Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study.

Background: Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recognized as a biomarker of critical illness, yet its prognostic significance in polytrauma remains underexplored. This multicenter study investigates the temporal dynamics of serum ferritin in polytrauma patients and its association with systemic inflammation, organ dysfunction, and mortality.

Bacterial cellulose membrane integrating phase-transited lysozyme nanofilm loaded with biguanides for dressing treatment of atopic dermatitis.

Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease often accompanied by severe itching that seriously affects patients' quality of life. Conventional topical medications, including glucocorticoids and calcineurin inhibitors, frequently cause varying adverse effects in a significant number of AD patients. Consequently, new topical treatments for AD require further investigation.

Association of hepatitis B virus infection with oocyte quality, embryo development, and ART outcomes in couples with a freeze-all strategy at a single center.

Study Question: Does female or male hepatitis B virus (HBV) infection affect the oocyte and embryo quality, pregnancy outcomes, and neonatal outcomes in infertile couples undergoing ART treatment?

Summary Answer: The female or male HBV infection did not have a statistically significant negative impact on the development of oocytes and embryos, pregnancy outcomes, or neonatal outcomes of ART.

What Is Known Already: Only few studies assessing the effects of HBV infection on the reproductive outcomes among infertile population have been conducted with inconsistent results. There is limited research that focuses on the oocyte and embryo development of HBV-infected females and males.

Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation.

Background/aims: The role of reactivation of Human cytomegalovirus (HCMV) in determining outcomes of cirrhotic patients with acute decompensation (AD) is unknown. We aimed to investigate HCMV incidence and potential correlation with hepatic outcomes in AD patients.

Methods: Two prospective multicentre cohorts with AD patients were investigated.

Cumulative Live Birth Rates in Women Undergoing Progestin-Primed Ovarian Stimulation Using Medroxyprogesterone Acetate, Dydrogesterone, and Progesterone: A Retrospective Analysis.

Purpose: To investigate possible differences in cumulative live birth rates (CLBRs) among three progestins medroxyprogesterone acetate (MPA), dydrogesterone (DYG), and Progesterone within the progestin-primed ovarian stimulation (PPOS) protocol.

Patients And Methods: This retrospective study included 21,159 women undergoing one of three ovarian stimulation protocols, hMG + MPA, hMG + DYG, or hMG + Progesterone, between September 2013 and January 2024 in our centre. Patients received oral progestins once daily as per their assigned protocol with human menopausal gonadotropin initiated on menstrual cycle day 3.

Downregulation of NNMT affects trophoblast function via inhibiting COMP/CD36/ERK1/2 axis in recurrent spontaneous abortion.

Recurrent spontaneous abortion (RSA) is closely associated with trophoblast dysfunction, yet the underlying regulatory mechanisms remain poorly understood. Herein, we found a significantly decreased level of nicotinamide N-methyltransferase (NNMT) in RSA villous tissues compared to normal pregnancies. NNMT knockdown suppressed trophoblast proliferation, migration and invasion in vitro, and increased embryo absorption rate in vivo.

A Contrastive-Learning Framework for Unsupervised Salient Object Detection.

Existing unsupervised salient object detection (USOD) methods usually rely on low-level saliency priors, such as center and background priors, to detect salient objects, resulting in insufficient high-level semantic understanding. These low-level priors can be fragile and lead to failure when the natural images do not satisfy the prior assumptions, e.g.

Causal relationship between tea intake and bone mineral density at different ages ̶ A Mendelian randomization study.

Introduction: bone mineral density (BMD) is strongly associated with the risk of osteoporosis and fractures. Furthermore, dietary tea consumption also has a great impact on the variation in BMD. The pathway mechanisms from tea consumption to BMD are not well known.

Association between Metabolic Syndrome Score and Subclinical Atherosclerosis.

Background: Previous studies have presented conflicting results on the correlation between metabolic syndrome (MetS) and subclinical atherosclerosis. However, the binary MetS definition cannot reflect the severity of metabolic disorders continuously and dynamically. The present study calculated the MetS score and explored the association between MetS score and subclinical atherosclerosis.

Photo-assisted synthesis of ternary metal (oxy)hydroxide electrode for enhanced seawater splitting and solar-to-hydrogen conversion.

Seawater electrolysis offers a sustainable route for large-scale hydrogen production, yet the development of non-noble metal electrocatalysts with high activity and chloride resistance remains challenging. Here, we report a photo-assisted synthesis method to fabricate a ternary metal (oxy)hydroxide electrocatalyst (p-S-Ni(Fe,Co)OOH) from nickel foam, utilizing photogenerated holes to achieve atomic-level Fe/Co co-doping. The p-S-Ni(Fe,Co)OOH exhibits bifunctional activity in alkaline seawater, requiring overpotentials of 108 and 186 mV for hydrogen- and oxygen-evolution reactions (HER and OER) at 10 mA cm in 1.

Comparing public willingness-to-pay for different low-carbon measures: A case study of Shenzhen, China.

Cities in China have made progressive strides in developing low-carbon societies and experimenting with various low-carbon measures. The successful implementation of these low-carbon measures and the subsequent maintenance of relevant amenities rely on the support of local residents. However, there is limited understanding of residents' awareness and support for the different types of low-carbon measures, which can involve different trade-offs.

tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway.

Background: Recurrent spontaneous abortion (RSA) affects approximately 1-5% of childbearing women and poses a significant threat to global reproductive health. Transfer RNA-derived small RNAs (tsRNAs) are a novel class of noncoding RNAs implicated in various human diseases. However, the role and mechanism of tsRNAs in regulating trophoblast function during RSA development remain unknown.

