Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma.

Tumors evolve to avoid immune destruction and establish an immunosuppressive microenvironment. Syngeneic mouse tumor models are critical for understanding tumor immune evasion and testing cancer immunotherapy. Derived from established mouse tumor cell lines that can already evade the immune system, these models cannot simulate early phases of immunoediting during initial tumorigenesis.

Urinary exposure to liquid crystal monomers (LCMs) in children near e-waste recycling sites: Occurrence and implications for physical growth.

Liquid crystal monomers (LCMs) are emerging contaminants extensively used in electronic displays, yet human exposure assessment studies remain scarce, particularly among children. This study presents the first comprehensive assessment of urinary LCMs in 194 children living near e-waste recycling areas in South China. Eighteen of thirty target LCMs were detected, with significantly higher concentrations in exposed children (median = 8.

Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning.

Background: Lumbar disc degeneration (LDD) displays considerable heterogeneity in terms of clinical features and pathological changes. However, researchers have not clearly determined whether the transcriptome variations in LDD could be used to identify or interpret the causes of heterogeneity in clinical features. This study aimed to identify the transcriptomic classification of degenerated discs in LDD patients and whether the molecular subtypes of LDD could be accurately predicted using clinical features.

A 28 mK Resolution, -0.45 °C/+0.51 °C Inaccuracy Temperature Sensor Using Dual-Comparator Architecture and Logic-Controlled Counting Method.

This paper presents an all-CMOS temperature sensor with low power consumption, wide temperature range, and high precision in a 180 nm CMOS process. Based on the I-V characteristics of MOSFETs in the subthreshold region and the negative exponential biasing current generated by the self-bootstrapped bias circuit, the proposed temperature-sensing front-end produces CTAT and PTAT voltages with high linearity and high sensitivity. The voltage-to-time converter (VTC) adopts a dual-comparator architecture to expand the time interval for improving resolution.

Co-Inoculation Between Bacteria and Algae from Biological Soil Crusts and Their Effects on the Growth of and Sandy Soils Quality.

Microorganisms (bacteria and algae) are important components of biological soil crusts, which exhibit crucial functions in promoting plant growth, maintaining soil structure, and improving soil nutrient content. To determine the effects of combined inoculation on the growth of and sandy soils, four species of bacteria and algae were isolated and identified from biological soil crusts (during different developmental stages in a karst rocky desertification area). The soil quality was evaluated based on a soil quality index (SQI), growth indicators of , soil physicochemical properties, and a stability analysis of aggregates.

Functional Analysis of NPC2 in Alarm Pheromone Recognition by the Red Imported Fire Ant, (Formicidae: ).

The red imported fire ant () is a dangerous invasive insect. These ants rely on releasing an alarm pheromone, mainly composed of 2-ethyl-3,6-dimethylptrazine (EDMP), to warn nestmates of danger and trigger group defense or escape behaviors. This study found two NPC2 proteins in the ant antennae: SinvNPC2a and SinvNPC2b.

Synthetic Mesh Reconstruction Improves Pelvic Floor Function and Quality of Life After Sacrectomy: A Preliminary Clinical Assessment.

Background: En bloc resection of the sacrum, whether in the form of total or partial sacrectomy, is the mainstay treatment for patients with primary malignant sacral tumors. However, these surgical procedures can lead to pelvic floor dysfunction, with symptoms such as incontinence and impaired rectal function that can severely impact patients' quality of life. Therefore, effective interventions to restore pelvic floor function would be helpful for affected patients.

Superior NO sensing semiconductor-metal transition in undoped HfCO MXene: doping-mediated trade-offs between surface reactivity and electronic properties.

In this paper, we employ density functional theory (DFT) and non-equilibrium Green's function (NEGF) calculations to investigate the gas-sensing properties of monolayer HfCO MXene, focusing on intrinsic vacancy defects and carbon-site substitutional doping. Among tested gases, NO exhibits exceptional sensitivity due to strong adsorption energy and significant charge transfer. Boron doping at carbon sites enhances charge transfer and adsorption strength through d-band center upshift (-0.

The efficacy and immune-mediated safety of PD-1/PD-L1 combined with neoadjuvant chemotherapy in triple-negative breast cancer: a meta-analysis.

