Comparative outcomes of revision total knee arthroplasty: a systematic review and meta-Analysis of high tibial osteotomy vs. unicompartmental knee arthroplasty.

Purpose: High tibial osteotomy (HTO) and unicompartmental knee arthroplasty (UKA) are two common approaches for managing unicompartmental knee osteoarthritis. However, both procedures may eventually require revision to total knee arthroplasty (TKA). This study aims to compare the clinical outcomes and functional performance of revision TKA following HTO (HTO-TKA) versus revision TKA following UKA (UKA-TKA).

Efficient PFOA decontamination using photoelectrocatalytic coupled PMS activation: Unleashing electrons and superoxide radicals for rapid degradation.

Direct oxidation of per- and polyfluoroalkyl substances (PFAS) necessitates excessive energy or prolonged treatment, while reductive defluorination effectively cleaves C-F bonds. However, strict anaerobic requirements hinder its practical implementation. Herein, a photoelectrocatalytic-peroxymonosulfate (PEC-PMS) integrated system was developed for perfluorooctanoic acid (PFOA) degradation under ambient conditions.

LncRNA H19 and miR-138 modulate retinal neovascularization and associated pathological features in hypoxia-induced disease models.

In this study, we investigated the mechanism of action of the long noncoding RNA (lncRNA) H19 to evaluate potential novel therapeutic targets in retinal neovascular diseases. Following establishment of an oxygen-induced mouse retinopathy (OIR) model, we knocked down lncRNA H19 and microRNA (miR)-138 by intravitreal injection of adenovirus and assessed the outcomes of interference and overexpression by real time quantitative polymerase chain reaction (RT-qPCR). Additionally, we observed vascular lesions of the retina by hematoxylin and eosin staining and retinal paving staining and detected the expression of relevant factors by Western blot, immunohistochemistry, and immunofluorescence.

Nonradical-dominated nanoconfined iron single-atom catalytic membrane to enhance peroxymonosulfate activation for efficient water decontamination.

Catalytic membrane reactors (CMRs) exhibit significant advantages in the removal of contaminants of emerging concern. However, the impairment inflicted on polymer membranes by radicals and the radical scavenging induced by natural organic matter constrain the advancement of CMRs. Herein, we designed an iron single-atom catalyst (FePc-O-CNT) dominated by nonradical oxidation mechanisms and combined it with peroxymonosulfate (PMS) to develop a CMR system (FePc-O-CNT membrane/PMS).

Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.

Hypoxia-induced inflammatory injury is an important pathological mechanism underlying the progression of acute mountain sickness (AMS). Recent studies reported that molecular clock could control mitochondrial pathways to involve hypoxic and inflammatory responses. Excessively released mitochondrial DNA (mtDNA) acts as a damage-associated molecular pattern (DAMP) to trigger inflammation in many diseases.

Interface-Facilitated Removal of Environmental Micropollutants by Nanofiltration Membranes Prepared from Amino Acid-Mediated Interfacial Polymerization: Mechanistic Insights into Micropollutant Interfacial Partitioning Regulation.

Environmental organic micropollutants in aquatic systems pose a threat to human health. Conventional nanofiltration membranes struggle with micropollutant removal due to inadequate steric hindrance and unfavorable interactions. This study focused on regulating micropollutant interfacial partitioning by constructing an enhanced separation interface for nanofiltration membranes.

Obesity and the accelerated decline in total sleep time increases the self-reported diagnoses of diabetes.

Introduction: The aim of this study was to investigate the relationship between obesity and the accelerated decline in Total Sleep Time (TST) and its potential impact on the self-reported diagnoses of diabetes.

Methods: Our study addresses this gap by analyzing trends in a longitudinal cohort study conducted in China, using data from the China Health and Nutrition Survey (CHNS). Employing a joint model, inter-individual variability and intra-individual variability in TST, and its impact on self-reported diagnoses of diabetes were considered.

