Comprehensive characterization of human aqueous humor proteomes from primary open-angle glaucoma using data-independent acquisition dataset on a TimsTOF pro mass spectrometer.

Primary open-angle glaucoma (POAG) is the foremost cause of irreversible visual impairment, attributed to a complex array of ocular diseases. The lack of reliable prognostic indicators necessitates the development of biomarkers that can be used to detect and monitor glaucoma early in its course. In this study, human aqueous humor databases dedicated to advanced and not advanced POAG from Chinese were compiled to facilitate research on POAG, using advanced label-free quantitative proteomics technology by a TimsTOF Pro mass spectrometer.

The effect of social suspicion on social media addiction among Chinese college students: A moderated mediation model.

Objective: This study investigates the impact of social suspicion on social media addiction among Chinese college students, examining the mediating role of the sense of meaning in life and the moderating effect of gender.

Methods: A cross-sectional survey was conducted from September 19, 2023, to November 2, 2023, involving 1,558 students from three universities in southern Anhui Province, China. Participants completed questionnaires assessing social suspicion, social media addiction, and the sense of meaning in life.

Neuroprotective effects of acteoside in a glaucoma mouse model by targeting Serta domain-containing protein 4.

Aim: To explore the therapeutic effect and main molecular mechanisms of acteoside in a glaucoma model in DBA/2J mice.

Methods: Proteomics was used to compare the differentially expressed proteins of C57 and DBA/2J mice. After acteoside administration in DBA/2J mice, anterior segment observation, intraocular pressure (IOP) monitoring, electrophysiology examination, and hematoxylin and eosin staining were used to analyze any potential effects.