediated lipophagy is required for triptolide to induce ferroptosis in hepatic cells.

The aim of this study was to investigate the regulation of triptolide on Rab7-mediated lipophagy to elucidate the potential association between lipophagy and ferroptosis in triptolide-induced hepatotoxicity. Human normal liver HL7702 cells and C57BL/6J mice were treated with triptolide to establish in vitro and in vivo models. The results revealed that triptolide caused a severe hepatic cell damage in vitro and in vivo.

Investigating the role of the Pon1-rs854560 (L55M) SNP in colorectal Cancer susceptibility.

Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with both genetic and environmental risk factors. The PON1 rs854560 (L55M) polymorphism has been implicated in cancer susceptibility through its role in oxidative stress regulation, but its association with CRC remains unclear, particularly in Asian populations.

Aim: This study aimed to investigate the association between the PON1 rs854560 polymorphism and CRC susceptibility in a Chinese cohort, while assessing its impact on PON1 expression and enzymatic activity.

Chromosome-level genome assembly and annotation of Gypsophila vaccaria.

Gypsophila vaccaria Sm., a member of the Caryophyllaceae family, is known for its dry mature seeds, which are widely used in traditional Chinese medicine as "Wang Bu Liu Xing". This study presents a high-quality, chromosome-scale genome assembly of G.

Effects of exercise on balance function in people with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.

Objective: This systematic review and meta-analysis aimed to evaluate the effect of exercise on balance function in multiple sclerosis (MS) patients and identify the optimal exercise prescription for this population.

Methods: A comprehensive search was conducted across PubMed, Web of Science, EBSCO, Cochrane, and Scopus up to February 21, 2025. The data were pooled using weighted mean differences (WMD) and 95% confidence interval.

Enhanced Interfacial Exciton Transport in Mixed 2D/3D Perovskites Approaching Bulk 3D Counterparts.

Mixed 2D/3D halide perovskites possess unique optoelectronic properties and strong structural stability, making them promising for various light-harvesting and -emitting applications. However, the long-chain organic cations have low charge conductivity and create potential barriers within the inorganic frameworks, which limit efficient exciton and carrier transport. In this study, we propose a method to improve exciton transport in 2D/3D perovskites by adjusting the conjugation interactions of long-chain ligands.

Enhancing survival predictions in lung cancer with cystic airspaces: a multimodal approach combining clinical and radiomic features.

Objective: To enhance the prognostic assessment and management of lung cancer with cystic airspaces (LCCA) by integrating temporal clinical and phenotypic dimensions of tumor growth.

Patients And Methods: A retrospective analysis was conducted on LCCA patients treated at two hospitals. Clinical and imaging characteristics were analyzed using the independent samples t-test, Mann-Whitney U test, and χ test.