The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis.

Cardiac hypertrophy is an adaptive cardiac response to overload. The ensuing decompensation eventually leads to heart failure or sudden death. Testosterone can induce cardiomyocyte hypertrophy, although the underlying mechanism has not been completely elucidated.

A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity.

Objective: This study aims to investigate the potential causal relationship between migraine and white matter (WM) structural connectivity using genetic data and the Mendelian randomization (MR) analyses method.

Methods: Genome-wide association study (GWAS) summary statistics for migraine (48,975 cases/540,381 controls) and 206 WM structural connectivity related imaging-derived phenotypes (IDPs) (26,333 samples) were collected. Based on instrumental variables (IVs) selected from the GWAS summary statistics, the bidirectional two-sample MR analyses were conducted to infer bidirectional causal associations between migraine and WM structural connectivity.

Acupuncture for migraine: a literature review of neuroimaging studies.

Background: Acupuncture is effective for migraine treatment with minimal side effects. Neuroimaging techniques have been extensively used to explore the central mechanisms of acupuncture for migraine. This review aims to summarize neuroimaging study of acupuncture for migraine, providing a valuable reference and foundation for future clinical and mechanistic research.

Tai Chi's synergistic modulation on autonomic nervous activity and central autonomic networks in functional constipation patients: a randomized controlled trial.

Functional constipation (FCon) is characterized by disrupted brain-gut communication, representing a core pathophysiological mechanism. Physical exercise, a safe and cost-effective intervention, has been proven efficacy in ameliorating constipation symptoms and is a vital self-management strategy. Tai Chi, a traditional Chinese exercise, has been demonstrated to benefit both the gastrointestinal tract and the brain.

Gut microbiota orchestrates skeletal muscle development and metabolism in germ-free and SPF pigs.

The gut microbiota, as a crucial symbiotic microbial community in the host, participates in regulating the host's metabolism, immunity, and tissue development. Skeletal muscle is a key tissue for movement and energy metabolism in the body, with its development and function regulated by multiple factors; however, the molecular mechanisms by which the gut microbiota influences skeletal muscle remain unclear. This study utilized germ-free (GF) and specific pathogen-free (SPF) pig models, combined with multiple analytical approaches, to systematically investigate the effects of gut microbiota absence on skeletal muscle development, muscle fiber typing, and metabolism.

Gray Matter Alterations in Medication Overuse Headache: A Voxel-Based Morphometry Meta-Analysis.

Background: Medication overuse headache (MOH) is a secondary headache disorder associated with the chronic use of pain-relieving medications, leading to significant alterations in brain structure and function. Previous studies have shown inconsistent findings in gray matter (GM) changes in MOH patients, making it necessary to conduct a comprehensive meta-analysis to synthesize these results.

Objectives: The objective is to conduct a thorough review and meta-analysis of the consistency among voxel-based morphometry (VBM) neuroimaging studies that focus on MOH.

Analysis of digestive products of silver carp (Hypophthalmichthys molitrix) surimi gels after improving by different additives: In vitro and in vivo gastrointestinal digestion and absorption.

The objective of this work was to investigate the impact of calcium hydrogen phosphate (CHP), curdlan gum (CUR), and TGase (TG) on the digestion and absorption of surimi gel. In this study, an In vitro digestion model combined with C57BL/6 mice was used to analyze digestive and absorbed juices comprehensively. The results showed that the addition of CHP and CUR surimi products showed a decreasing trend in the α-helix content in the secondary structure of substrate proteins after digestion, which slowed down the In vitro digestibility of surimi gel by 4.

Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.

Objectives: Neuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings have often been inconsistent. In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.

Methods: A systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024.

Enoxacin-embedded EuMOF-based ratio fluorescent sensing platform integrated with paper-based sensor and skin-attachable hydrogel for glyphosate detection in foods.

To address the urgent requirement for food safety and ecological environmental protection, there is a need for a sensitive and user-friendly method for detecting glyphosate (GLY). Herein, we developed a novel enoxacin-embedded Eu(III) metal-organic frameworks (ENX@EuMOF) sensing platform for fluorescent and visual dual-modes GLY detection in food samples. The ENX@EuMOF exhibited dual fluorescent signal responses to GLY at 613 nm (decrease) and 520 nm (increase) wavelengths, attributed to alterations in energy transfer efficiency and the ligand-to-metal charge transfer effects.

White Matter-Gray Matter Correlation Analysis Based on White Matter Functional Gradient.

Background: The spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain's gray matter (GM) have been interpreted as representations of neural activity variations. In previous research, white matter (WM) signals, often considered noise, have also been demonstrated to reflect characteristics of functional activity and interactions among different brain regions. Recently, functional gradients have gained significant attention due to their success in characterizing the functional organization of the whole brain.

Convenient and visual ethephon detection in fruits by enhanced fluorescence of metal-organic framework.

For the first time a novel fluorescent La@ZrMOF nanomaterial was synthesized for the convenient and visual detection of ethephon (ETH) based on the ligand-metal charge transfer process. The fluorescence signal gradually enhanced as the concentration of ETH increased, accompanied by a change in the color from colorless to blue. The assay can be completed within 75 min with a detection limit of 0.

A Multimodal Meta-Analysis of Structural and Functional Alterations in the Brain of Knee Osteoarthritis Systematic Review.

