Investigating the Potential Effects of 6PPDQ on Clear Cell Renal Cell Carcinoma via Network Toxicology and Molecular Docking Analysis With In Vitro Experimental Validation.

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ), as a recently identified environmental toxicant, has garnered significant attention because of its widespread detection in ecosystems and human habitats. Emerging evidence highlights its potential detrimental effects on various organs. However, its carcinogenic potential remains poorly understood, particularly its role in clear cell renal cell carcinoma (ccRCC).

Diagnostic utility of hematological and biochemical markers for cystic echinococcosis in Tibetan patients of Sichuan, China.

Objective: This hospital-based case-control study aims to evaluate hematological and biochemical markers for the diagnosis of cystic echinococcosis (CE) in the Tibetan population of Sichuan.

Methods: This study involved 83 patients diagnosed with CE and 45 healthy controls. Diagnosis of CE was confirmed through antibody and imaging tests, followed by an analysis of differences in blood and biochemical markers.

A Transformer-Based Framework With Data Augmentation for Robust Seizure Detection Across Invasive and Noninvasive Neural Recordings.

Aims: Epilepsy affects more than 50 million peolple worldwide and requires reliable seizure detection systems to mitigate risks associated with unpredictable seizures. Existing machine learning frameworks are limited in generalizability, signal fidelity, and clinical translation, particularly when bridging invasive and non-invasive modalities. This study aims to develop a robust and generalizable seizure detection model capable of supporting cross-modal applicability.

High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography.

DNA origami information storage is a promising alternative to silicon-based data storage, offering a secure molecular cryptography technique that conceals information within arbitrarily folded DNA origami nanostructures. Routing, sliding, and interlacing staple strands lead to the creation of a large 700-bit key size. The realization of practical DNA data storage requires high information density, robust security, and accurate and rapid information retrieval.

Noble Metal Coating on Perovskite Microcrystals for Robust and Plasmonic Lasing Applications.

Lead halide perovskites (LHP) are solution-processible semiconductor materials with high optical gain and broad wavelength tunability, making them well-suited for laser applications. Here, we present a solution-based method for the three-dimensional conformal coating of LHP microcrystals with noble metals. A nanoscale metal coating layer was found to significantly enhance both laser performance and environmental stability.

Sterically Engineered Polymeric HTM with Suppressed Torsion for High-Efficiency and Long-Lifetime Solution-Processed OLEDs.

Achieving both high efficiency and operational stability in solution-processed organic light-emitting diodes (OLEDs) remains a significant challenge due to charge imbalance and the limited structural robustness of polymeric hole transport layers (HTLs). Herein, we report a sterically engineered polymer HTM, TFPHS, designed by incorporating a bulky 1-methyl-4-phenylnaphthalene side group into a TFB-derived conjugated backbone. This structural modification enhances backbone rigidity, suppresses dihedral torsion, and enables balanced hole and electron transport.

X-FASNet: cross-scale feature-aware with self-attention network for cognitive decline assessment in Alzheimer's disease.

Early diagnosis of Alzheimer's disease is critical for effective therapeutic intervention. The progressive nature of cognitive decline requires precise computational methods to detect subtle neuroanatomical changes in prodromal stages. Current multi-scale neural networks have limited cross-scale feature integration capabilities, which constrain their effectiveness in identifying early neurodegenerative markers.

Imaging hypoxia for head and neck cancer: current status, challenges, and prospects.

Hypoxia can substantially impact clinical outcomes in patients with head and neck cancer (HNC) by promoting tumor invasion, metastasis, immune escape, and therapy resistance. Given the growing interest in targeting hypoxia for cancer therapy, noninvasive methods are needed to accurately detect hypoxia and evaluate the tumor response to treatment. This review summarizes recent advances in hypoxia-targeted probes and imaging techniques, emphasizing their imaging mechanisms, strengths, and limitations.

Advancing Spherical Nucleic Acid Synthesis in Less-Polar Solvents.

