Molecular characterization of a new wheat-Thinopyrum ponticum translocation line with resistance to stripe rust.

Stripe rust (Puccinia striiformis f. sp. tritici) is a globally devastating foliar disease affecting common wheat.

A viral infection-biomimetic strategy for antibody-guided targeted protein degradation.

Targeted protein degradation (TPD) is a valuable strategy for investigating protein functionality in cell biology and drug discovery. Among the various emerging TPD technologies, antibody-guided TPD offers key advantages over other protein degradation methods in terms of compatibility with different proteins of interest (POIs) and cell types. However, increasing the efficiency of cellular antibody internalisation and protein degradation remains challenges.

Enhanced recovery after surgery programs versus conventional rehabilitation for patients undergoing thoracoscopic radical resection of lung cancer in local regional hospitals: a prospective randomized controlled trial.

Background: An appropriate rehabilitation program should follow thoracoscopic lung cancer radical surgery (TLCRS) to promote patient recovery during the perioperative period. However, enhanced recovery after surgery (ERAS) and conventional rehabilitation mode (CRM) programs remain a subject of debate to date. Therefore, in this randomized controlled trial, we compared the effectiveness and safety of an ERAS program with those of a CRM program after TLCRS in local regional hospitals.

Dysfunctional Decidual CD4T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation.

Palmitoylation is a fully reversible post-translational modification that regulates the functions of various proteins. While its dysregulation has been implicated in numerous pathological processes, there has been scarce researches on palmitoylation changes in proteins associated with recurrent pregnancy loss (RPL). Utilizing palmitoylation proteomics, 3262 proteins are identified with increased palmitoylation and 1577 proteins with decreased palmitoylation in the decidual immune cells from RPL patients compared to those from normal early pregnancies.

Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ-Mediated Immunotherapy.

Immune checkpoint inhibitors have revolutionized cancer therapy; however, many patients exhibit suboptimal responses, which is due to inadequate T cell priming by the innate immune response. Metal ions play a critical role in modulating the innate immune response. However, the mechanisms by which metal ions facilitate dendritic cell maturation through the activation of interferon remain poorly understood.

Global and regional burden of nasopharyngeal cancer in older adults attributable to smoking and high alcohol use from 1990 to 2021.

Background: Nasopharyngeal cancer (NPC) poses a considerable global health burden, with behavioral risk factors such as smoking and high alcohol use contributing to disparities across sociodemographic groups. The growing aging population faces heightened vulnerability to NPC due to prolonged exposure to these modifiable risks, yet comprehensive analyses of aging-specific burden patterns remain limited.

Methods: Utilizing the Global Burden of Disease 2021 data, we conducted a systematic evaluation of NPC burden attributable to smoking and alcohol use across 204 countries from 1990 to 2021.

SNP array analysis facilitates the identification of novel chromosomal alterations associated with disease and SNPs related to adverse drug reactions in neuroblastoma.

Chromosomal abnormalities are common characteristics of neuroblastoma, and have been associated with treatment, relapse and survival risk factors. The processes governing the incidence or advancement of chromosomal copy number abnormalities remain unclear, despite progress in understanding their prognostic implications. The present study aimed to provide a comprehensive understanding of genetic alterations, clinical implications, and the association between copy number aberrations (CNAs) and clinical parameters.

Characterization of a New Stripe Rust Resistance Gene on Chromosome 2StS from in Wheat.

Stripe rust, caused by f. sp. , is a highly destructive disease prevalent across most wheat-growing regions globally.

Differential Expression Profile of miRNA in Urine Exosomes of Patients with Calcium Oxalate Stones and Its Bioinformatics Analysis.

Background: Extracellular microRNA (miRNA) (exosomal miRNA) embedded in exosomes plays a vital role in the progression of calcium oxalate disease. This study aimed to identify dysregulated miRNA expression profiles and their biological functions in the urinary exosomes of patients with calcium oxalate.

Methods: Ultrahigh-speed centrifugation and Illumina high-throughput sequencing were used to isolate and detect the expression levels of exocrine miRNAs in urine samples from 10 patients with calcium oxalate stones and 10 matched normal persons, and construct their differential expression profiles.

Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway.

The establishment of placentation and maternal-fetal tolerance are important determinants of a successful pregnancy. Tacrolimus, also known as FK506, is a calcineurin inhibitor that has often been used for pregnant women after solid organ transplantation. Previous therapeutic interventions have shown the benefits of using the immuno-suppressive agent FK506 in improving clinical pregnancy and live birth rates and reducing the risk of spontaneous miscarriage.

Machine Learning Model for Risk Stratification of Papillary Thyroid Carcinoma Based on Radiopathomics.

Rationale And Objectives: This study aims to develop a radiopathomics model based on preoperative ultrasound and fine-needle aspiration cytology (FNAC) images to enable accurate, non-invasive preoperative risk stratification for patients with papillary thyroid carcinoma (PTC). The model seeks to enhance clinical decision-making by optimizing preoperative treatment strategies.

Methods: A retrospective analysis was conducted on data from PTC patients who underwent thyroidectomy between October 2022 and May 2024 across six centers.

Involvement of Tim-3 in Maternal-fetal Tolerance: A Review of Current Understanding.

As the first T cell immunoglobulin mucin (Tim) family member to be identified, Tim-3 is a powerful immune checkpoint that functions in immunoregulation and induction of tolerance. Conventionally, Tim-3 is considered to play a role in adaptive immunity, especially in helper T cell-mediated immune responses. As researches progress, Tim-3 has been detected in a wider range of cell types, modulating cell function through ligand-receptor interactions and other pathways.

