Case Report: Hepatocellular adenoma due to long-term oral stanozolol administration.

This article presents a case of a 15-year-old male with a 6-year history of aplastic anemia treated with long-term oral stanozolol to promote hematopoiesis. Throughout this period, he underwent regular outpatient follow-up assessments of blood and liver function parameters. While abnormal liver function was recorded on several occasions and treated with oral hepatoprotective drugs, no abdominal imaging test was conducted.

Combined transcriptome and metabolome analysis of Hua in response to infection.

The fungal pathogen , first identified as the causative agent of gray mold disease in China, has become a critical biotic constraint limiting the sustainable production of Hua in major cultivation regions. To investigate the physiological reactions and transcriptome gene changes of after infection, in this study, we investigated the defense enzyme activity, transcriptome differential genes (DEGs), and differential metabolites (DAMs) of . When invaded the leaves of , the activities of phenylalanine deaminase (PAL), catalase (CAT), and peroxidase (POD) increased.

Enhancing the encapsulation efficiency, bioavailability, and antioxidant efficacy of quercetin and maize peptide by a novel multi-frequency pulsed ultrasonic-assisted nanoliposomal encapsulation system.

To enhance the embedding rate, bioavailability, and antioxidant efficacy of quercetin (Qu) and maize peptide (MP), a maize peptide-quercetin nanoliposome (MP-Qu-Lipo) was synthesized using a novel multi-frequency pulsed ultrasound treatment (UT) technology. The effects of ultrasonic parameters on preparation performance were evaluated, along with their influence on the structure, digestion, cellular uptake, and cellular protection against oxidative stress. The results showed that both encapsulation and ultrasonic treatment significantly enhanced the Qu embedding rate (ER), yield, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the nanoliposome by 43.

One-pot construction of monodisperse core-shell silica microsphere with quinine-containing hybrid fibrous shell for racemates separation.

Background: The traditional chiral stationary phases (CSPs) preparation process involved two main parts: matrix microsphere structure regulation and surface bonding of chiral selector, demonstrating cumbersome preparation steps and long time consumption, while the currently spherical chiral hybrid CSPs could easily solve this problem by using chiral selectors as silicone precursors to participate in hybridization of CSPs directly, the preparation efficiency would be significantly improved, while the development of chiral hybrid core-shell silica CSPs with excellent monodispersity, uniform shell thickness and suitable pore structure was a challenging problem.

Results: In this work, an oil-water bi-phase method was been precisely designed to fabricate the sub-2 μm core-shell silica microspheres with quinine-containing hybrid fibrous shell (SiO@SiO-t-BuCQN) in one-pot process, the hybrid shell thickness and specific surface area were measured about 171 nm and 120.4 m g.

Pathogen identification and biological fungicides screening for blight in China.

is an important ornamental horticultural plant with high ornamental value. blight was first detected in 2023 in Wanzhou District, Chongqing City, China. This disease seriously reduces the ornamental value of .

Bioelectronic Drug-free Control of Opportunistic Pathogens through Selective Excitability.

The natural excitability in mammalian tissues has been extensively exploited for drug-free electroceutical therapies. However, it is unclear whether bacterial residents on the human body are equally excitable and if their excitability can also be leveraged for drug-free bioelectronic treatment. Using a microelectronic platform, we examined the electrical excitability of , a skin-residing bacterium responsible for widespread clinical infections.

Self-esteem mediates the link between subjective family socioeconomic status and daily depressed mood during emerging adulthood: A daily diary study.

Background: Previous investigations have demonstrated the link between subjective socioeconomic status and depressed mood. However, the relationship and mechanisms of subjective socioeconomic status with daily depressed mood remain unclear in emerging adulthood.

Methods: This study investigated whether and how family subjective socioeconomic status is associated with depressed mood using a 14-day daily diary design with multilevel modeling.

Chronic intermittent hypoxia affects the expression of IRS - 2/p - Akt/GSK - 3 in the liver of SD rats and its impact on glucose metabolism.

Background: Epidemiological studies indicate a strong association between OSA and type 2 diabetes. Currently, the insulin signal transduction pathway and its associated effector proteins have emerged as a focal point in type 2 diabetes research. However, the underlying mechanisms in OSA remain elusive.

Design of a five peak tunnable metasurface for terahertz biological detection with vanadium dioxide.

This paper introduces the design of a five-peak tunnable metasurface unit cell. The unit adopts a three-layer multi-resonant structure to construct five absorption frequencies, and the absorptive and reflective states are controlled by the phase change material vanadium dioxide. The author explains the working principle of the five absorption frequencies generated by the unit cell based on the electrical field diagram of the unit cell.

An in-depth analysis of the effects of excessive acetochlor exposure on chicken liver health.

Acetochlor, a commonly used herbicide, poses significant risks to ecosystem and organism health through contamination of the food chain. Despite its widespread use, there is a lack of comprehensive studies on its toxicological effects on avian species. This study investigates the impact of environmental acetochlor exposure on chicken liver health using metabolomics analysis and histopathological techniques.

The antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.

Background: To investigate the antibiofilm effect and mechanism of the silver nanowire (AgNW)-modified glass ionomer cement (GIC) against multi-species oral biofilm, and to examine the mechanical and biochemical properties of this novel GIC material.

