Integrated Photoelectrochemical-Fluorescence Dual-Mode Aptasensor for Sensitive Detection of Fumonisin B1.

Long-term intake of fumonisin B1 (FB1) can pose a threat to human health. It is essential to develop an accurate and sensitive method to detect FB1. In this work, a photoelectrochemical-fluorescence (PEC-FL) dual-mode aptamer sensing platform was proposed for FB1 analysis.

Oxygen vacancies-driven self-powered photoelectrochemical sensor for acetamiprid detection.

Residues of acetamiprid (ACT) in agricultural products may enter the human body with the diet and subsequently cause potential harm to humans. Therefore, it is necessary to establish a rapid and sensitive method to detect ACT. In this work, a self-powered ACT photoelectrochemical (PEC) sensor using WO/CdS as photoanode, BiOCl as photocathode, and Au@PANI as the signal amplification marker was constructed.

Ultrasonography in granulomatous mastitis: diagnostic differentiation, treatment response, and prognostic value.

Objective: This study aimed to evaluate the diagnostic value of ultrasonography in distinguishing granulomatous mastitis (GM) from ductal carcinoma in situ (DCIS), and to assess its prognostic relevance in monitoring treatment response and predicting recurrence.

Methods: In this retrospective study, we analyzed conventional B-mode ultrasound and contrast-enhanced ultrasound (CEUS) features in 146 patients with histologically confirmed GM and 140 with DCIS. Key comparisons included: (1) B-mode characteristics (lesion morphology, posterior acoustic features, microcalcifications, vascular patterns, etc.

Peptide-based strategies for glioblastoma therapy: From small molecular drugs to delivery vehicles.

Glioblastoma (GBM) remains one of the most invasive and treatment-resistant brain tumors. Efficient GBM treatment represents a significant challenge in clinical oncology, thereby underscoring the demand on novel therapeutic strategies. Peptide-based therapeutics have emerged as promising alternatives to conventional drugs, due to their precise targeting capabilities, broad bioactivities, and the prospective to overcome the blood-brain barrier (BBB).

Rational design of strongly coupled inorganic/organic bismuth tungstate/hydrogen-bonded organic frameworks heterojunctions with optimized interface interactions for enhanced photocatalytic performance.

The development of high-performance hydrogen-bonded organic framework (HOF)-based materials holds significant scientific importance and practical value, yet it also presents substantial challenges. In this study, we constructed an inorganic-organic BiWO-HOF (BiWOH, BiWO=BiWO, HHOF) heterojunction, which significantly enhanced the separation efficiency of photogenerated electron-hole pairs. Experimental results demonstrate that under visible light irradiation, the photocatalytic hydrogen production performance of the BiWOH heterojunction is markedly superior to that of pure HOF materials.

[Analysis of Risk Factors for Mortality of Children with Severe Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation].

Objective: To analyze the factors associated with mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with severe aplastic anemia (SAA).

Methods: The clinical data of 90 children with SAA who received allo-HSCT in the Department of Hematology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology from August 2016 to July 2023 were collected. The clinical features and causes of death were analyzed retrospectively.

Multicenter Evaluation of Myocardial Flow Reserve as a Prognostic Marker for Mortality in N-Ammonia PET Myocardial Perfusion Imaging.

Background: Myocardial flow reserve (MFR), measured by PET MPI, provides valuable information on epicardial coronary disease, diffuse atherosclerosis, and microvascular function. Despite its routine use, the prognostic efficacy of N-ammonia PET MFR remains unconfirmed in larger multicenter cohorts of patients with suspected or known coronary artery disease (CAD).

Methods: We considered patients from five sites in the REFINE PET registry who underwent N-ammonia PET MPI for CAD.

Critical factors affecting rheological properties of surface fluid sediment in one large shallow lake.

Large shallow lakes have been plagued by issues such as eutrophication and low water transparency, most of which are related to sediment suspension. Fluid sediment on the surface is gradually receiving attention due to its low density. Here, a typical large shallow lake, the Taihu Lake, was selected to conduct on temporal and spatial variation in surface fluid sediment.

