Addressing Frailty in Cardiology: Identifying Barriers Faced by Cardiologists and Health Care Professionals in Asia.

Background: Preventing frailty is crucial for improving outcomes in aging populations at heightened cardiovascular risk, yet implementation in real-world practice remains challenging. The authors previously reported low use of frailty strategies among cardiologists in Asia.

Objectives: The aim of this study was to explore the barriers to frailty implementation among cardiologists, other physicians, and nurses.

Role of Metabolic Nuclear Receptors in Acute Liver Injury and Drug-Induced Hepatotoxicity.

Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been extensively reviewed, comprehensive review of metabolic NRs in acute liver injury (ALI) is scarce. This review summarizes the current knowledge on how metabolic NRs modulate ALI, with particular focus on those frequently-studied NRs including farnesoid X receptor, peroxisome proliferator-activated receptors and pregnane X receptor, as well as on the less-characterized liver X receptor and constitutive androstane receptor.

Sensory Attenuation of Auditory P2 Responses is Modulated by the Sense of Action Timing Control.

Sensory attenuation is a well-established phenomenon in which the neurophysiological response elicited by self-initiated stimuli is attenuated compared to identical externally generated stimuli. This phenomenon is mostly studied by comparing the N1 and P2 components of the auditory ERP. Sensory attenuation has also been linked to our sense of agency and control.

Involvement of four alga toxins in the risks of human neurodegenerative diseases: Toxicogenomic data mining and bioinformatics analysis.

Alga toxins have recently emerged as an environmental risk factor, especially to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. However, the association between the alga toxins β-N-methylamino-L-alanine (BMAA), brevetoxin B, cyanoginosin LR, okadaic acid and neurodegenerative diseases remains inadequately investigated. Therefore, the aim of this study was to elucidate the potential associations.

CYP82G1 Enzyme Functions as Chromone Hydroxylase in the Biosynthesis of 6-Hydroxy-2-(2-Phenylethyl)chromone in Aquilaria sinensis.

Aquilaria sinensis, a plant of the genus Aquilaria in the family Thymelaeaceae, can form resinous and fragrant agarwood in response to wounding or infection. The resin physically occludes xylem vessels and ray parenchyma, limiting pathogen mobility and resource loss. The quality of agarwood is often evaluated using highly oxygenated 2-(2-phenylethyl)chromones, such as agarotetrol, 2-[2-(4-methoxy)phenylethyl]chromone, 4'-methoxyagarotetrol and 6,7-dimethoxy-2-(2-phenylethyl)chromone.

Magnetic FeO Nanoparticles Modified Hydroxyapatite Whisker: A Novel Framework with Superior Osteogenic Efficacy.

The valid repair of bone defects requires considering precise elements mirroring native tissue and the efficiency of treatment reality. Magnetic biomaterial-mediated mechanotransduction emerges as a critical mechanism for enhancing osteogenic differentiation and bone regeneration. Here, enhancement of osteogenic capacity is achieved in a hydroxyapatite whisker (HAw) by integrating with magnetic FeO nanoparticles (HAw/FeO).

Identifying the Ongoing Risk and the Critical Time Point of Cardiovascular Diseases in Women With Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies.

This study assessed the risk of cardiovascular diseases (CVD) at various stages in women with gestational diabetes mellitus (GDM) and aimed to identify critical time points when the risk increases. Fifteen cohort studies including a total of 7,515,168 pregnant women were analyzed, among whom 429,564 had GDM and 13,773 developed CVD. Participants were grouped based on follow-up periods of approximately 5, 10, 15, and 25 years.

Spatial mapping of phosphatidylcholine -positional isomers using CID of divalent metal complexes in imaging mass spectrometry.

Phosphatidylcholines (PCs) are the main components of cellular membranes. The high degree of structural heterogeneity leads to significant variations in PC functions and complicates structural characterization. For example, the complex mixtures of lipid structures create challenges when analyzing and identifying these compounds directly from tissue in matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry experiments.

Stokes/anti-Stokes luminescence in Er-doped fluoride glass enabled dual-mode ultraviolet/infrared photodetection and visible-display integration for secure optical communication.

