Case Report: Hepatocellular adenoma due to long-term oral stanozolol administration.

This article presents a case of a 15-year-old male with a 6-year history of aplastic anemia treated with long-term oral stanozolol to promote hematopoiesis. Throughout this period, he underwent regular outpatient follow-up assessments of blood and liver function parameters. While abnormal liver function was recorded on several occasions and treated with oral hepatoprotective drugs, no abdominal imaging test was conducted.

[Research progress in key technologies for the development of Dendrobium officinale: from a rare and endangered species to a 10-billion-RMB-level industry].

Dendrobium officinale(DO) is a traditional Chinese medicinal and edible plant, while it is critically endangered worldwide. This article, primarily based on the original research findings of the author's team and available articles, provides a comprehensive overview of the factors contributing to the endangerment of DO and the key technologies for the conservation, efficient cultivation, and value-added utilization of this plant. The scarcity of wild populations, low seed-setting rates, lack of endosperm in seeds, and the need for symbiosis with endophytic fungi for seed germination under natural conditions are identified as the primary causes for the rarity and endangerment of DO.

Interplatform Agreement Between Liver Steatosis Analysis and Ultrasound-Guided Attenuation Parameter in the Evaluation of Hepatic Steatosis.

Objective: Liver steatosis analysis (LiSA) and the ultrasound-guided attenuation parameter (UGAP) are recently introduced commercially available techniques for the non-invasive evaluation of hepatic steatosis. This study aimed to assess the interplatform agreement between LiSA and UGAP in quantifying hepatic fat content.

Methods: Individuals diagnosed with or suspected of having fatty liver disease were included in the study.

A study on the diagnostic value of artificial intelligence combined with a contrast-enhanced ultrasound scoring system in partially cystic thyroid carcinoma.

Objectives: The aim of this study was to investigate the diagnostic value of the contrast-enhanced ultrasound (CEUS) scoring system, artificial intelligence (AI) and the American College of Radiology Thyroid Imaging and Reporting Data System when used by sonographers of different seniority levels individually and in combination for the diagnosis of partial cystic thyroid nodules (PCTNs).

Materials And Methods: A retrospective analysis of conventional ultrasound and CEUS images of enrolled patients was performed, and a CEUS scoring system was established. The sensitivity, specificity, and area under the curve (AUC) of CEUS and AI individually and in combination for diagnosis were compared among sonographers with different seniority levels.

[Molecular targeted therapy for progressive low-grade gliomas in children].

Objectives: To evaluate the efficacy of molecular targeted agents in children with progressive pediatric low-grade gliomas (pLGG).

Methods: A retrospective analysis was conducted on pLGG patients treated with oral targeted therapies at the Department of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, from July 2021. Treatment responses and safety profiles were assessed.

Skeletal muscle, neuromuscular organoids and assembloids: a scoping review.

Skeletal muscle organoids (SKMOs), neuromuscular organoids (NMOs), and assembloids have emerged as powerful in vitro models that simulate the intricate cellular interactions between muscle and nerve, offering a promising approach to study function, development, and disease at the neuromuscular junction (NMJ). Given the relevance of NMJ dysfunction in diseases such as amyotrophic lateral sclerosis (ALS), these models provide insights into disease modelling. Scoping reviews are particularly valuable when exploring broad or emerging areas, as they help identify key concepts and evolving methodologies.

IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.

Background: Interleukin-10 (IL-10), an anti-inflammatory cytokine, has shown therapeutic effect on autoimmune diseases, yet its effects on UC remain unclear. This study aims to investigate whether the administration of IL-10 can suppress disease flares in ulcerative colitis (UC).

Methods: A UC model was established in mice using dextran sulfate sodium (DSS) to evaluate the therapeutic effect of IL-10.

Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition.

Background: Hepatic fibrosis, a progressive fibrotic response to chronic liver injury, is characterized by excessive collagen deposition and impaired tissue repair. This pathological process leads to liver dysfunction and potential progression to irreversible cirrhosis or hepatocellular carcinoma. Currently, therapeutic options targeting the underlying mechanisms remain limited.

