Filamentous Microalgae Screening for Carotenoid and Lipid Production: A Promising Candidate with High Ammonium Tolerance for Wastewater Treatment.

High-ammonium wastewater can be simultaneously remediated and valorized through phototrophic cultivation of stress-resilient microalgae. This study evaluated the growth performance of 16 microalgae strains (specific growth rate μ = 0.108-0.

Association of Distinct Initial β-Amyloid Levels With Tau Pathology Expansion Beyond the Entorhinal Cortex.

Background And Objectives: β-Amyloid (Aβ) likely triggers the spread of pathologic tau from the entorhinal cortex (EC) to the neocortex, but whether distinct Aβ levels exert differential influences on tau propagation beyond the EC remains unclear. We aimed to investigate the modifying effect of Aβ on the association of initial tau deposition with successive tau accumulation.

Methods: A retrospective analysis was performed using data from 2 longitudinal observational cohort studies, the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Harvard Aging Brain Study (HABS), both conducted in the United States.

Dietary supplementation with dihydroartemisinin improves the slaughter performance, serum biochemistry, and intestinal health of broiler chickens.

The medicinal herb Artemisia annua L. has traditionally been used to promote human and animal health. One of the most important bioactive metabolites is dihydroartemisinin; however, its impact on intestinal health in broilers has not been sufficiently researched.

Unimolecular decomposition of pentacyclic carbonates: a computational kinetic study.

To develop chemical kinetic models for the pyrolysis and combustion of pentacyclic carbonates, including ethylene carbonate (EC), propylene carbonate (PC), 2,3-butylene carbonate (23BC), and 1,2-butylene carbonate (12BC), which are always focused on in the battery industry as representative solvents and alternative fuels, theoretical aspects of unimolecular decomposition reactions were studied. According to the calculations, CO, H, and CH elimination channels and isomerization channels were found based on the potential energy surface of the unimolecular decomposition channels. These pentacyclic carbonates predominantly tend to eliminate CO, thereby generating aldehydes, ketones, and oxiranes.

Lattice modulation of bimetallic zero-valent iron to boost selective hydrodechlorination of organic pollutants.

Atomic hydrogen (*H) in bimetallic nanoscale zero-valent iron (M-nFe)-water system plays a dominant role for realizing in-situ deep dechlorination reactions, yet its selective generation and sustainable utilization remain challenging. Herein, a structural modulation strategy was proposed to design lattice engineered M-nFe (M-nFe), which generated controllable lattice strain and strong M-Fe chemical bonds, thus steering *H generation/accumulation and achieving deep dechlorination of various organic pollutants. Compared with traditional surface nickel-modified nFe (Ni-Fe), the dechlorination rate of Ni-Fe for TCE and 4-CP was improved by 3.

Sex-specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment.

Introduction: Sex differences in the association between depressive symptoms and cognitive decline or dementia risk among older adults remain controversial. Reliance on single time point assessments of depressive symptoms, which fail to capture their dynamic course, may contribute to the inconsistencies.

Methods: We investigated the sex-specific associations of longitudinal trajectories of depressive symptoms with cognitive decline and progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia among 811 individuals with MCI.

Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b/NF-κB-mediated macrophage polarization.

Gut microbiota-derived extracellular vesicles (EVs) are emerging mediators of microbiota-host crosstalk, but their roles in diarrheal diseases remain poorly understood. Here, we revealed that EVs isolated from diarrheal donors' intestinal microbiota trigger pro-inflammatory macrophage polarization and compromise intestinal epithelial barrier integrity in both conventional and pseudo-germ-free mice, demonstrating their intrinsic pathogenicity independent of viable microbes. miRNAs sequencing analysis identified miR-125b as a highly enriched miRNA in diarrheal microbiota-derived EVs, which directly targets the 3' untranslated region of NF-κBIA, leading to its degradation and subsequent activation of the NF-κB signaling pathway.

The current landscape of quinazoline derivatives with anticancer therapeutic potential-part II.

Cancer, which can invade and metastasize to almost all organs or tissues, is one of the deadliest diseases across the world. Drug resistance, especially multidrug resistance, is a principal obstacle to effective therapeutic interventions against cancer, creating an urgent demand for the exploration of novel anticancer chemotherapeutics. Quinazoline derivatives are useful templates for exploring new anticancer chemotherapeutics due to their ability to exert anticancer effects through various mechanisms, mainly associated with alterations in cell cycle progression, induction of apoptosis, and modification of autophagy.