Undescribed Phenylpropanoid-Substituted Ester-Type Catechins from Green Tea Exert Antiaging Effects in via Activating DAF-16, HSF-1, and Heat Shock Proteins.

Green tea processing creates a hot acidic environment that facilitates reactions between catechins and hydroxycinnamic acids (HCAs), generating new catechins. Accordingly, we developed a one-pot method incorporating a Michael addition reaction to synthesize 13 phenylpropanoid-substituted ester-type catechins (PSECs), whose contents exhibit seasonal changes in tea leaves similar to those observed for common catechins. These PSECs showed antiaging effects in (), among which extended the longest lifespan by 57%, formed through the reaction between sinapic acid and EGCG with an configuration.

Molecular and physiological adaptations of Scartelaos histophorus to air exposure: Implications for amphibious fish survival.

Intertidal habitats present extreme environmental fluctuations, such as periodic air exposure that exposes aquatic organisms to desiccation, oxidative stress, and osmotic imbalance. Scartelaos histophorus, an amphibious fish, demonstrates exceptional physiological resilience in these dynamic ecosystems. This study investigates the physiological, histological, and transcriptomic responses of S.

Integrative analysis of microbiota and metabolomics in individuals exhibiting different TCM constitutions utilizing 16S rDNA sequencing and LC/MS metabolomics.

Background: Traditional Chinese Medicine (TCM) theory posits a close relationship between an individual's constitutional types and the overall health. Variations in metabolic processes and microbial composition have been observed across different constitution types. This study aims to explore the relationship between TCM constitutions, intestinal flora, and metabolites to devise personalized TCM treatment strategies, enhancing evidence-based guidance for clinical practice.

Impact of Ruminative Thinking on Breathlessness Catastrophizing With Elderly COPD Patients: The Mediating Role of Self-Efficacy.

Background: It is extremely significant to explore the relationship between ruminative thinking and breathlessness catastrophizing among elderly COPD patients. However, the impact of self-efficacy on this relationship is still unclear. This study attempted to explore the mediating role of self-efficacy between ruminative thinking and breathlessness catastrophizing.

A case report of Henoch-Schönlein purpura in the elderly complicated by multisystem involvement.

Rationale: Henoch-Schönlein purpura (HSP), a vasculitis caused predominantly by immunoglobulin A vasculitis deposition in the blood vessel wall. It frequently affects multiple organs, however, intussusception and cardiac involvement in the elderly is extremely rare. Currently, the diagnosis of patients with atypical HSP is very difficult.

A bioinformatics analysis of the target role of miRNA-431-5p on KLK6 in colorectal cancer.

Background: Although increasing evidence suggests that microRNAs (miRNAs) play different roles in the occurrence, development, and prognosis of colorectal cancer (CRC), investigations on miRNA-targeted regulation in CRC are sparse. However, the high morbidity and mortality of CRC necessitates exploring this area of research for potential alternative therapeutic approaches to CRC.

Methods: Bioinformatics analysis was used to obtain the key Hub genes related to CRC, and survival analysis was performed to screen out the core genes.

Stroke survivors' patient activation and self-management: The serial mediating role of social support and resilience.

Stroke is the leading cause of death and disability in Chinese adults. Self-management is closely related to stroke prognosis. This study was to investigate the relationship between patient activation and stroke survivors' self-management and the serial mediating role of social support and resilience.

Study on Rapid Detection Technology of Illegal Chemical Compounds Added to External Poultices.

Topical poultices and applied medical devices that can relieve a variety of cervical vertebrae and lumbar vertebrae pain may have illegal additives of pharmaceutical drugs or analogues have additional health risks, but customers may not be aware of what they are using. National Medical Products Administration reviewed and approved "Supplementary test method for identification and content determination of 17 chemicals in affixed medical devices" drafted by Shandong Provincial Institute of Medical Devices and Drug Packaging Inspection in January 2022, but the test method is simple in sample processing and difficult to extract the chemical components in the paste that may cause the phenomenon of missing detection of most illegal added chemical drugs. In this work, the sample handling and extraction methods have been improved and optimized, the content of illegal added chemicals in 47 batches of affixed medical devices was determined by HPLC-MS/MS method and was detected in 37 batches, and the non-steroidal anti-inflammatory drug nimesulide and aspirin were detected in most samples.