Sealing mechanisms and enrichment patterns of deep coalbed methane: insights from the Jiaxian block, Ordos Basin.

The enrichment of deep coalbed methane (CBM) in the Jiaxian block of the Ordos Basin is strongly influenced by the sealing capacity of coal seam roofs and floors, which play a pivotal role in CBM preservation under conditions of high temperature and pressure. Despite its importance, the mechanisms underlying the sealing capacity remain poorly understood, and their quantitative evaluation is rarely explored. This study starts from the influence of gas transport channels, and summarizes the key factors that affect sealing capability.

The main active components of Prunella vulgaris L. alleviate myocardial ischemia-reperfusion injury by inhibiting oxidative stress and ferroptosis via the NRF2/GPX4 pathway.

Ethnopharmacological Relevance: Prunella vulgaris L. (PV) is a widely distributed medicinal and edible plant used in traditional Chinese medicine for its anti-tumor, anti-inflammatory, anti-oxidant, hypoglycemic, and anti-hypertensive effects. Despite the numerous studies reporting on its cardiovascular protective effects, it is still unknown whether PV could relieve myocardial ischemia-reperfusion (MI/R) injury.

Post-TIPS Overt Hepatic Encephalopathy Increases Long-Term but Not Short-Term Mortality in Cirrhotic Patients With Variceal Bleeding: A Large-Scale, Multicenter Real-World Study.

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for managing portal hypertension in cirrhotic patients, but the impact of post-TIPS overt hepatic encephalopathy (OHE) on survival remains controversial. While its effect on short-term survival is well-documented, its long-term implications remain unclear.

Aims: This study aims to investigate the long-term impact of post-TIPS OHE on mortality in cirrhotic patients for variceal bleeding, focusing on the timing and predictive value of OHE beyond the first year post-TIPS.

Giant dedifferentiated liposarcoma of the neck with osteosarcoma and chondrosarcoma components: A case report.

Dedifferentiated liposarcoma (DDLPS) is a subtype of LPS characterized by two distinct levels of differentiation and morphological structures, comprising areas of well-differentiated LPS and dedifferentiated, non-lipogenic, highly malignant components. DDLPS most frequently occurs in the retroperitoneum and the soft tissues of the pelvis and limbs, and is rare in the head and neck region, accounting for only 1% of head and neck sarcomas. The present study describes the case of a 72-year-old male with a 30-year history of left upper limb numbness and heaviness.

Phillygenin ameliorates tight junction proteins reduction, fibrosis, and apoptosis in mice with chronic colitis via TGR5-mediated PERK-eIF2α-Ca pathway.

Ulcerative colitis (UC) is an idiopathic, relapsing, and etiologically complicated chronic inflammatory bowel disease. Despite substantial progress in the management of UC, the outcomes of mucosal barrier repair are unsatisfactory. In this study, phillygenin (PHI) treatment alleviated the symptoms of chronic colitis in mice, including body weight loss, severe disease activity index scores, colon shortening, splenomegaly, oxidative stress, and inflammatory response.

A systematic review and meta-analysis on the effects of intravenous dexamethasone on postoperative outcomes in patients undergoing total knee arthroplasty.

Purpose: Dexamethasone has shown promising efficacy in alleviating pain and enhancing outcomes undergoing TKA. However, an optimal route of administration, dosage, and treatment duration have not yet been established. This study is to assess the effects of intravenous dexamethasone administration on postoperative pain management and prognosis in patients undergoing TKA.

Intensive electron transfer of a single-atom Fe-based catalytic ceramic membrane for municipal wastewater treatment: The synergistic effects of nitrogen vacancy defect and ultrathin nanostructure.

The integration of membrane separation with heterogeneous advanced oxidation processes is a prospective strategy for the elimination of contaminants during wastewater treatment. Fe-based catalysts and the green oxidant peracetic acid (PAA) are desirable candidates for the development of catalytic membranes because they are environmentally friendly. However, the construction of catalytic ceramic membranes (CMs) modified with efficient Fe-based catalysts that generate increased amounts of high-valent Fe-O species during PAA activation for the degradation of specific pollutants, especially during instantaneous membrane filtration, remains challenging.