Enzyme-independent functions of HDAC3 in the adult heart.

The cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious effects of HDAC depletion. Here, we use HDAC3 as a prototype HDAC to address this contradiction. We show that adult-onset cardiac-specific depletion of HDAC3 in mice causes cardiac hypertrophy and contractile dysfunction on a high-fat diet (HFD), excluding developmental disruption as a major reason for the contradiction.

Label-free isolation of lipid-rich Saccharomyces cerevisiae mutant by high-throughput flow-mode Raman-activated cell sorting and multi-omics analysis for uncovering the mechanism of enhanced lipid accumulation.

Background: Palmitoleic acid, a valuable functional fatty acid, is notably scarce in traditional oil crops, with the exception of certain wild plants such as macadamia nuts and sea buckthorn. Recently, the lipid from Saccharomyces cerevisiae was found to contain approximately 50% palmitoleic acid. Consequently, S.

Aliphatic Disinfection Byproducts Induced Antibiotic Resistance in through Cell Wall Alteration.

Disinfection is a critical step in drinking water treatment, yet studies revealed that it would promote the dissemination of antibiotic resistance, and disinfection byproducts (DBPs) may act as contributors. In this study, we conducted a high-throughput assessment of antibiotic resistance development in the model strain K12 after 50-day exposure to 15 aliphatic DBPs commonly found in drinking water against 8 different classes of antibiotics. The results showed that most treated bacteria developed resistance to cell wall-targeting antibiotics such as ampicillin and fosfomycin, with resistance levels increasing by 1.

A homotopy estimation based temporal-spatial spectrum prediction for UAV communications with arbitrary flight paths.

Due to the rapid growth of unmanned aerial vehicles (UAVs), their spectrum resources become scarce, leading to UAVs requiring spectrum prediction to share the spectrum with other users. However, contemporary prediction methods may have difficulty in predicting the spectrum states at the next location, because the UAVs cannot obtain the historical data in advance to train prediction models. This paper introduces a temporal-spatial spectrum prediction approach for arbitrary flight within a specific region.

Analysis of ESKAPE pathogens in clinical isolates in a tertiary care hospital in China from 2018 to 2023.

The widespread use of antimicrobial agents correlated with the increasing incidence of nosocomial infections and bacterial antibiotic resistance. These have become major challenges in the prevention and control of hospital-acquired infections worldwide. The aims of this study were to analyze the distribution and characteristics of ESKAPE pathogenic bacteria and their antibiotic resistance profile among clinical isolates from a tertiary hospital in China from 2018 to 2023.

Effectiveness of the BOPPPS-MDT Model in Enhancing ECMO Training for ICU Staff: A Randomized Controlled Trial Assessing Knowledge, Skills, and Teamwork Outcomes.

Background: Extracorporeal membrane oxygenation (ECMO) is a life-saving therapy for critically ill patients, and effective training for ICU staff is essential. This study aimed to evaluate the effectiveness of the BOPPPS-MDT (Bridge-in, Objectives, Pre-assessment, Participatory Learning, Post-assessment, and Summary model integrated with Multidisciplinary Team) teaching model in enhancing ECMO training for ICU staff.

Methods: A total of 108 ICU interns with diverse educational backgrounds and majors were randomly assigned to two groups: 54 in the control group and 54 in the experimental group.

Research Progress of CLE and Its Prospects in Woody Plants.

The peptide ligands of the CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) family have been previously identified as essential signals for both short- and long-distance communication in plants, particularly during stem cell homeostasis, cell fate determination, and growth and development. To date, most studies on the CLE family have focused on model plants and especially those involving stem and apical meristems. Relatively little is known about the role of CLE peptides in tall trees and other plant meristems.

Interpretable multiparametric MRI radiomics-based machine learning model for preoperative differentiation between benign and malignant prostate masses: a diagnostic, multicenter study.

Objective: The study aimed to develop and externally validate multiparametric MRI (mpMRI) radiomics-based interpretable machine learning (ML) model for preoperative differentiating between benign and malignant prostate masses.