Methods: Conventional GIC was incorporated with different concentrations of AgNW and silver nanoparticles (AgNP). Multi-species biofilms of Streptococcus mutans, Streptococcus sobrinus, Lactobacillus fermentum, and Lactobacillus rhamnosus were cultured for 72 h on GIC specimens.

Facile Fabrication of Monodisperse Vinyl Hybrid Core-Shell Silica Microsphere with Short Range Radial Channel in bi-phase System.

The development of monodisperse hybrid silica microspheres with highly regular pore structure and uniform distribution of functional groups have significant value in the biomolecular separation field. In this work, the short range ordered pore channels are precisely constructed onto the non-porous silica microsphere surface by a bi-phase assembly method, and the cylindrical silica channel introduced a plethora of vinyl groups by "one-pot" co-condensation to form vinyl hybrid silica shell. As hydrophilic interaction chromatography (HILIC) stationary phase, the vinyl hybrid core-shell silica microsphere is simply modified with zwitterion glutathione (SiO@SiO-GSH), in which the HILIC enrichment process is significantly shortened due to its specific porous characteristics.

Barriers and Facilitators to the Participation of Pregnant Women in Clinical Research: A Mixed-Methods Systematic Review.

Objectives: Pregnant women had a large demand for diagnosis and treatment, but the clinical research was not sufficient, and there were many barriers for pregnant women to participate in clinical research. This study aimed to systematically identify these barriers and facilitators, map them with Theoretical Domains Framework (TDF) and Behavior Change Techniques (BCTs) to inform the development of interventions promoting pregnant women's involvement in clinical research.

Methods: This was a mixed-methods systematic review.

GPR120 exacerbates the immune-inflammatory response in chicken liver by mediating acetochlor induced macrophage M1 polarization.

Acetochlor is a widely used and highly effective herbicide. Its overuse poses significant threats to biosecurity and ecological integrity, particularly affecting free-ranging birds. Data on its impact, especially mechanisms of liver toxicity in chickens, are lacking.

Microglial CD2AP deficiency exerts protection in an Alzheimer's disease model of amyloidosis.

Background: The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton and protein trafficking. Single nucleotide polymorphisms (SNPs) in the CD2AP gene have been associated with Alzheimer's disease (AD). However, the functional role of CD2AP, especially its role in microglia during AD onset, remains elusive.

Immune-mediated liver injury caused by immune checkpoint inhibitors exhibits distinct clinical features that differ from autoimmune hepatitis.

Background: Immune-mediated liver injury caused by immune checkpoint inhibitors (ILICI) and autoimmune hepatitis (AIH) are both related to the distorted immune system. However, ILICI differs from AIH in several distinct ways. We aimed to study the differences between ILICI and AIH.

Childhood emotional maltreatment and emotional intelligence in adolescents: The mediating role of mindfulness.

Background: Childhood emotional maltreatment is detrimental to adolescents' emotional intelligence. However, most research has concentrated on the overall experience of childhood emotional maltreatment, leaving the outcomes of specific types of emotional maltreatment (i.e.

Childhood emotional maltreatment and psychological richness among Chinese adolescents: The mediating effect of gratitude.

Background: Childhood emotional maltreatment impairs adolescents' well-being, but less is known about the link between childhood emotional maltreatment and adolescents' psychological richness, a new form of well-being and the mechanism underlying the link.

Objective: This study aimed to reveal the longitudinal effect of childhood emotional maltreatment on psychological richness as well as the mediating role of gratitude among Chinese adolescents.

Methods: A total of 577 (354 females; M = 16.

New insights into zinc alleviating renal toxicity of arsenic-exposed carp (Cyprinus carpio) through YAP-TFR/ROS signaling pathway.

Environmental pollution caused by arsenic or its compounds is called arsenic pollution. Arsenic pollution mainly comes from people mining and smelting arsenic compounds. In addition, arsenic compounds' widespread use and production of arsenic-containing pesticides, arsenic-rich water used to irrigate farms, or high arsenic levels in foods caused by coal burning are all sources of arsenic contamination.

Orally administered recombinant Lactobacillus expressing PEDV neutralizing antibody protects piglets against PEDV infection.

Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus, causing fatal acute diarrhea in suckling pigs, with mortality rates as high as 100 % in 7-day-old piglets. Due to the challenge of quickly establishing effective active immunity, the main strategy for protecting piglets from PEDV infection relies on antibodies, particularly neutralizing antibodies, to provide passive immune protection. In this study, a recombinant Lactobacillus strain for secreting the Fab fragment of neutralizing antibody against PEDV was constructed (pPG-Fab/J31).

Sialic acid-modified docetaxel cationic liposomes: double targeting of tumor-associated macrophages and tumor endothelial cells.

Taxane drugs are clinically used for the treatment of many types of cancers due to their excellent antitumor effects. However, the surfactants contained in the injections currently used in the clinic may have serious toxic side effects on the organism, making it necessary to develop new dosage forms. Cationic liposomes have been widely used in antitumor research because of their advantage of preferentially targeting tumor neovascularization, but antitumor by targeting tumor vasculature alone does not necessarily provide good results.