Integrating photodetection and display functions within a single electronic device holds significant application prospects. However, to date, most of them relied on complex device structures that involve photodetectors with readout circuits or integration with light-emitting diodes (LEDs). Here, we introduce infrared optical material-Er doped fluoride glass-into conventional organic photodetectors, enabling new material options for advanced photodetection and imaging technologies.

Preclinical characterization of TGRX-678, a brain-penetrant allosteric inhibitor of BCR::ABL1.

Clinical resistance or intolerance to tyrosine kinase inhibitors (TKIs) remains challenging for the treatment of chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) with central nervous system (CNS) relapse. Therapeutic options are currently limited for patients who developed the gatekeeper mutations or compound mutations. Here, we describe the preclinical profile of TGRX-678, an allosteric inhibitor designed to Specifically Target the ABL1 Myristoyl Pocket (STAMP), with potent anti-proliferative activity against the majority of ATP site mutants of BCR::ABL1 and minimal off-target cytotoxicity.

Discontinuation of belimumab in systemic lupus erythematosus patients who achieved disease stability: a retrospective cohort study.

Objectives: To investigate the changes in various indicators of systemic lupus erythematosus (SLE) patients who discontinue belimumab after achieving disease stability, assess the potential impacts and risks of discontinuing belimumab, and provide scientific evidence and references for clinical decision-making.

Methods: Pertinent data were retrospectively collected from SLE patients at the Second Affiliated Hospital of Jiaxing University who either discontinued or continued belimumab treatment after achieving disease stability. The study compared changes in disease activity, glucocorticoid usage, immunological markers, and other relevant indicators between the two groups after 6 months of follow-up.

In Vivo Confocal Microscopy: A Standard Operating Procedure for The Detection of Demodex Mites at The Eyelid Margin.

Demodex mite infestation can cause inflammation of the eyelid margin, and Demodex blepharitis could give rise to a series of ocular conditions in clinical cases. Numerous physicians diagnose ocular infestation of Demodex mites through eyelash epilation and the observation of eyelashes under light microscopy in vitro. However, the presence of residual mites following eyelash removal and the pain associated with the procedure are limitations of standard clinical care.

A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain.

We present a correlated light and electron microscopy (CLEM) dataset from a 7-day-old larval zebrafish, integrating confocal imaging of genetically labeled excitatory () and inhibitory () neurons with nanometer-resolution serial section EM. The dataset spans the brain and anterior spinal cord, capturing >180,000 segmented soma, >40,000 molecularly annotated neurons, and 30 million synapses, most of which were classified as excitatory, inhibitory, or modulatory. To characterize the directional flow of activity across the brain, we leverage the synaptic and cell body annotations to compute region-wise input and output drive indices at single cell resolution.

Evaluated anatomical variations in children by sacrococcygeal ultrasonography as a new tool: a report from a Chinese tertiary hospital.

Objective: Anatomical variations in the sacrococcygeal region can lead to complications such as accidental dural puncture during caudal block. This study aimed to determine the prevalence of sacrococcygeal anatomical variations using ultrasonography and to evaluate the necessity of ultrasound guidance in sacral block procedures.

Methods: Ultrasound findings of sacrococcygeal anatomy were validated against magnetic resonance imaging (MRI).

F-box ubiquitin-ligating enzyme ZEITLUPE 1 inhibits the promotion of caffeic acid O-methyltransferase 1 in salt tolerance of apple by the multimeric E3 protein complex SCF-mediated ubiquitination modification and protein degradation.

Caffeic acid O-methyltransferase (COMT) is involved in melatonin biosynthesis and regulates salt tolerance in plants, but no COMT homologs have been reported in apple. The post-translational mechanisms through which COMT regulates salt tolerance remain elusive in apple. In this study, we identified a novel protein module MdZTL1-MdCOMT1 regulating melatonin biosynthesis and salt tolerance.

Acid-Enabled Dearomative Umpolung of 3-Indolylquinones toward C3-Oxygenated Benzofuro[2,3-]indolines.

We report an acid-enabled dearomative umpolung of 3-indolylquinones for the synthesis of C3-oxygenated benzofuro[2,3-]indolines. This transformation proceeds via an intramolecular annulation, initiated by acid-facilitated formation of a dearomatized iminium intermediate. The resulting -quinone methide motif undergoes intramolecular cyclization to generate a C3-carbocation intermediate, which is subsequently trapped by nucleophiles.