Targeted elimination of tetravalent-Sn-induced defects for enhanced efficiency and stability in lead-free NIR-II perovskite LEDs.

Eco-friendly Sn-based perovskites show significant potential for high-performance second near-infrared window light-emitting diodes (900 nm - 1700 nm). Nevertheless, achieving efficient and stable Sn-based perovskite second near-infrared window light-emitting diodes remains challenging due to the propensity of Sn to oxidize, resulting in detrimental Sn-induced defects and compromised device performance. Here, we present a targeted strategy to eliminate Sn-induced defects through moisture-triggered hydrolysis of tin tetrahalide, without degrading Sn in the CsSnI film.

Safety and efficacy of the amino acid crosslinked hyaluronic acid in the treatment of temple hollowing.

Background: Loss of volume in the temples is an early sign of aging and often gives the impression of a gaunt and emaciated appearance.

Objective: The authors conduct a clinical study to investigate the safety and effectiveness of the amino acid crosslinked hyaluronic acid (ACHA) for the treatment of temple hollowing.

Methods: 75 subjects with Temple Hollowing Scale (THS) from 2 to 4 were enrolled and assigned according to the ratio of 2 (ACHA group, n = 50): 1 (no treatment control group, n = 25).

Circadian Regulation of Lipid Metabolism during Pregnancy.

A cluster of metabolic changes occur to provide energy for fetal growth and development during pregnancy. There is a burgeoning body of research highlighting the pivotal role of circadian rhythms in the pathogenesis of metabolic disorders and lipid homeostasis in mammals. Perturbations of the circadian system and lipid metabolism during gestation might be responsible for a variety of adverse reproductive outcomes comprising miscarriage, gestational diabetes mellitus, and preeclampsia.

Bifunctional In-MOFs for Selective and Sensitive Detection of Trace Nitrobenzene Compounds in Water and Possessing High Proton Conductivity.

With the escalating prevalence of terrorism and global environmental pollution, nitroaromatic compounds (NACs) have increasingly come into focus as the primary culprit. To counter these challenges, it is imperative to develop simple and efficient methods for detecting NACs. Considering the electron-deficient structure of NAC molecules, this paper constructed a novel three-dimensional In-MOF with permanent porosity using electron-rich organic molecules 4'-[1,2,2-tris(3',5'-dicarboxy[1,1'-biphenyl]-4-yl)ethenyl]-[1,1'-biphenyl]-3,5-dicarboxylic acid (HETTB) for fluorescence detection by photoinduced electron transfer.

A Highly Stable Multifunctional Bi-Based MOF for Rapid Visual Detection of S and HS Gas with High Proton Conductivity.

Metal organic frameworks (MOFs) constructed with bismuth metal have not been widely reported, especially multifunctional Bi-MOFs. Therefore, developing multifunctional MOFs is of great significance due to the increasing requirements of materials. In this work, a 3D Bi-MOF (Bi-TCPE) with multifunctionality was successfully constructed, demonstrating high thermal stability, water stability, a porous structure, and strong blue fluorescence emission.

Ultrasound contrast-enhanced radiomics model for preoperative prediction of the tumor grade of clear cell renal cell carcinoma: an exploratory study.

Background: This study aims to explore machine learning(ML) methods for non-invasive assessment of WHO/ISUP nuclear grading in clear cell renal cell carcinoma(ccRCC) using contrast-enhanced ultrasound(CEUS) radiomics.

Methods: This retrospective study included 122 patients diagnosed as ccRCC after surgical resection. They were divided into a training set (n = 86) and a testing set(n = 36).

Identification and sex expression profiles of candidate chemosensory genes from Atherigona orientalis via the antennae and leg transcriptome analysis.

Atherigona orientalis Schiner (1868) is an acknowledged agricultural pest owing to its feeding habits and breeding locations. This insect is a tropical and subtropical pest in fruits and vegetables, in which >50 varieties of fruits and vegetables in 26 families, such as Capsicum annuum, Lycopersicon esculentum, and Cucumis melo have been attacked. Moreover, A.

Screening and identification of differential-expressed RNAs in thrombin-induced in vitro model of intracerebral hemorrhage.

Survival of olfactory mucosal mesenchymal stem cells (OM-MSCs) remains the low level in the cerebral microenvironment during intracerebral hemorrhage (ICH). This article aims to reveal the differential expression profile of ICH-stimulated OM-MSCs based on whole transcriptome sequence analysis. OM-MSCs were isolated from 6-week C57BL/6 mice.

Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13.

OTUD6A is a deubiquitinase that plays crucial roles in various human diseases. However, the precise regulatory mechanism of OTUD6A remains unclear. In this study, we found that OTUD6A significantly inhibited the production of type I interferon.

Combining conventional ultrasound and ultrasound elastography to predict HER2 status in patients with breast cancer.

Identifying the HER2 status of breast cancer patients is important for treatment options. Previous studies have shown that ultrasound features are closely related to the subtype of breast cancer. In this study, we used features of conventional ultrasound and ultrasound elastography to predict HER2 status.

MicroRNA-15a/β1,4-GalT-I axis contributes to cartilage degeneration via NF-κB signaling in osteoarthritis.

Objective: Osteoarthritis is a condition characterized by articular cartilage degradation. The increased expression of β1,4-Galactosyltransferase-I (β1,4-GalT-I) in the articular cartilage of osteoarthritis patients was related to an inflammatory response. The aim of this study was to elucidate the role of β1,4-GalT-I in osteoarthritis.