Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study.

Background: Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recognized as a biomarker of critical illness, yet its prognostic significance in polytrauma remains underexplored. This multicenter study investigates the temporal dynamics of serum ferritin in polytrauma patients and its association with systemic inflammation, organ dysfunction, and mortality.

Two Cases of Charcot-Marie-Tooth Disease Diagnosed in a 53-Year-Old Mother and a 24-Year-Old Daughter.

BACKGROUND Charcot-Marie-Tooth disease (CMT) is the most common hereditary peripheral neuropathy, affecting an estimated 17.7-40 per 100 000 population. CMT exhibits diverse clinical manifestations, including gradually progressive bilateral atrophy, weakness of the lower-extremity muscles, sensory abnormalities, and abnormal nerve conduction velocities or amplitudes.

A viral infection-biomimetic strategy for antibody-guided targeted protein degradation.

Targeted protein degradation (TPD) is a valuable strategy for investigating protein functionality in cell biology and drug discovery. Among the various emerging TPD technologies, antibody-guided TPD offers key advantages over other protein degradation methods in terms of compatibility with different proteins of interest (POIs) and cell types. However, increasing the efficiency of cellular antibody internalisation and protein degradation remains challenges.

Comparative outcomes of revision total knee arthroplasty: a systematic review and meta-Analysis of high tibial osteotomy vs. unicompartmental knee arthroplasty.

Purpose: High tibial osteotomy (HTO) and unicompartmental knee arthroplasty (UKA) are two common approaches for managing unicompartmental knee osteoarthritis. However, both procedures may eventually require revision to total knee arthroplasty (TKA). This study aims to compare the clinical outcomes and functional performance of revision TKA following HTO (HTO-TKA) versus revision TKA following UKA (UKA-TKA).

Heme oxygenase-1 leads to cisplatin resistance in nasopharyngeal carcinoma by reducing oxidative stress and ferroptosis.

Background: Nasopharyngeal carcinoma (NPC) is a malignancy with high a mortality rate. This study investigates the impact of heme oxygenase-1 (HO-1) in cisplatin (CDDP) resistance in NPC.

Methods: The time-dependent effect of CDDP on two NPC cell lines (HK1 and C666-1) were investigated.

Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics.

Cellular senescence is a double-edged sword in cancer biology, functioning as both a tumor-suppressive mechanism and a driver of malignancy. Initially, senescence acts as a protective barrier by arresting the proliferation of damaged or oncogene-expressing cells via pathways such as oncogene-induced senescence and the DNA damage response. However, persistent senescence-associated secretory phenotype and metabolic reprogramming in senescent cells create a pro-inflammatory, immunosuppressive tumor microenvironment, fueling cancer progression, therapy resistance, and metastasis.

Treatment of infective endocarditis caused by with a combination of penicillin G and ceftriaxone: a case report and literature review.

This report presents a case of Infective Endocarditis (IE) caused by (). The isolates were sensitive to ampicillin, penicillin G, and vancomycin. However, the outcome of anti-infection therapy was poor, and the patient was suspected to be allergic to vancomycin and ampicillin-sulbactam.

[Clinical observation on the efficacy of self-made anatomical tower-shaped pad combined with splint plaster fixation in the treatment of unstable the 2nd to 5th metacarpal fractures].

Objective: To evaluate the clinical efficacy of self-made anatomical tower-shaped pads combined with splint plaster fixation in the treatment of unstable 2nd to 5th metacarpal fractures and to provide a reference for clinical practice.

Methods: A retrospective analysis was conducted on 98 patients with unstable 2nd to 5th metacarpal fractures treated with self-made anatomical tower-shaped pads combined with splint plaster fixation between January 2019 and December 2022. There were 74 males and 24 females, aged from 19 to 63 years old with an average of (41.

Pharmacovigilance analysis of drug-induced hypertrophic rhinitis using FAERS data.

Our study aims to evaluate the risk of drug-induced hypertrophic rhinitis and analyze its epidemiological characteristics utilizing real-world data. We employed reporting odds ratios (ROR) to assess the disproportionality in reports of drug-induced hypertrophic rhinitis between January 2004 and September 2024. Single-factor, LASSO, and multi-factor regression analyses were conducted to investigate drugs associated with hypertrophic rhinitis.

Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ-Mediated Immunotherapy.

Immune checkpoint inhibitors have revolutionized cancer therapy; however, many patients exhibit suboptimal responses, which is due to inadequate T cell priming by the innate immune response. Metal ions play a critical role in modulating the innate immune response. However, the mechanisms by which metal ions facilitate dendritic cell maturation through the activation of interferon remain poorly understood.

Mechanistic insights and therapeutic applications of metal-based nanomaterials in oral infectious diseases: Current advances and future perspectives.

Oral infectious diseases, including dental caries, pulpitis, periodontitis, peri-implantitis, and osteomyelitis of the jaws, are among the most prevalent conditions in dentistry, primarily caused by bacterial infections. Traditional treatment approaches, such as mechanical debridement and antibiotic therapy, face limitations due to bacterial resistance, inadequate infection control, and the inability to promote tissue regeneration effectively. Metal-based nanomaterials have emerged as promising candidates for addressing these challenges, offering broad-spectrum antibacterial activity, immunomodulation, and regenerative properties.

Metal Ion Nanodepots Orchestrate Neuronal Axon and Dendrite Growth via the Actin-PFN1 Pathway.

Neurodevelopment is a highly coordinated process involving cell differentiation, neurite extension, axon guidance, and dendritic formation, forming the structural basis for cognitive function. Metal ions such as silver and zinc play essential roles in neuronal disease; however, their precise function in neurodevelopment remains elusive. Due to the solubility characteristics of metal ions and the presence of ion channels on the cell membrane, studying the effects of metal ions within cells presents certain challenges.

Molecular hybridization-driven FAK inhibitors: N-2,4-diarylaminopyrimidine-3-sulfamoyl-benzamide derivatives with improved antitumor potency.

A series of novel 2,4-diarylaminopyrimidine derivatives incorporating a 3-sulfamoylbenzamide moiety were designed and synthesized as potent focal adhesion kinase (FAK) inhibitors. Three compounds (5f, 10b, and 10c) demonstrated FAK inhibitory activities comparable to the reference inhibitor TAE226. In cellular assays, most analogues exhibited significant antiproliferative effects against four FAK-overexpressing tumor cell lines (HCT116, HeLa, MDA-MB-231, and A375), with IC values below 1 μM.

Antiviral nanomedicine: Advantages, mechanisms and advanced therapies.

The emergence of novel viral pathogens and the limitations of conventional antiviral therapies necessitate innovative strategies to combat persistent and pandemic threats. This review details the role of viral infections and antiviral nanomedicines, delving into the mechanisms of action and antiviral advantages of nanomedicines, as well as the latest research advances in this field. The review systematically categorizes the mechanisms of antiviral nanodrugs into a framework that integrates previously fragmented knowledge, and innovatively summarizes the unique attributes and advantages of antiviral nanodrugs compared to small-molecule drugs.

Ultra-sensitive detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a.

() invades and survives inside macrophages, evading detection and resisting antibiotic treatment, which results in severe clinical consequences such as fatal respiratory failure and systemic inflammation. Rapid and specific detection of intracellular is crucial for accurate diagnosis and optimizing treatment strategies. In this study, we developed a one-step CRISPR/Cas12a assay targeting the gene for the specific and rapid detection of intracellular .

Projecting future fluid intake of Chinese children in a warming world.

Background: Adequate water intake is essential for maintaining health, particularly in children and adolescents. In the context of global warming, the likelihood of experiencing more frequent and intense heatwaves increases, posing a serious threat to regions already grappling with water scarcity. Therefore, we aim to explore the exposure-response relationship between ambient temperature and daily total fluid intake (TFI) among Chinese children and adolescents and to forecast their fluid consumption patterns up to the year 2099 in China, considering different climate change scenarios.

Identification of regulatory cell death-related genes during MASH progression using bioinformatics analysis and machine learning strategies.