Development and psychometric validation of a clinical instrument for infant feeding and lifestyle evaluation.

Objective: There is an absence of a comprehensive clinical instrument to assess and track the development of non-ideal feeding practices and lifestyle behaviours in early childhood. Our primary aim was to develop and validate an assessment instrument, called Feeding, Lifestyle, Activity Goals (FLAGs), designed to serve as a feeding, lifestyle and activity behaviour checklist for children aged 0-2 years.

Methods: This study took place between January and May 2023.

SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor.

The genus Streptomyces comprises gram-positive bacteria that produce large numbers of secondary metabolites, which have promising commercial applications and deserve extensive study. Most bacteria synthesize fatty acids using a type II fatty acid synthase, with each step catalyzed by a discrete protein. Fatty acid synthesis has been intensively studied in the model strain Streptomyces coelicolor, in which 3-ketoacyl-acyl carrier protein synthase III (KAS III, FabH) is essential for growth and fatty acid biosynthesis.

Predicting the risk of invasive fungal infections in ICU sepsis population: the AMI risk assessment tool.

Background: Invasive fungal infections (IFI) represent a significant contributor to mortality among sepsis patients in the Intensive Care Unit (ICU). Early diagnosis of IFI is challenging, and currently, there are no predictive tools for identifying sepsis patients who may develop IFI. Our study aims to develop a predictive scoring system to assess the risk of IFI in patients with sepsis admitted to the ICU.

Measuring China's Policy Stringency on Climate Change for 1954-2022.

Efforts on climate change have demonstrated tangible impacts through various actions and policies. However, a significant knowledge gap remains: comparing the stringency of climate change policies over time or across jurisdictions is challenging due to ambiguous definitions, the lack of a unified assessment framework, complex causal effects, and the difficulty in achieving effective measurement. Furthermore, China's climate governance is expected to address multiple objectives by integrating main effects and side effects, to achieve synergies that encompass environmental, economic, and social impacts.

Enhancing cellulose and hemicellulose degradation in wheat straw composting by inoculation with : key factors and microbial community dynamics.

Actinobacteria are widely used in aerobic composting of straw waste because of their good degradation effect on lignocellulose. However, there are few studies on the degradation effect of on straw. In this study, six laboratory-scale treatments were conducted: corn straw composting with inoculation (CSI), rice straw composting with inoculation (RSI), and wheat straw composting with inoculation (WSI).

Global and Regional Burden of Type 2 Diabetes Mellitus Attributable to Low Physical Activity From 1990 to 2021.

Aim: Type 2 diabetes mellitus (T2DM) contributes to the heavy burden, but there lacks latest and comprehensive global research on the burden of T2DM attributable to low physical activity (LPA). This study aimed to quantify the global and regional burden of T2DM attributable to LPA from 1990 to 2021.

Methods: We utilized data including disability-adjusted life years (DALYs), mortality, age-standardized disability-adjusted life years (ASDR), and age-standardized mortality rates (ASMR) from the Global Burden of Disease (GBD) 2021.

Optimal fluid resuscitation targets in septic patients with acutely decompensated heart failure.

Background: To determine the optimal fluid resuscitation volume in septic patients with acutely decompensated heart failure (ADHF).

Methods: Septic patients with ADHF were identified from a tertiary urban medical center. The generalized additive models were used to explore the association between fluid resuscitation volume and endpoints, and the initial 3 h fluid resuscitation volume was divided into four groups according to this model: < 10 mL/kg group, ≥ 10 to ≤ 15 mL/kg group, > 15 to ≤ 20 mL/kg group, and > 20 mL/kg group.

Application of MIDD to accelerate the development of anti-infectives: Current status and future perspectives.

This review examines the role of model-informed drug development (MIDD) in advancing antibacterial and antiviral drug development, with an emphasis on the inclusion of host system dynamics into modeling efforts. Amidst the growing challenges of multidrug resistance and diminishing market returns, innovative methodologies are crucial for continuous drug discovery and development. The MIDD approach, with its robust capacity to integrate diverse data types, offers a promising solution.

Deep-learning-based segmentation of perivascular spaces on T2-Weighted 3T magnetic resonance images.

Purpose: Studying perivascular spaces (PVSs) is important for understanding the pathogenesis and pathological changes of neurological disorders. Although some methods for automated segmentation of PVSs have been proposed, most of them were based on 7T MR images that were majorly acquired in healthy young people. Notably, 7T MR imaging is rarely used in clinical practice.

Identification of Hub Genes in Comorbidity of Psoriasis and Vitiligo Using Bioinformatics Analysis.

Background: Psoriasis and vitiligo are two common autoimmune skin diseases with increased risk of comorbidities, but the common molecular mechanism about the occurrence of these two diseases is still unknown.

Objective: This study aimed to identify the combined genetic profiles and evaluate the potential mechanism underlying the occurrence of this complication.

Methods: The Gene Expression Omnibus (GEO) database was used to obtain the gene expression profiles of psoriasis (GSE30999) and vitiligo (GSE75819), and common differentially expressed genes (DEGs) were identified using GEO2R.

Letrozole co-treatment in an antagonist protocol for overweight women undergoing IVF treatment: a retrospective study.

Background: Overweight women undergoing IVF treatment have lower success rates. Letrozole, an aromatase inhibitor, has been used as an adjunct for IVF treatment, but its specific effects in overweight women have not been investigated. This study was to explore the effects of letrozole co-treatment in an antagonist protocol for overweight infertile women undergoing IVF treatment.