[Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss].

Hearing loss is the most prevalent disabling disease. Cochlear implantation（CI） serves as the primary intervention for severe to profound hearing loss. This consensus systematically explores the value of genetic diagnosis in the pre-operative assessment and efficacy prognosis for CI.

Fusion model integrating multi-sequence MRI radiomics and habitat imaging for predicting pathological complete response in breast cancer treated with neoadjuvant therapy.

Background: This study aimed to develop a predictive model integrating multi-sequence MRI radiomics, deep learning features, and habitat imaging to forecast pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant therapy (NAT).

Methods: A retrospective analysis included 203 breast cancer patients treated with NAT from May 2018 to January 2023. Patients were divided into training (n = 162) and test (n = 41) sets.

Incidence of pneumonitis with CTLA-4 inhibitors in non-small cell lung cancer: a systematic review and meta-analysis.

Background: CTLA-4 inhibitors, such as tremelimumab and ipilimumab, are increasingly used in the treatment of non-small cell lung cancer (NSCLC). This meta-analysis aims to evaluate the incidence of pneumonitis associated with these inhibitors and explore potential differences between individual agents.

Methods: A systematic search across three online databases identified 911 records.

Lactylation-mediated miRNA regulation in cancer therapy resistance.

Therapeutic resistance in cancer is increasingly understood as a dynamic outcome of the interplay among tumour metabolism, epigenetic regulation, and immune modulation, rather than a consequence of genetic mutations alone. At this intersection, lactylation-a recently discovered lactate-derived post-translational modification (PTM)-acts as a molecular bridge linking metabolic rewiring to transcriptional and post-transcriptional control. Meanwhile, microRNAs (miRNAs) have emerged as essential regulators of metabolic adaptation and epigenetic plasticity.

Virtual reality combined with task-oriented circuit training for upper limb rehabilitation in subacute stroke patients: A randomized controlled trial.

Background: Task-oriented circuit training (TOCT) and virtual reality (VR) are innovative clinical treatment approaches based on motor relearning and neuroplasticity principles. However, the synergistic effects of these 2 methods on improving upper extremity function in stroke patients remain unclear. This study investigates the impact of VR combined with TOCT on upper limb functions and quality of life (QoL) in subacute stroke patients.

In Situ Quantitative Imaging of Nonuniformly Distributed Molecules in Zeolites.

Accurate assessment of molecular uptake and interactions at pore surfaces is crucial for advancing functional porous materials. However, these processes are governed by the intricate interplay of geometry constraints, local electric fields, and operational conditions, requiring in situ atomic-resolution characterization. Here, we present sub-angstrom-resolution (0.

Uncertainty-guided attention learning for malaria parasite detection in thick blood smears.

Malaria may seriously threaten an individual's health and wellbeing, and early screening is pivotal for timely treatment and recovery. In malaria screening, thick blood smears are exploited to count the parasites and assess the severity of the disease. Parasites are tiny objects that can be found in high resolution blood smear images, which renders them difficult for detection.

[Analysis of Risk Factors for Mortality of Children with Severe Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation].

Objective: To analyze the factors associated with mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with severe aplastic anemia (SAA).

Methods: The clinical data of 90 children with SAA who received allo-HSCT in the Department of Hematology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology from August 2016 to July 2023 were collected. The clinical features and causes of death were analyzed retrospectively.

Urea cycle dysregulation: a new frontier in cancer metabolism and immune evasion.

Cancer cells experience metabolic reprogramming to enhance the synthesis of nitrogen and carbon, facilitating the production of macromolecules essential for tumor proliferation and growth. A central strategy in this process involves reducing catabolic activities and managing nitrogen, thereby improving the efficiency of nitrogen utilization. The urea cycle (UC), conventionally recognized for its role in detoxifying excess nitrogen in the liver, is pivotal in this metabolic transition.

[Prognostic significance of molecular minimal residual disease before and after allogeneic hematopoietic stem cell transplantation in children with acute myeloid leukemia].

Objectives: To investigate the prognostic value of molecular minimal residual disease (Mol-MRD) monitored before and after allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric acute myeloid leukemia (AML).