Occupational Burnout in Nurses Is due to Long-Term Work Stress Rather Than COVID-19 Pandemic Event.

Aim: This study aims to explore occupational burnout among Chinese nurses from two perspectives: first, by comparing changes in emotional exhaustion, depersonalisation and personal accomplishment before and after the COVID-19 pandemic; and second, by identifying long-term work-related stressors and structural factors contributing to burnout.

Design: A mixed-methods approach was adopted, combining a systematic review with qualitative interviews. The qualitative component involved semi-structured interviews with 53 hospital-employed nurses from various departments and regions across China, focusing on the three core dimensions of occupational burnout.

Perceived ability and influencing factors of the signage system for color vision deficiency groups: A case study of metro travel process.

Introduction: Color plays a crucial role in wayfinding signage, enhancing information filtering and reception. However, individuals with color vision deficiency (CVD) struggle to interpret color-coded information, impeding navigation and daily mobility. With the rapid development of urban rail transit in China, metro systems rely heavily on color-coded signage, exacerbating challenges for CVD individuals.

Epidemiological and Clinical Features of Meningococcal Meningitis in Infants - China, 2006-2023.

Introduction: Infants have the highest incidence of meningococcal meningitis (MM) among all age groups in China. Infants receive their first and second doses of serogroup A meningococcal polysaccharide vaccine at 6 and 9 months of age.

Methods: We extracted data on MM cases among 0-11-month-old children reported during 2006-2023 from the National Notifiable Diseases Registry System and the National Meningococcal Disease Surveillance System and conducted an epidemiological and clinical analysis.

Auxin Dynamics and Transcriptome-Metabolome Integration Determine Graft Compatibility in Litchi ( Sonn.).

Grafting is a prevalent horticultural technique that enhances crop yields and stress resilience; nevertheless, compatibility issues frequently constrain its efficacy. This research examined the physiological, hormonal, and transcriptional factors regulating compatibility between the litchi ( Sonn.) cultivars Feizixiao (FZX) and Ziniangxi (ZNX).

Antimicrobial peptide mimic 329 potentiates minocycline against carbapenem-resistant Klebsiella pneumoniae.

As antibiotic resistance increases and new drug development lags, the effectiveness of single antibiotics has drastically diminished for clinical infection treatment. The resistance crisis is exacerbated by the swift development and dissemination of Gram-negative bacteria that are extensively drug-resistant (XDR), particularly strains resistant to carbapenems in clinical settings. In this scenario, antibiotic adjuvants play a crucial role in revitalizing existing treatments to combat carbapenem-resistant bacterial infections.

A heterojunction-engineering nanodrug with tumor microenvironment responsiveness for tumor-specific cuproptosis and chemotherapy amplified sono-immunotherapy.

Cuproptosis has recently identified as a unique copper-dependent cell death mechanism that may provide new opportunities for improving the therapeutic effect of tumor therapy through triggering efficient adaptive immune responses. However, the poor delivery efficiency and non-tumor-specific release of Cu ions would restrict the potential clinical applications of cuproptosis inducers. Herein, we report for the first time the development of hollow CuSe nanocubes as the tumor microenvironment (TME)-responsive drug delivery systems and cuproptosis inducers for tumor-specific chemotherapy and cuproptosis.

Genomic Insights Into Early Relapsed Breast Cancer: Prognostic Challenges and Mutation Landscape.

Purpose: Early relapsed breast cancer, characterized by recurrence within two years post-surgery, often results from drug resistance and rapid progression. The clinicopathological, prognostic and molecular features of these patients still await exploration.

Methods: In this study, 43 patients with early relapsed breast cancer were included as well as 42 advanced breast cancer patients who experienced a recurrence after two years since surgery as the control group.

Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders.

Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the rate-limiting step of lipogenesis and modulates lipid homeostasis. Although numerous SCD1 inhibitors were tested for treating metabolic disorders both in preclinical and clinic studies, the tissue-specific roles of SCD1 in modulating obesity-associated metabolic disorders and determining the pharmacological effect of chemical SCD1 inhibition remain unclear. Here a novel role for intestinal SCD1 in obesity-associated metabolic disorders was uncovered.