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is becoming increasingly prevalent. Regulated cell death (RCD) has emerged as a significant disease phenotype and may act as a marker for liver fibrosis. The present study aimed to investigate the regulation of RCD-related genes in MASH to elucidate the role of RCD in the progression of MASH.

[Spatiotemporal Changes and Multi-scale Driving Mechanism Analysis of Nitrogen and Phosphorus Export in Yunnan Province from 2000 to 2020].

The issue of eutrophication caused by the excessive discharge of nutrients such as nitrogen and phosphorus has become a global concern. Yunnan Province, an essential part of the ecological security barrier in Southwest China, is ecologically sensitive and vulnerable. Rapid urbanization has drastically altered land use patterns, notably affecting regional nitrogen and phosphorus output.

ALOX15-Mediated Neuron Ferroptosis Was Involved in Diabetic Peripheral Neuropathic Pain.

Background: Diabetic peripheral neuropathic pain (DPNP) is one of the most common complications in diabetic patients. Current treatment strategies primarily focus on blood glucose control and pain relief, but they often yield limited effects. Ferroptosis, a regulated form of cell death driven by lipid peroxidation and iron imbalance, plays a crucial role in various diseases, including neuropathic pain.

Progress of near infrared spectroscopy in tea research.

Tea is a widely favored health beverage, with its quality influenced by a range of factors including cultivar, geographic origin, and processing methods. With the growing consumer demand for high-quality tea, fresh leaf quality assessment has traditionally relied on manual evaluation or physicochemical analyses. However, these approaches are often time-consuming and destructive.

Identification of high-risk soil erosion areas in the central Yunnan urban agglomeration and the differentiated driving mechanisms compared to the overall agglomeration.

Revealing the complex driving mechanisms of soil erosion is essential for assessing regional ecological security. Focusing on the Central Yunnan Urban Agglomeration (CYUA), a typical mountainous urban region, this study analyzed the spatiotemporal dynamics of soil erosion from 1990 to 2020 using the RUSLE model and the Improved Stability Mapping (STD) method, identifying high-risk soil erosion areas. Additionally, it applied the OPGD and MGWR models to reveal differentiated driving mechanisms of soil erosion across the urban agglomeration and in high-risk zones.

Smart Organic-Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma.

The stimulator of interferon genes (STING) pathway has emerged as a new immunotherapy strategy with potent local stimulation specificity, showing promising potential to counteract the immunosuppression in glioma. Herein, a tumor microenvironment (TME) responsive nanoagonists are developed based on an organic-inorganic copolymer composed of the polymer PC6AB coupled with manganous phosphate ionic oligomers (MnP). The degradation of nanoagonists into PC6AB and MnP in the acidic TME enables spatiotemporal control of their delivery to tumor cells and immune cells, respectively.

DOCK9 as a predictive biomarker linked to angiogenesis and immune response in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) remains a serious health concern due to its high prevalence and mortality rates. Identifying prognostic biomarkers is essential to improving patient outcomes and treatment strategies. DOCK9, a gene implicated in various cellular functions, may play a significant role in ESCC progression and prognosis.

Imaging probes for the detection of brain microenvironment.

The brain microenvironment (BME) is a highly dynamic system that plays a critical role in neural excitation, signal transmission, development, aging, and neurological disorders. BME consists of three key components: neural cells, extracellular spaces, and physical fields, which provide structures and physicochemical properties to synergistically and antagonistically regulate cell behaviors and functions such as nutrient transport, waste metabolism and intercellular communication. Consequently, monitoring the BME is vital to acquire a better understanding of the maintenance of neural homeostasis and the mechanisms underlying neurological diseases.

Association between alcohol consumption and allergic rhinitis in US adults.

Introduction: Increasing evidence suggests that alcohol consumption may be associated with allergic diseases. This cross-sectional analysis aimed to determine the correlation between alcohol consumption patterns and allergic rhinitis (AR) in US adults.

Methods: A cross-sectional study was conducted involving 2,179 individuals aged 20 years and older who took part in the 2005-2006 National Health and Nutrition Examination Survey (NHANES), which assessed AR and alcohol consumption patterns.