Development of a monoclonal antibody specifically recognizing a linear epitope on the E1 protein of Getah virus.

Getah virus (GETV) is a mosquito-borne alphavirus that can cause disease outbreaks in domesticated mammals. The E1 protein of GETV plays a crucial role in mediating the fusion of viruses and host cells. In this study, the recombinant GETV E1 protein was expressed and administered to BALB/c mice.

Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease.

Arteriosclerotic cerebral small vessel disease (aCSVD) is a major cause of stroke and dementia. Although its underlying pathogenesis remains poorly understood, both inflammaging and gut microbiota dysbiosis have been hypothesized to play significant roles. This study investigated the role of gut microbiota in the pathogenesis of aCSVD through a comparative analysis of the gut microbiome and metabolome between CSVD patients and healthy controls.

Nano-confined catalysis with Co nanoparticles-encapsulated carbon nanotubes for enhanced peroxymonosulfate oxidation in secondary effluent treatment: Water quality improvement and membrane fouling alleviation.

Despite widespread deployment and investigation of ultrafiltration (UF) for secondary effluent purification, the challenge of membrane fouling due to effluent organic matter (EfOM) remains formidable. This study introduced a novel pretreatment method utilizing Co nanoparticles-encapsulated carbon nanotubes activated peroxymonosulfate (Co@CNT/PMS) to degrade EfOM and mitigate membrane fouling. Characterization of Co@CNT revealed the efficient encapsulation of Co nanoparticles within nanotubes, which notably enhanced the catalytic degradation of bisphenol A and typical organics.

A systematic review and meta-analysis:comparing the efficacy of the Ilizarov technique alone with lengthening over a nail for lower extremity bone defects.

Purpose: The task faced by surgeons becomes significantly more challenging when they encounter lower extremity bone defects due to a variety of causes requiring lengthening. The most discussed and successful approach is the Illizarov technique, or lengthening over a nail (LON):distraction osteogenesis is also widely performed with monoliteral external fixators and intramedullarylengthening nails have increasingly been used in the last decade.

Methods: The data were collected from PubMed, Cochrane Library, Embase, and the Web of Science for all available studies comparing the outcomes of Ilizarov technique alone and LON technique (from January 1, 1997, to November 30, 2023).

Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn's disease.

Background: Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat, is a pathologic characteristic of Crohn's disease (CD). In our previously reported cohort, we observed that Achromobacter pulmonis was the most abundant and prevalent bacteria cultivated from creeping fat.

Methods: A whole genomic sequencing and identification of T3SS orthologs of mAT-derived A.

TNF-α and RPLP0 drive the apoptosis of endothelial cells and increase susceptibility to high-altitude pulmonary edema.

High-altitude pulmonary edema (HAPE) is a fatal threat for sojourners who ascend rapidly without sufficient acclimatization. Acclimatized sojourners and adapted natives are both insensitive to HAPE but have different physiological traits and molecular bases. In this study, based on GSE52209, the gene expression profiles of HAPE patients were compared with those of acclimatized sojourners and adapted natives, with the common and divergent differentially expressed genes (DEGs) and their hub genes identified, respectively.

Ferrate(VI)-based oxidation for ultrafiltration membrane fouling mitigation in shale gas produced water pretreatment: Role of high-valent iron intermediates and hydroxyl radicals.

Ultrafiltration (UF) is increasingly used in the pretreatment of shale gas produced water (SGPW), whereas severe membrane fouling hampers its actual operation. In this work, ferrate(VI)-based oxidation was proposed for membrane fouling alleviation in SGPW pretreatment, and the activation strategies of calcium peroxide (CaO) and ultraviolet (UV) were selected for comparison. The findings indicated that UV/Fe(VI) was more effective in removing fluorescent components, and the concentration of dissolved organic carbon was reduced by 24.