Background: The efficacy and immune-mediated safety of PD-1/PD-L1 inhibitors in triple-negative breast cancer (TNBC) remain controversial. Given TNBC's aggressive biology and poor prognosis, definitive evidence is urgently needed. We performed this meta-analysis to comprehensively assess the benefits and safety of these inhibitors by examining clinical trial data for TNBC.

Hemocytes facilitate interclonal cooperation-induced tumor malignancy by hijacking the innate immune system in Drosophila.

Tumor heterogeneity, a hallmark of cancer, frequently leads to treatment failure and relapse. However, the intricate communication between various cell types within the tumor microenvironment and their roles in tumor progression in vivo remain poorly understood. Here we establish a novel tumor heterogeneity model in the Drosophila larval eye disc epithelium and dissect the in vivo mechanisms by combining sophisticated genetics with single-cell RNA sequencing.

Efficacy analysis of microvascular decompression and percutaneous balloon compression for trigeminal neuralgia secondary to vertebrobasilar dolichoectasia: a retrospective cohort study.

Background: Trigeminal neuralgia secondary to vertebrobasilar dolichoectasia (VBD-TN) poses a significant challenge in the surgical management of trigeminal neuralgia. This study aimed to evaluate and compare the therapeutic efficacy of microvascular decompression (MVD) and percutaneous balloon compression (PBC) in patients with VBD-TN.

Methods: We conducted a retrospective cohort analysis of consecutive VBD-TN patients treated at a tertiary hospital in China between September 2013 and August 2022.

Fluorescence quantitative assessment of blood perfusion in the gastric conduit to reduce anastomotic leakage after esophagectomy: a randomized controlled trial.

Objectives: Indocyanine green (ICG) can help surgeons identify the blood perfusion distribution of the gastric conduit. The aim of our study is to utilize ICG fluorescence for quantitative assessment of blood perfusion at the anastomotic site to minimize postoperative anastomotic leakage.

Methods: Patients who underwent McKeown esophagectomy with esophageal squamous cell carcinoma between August 1, 2019, and July 31, 2021, were enrolled in the study and randomly assigned to two groups.

Patient-reported outcomes of the prognostic nutritional index for resectable esophageal squamous cell carcinoma.

Background: The prognostic nutritional index (PNI) involves both the nutritional status and immune function as crucial factors linked to the prognosis of various gastrointestinal cancers. The relationship between the PNI and postoperative quality of life (QOL) in patients with esophageal cancer (EC) has not been examined. This study sought to examine the effects of the PNI on the postoperative patient-reported outcomes (PROs) of patients with esophageal squamous cell carcinoma (ESCC).

Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations.

Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy with distinct regional variations, particularly concentrated in East Asia, including China and Japan. The Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) system offers simplicity but lacks emphasis on anatomical specificity, such as upper mediastinal metastases. Conversely, the Japan Esophageal Society (JES) system provides detailed regional stratification, aiding preoperative planning and tailored therapy, though it demands greater clinical expertise.

The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese Cohort Data.

Purpose: The association between inflammatory dysregulation and cervical carcinogenesis and progression has not yet been fully elucidated. We aimed to comprehensively evaluate the genetic association between inflammation and cervical cancer, and construct an accurate prognosis model based on circulating inflammatory parameters and indexes with machine learning (ML) algorithms.

Patients And Methods: We tested the genome-wide association of circulating inflammatory molecules (CIMs) (91 circulating inflammatory cytokines and 10 inflammatory cells) and summary data retrieved from the UK biobank (cases = 1659 and controls =381,902) with two-sample Mendelian randomization (MR) and colocalization analyses.

Immunogenicity and safety of quadrivalent recombinant influenza vaccine in Korean adults: Phase III, randomized study.

Quadrivalent recombinant influenza vaccine (RIV4) is indicated for active immunization against influenza virus in adults (≥18 years) in countries where it is currently registered. This Phase III, parallel, randomized, modified double-blind, active controlled, multi-center study was designed to compare the immunogenicity and safety of single dose intramuscular RIV4 with a locally-licensed quadrivalent-inactivated influenza vaccine (IIV4, Fluarix® quadrivalent) in participants aged ≥18 years during 2021-22 Northern Hemisphere influenza season at three tertiary care centers in South Korea. Participants were randomized (1:1) to receive single dose intramuscular RIV4 or IIV4.

