The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis.

Cardiac hypertrophy is an adaptive cardiac response to overload. The ensuing decompensation eventually leads to heart failure or sudden death. Testosterone can induce cardiomyocyte hypertrophy, although the underlying mechanism has not been completely elucidated.

Sex-dependent behavioral and neuronal alterations in the F2 generation of a neurodevelopmental mouse model for schizophrenia.

Schizophrenia is a complex neurodevelopmental disorder influenced by genetic and environmental factors. Using a maternal methylazoxymethanol acetate (MAM) exposure model, we investigated behavioral, neuronal, and glial alterations in the F2 generation to explore the intergenerational effects of prenatal neurodevelopmental disruption. Our study demonstrates that prenatal MAM exposure induces the transgenerational transmission of schizophrenia-like phenotypes in F2 offspring.

Vitamin D deficiency in Hashimoto's thyroiditis: mechanisms, immune modulation, and therapeutic implications.

Background: To evaluate vitamin D's role in thyroid autoimmunity modulation, establish evidence-based supplementation protocols, and address surgical implications in Hashimoto's thyroiditis (HT) care. Vitamin D deficiency is prevalent in HT patients and correlates with accelerated autoimmune progression. This review synthesizes mechanistic insights and clinical implications of vitamin D repletion in HT management.

High-Entropy Single-Atom Evaporator: Collaborative Omnibearing Light Trapping Stereo Structures for Efficient Water Transport Dynamics.

Achieving efficient photothermal evaporation requires a synergistic integration of thermal management, water transport dynamics, and light trapping-key elements often challenging to harmonize. Herein, A high-entropy single-atomic metal doped porous carbon (HESA) with ultra-low metal content of 1.77 wt.

Empagliflozin attenuates sorafenib-promoted renal ferroptosis and inflammation by targeting cyclooxygenase-2/prostaglandin E axis.

The increased risk of nephrotoxicity may impact the life quality and survival outcome in cancer patients receiving sorafenib therapy. Therefore, the development of novel strategy against sorafenib nephrotoxicity is an urgent work. Sodium-glucose co-transporter-2 (SGLT2) inhibitors such as empagliflozin have been approved for renal failure treatment.

Parishin C Attenuates Oxidative Stress and Inflammation in HT22 Hippocampal Neurons and BV2 Microglia Through Nrf2 Signaling Pathway.

Parishin C (PaC) is an active ingredient in Bl. that has neuroprotective effects. However, research on its role in oxidative stress and neuroinflammation is still limited.

Establishing an AI Pressure Injury Database to Improve Clinical Nursing Efficiency.

Treatment varies depending on the condition and stage of the pressure injury. Therefore, there is a need for a friendly non-invasive assessment method for pressure injuries, as well as regular assessment and monitoring of the extent of the injury. This study used over 20,000 pressure injury images collected in the the Comprehensive Medical Data Center.

4in1 Procedure in Treating Congenital Dislocation of Patella in Children.

Objectives: Congenital dislocation of patella (CDP) is a rare condition and surgery is needed to treat CDP once a diagnosis is made. The 4in1 procedure includes lateral release, correction of quadriceps, Roux-Goldthwait procedure, and medial patello-femoral ligament (MPFL) reconstruction. This study was aimed at evaluating the efficacy and outcome of the 4in1 procedure in the operative treatment of CDP.

Stigmatizing Language in Large Language Models for Alcohol and Substance Use Disorders: A Multimodel Evaluation and Prompt Engineering Approach.

Objectives: Large language models (LLMs) are increasingly used in health care communication but can inadvertently perpetuate stigmatizing language toward individuals with alcohol and substance use disorders. Despite growing interest in LLM performance, a focused evaluation of their propensity for SL and strategies to mitigate it remains lacking.

Methods: We generated 60 clinically relevant questions ["prompts"; 20 each for alcohol use disorder (AUD), alcohol-associated liver disease (ALD), and substance use disorder (SUD)] and tested 14 LLMs.

Trophic ecology of moonfish in southwest Taiwan: Insights from stable isotopes and stomach content approach in connection to marine environmental factors.

Moonfish (Mene maculata) has been recognized as a prospective commercial species in Taiwanese waters; however, its diet and trophic ecology remain poorly understood. It was hypothesized that diet composition and trophic position (TP) vary with body size and monsoonal environmental changes. This study presents the first investigation of its feeding ecology in southwest Taiwan (SWT), focusing on seasonal and ontogenetic variation.

Cellular optical imaging techniques: a dynamic advancing frontier.

This article reviews recent super-resolution (SR) optical imaging techniques for cellular study, encompassing structured illumination microscopy (SIM), point-scanning super-resolution (PS-SR) microscopy, single-molecule localization microscopy (SMLM), mathematical and deep learning (DL) SR algorithms. Historically, the resolution of traditional far-field optical imaging was constrained by the diffraction limit. The emergence of SR imaging techniques and image processing algorithms has propelled biological research into nanoscale realm.

Single-cell multi-omic analysis of mesenchymal cells reveals molecular signatures and putative regulators of lung allograft fibrosis.