Assessment of the respiratory chain enzyme activity in peripheral blood monocytes for the noninvasive diagnostics of mitochondrial disease.

Background: Mitochondrial diseases are among the most common metabolic disorders caused by mitochondrial dysfunction. Analyzing mitochondrial respiratory chain enzyme activity is essential for diagnosis. However, clinical laboratories often rely on mitochondria isolated from muscle biopsies or cultured skin fibroblasts, which may be unacceptable for some pediatric patients.

Preparation of 5-hydroxymethylfurfural from cellulose catalyzed by silicon-based composite solid acids.

In order to improve the efficiency of solid acid catalyzed cellulose preparation of 5-hydroxymethylfurfural (HMF), this study prepared a silica-based solid acid with dual acid sites comprising both Lewis and Brønsted acids. Firstly, SiO microspheres prepared by reverse microemulsion method were used as the carrier, and the surface was modified with -SOH and -NH, and finally Cr was loaded on to SiO to prepare the composite solid acid catalyst Cr-SiO-SOH, and its characterization and catalytic performance were determined. The experimental results showed that in the two-phase reaction system composed of [BMIM]Cl and THF, using microcrystalline cellulose (MCC) as the substrate, when the reaction temperature was 160 °C, the reaction time was 4 h, the addition amount of Cr-SiO-SOH was 1 g/g (cellulose), and the volume ratio of [BMIM]Cl to THF was 1:3, the maximum yield of HMF could reach 54.

The effect of social suspicion on social media addiction among Chinese college students: A moderated mediation model.

Objective: This study investigates the impact of social suspicion on social media addiction among Chinese college students, examining the mediating role of the sense of meaning in life and the moderating effect of gender.

Methods: A cross-sectional survey was conducted from September 19, 2023, to November 2, 2023, involving 1,558 students from three universities in southern Anhui Province, China. Participants completed questionnaires assessing social suspicion, social media addiction, and the sense of meaning in life.

[Analysis of Spatial-temporal Variation and Driving Forces of Carbon Storage in Suzhou City Based on the PLUS-InVEST-Geodetector Model].

The changes in urban land use and land cover have profound impacts on carbon storage, directly affecting urban carbon balance and climate adaptation capacity. Taking Suzhou City as the study area, this study first conducts a transition matrix analysis of land use data from 2000 to 2020. Then, based on the modified carbon density coefficient coupled with the PLUS and InVEST models, predictions are made for the land use pattern of Suzhou City in 2030 under four scenarios （business-as-usual development, urban sprawl prevention, farmland protection, and ecological conservation）.

Current situation, problems and suggestions of ancient and notable tree resources in Gansu Province, China.

The diverse natural landscapes and rich historical-cultural heritage have bestowed an abundant resource of ancient and notable trees (ANT) in Gansu Province. Currently, the green economy of ANT has become a pivotal avenue for the construction of ecological civilization in Gansu Province. Based on literature synthesis, we reviewed the current status of ANT resources in Gansu Province.

Correlations of resilience with coping styles and quality of life in patients with malignancies.

Background: Resilience is an individual's ability and psychological rebound capacity to adapt well after experiencing adversity, trauma, Patients with strong resilience can face illnesses actively.

Aim: To determine the association of resilience with coping styles and quality of life in patients with malignancies.

Methods: This study included patients with malignant tumors who were hospitalized at Fuyang Hospital Affiliated to Anhui Medical University from March 2022 to March 2024.

Identifying biomarkers distinguishing sepsis after trauma from trauma-induced SIRS based on metabolomics data: a retrospective study.

Sepsis after trauma and trauma-induced SIRS have similar symptoms, making their differentiation challenging. Therefore, biomarkers are needed to differentiate between sepsis after trauma and trauma-induced SIRS. We hypothesized that sepsis following trauma induces distinct alterations in blood metabolism compared to trauma-induced SIRS and sought to identify metabolite biomarkers in blood that could differentiate between the two.

Identifying early predictive and diagnostic biomarkers and exploring metabolic pathways for sepsis after trauma based on an untargeted metabolomics approach.