Modulation code optimization for holographic data storage.

The performance of page-oriented holographic data storage systems, especially capacity, transmission speed, and symbol error rate, critically depends on the modulation code design. Under the constraint of maintaining approximately 20% code weight, this paper proposes an optimized 5:22 two-dimensional equal-weight sparse modulation code featuring elongated code block geometry. We theoretically evaluated the code rates and decoding efficiencies of various encoding formats with equivalent code weights, demonstrating that this design achieves optimal performance among existing binary encodings.

Multifunctional N-doped carbon dot- polyvinyl alcohol composite film/label enables real-time freshness monitoring and synergistic preservation for shrimp.

Conventional food packaging lacks active preservation and real-time monitoring. This study presents a novel polyvinyl alcohol -based film/label incorporating N-doped carbon dot, exhibiting enhanced pH responsiveness, potent antimicrobial/ antioxidant properties and biosafety (cell relative viability >90 %). The pH-sensitive label can capture the volatile amines from food spoilage, triggering its real-time dual-mode colorimetric/fluorescent signal changes with trimethylamine detection limit of 0.

BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma.

Long-term survival of glioblastoma multiforme (GBM) remains challenging, spurring the development of novel therapies such as oncolytic virus therapy. While oncolytic virus shows promise in clinical trials, many patients do not respond to this therapy. Here, we perform a CRISPR screening and identify the non-canonical BRG1/BRM-associated factor (ncBAF) complex as a pivotal tumor-intrinsic factor for oncolytic virotherapy resistance.

Low-carbon transition of China's monocrystalline module and its global contributions.

Although photovoltaic (PV) power is widely viewed as a zero-carbon solution, its upstream module production remains highly carbon-intensive. Existing studies often fail to capture supply chain heterogeneity and spatial differences in production, limiting assessments of the sector's low-carbon transition. This study conducted a carbon footprint analysis of monocrystalline modules manufactured in China from 2008 to 2023, incorporating refined data for supplier-specific configurations and province-level electricity carbon intensity.

The impact of mental toughness on subjective well-being among Chinese college students in the post-COVID-19 era.

The COVID-19 pandemic has profoundly impacted mental health worldwide, particularly within campus environments, where it has heightened issues such as anxiety, depression, and stress. Despite the increasing recognition of these challenges, the role of psychological resilience-defined as personal and external support resources that aid in coping-remains underexplored in relation to mental health outcomes. To address this gap, the present study investigates the relationships between subjective well-being, psychological resilience, and mental health symptoms, measured using the DASS-21 (Depression, Anxiety, and Stress Scale), 3 years after the pandemic's onset.

Global and China burden of ectopic pregnancy (1990-2021): Trends, patterns, and future projections.

Objective: This study evaluated the burden of ectopic pregnancy (EP) in China and globally from 1990 to 2021, aiming to enhance public awareness of EP and provide a scientific basis for formulating prevention and control strategies.

Methods: Data on incidence, prevalence, deaths, and disability-adjusted life years (DALYs) were obtained from the Global Burden of Disease 2021. This systematic review evaluates temporal variations in EP, demographic disparities in exposure, and associated risk determinants.

Evolution of cooperation under a time-varying peer pressure model in complex networks.

In this paper, based on the traditional prisoner's dilemma model, we introduce time-varying peer pressure and verify the enhancing effect of this time-varying peer pressure model on cooperation in different types of networks. We decompose peer pressure into two aspects: pressure intensity, reflecting the degree of punishment an individual receives due to strategy inconsistency with neighbors, and pressure sensitivity, indicating the likelihood of an individual being influenced by peer pressure, which can be regarded as an individual characteristic. Considering individuals' continuous development over time, it is possible for individual characteristics to change over time.

Potential of vitamin D for the prevention of 3 types of cerebrovascular diseases: A 2-sample Mendelian randomization study.

While nutritional and dietary interventions play a critical role in stroke prevention, the specific contributions of micronutrients remain incompletely understood. Observational studies suggest a potential association between vitamin D levels and cerebrovascular risk, but the causal role of vitamin D in distinct stroke subtypes - subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and ischemic stroke (IS) - remains underexplored. Instrumental variables for vitamin D levels and stroke outcomes were derived from genome-wide association studies in the IEU Open genome-wide association studies database.