Survival after lung transplantation is limited by chronic progressive graft failure, termed chronic lung allograft dysfunction (CLAD). Graft-resident mesenchymal cells (MCs) drive CLAD pathogenesis and exhibit stable, dysregulated signaling; however, the transcriptomic and epigenomic drivers behind this fibrogenic transformation remain elusive. Here, we utilize single-cell multi-omic technologies to study gene expression and chromatin accessibility of MCs from the lavage fluid of lung transplant recipients with and without CLAD, obtained either early post-transplantation or after disease onset.

Global, regional, and national epilepsy of unknown cause incidence and mortality, 1990-2036: cross-national health inequalities and predictive analytics.

Background: The responsibility for the disease burden associated with epilepsy of unknown cause is unevenly distributed across different nations. It is crucial to describe and forecast cross-national health disparities in terms of years lived with disability (YLDs) for the forthcoming 15-year period. We examined and projected trends in the burden of disease and cross-national inequalities in epilepsy of unknown cause globally, by region and country from 1990 to 2036.

Human-Interface Dynamics of Knee Exoskeletons with Lateral and Anteroposterior Attachment.

Assistive lower-body exoskeletons aim to improve quality of life for broad populations including older adults and people in physically exhausting manual jobs. By applying torque to augment human motion with backdrivable actuators, these devices can reduce human joint effort without restricting volitional motion. However, these backdrivable actuators are coupled by mechanical interfaces to soft tissues of the human body that together introduce resonator dynamics that can delay or diminish the torque assistance.

Recombinant Herpes Zoster Vaccine Lowers Shingles Complication Risk in Patients with Inflammatory Bowel Disease.

Background: Patients with inflammatory bowel disease (IBD) are at increased risk of herpes zoster (HZ) due to innate immune abnormalities in patients with IBD and use of immunosuppressive therapy. The recombinant zoster vaccine (RZV) is recommended, but its efficacy in preventing recurrent HZ among patients with IBD is not well established.

Methods: Using data from the TriNetX Linked Network, we conducted a retrospective cohort study of adults (≥18 years) with IBD and a prior uncomplicated HZ episode.

Hybrid framework for improved PM2.5 prediction based on seasonal-trend decomposition and tailored component processing.

Precise prediction of PM2.5 concentrations is crucial for effective environmental management and the safeguarding of public health. However, accurately forecasting PM2.

Spatiotemporal distribution of sustained dengue hotspots associated with climate and urbanisation in Singapore.

This study aimed to explore the spatiotemporal dynamics of sustained dengue hotspots in relation to climatic and urbanization factors in Singapore. Geographically Weighted Regression (GWR) model was employed to evaluate monthly dengue incidence and associated spatiotemporal hotspot patterns between May 2013 and March 2020. The combination of rainfall, temperature, population density, urbanization, building age and flood vulnerability was significantly correlated with dengue incidence in different subzones of Singapore.

Impact of CKD/Kidney Failure on Angiodysplasia-Related Gastrointestinal Bleeding: Incidence, Outcomes, and Readmission Risk in a National Cohort.

Background: Angiodysplasia-related gastrointestinal bleeding (AGIB) is an increasingly recognized cause of hospitalization, particularly among patients with chronic kidney disease (CKD). While AGIB has been linked to kidney failure (KF), its burden across CKD stages remains unclear. This study aimed to evaluate AGIB incidence, outcomes, and readmissions across CKD stages using the largest inpatient and readmission databases in the United States.

Minimizing Color Difference in AAO-Based Coatings for Urban Camouflage.

We explored anodic aluminum oxide (AAO) stealth materials combining low infrared emissivity and visible structural coloration through multi-parameter modulation. Using DC ion gold sputtering and UHV magnetron chromium sputtering, we successfully prepared an AAO stealth material with high-saturation visible structural coloration and low infrared emissivity (ε < 0.17).

Sepsis impairs immunocompetent plasmacytoid dendritic cell reconstitution from hematopoietic stem/progenitor cell through altered bone marrow environment.

Plasmacytoid dendritic cells (pDCs) are crucial components of the immune response during viral infections, yet their function and development in the late phase of sepsis remain poorly understood. In this study, we investigated the impact of prolonged sepsis on pDCs and their progenitors in cecal ligation and puncture (CLP)-induced septic mice. We observed a significant reduction in both pDCs and their progenitors, alongside the presence of mature and regulatory pDCs.

Four novel endolichenic fungi from spp. (Lecanorales, Parmeliaceae) in Yunnan and Guizhou, China: Taxonomic description and preliminary assessment of bioactive potentials.

is one of the largest and most diverse genera of fruticose lichens with global distribution. Endolichenic fungi, which thrive within lichen thalli, have emerged as a promising source of bioactive compounds, with the ability to synthesise a variety of metabolites with biopharmaceutical potential. In this study, four isolates of endolichenic fungi isolated from spp.

Intracerebral Delivery of rhFGF20 via Heparin-Poloxamer Hydrogel Promotes Neurological Recovery in Ischemic Stroke.

Background: Ischemic stroke poses a significant threat to human health. FGF (fibroblast growth factor) 20 is involved in the repair of central nervous system diseases, but it has the shortcomings of short half-life and inability to penetrate the blood-brain barrier. Therefore, to overcome the drawbacks of rhFGF20 (recombinant human FGF20) and explore its role in ischemic stroke, the effects of intracerebral administration of rhFGF20 by heparin-poloxamer hydrogel (HP-rhFGF20 [heparin-poloxamer hydrogel-encapsulated rhFGF20]) in a rat stroke model were the focus of this study.