Methods: Clinical data of 71 pediatric AML patients who underwent HSCT between August 2016 and December 2023 were analyzed. Mol-MRD levels were dynamically monitored in MRD-positive patients, and survival outcomes were evaluated.

Whole Exome Sequencing Identifies a Novel Frameshift Mutation of the WRN Gene in a Werner Syndrome Family and Functional Analysis.

Introduction: Werner syndrome (WS) is a rare recessive disorder characterized by premature aging and metabolic abnormalities. WS is caused by mutations in the WS RecQ-like helicase gene (WRN), which encodes the WRN RecQ-like helicase protein. This study aimed to identify the deletion mutation in the WRN gene within the WS family and comprehensively analyze its regulatory role.

Prediction of Insulin Resistance in Nondiabetic Population Using LightGBM and Cohort Validation of Its Clinical Value: Cross-Sectional and Retrospective Cohort Study.

Background: Insulin resistance (IR), a precursor to type 2 diabetes and a major risk factor for various chronic diseases, is becoming increasingly prevalent in China due to population aging and unhealthy lifestyles. Current methods like the gold-standard hyperinsulinemic-euglycemic clamp has limitations in practical application. The development of more convenient and efficient methods to predict and manage IR in nondiabetic populations will have prevention and control value.

Branched-chain amino acid and cancer: metabolism, immune microenvironment and therapeutic targets.

Cancer is one of the major diseases threatening human health in the world. According to the latest global cancer statistics from the International Agency for Research on Cancer (IARC), there were approximately 20 million new cancer cases and 10 million cancer deaths worldwide. Amidst this global health concern, branched chain amino acids have emerged as key players, playing an important role in the occurrence and development of cancer.

MTSA-SC: A multi-task learning approach for individual trip destination prediction with multi-trajectory subsequence alignment and space-aware loss functions.

Individual Trip Destination Prediction aims to accurately forecast an individual's future travel destinations by analyzing their historical trajectory data, holding significant application value in intelligent navigation, personalized recommendations, and urban traffic management. However, challenges such as data sparsity, low quality, and complex spatiotemporal volatility pose substantial difficulties for prediction tasks. Existing studies exhibit notable limitations in insufficient integration of sparsity handling and prediction tasks, constrained modeling capability for local volatility, and inadequate exploration of fine-grained spatial dependencies, struggling to balance global patterns and local features in trajectory data.

Inflammatory Bowel Disease and Risk of Rheumatoid Arthritis: A UK Biobank Cohort Study.

Objectives: Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are both prevalent inflammatory conditions within the population. Our objective was to explore the relationship between IBD and RA, while examining the role of inflammatory mediators in the observed association.

Methods: We used data from the UK Biobank, a population-based prospective cohort study that recruited adults aged 37-73 years from 22 centers in England, Scotland, and Wales between 2006 and 2010.

Pathogenesis, Diagnosis, Treatment, and Prognosis of CD20-Positive T and NK Cell Lymphoma: A Review.

T and NK cell lymphoma with abnormal CD20 expression is a condition that primarily seen in Asians. Due to the variable expression of CD20, it is difficult to generalize its origin, leading to controversial conclusions about the role of CD20. In this review, we provide an overview of CD20 localization and function in three cell types.

Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy.

Background: Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in treating hematologic malignancies. However, its efficacy against solid tumors remains limited. One of the major challenges is the lack of specific tumor antigens.

Revealing the Crucial Roles of Pore Interconnectivity between Zeolitic and Nonzeolitic Components in Enhancing Diffusion and Catalytic Efficiency of Industrial Zeolite-Based Catalysts.

One of the utmost targets for catalysis research is to meet social needs in a profitable manner. Zeolitic and "nonzeolitic components" (such as silica, alumina, amorphous aluminosilicate, clay, etc.), as indispensable constituents of an industrial catalyst, both actively participate in industrial processes like polyolefin catalytic cracking and residue fluid catalytic cracking.

LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses.