Transcriptome analysis and reverse engineering verification of SNZ3 and Pho3 revealed the mechanism of adaptive laboratory evolution to increase the yield of tyrosol in Saccharomyces cerevisiae strain S26-AE2.

Background: Tyrosol is an important drug precursor, and Saccharomyces cerevisiae is one of the main microorganisms that produces tyrosol. Although excessive metabolic modification increases the production of tyrosol, it also causes a decrease in the growth rate of yeast. Therefore, this study attempted to restore the growth of S.

Deletion of Xist repeat B disrupts cell cycle and asymmetric cell division through Usp9x hyperactivation in mice.

During X chromosome inactivation (XCI), Xist RNA establishes silencing by coating the chromosome in cis and binding diverse proteins to promote formation of a heterochromatic domain. However, Xist repeat B role beyond initiation of XCI remains unclear. Here, we find that loss of Xist repeat B in female mice allows survival and leads to a small body size persisting throughout life.

Chromosome-Level Genome Assembly and Comparative Genomic Analysis of Planiliza haematocheilus: Insights into Environmental Adaptation and Hypoxia Tolerance Mechanisms.

Planiliza haematocheilus, a teleostan species noted for its ecological adaptability and economic significance, thrives in both freshwater and marine environments. This study presents a novel chromosome-level genome assembly through Hi-C, PacBio CCS, and Illumina sequencing methods. The assembled genome has a final size of 651.

Functionalization of Graphene by Interfacial Engineering in Thermally Conductive Nanofibrillated Cellulose Films.

Flexible nanocomposites incorporating nanofibrillated cellulose (NFC) hold significant promise for thermal management applications. However, their heat dissipation performance is primarily constrained by the interfacial thermal resistance (). In this work, 1-pyrenemethylamine hydrochloride (PyNH) noncovalent functionalized graphene subsequently self-assembled with NFC through a vacuum-assisted filtration technique.

[Construction of a diagnostic model and scoring system for central precocious puberty in girls, with external validation].

Objectives: To establish an efficient and clinically applicable predictive model and scoring system for central precocious puberty (CPP) in girls, and to develop a diagnostic prediction application.

Methods: A total of 342 girls aged 4 to 9 years with precocious puberty were included, comprising 216 cases of CPP and 126 cases of isolated premature thelarche. Lasso regression was used to screen for predictive factors, and logistic regression was employed to establish the predictive model.

Semi-rational design and modification of phosphoketolase to improve the yield of tyrosol in .

Tyrosol is an important component of pharmaceuticals, nutraceuticals, and cosmetics, and their biosynthetic pathways are currently a hot research topic. d-Erythrose 4-phosphate is a key precursor for the biosynthesis of tyrosol in . Hence, the flux of d-Erythrose 4-phosphate determined the yield of tyrosol synthesis.

Zoledronic Acid Inhibits Lipopolysaccharide-Induced Osteoclastogenesis by Suppressing Macrophage NLRP3-Mediated Autophagy Pathway.

Introduction: Inflammatory factors leading to bone loss significantly increase the risk of tooth loosening or implantation failure. Zoledronic acid (ZOL) is a widely used medication for effectively inhibiting excessive bone destruction, but its effect on alleviating inflammatory bone loss remains to be elucidated. In this study, we investigated whether ZOL alleviates inflammatory bone resorption through immunomodulatory effect.

A novel anti-HER2 monoclonal antibody IAH0968 in HER2-positive heavily pretreated solid tumors: results from a phase Ia/Ib first-in-human, open-label, single center study.

Background: IAH0968 is an afucosylated anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody which improved the activity of antibody-dependent cellular cytotoxicity (ADCC) and superior anti-tumor efficacy.

Methods: To determine the maximum tolerated dose (MTD) with dose-limiting toxicity (DLT), a single institution, phase Ia/Ib study was undertaken, using 3 + 3 design. The primary endpoints were safety, tolerability and preliminary clinical activity.