Background: Abnormalities of structural and functional brain regions might influence the persistence of knee pain, the progression, and the response to treatments in knee osteoarthritis (KOA). These complex alterations present a challenge to the understanding of its mechanism.

Objectives: To meta-analyze the concurrence across structural and functional magnetic resonance imaging studies.

Diamino-functionalized metal-organic framework for selective capture of gold ions.

Adsorptive recovery of valuable gold (Au) ions from wastes is vital but still challenged, especially regarding adsorption capacity and selectivity. A novel M - 3,5-DABA metal-organic framework (MOF) adsorbent was prepared via anchoring 3,5-diaminobenzoic acid (3,5-DABA) molecule in the MOF-808 matrix. Benefiting from the positive charge property, dense amino groups (3.

Curcumin in the treatment of inflammation and oxidative stress responses in traumatic brain injury: a systematic review and meta-analysis.

Background And Aim: Traumatic brain injury (TBI), a leading cause of high morbidity and mortality, represents a significant global public health challenge. Currently, no effective treatment for TBI exists. Curcumin, an active compound extracted from the root of , has demonstrated neuroprotective properties both and .

[Brief discussion of the differences in the acupoint location between and ].

There are the differences in the location of some acupoints between textbooks and . Both of the textbooks are in the category of the "14 Five-Year Plan". The differences in acupoint location have brought some confusion for students, full-time teachers and researchers in the field of traditional Chinese medicine.

Carbon fluxes of China's coastal wetlands and impacts of reclamation and restoration.

Coastal wetlands play an important role in regulating atmospheric carbon dioxide (CO) concentrations and contribute significantly to climate change mitigation. However, climate change, reclamation, and restoration have been causing substantial changes in coastal wetland areas and carbon exchange in China during recent decades. Here we compiled a carbon flux database consisting of 15 coastal wetland sites to assess the magnitude, patterns, and drivers of carbon fluxes and to compare fluxes among contrasting natural, disturbed, and restored wetlands.

Progressive Insights into Metal-Organic Frameworks and Metal-Organic Framework-Membrane Composite Systems for Wastewater Management.

The sustainable management of wastewater through recycling and utilization stands as a pressing concern in the trajectory of societal advancement. Prioritizing the elimination of diverse organic contaminants is paramount in wastewater treatment, garnering significant attention from researchers worldwide. Emerging metal-organic framework materials (MOFs), bridging organic and inorganic attributes, have surfaced as novel adsorbents, showcasing pivotal potential in wastewater remediation.

Altered static and dynamic functional brain network in knee osteoarthritis: A resting-state functional magnetic resonance imaging study: Static and dynamic FNC in KOA.

This study aimed to investigate altered static and dynamic functional network connectivity (FNC) and its correlation with clinical symptoms in patients with knee osteoarthritis (KOA). One hundred and fifty-nine patients with KOA and 73 age- and gender-matched healthy subjects (HS) underwent resting-state functional magnetic resonance imaging (rs-fMRI) and clinical evaluations. Group independent component analysis (GICA) was applied, and seven resting-state networks were identified.

E-Tattoos: Toward Functional but Imperceptible Interfacing with Human Skin.

The human body continuously emits physiological and psychological information from head to toe. Wearable electronics capable of noninvasively and accurately digitizing this information without compromising user comfort or mobility have the potential to revolutionize telemedicine, mobile health, and both human-machine or human-metaverse interactions. However, state-of-the-art wearable electronics face limitations regarding wearability and functionality due to the mechanical incompatibility between conventional rigid, planar electronics and soft, curvy human skin surfaces.

Nitrogen isotopic characteristics of aerosol ammonium in a Chinese megacity indicate the reduction from vehicle emissions during the lockdown period.

The role of agricultural versus vehicle emissions in urban atmospheric ammonia (NH) remains unclear. The lockdown due to the outbreak of COVID-19 provided an opportunity to assess the role of source emissions on urban NH. Concentrations and δN of aerosol ammonium (NH) were measured before (autumn in 2017) and during the lockdown (summer, autumn, and winter in 2020), and source contributions were quantified using SIAR.

Efficacy of TIPS plus extrahepatic collateral embolisation in real-world data: a validation study.

Objectives: The efficacy of transjugular intrahepatic portosystemic shunt (TIPS) plus extrahepatic collateral embolisation (TIPS+E) in reducing rebleeding and hepatic encephalopathy (HE) post-TIPS was recently reported in a meta-analysis, but further validation is essential. This study aims to confirm the effectiveness of TIPS+E using real-world data.

Methods: The multicentre retrospective cohort included 2077 patients with cirrhosis who underwent TIPS±E (TIPS: 631, TIPS+E: 1446) between January 2010 and December 2022.

Large Seasonal Variation in Nitrogen Isotopic Abundances of Ammonia Volatilized from a Cropland Ecosystem and Implications for Regional NH Source Partitioning.

Ammonia (NH) volatilization from agricultural lands is a main source of atmospheric reduced nitrogen species (NH). Accurately quantifying its contribution to regional atmospheric NH deposition is critical for controlling regional air nitrogen pollution. The stable nitrogen isotope composition (expressed by δN) is a promising indicator to trace atmospheric NH sources, presupposing a reliable nitrogen isotopic signature of NH emission sources.