The rising mortality rate from cancer, driven by the absence of reliable biomarkers, highlights the pressing need for advanced diagnostic and prognostic strategies. This study investigates LZTS2's role as a pan-cancer biomarker, emphasizing its predictive value for immunotherapy and therapeutic targeting. Unlike existing biomarkers such as AFP in hepatocellular carcinoma or HER2 in gastric cancer, which exhibit tissue-specific utility, LZTS2 demonstrates unique cross-cancer applicability, as evidenced by its consistent dysregulation in both liver hepatocellular carcinoma (LIHC) and stomach adenocarcinoma (STAD) alongside emerging associations with other malignancies.

Visfatin promotes multiple myeloma cell proliferation and inhibits apoptosis by inducing IL-6 production via NF-κB pathways.

Background: Multiple myeloma (MM) is the second most prevalent hematological malignancy that results in the proliferation of malignant plasma cells and the overproduction of monoclonal immunoglobulin. Visfatin plays an important role in the regulation of apoptosis, oxidative stress, and inflammation; however, to this date, the role of visfatin in multiple myeloma is unclear.

Objective: To explore the role of visfatin in multiple myeloma and find new targets for MM treatment.

Elucidating the Genetic Underpinnings of Human Musculoskeletal System Aging Through Genomic Structural Equation Modeling.

The genetic architecture underlying traits related to Human Musculoskeletal System Aging (MSA) remains largely unexplored. In this study, we conducted a large-scale multivariate genome-wide association study (GWAS) of MSA utilizing Genomic Structural Equation Modeling (Genomic SEM). We estimated causal single nucleotide polymorphisms (SNPs) associated with independent variation and identified 14 genome-wide significant loci (mean.

Single-cell mitochondrial morphomics reveals cellular heterogeneity and predicts complex I, III, and ATP synthase Inhibition responses.

Mitochondrial heterogeneity drives diverse cellular responses in neurodegenerative diseases, complicating the evaluation of mitochondrial dysfunction. In this study, we describe a high-throughput imaging and analysis approach to investigate cell-to-cell mitochondrial variability. We applied known mitochondrial function inhibitors - rotenone, antimycin, and oligomycin to inhibit complexes I, III, and V (ATP synthase) function in human induced pluripotent stem cell-derived cortical neurons, a model commonly used in neurodegenerative disease research.

Use of Model-Based Meta-Analysis to Inform the Design of Early Clinical Trials of Anti-Amyloid Beta Therapies in Alzheimer's Disease.

To inform an efficient development of new investigational anti-amyloid beta (anti-Aβ) monoclonal antibodies (mAbs), a modeling-and-simulation-based strategy was proposed. A general modeling framework that links drug exposures to the time course of amyloid plaque removal and amyloid-related imaging abnormalities characterized by edema and effusion (ARIA-E) was developed based on publicly available data on aducanumab, lecanemab, and donanemab. A non-linear mixed effect model with shared model parameters described the dose response data from aducanumab, lecanemab, and donanemab studies after adjusting for different potency for different antibodies, which allowed the rate of amyloid plaque removal to vary by drug.

Targeting Hepatic Stellate Cells for the Prevention and Treatment of Liver Cirrhosis and Hepatocellular Carcinoma: Strategies and Clinical Translation.

Hepatic stellate cells (HSC) are the major source of myofibroblasts (MFB) in fibrosis and cancer- associated fibroblasts (CAF) in both primary and metastatic liver cancer. Over the past few decades, there has been significant progress in understanding the cellular and molecular mechanisms by which liver fibrosis and HCC occur, as well as the key roles of HSC in their pathogenesis. HSC-targeted approaches using specific surface markers and receptors may enable the selective delivery of drugs, oligonucleotides, and therapeutic peptides that exert optimized anti-fibrotic and anti-HCC effects.

Enhancing Neural Activation in Older Adults: Action Observation-Primed Swallowing Imagery Reveals Age-Related Connectivity Patterns.

Aging-related swallowing decline, known as presbyphagia, significantly increases the risk of dysphagia and aspiration pneumonia in older adults. Enhancing cortical activation and functional connectivity through non-invasive methods is crucial for improving swallowing function. This study investigates the use of action observation (AO) as a priming method to enhance motor imagery (MI) for promoting swallowing-related cortical activity.