The Impact of Adjuvant Drug Therapy on Overall Survival in Patients with Clear Cell Renal Cell Carcinoma: A Systematic Review and Meta-Analysis.

Purpose Clear cell renal cell carcinoma (ccRCC), the dominant subtype of renal malignancy, has a rising global incidence and mortality. While surgery is the standard of care for localized cases, adjuvant therapy aims to improve outcomes in high-risk postoperative patients. To quantify the clinical value of adjuvant pharmacotherapy, this systematic review and meta-analysis assesses its effect on overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) in patients with ccRCC.

Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction.

Haploid induction (HI) through stress-treated microspore culture has gained significant attention for over half a century, yet the molecular mechanism underlying microspore fate transition for androgenesis remains poorly understood. Here, we demonstrate that microspore-specific expression of BABY BOOM (BBM) is sufficient to induce microspore cell fate transition and in vivo androgenesis in both tobacco and rice, effectively bypassing the requirement for stress treatment. We further identify BBM-activated Androgenesis Regulator 1 (BAR1) as a novel downstream effector of BBM that promotes microspore reprogramming.

Flexibility meets rigidity: a self-assembled monolayer materials strategy for perovskite solar cells.

Self-assembled monolayer (SAM) materials have emerged as promising materials for interface engineering in perovskite solar cells. However, achieving an optimal balance between molecular packing density, charge transport efficiency, and defect passivation remains a challenge. In this work, we propose a SAM material design strategy that synergizes flexible head groups with rigid linking groups.

Mechanisms of di (2-Ethylhexyl) Phthalate-Induced Lipid Metabolism Disorders: A Review.

Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that can be absorbed by the human body through various pathways. Numerous studies have indicated the adverse effects of DEHP on lipid metabolism. Experimental and population studies have provided evidence for DEHP-induced lipid metabolism disorder.

Deep learning-based lung cancer classification of CT images.

Lung cancer remains a leading cause of cancer-related deaths worldwide, with accurate classification of lung nodules being critical for early diagnosis. Traditional radiological methods often struggle with high false-positive rates, underscoring the need for advanced diagnostic tools. In this work, we introduce DCSwinB, a novel deep learning-based lung nodule classifier designed to improve the accuracy and efficiency of benign and malignant nodule classification in CT images.

Comprehensive metabolomic and microbial analysis of tobacco rhizosphere soil responses to crop rotation and fertilization.

Tobacco ( L.) is a crucial Solanaceae crop globally, but its continuous cultivation can lead to soil degradation. Crop rotation offers numerous benefits, including enhanced soil fertility, improved microbial communities, and pest control.

Comparison of prostate cancer detection rates and complications between transrectal ultrasound-guided transperineal and transrectal biopsies: a systematic review and meta-analysis.

Background: Transrectal ultrasound (TRUS)-guided transperineal (TP) and transrectal (TR) approaches have been used for systematic prostate biopsy. A meta-analysis was conducted to compare the cancer detection rates (CDRs) and associated complications between TP and TR prostate biopsies.

Methods: PubMed, Web of Science, Embase, Cochrane Library, China Wanfang data, and China National Knowledge Infrastructure (CNKI) were searched for literature on TP and TR biopsies of the prostate from inception to September 2024.

Translation regulation in Bacillus subtilis and its applications in heterologous protein expression: A review.

Bacillus subtilis is widely used for industrial enzyme production due to its food safety and good capability of protein synthesis and secretion. However, the production of heterologous proteins is often inefficient, partly due to poor compatibility and versatility of genetic elements in B. subtilis.

Development and validation of a CT-based radiomics nomogram for predicting cervical lymph node metastasis in papillary thyroid carcinoma.

ObjectiveThis study aimed to develop and validate a radiomics nomogram based on 40 KeV images and iodine density maps derived from dual-layer spectral detector CT (DLSDCT) for predicting cervical lymph node (LN) metastasis in patients with papillary thyroid carcinoma (PTC).MethodsA total of 214 LNs from 143 patients with histopathologically confirmed PTC in our hospital were included in the study. The LNs were randomly divided into a training group (n = 150) and a validation group (n = 64) in a 7:3 ratio.

Comparison of safety signals for ibuprofen in children and adults: A real-world pharmacovigilance analysis.

Ibuprofen is commonly used as an over-the-counter antipyretic and analgesic. However, children, as vulnerable population, are frequently excluded from pre-market clinical trials. Furthermore, there is a lack of post-marketing safety study.

Differential Expression Profile of miRNA in Urine Exosomes of Patients with Calcium Oxalate Stones and Its Bioinformatics Analysis.