Spherical nucleic acids (SNAs) are radially packed, highly dense DNA "forests" on nanoparticle cores, depicting a useful class of artificially engineered bionanomaterials. The widespread uses of SNAs in diverse chemistry and nanotechnology areas have driven their synthetic innovations toward reduced time/cost and ever-improved quality. Different from existing methods based on salt-aging, low-pH, freezing, and dehydration conditions, herein a speedy and facile way is reported to produce SNAs in miscible aqueous-alcoholic media with easily adjustable solvent polarities.

Potential saviour of pulmonary fibrosis: multi-pathway treatment of natural products.

Background: Pulmonary fibrosis (PF), a terminal manifestation of diverse interstitial lung diseases, remains incompletely understood in its pathogenesis. Natural products possess multifaceted biological activities and relatively favorable safety profiles, showing great advantage in treating complex disease including PF, though bioavailability limitations require formulation optimization.

Purpose: This review systematically consolidates insights into the underlying mechanisms of natural products and prospects several promising targets for the treatment of PF.

An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview.

The JAK-STAT signaling pathway serves as a central regulator of diverse cellular processes encompassing proliferation, apoptosis, inflammation, and differentiation. Specifically, extracellular ligands such as interleukins, and colony-stimulating factors induce JAKs phosphorylation, subsequently triggering dimerization and nuclear translocation of STATs protein. In this way, the JAK-STAT pathway modulates target gene expression.

Multimodal Integration in Health Care: Development With Applications in Disease Management.

Multimodal data integration has emerged as a transformative approach in the health care sector, systematically combining complementary biological and clinical data sources such as genomics, medical imaging, electronic health records, and wearable device outputs. This approach provides a multidimensional perspective of patient health that enhances the diagnosis, treatment, and management of various medical conditions. This viewpoint presents an overview of the current state of multimodal integration in health care, spanning clinical applications, current challenges, and future directions.

Conversion of IscB and Cas9 into RNA-guided RNA editors.

RNA-guided RNA editing represents an attractive alternative to DNA editing. However, the prevailing tool, CRISPR-Cas13, has collateral RNA cleavage activity that causes undesirable cytotoxicity in human cells. Here, we report an ultracompact RNA-editing platform engineered from IscB, which has comparable or higher activity than Cas13 but without cytotoxicity concerns.

Experimental study of the rotation characteristics of magnetically driven vacuum-arc cathode spots.

Achieving uniform, stable, and reliable erosion of electrode materials is crucial for enhancing the performance and lifespan of vacuum-arc devices. This study investigates the rotation and erosion characteristics of cathode spots on Cu and Ti cathodes with various applied magnetic fields. The results indicate that with the discharge current changes, cathode spots evolve from a single spot to multiple spots and then back to a single spot.

Impact of repeated vitrification and biopsy on the developmental potential of blastocysts and clinical outcomes: A retrospective propensity-score-matched cohort study.

Purpose: This study aimed to investigate the effects of repeated vitrification and trophectoderm (TE) biopsy procedures during preimplantation genetic testing (PGT) on blastocyst developmental potential and clinical outcomes.

Methods: This retrospective study analyzed data from January 2018 to January 2024. The study group included 229 blastocysts from 85 patients that underwent double vitrification (with either single or double biopsy).

Scalable secondary metabolite production in Streptomyces using a plug-and-play system.

Streptomyces species are producers of bioactive secondary metabolites with clinical, agricultural and biotechnological applications. To scale these strains for industrial production, a plug-and-play system that orchestrates multitarget engineering for maximizing cellular contributions to secondary metabolites is needed. Building on the discovery that distinct quorum-sensing receptors within the Streptomyces genus can recognize an identical DNA-binding site, we build a quorum-sensing-triggered promoter applicable across various Streptomyces.

Single-shot digital image-correlation-assisted digital holography for simultaneous 3D shape and displacement measurement.

To measure surface 3D shape and displacement of curved diffuse objects, existing holographic techniques usually rely on complex optical systems or multiple shots. This is because digital holography (DH) can only measure displacement along the direction of the sensitivity vector. To realize 3D displacement measurement, three DH setups are needed.

CAS-Colon: A Comprehensive Colonoscopy Anatomical Segmentation Dataset for Artificial Intelligence Development.