Systemic inflammatory response syndrome (SIRS) and organ dysfunction make it challenging to predict which major trauma patients are at risk of developing sepsis. Additionally, the unclear pathogenesis of sepsis after trauma contributes to its high morbidity and mortality. Identifying early predictive and diagnostic biomarkers, as well as exploring related metabolic pathways, is crucial for improving early prevention, diagnosis, and treatment.

A combined "eat me/don't eat me" strategy based on exosome for acute liver injury treatment.

Drug-induced liver injury (DILI) involves multifaceted pathogenesis, necessitating effective therapeutic strategies. Wnt2, secreted by liver sinusoidal endothelial cell (LSEC), activates the Wnt/β-catenin signaling pathway to promote hepatocyte proliferation after injury. To address the dual challenges of targeted delivery and phagocytosis evasion, we develop a combined "eat me/don't eat me" strategy.

Sulfuretin: Unraveling its potent therapeutic potential in a holistic literature review.

Sulfuretin is widely distributed in different families of nature, such as Anacardiaceae, Compositae and Leguminosae. Since it was isolated, modern pharmacological researches revealed that this compound exhibited various bioactivities, namely neuroprotection, antioxidant, anti-cancer, hepatoprotection, anti-microbial, anti-inflammation, anti-diabetes, etc., which were attributed to many important molecular targets, such as NF-κB, PI3K/AKT/mTOR, Nrf2/HO1, MAPKs and JNK/ERK.

Neutrophil extracellular traps-triggered hepatocellular senescence exacerbates lipotoxicity in non-alcoholic steatohepatitis.

Introduction: Neutrophils are initial responders in inflammation and contribute to non-alcoholic fatty liver disease (NAFLD) progression to steatohepatitis (NASH). Neutrophil extracellular traps (NETs) are implicated in liver injury, yet their precise mechanisms in NASH progression remains unclear.

Objectives: This study investigates how NETs drive NASH progression by exacerbating hepatocyte lipotoxicity and explore the regulatory mechanism of NETs formation and its downstream effects on liver pathology.

Self-luminescent dual-ligand metal-organic framework based electrochemiluminescence probes for organophosphorus pesticides determination.

In this study, a signal amplification strategy was developed, which tris (2, 2'-bipyridyl) ruthenium (II) (Ru(bpy)) was incorporated as a guest molecule into the preparation system of lanthanide-based metal-organic framework (MOF). This strategy relied on strong electrostatic interactions and coordination competition to influence the growth process of the MOF, resulting in the firm immobilization of Ru(bpy) within the MOF structure. The spatial confinement effect of the MOF effectively improved the efficiency of electron transfer in the electrochemiluminescence (ECL) reaction.

and formula protects brain function in Alzheimer's disease.

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no effective treatment currently available. The C.A.

Diagnosis of Sacroiliitis Through Semi-Supervised Segmentation and Radiomics Feature Analysis of MRI Images.

Background: Sacroiliitis is a hallmark of ankylosing spondylitis (AS), and early detection plays an important role in managing the condition effectively. MRI is commonly used for diagnosing sacroiliitis, traditional methods often depend on subjective interpretation or limited automation which can introduce variability in diagnoses. The integration of semi-supervised segmentation and radiomics features may reduce reliance on expert interpretation and the need for large annotated datasets, potentially enhancing diagnostic workflows.

AhASRK1, a peanut dual-specificity kinase that activates the Ca-ROS-MAPK signalling cascade to mediate programmed cell death induced by aluminium toxicity via ABA.

Aluminium (Al)-induced programmed cell death (PCD) is thought to be a main cause of Al phytotoxicity. However, the underlying mechanism by which Al induces PCD in plants is unclear. In this study, we characterized the function of AhASRK1 (Aluminum Sensitive Receptor-like protein Kinase1), an Al-induced LRR-type receptor-like kinase gene.

Altered asymmetry of amygdala volume mediates food addiction and weight gain.

Background: Food addiction and an impulsive personality can increase overeating, which can lead to weight gain. The amygdala and nucleus accumbens (NAcc) are critical for regulating obesogenic behaviour. However, whether the amygdala or the NAcc acts as the neural basis for the regulation of food addiction, impulsive personality, and body weight remains unclear.