Background: Extracellular microRNA (miRNA) (exosomal miRNA) embedded in exosomes plays a vital role in the progression of calcium oxalate disease. This study aimed to identify dysregulated miRNA expression profiles and their biological functions in the urinary exosomes of patients with calcium oxalate.

Methods: Ultrahigh-speed centrifugation and Illumina high-throughput sequencing were used to isolate and detect the expression levels of exocrine miRNAs in urine samples from 10 patients with calcium oxalate stones and 10 matched normal persons, and construct their differential expression profiles.

Dual-threshold sample selection with latent tendency difference for label-noise-robust pneumoconiosis staging.

BackgroundThe precise pneumoconiosis staging suffers from progressive pair label noise (PPLN) in chest X-ray datasets, because adjacent stages are confused due to unidentifialble and diffuse opacities in the lung fields. As deep neural networks are employed to aid the disease staging, the performance is degraded under such label noise.ObjectiveThis study improves the effectiveness of pneumoconiosis staging by mitigating the impact of PPLN through network architecture refinement and sample selection mechanism adjustment.

Rapid quality evaluation of moutan cortex (Paeonia suffruticosa Andrews) by near-infrared spectroscopy and bionic swarm intelligent optimization algorithm.

Moutan Cortex (MC), recognized as a traditional Chinese medicinal herb, possesses significant therapeutic properties. The existing quality assessment method only measures the content of one component in MC, which is obviously not comprehensive enough. Besides, the determination process is time-consuming and laborious.

Effect of thermal stress on the life of DC link capacitors for smart grid.

Thermal stress is an important factor affecting the life of a DC link capacitor (DCLC). However, relevant studies on thermal stress mechanism directly influencing the lifetime of the capacitor are rarely reported. In this paper, the heat setting and thermal stress of DCLC has been analyzed, and the relevant experimental platforms have been developed to evaluate the breakdown strength of DCLC at two heat setting temperatures (HSTs).

Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies.

Melanocortin therapeutics, exemplified by adrenocorticotropic hormone, have a proven steroidogenic-independent anti-proteinuric and glomerular protective effect. The biological functions of melanocortins are mediated by melanocortin receptors (MCR), including MC1R, which recent studies have shown to protect against glomerular disease. However, the role of other MCRs like MC5R is unknown.

Self-assembled materials with an ordered hydrophilic bilayer for high performance inverted Perovskite solar cells.

While self-assembled material based inverted perovskite solar cells have surpassed power conversion efficiencies of 26%, enhancing their performance in large-area configurations remains a significant challenge. In this work, we report a self-assembled material based hole-selective layer 4-(7H-dibenzo[c,g]carbazol-7-yl)phenyl)phosphonic acid, with a π-expanded conjugation. The enhanced intermolecular π-π interactions facilitate the self-assembly of 4-(7H-dibenzo[c,g]carbazol-7-yl)phenyl)phosphonic acid molecules to form an ordered bilayer with a hydrophilic surface, which passivates the buried perovskite interface defect and enables high-quality and large-area perovskite preparation, while simultaneously enhancing interfacial charge extraction and transport.

Expression of Recombinant Human α-Glucosidase in HEK293 Cells.

In mammals, intestinal α-glucosidase exists as a maltase-glucoamylase complex (MGAM) and a sucrase-isomaltase complex (SI). In this study, we transiently expressed human MGAM and SI in human embryonic kidney 293 (HEK293) cells. At pH 6.

Mucosal Exosome Proteomics of Hybrid Grouper ♀ × ♂ Infected by .

infection, which causes visceral white spot disease, is a significant and economically devastating disease in aquaculture. In this study, we investigated the impact of bacterial infection on the protein composition of exosomes derived from the surface mucus of the hybrid grouper ♀ × ♂. Two hundred healthy fish were randomly separated into challenge and control groups.

Semi-quantitative CT score reflecting the degree of pulmonary infection as a risk factor of hypokalemia in COVID-19 patients: a cross-sectional study.

Background: Hypokalemia is a common electrolyte disorder observed in patients afflicted with coronavirus disease 2019 (COVID-19). When COVID-19 is accompanied by pulmonary infection, chest computed tomography (CT) is the preferred diagnostic modality. This study aimed to explore the relationship between CT semi-quantitative score reflecting the degree of pulmonary infection and hypokalemia from COVID-19 patients.

Rutin ameliorates HCD-induced cholesterol metabolism disorder in zebrafish larvae revealed by transcriptome and metabolome analysis.

Changes in modern lifestyles have led to an increase in obesity rates. Excessive lipid accumulation leads to abnormal cholesterol metabolism, and maintaining a balanced cholesterol metabolism is essential for the normal functioning of cells and the body. Rutin belongs to the group of flavonoids with hypolipidemic, anti-inflammatory and antioxidant effects.