Artificial intelligence (AI) holds immense potential to transform gastrointestinal endoscopy by reducing manual workload and enhancing procedural efficiency. However, the development of robust AI algorithms is hindered by limited access to high-quality medical datasets and the labor-intensive nature of data annotation. Here, we present CAS-Colon, a novel dataset comprising 78 high-resolution colonoscopy videos captured during the withdrawal phase.

Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial.

Both SARS-CoV-2 mRNA and mucosal vaccines induce protective immunity against COVID-19 but showed different immune profiles. We conducted a longitudinal head-to-head analysis of the safety and immunogenicity of the aerosolized adenovirus-vectored and mRNA COVID-19 vaccines. 450 participants were enrolled and randomly assigned into three groups to be vaccinated with an aerosolized Ad5-vectored bivalent vaccine (wild-type and BA.

Constructing Continuously-Distributed and Crystalline-NaF-Rich SEI on Hard Carbon Anode Through Binder Chemistry for High-Performance Sodium-Ion Batteries.

Constructing the continuously-distributed and crystalline-NaF-rich solid electrolyte interface (CC-NaF-SEI) is expected to greatly promote the sodium storage performance of hard carbon (HC) anodes. However, such an impressive concept remains extremely intractable to achieve and lacks an efficiently cost-less strategy. Herein, the application of the commercially available LA133 binder is pioneered to engineer such a CC-NaF-SEI.

Fully exposed Pt cluster catalysts enable cascade oxidation of polyol to dicarboxylic acid.

The polyol oxidation to dicarboxylic acid, a crucial value-accretive reaction, is still challenging due to the paradoxical relationship between efficient activation of C-H bond and rapid desorption of carboxylic acid. Herein, we break this contradiction by constructing fully exposed Pt cluster supported on hydroxyapatite (Pt/HAP) to promote two primary hydroxyl groups of polyol oxidation to dicarboxylic acid. Such fully exposed Pt cluster with an average Pt-Pt coordination number of ∼3.

The neural mechanisms underlying semantic unification and semanteme integration.

The basic composition processing of human language (at least) contains semantic unification and semanteme integration. However, previous researchers only focused on the neural mechanism underlying semantic unification. In the current study, participants were asked to complete both the semantic unification and semanteme integration tasks while undergoing functional magnetic resonance imaging (fMRI) scanning.

Boundary-Lubricated Hydrogels with Load-Bearing Capacity via Microphase Separation Strategy.

Lubricating hydrogels show promise as cartilage substitutes but face mechanical fragility (elastic modulus <100 kPa) and fluid-dependent lubrication failure under physiological loads. hydrogels are presented with nanoconfined water via microphase-separated structures, combining hydrogen-bond-stabilized polymer-dense domains and hydrated regions. By tuning hydrated nanopore size (≈10 nm) and enhancing bound water content, these hydrogels achieve boundary lubrication with ultralow friction (coefficient of friction, COF≈0.

Emergency Management of Extensive Spinal Epidural Hematoma Causing Medullary Compression After Single-Level Anterior Cervical Discectomy and Fusion (ACDF): A Novel Segmental Decompression and Catheter Irrigation Strategy.

Here, we present a retrospective analysis of a 48-year-old male patient who developed a rare complication of extensive spinal epidural hematoma (SEH) with spinal cord and medullary compression following single-level anterior cervical discectomy and fusion (ACDF), manifesting as acute dyspnea, coma, and quadriplegia. The emergency treatment entailed anterior segmental decompression under general anesthesia, removal of internal fixation devices, and targeted catheter irrigation to evacuate the hematoma spanning from C1 to C7. Postoperatively, the patient demonstrated remarkable neurological recovery, with the American Spinal Injury Association (ASIA) impairment grade improving from preoperative grade A (complete paralysis) to grade E (normal function), and was discharged after uneventful rehabilitation.

Pathogen identification and biological fungicides screening for blight in China.

is an important ornamental horticultural plant with high ornamental value. blight was first detected in 2023 in Wanzhou District, Chongqing City, China. This disease seriously reduces the ornamental value of .