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http://dx.doi.org/10.1186/s12957-025-03995-9 | DOI Listing |
Nat Commun
September 2025
Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan.
Since Hans Driesch's pioneering work in 1891, it has been known that animal embryos can develop into complete individuals even when divided. However, the developmental processes and molecular mechanisms enabling this self-organization remain poorly understood. In this study, we revisit Driesch's experiments by examining the development of isolated 2-cell stage blastomeres in the sea urchin, Hemicentrotus pulcherrimus.
View Article and Find Full Text PDFWorld J Surg Oncol
August 2025
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Phytomedicine
August 2025
Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, Chi
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease driven by steatosis, inflammation, and fibrosis. Celastrol (CEL), a natural bioactive compound, has exhibited promise in preclinical models in MASH treatment. However, its precise mechanism, particularly regarding bile acid (BA) metabolism, remains unclear.
View Article and Find Full Text PDFCell
August 2025
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06512, USA. Electronic address:
RNA-guided RNA editing represents an attractive alternative to DNA editing. However, the prevailing tool, CRISPR-Cas13, has collateral RNA cleavage activity that causes undesirable cytotoxicity in human cells. Here, we report an ultracompact RNA-editing platform engineered from IscB, which has comparable or higher activity than Cas13 but without cytotoxicity concerns.
View Article and Find Full Text PDFFASEB J
August 2025
Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
The proper assembly and migration of the spindle and the correct segregation of the chromosomes play a crucial role in oocyte quality. In somatic cells, Psrc1 regulates spindle dynamics and mitotic progression; however, its functions in oocyte meiosis have not been fully elucidated. This study aims to elucidate the functions of Psrc1 in mouse oocyte meiosis.
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