Methods: Patients who underwent mpMRI with suspected malignant prostate masses were retrospectively recruited from two independent hospitals between May 2016 and May 2023. The prostate mass regions in T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) MRI images were segmented by ITK-SNAP.

Ni/Pd Dual-Catalysis Strategy for C(sp)-Sb Cross-Coupling of Halostibines with Aryl Triflates and Applications of Products as Coupling Reagents, Ligands, and Anticancer Compounds.

A novel and efficient dual-catalysis strategy using nickel and palladium has been developed for the cross-coupling of halostibines with aryl triflates to form C(sp)-Sb bonds. This approach shows a wide substrate scope and high functional group tolerance and could be conducted on a gram scale. The synthesized arylstibines also could be arylation reagents reacting with alkyl and phenyl alkenes to form olefins and ligands to regulate the hydrogenation of diphenylacetylene.

Advances in cardiac ultrasound speckle tracking technology for assessing left ventricular systolic function after adjuvant radiotherapy following breast-conserving surgery for breast cancer.

Breast-conserving surgery is a widely used treatment for breast cancer, often followed by adjuvant therapy such as adjuvant paclitaxel and trastuzumab (APT). While APT effectively reduces local recurrence and distant metastasis, it may also impair left ventricular systolic function. Speckle tracking imaging (STI) is a noninvasive ultrasound technique that quantitatively evaluates overall cardiac function.

Provenance and Tectonic Evolution of the Kongtongshan Formation Conglomerate in Southwest Ordos Basin, China.

The Kongtongshan Formation (KTSF) conglomerate in the southwestern Ordos Basin is located at the intersection of China's North-South Tectonic Belt (NSTB) and the East-West Central China Orogenic Belt (CCOB), which are crucial for reconstructing the Early Mesozoic prototype basin and understanding the regional tectonic evolution of the North China Craton (NCC). However, the depositional age and material sources of the KTSF conglomerate remain controversial. In this study, we conducted zircon LA-ICP-MS U-Pb dating and trace element analysis on sandstones, combined with paleocurrent direction measurements and field outcrop surveys, to constrain the sedimentary age and provenance of the KTSF conglomerates and reconstruct the regional tectonic evolution.

Current status and recent progress of nanomaterials in transcatheter arterial chemoembolization therapy for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide. Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC. Since the introduction of nanomaterials in 1974, their use in various fields has evolved rapidly.

Impact of prolonged cardiopulmonary bypass on gastrointestinal complications in cardiac surgery: a retrospective cohort study.

Background: Gastrointestinal complications (GICs) following cardiac surgery with cardiopulmonary bypass (CPB) significantly impact postoperative recovery and clinical outcomes.

Methods: This single-center, retrospective cohort study evaluated the incidence, risk factors, and outcomes of GICs in patients undergoing cardiac surgery with CPB between January 2018 and December 2023. Patients were stratified by CPB duration (≥ 120 min vs.

Simultaneous removal of cadmium and tetracycline from aqueous solutions by oxalic acid and pyrite co-modified biochar: Performance and mechanism.

The remediation of combined contamination with heavy metals and antibiotics in soil and aqueous environments represents an ongoing challenge. In this study, a novel highly functionalized biochar-based composite (FeS@OA-BC) was synthesised by combining oxalic acid (OA) pre-treatment with ball-milling of FeS for the simultaneous removal of cadmium (Cd) and tetracycline (TC) from aqueous solutions. FeS@OA-BC demonstrated exceptional performance in simultaneously removing 74.

A case of bloodstream infection caused by .

is fastidious, visual etiological evidence is extremely difficult to obtain, and positive results from blood cultures are even rarer. A 51-year-old female patient was admitted to our hospital for 3 days with fever, and polyarticular pain was diagnosed as infectious fever by a series of examinations, but the pathogen could not be determined. was identified by blood culture and mass spectrometry.

Differential Expression Profile of miRNA in Urine Exosomes of Patients with Calcium Oxalate Stones and Its Bioinformatics Analysis.

Background: Extracellular microRNA (miRNA) (exosomal miRNA) embedded in exosomes plays a vital role in the progression of calcium oxalate disease. This study aimed to identify dysregulated miRNA expression profiles and their biological functions in the urinary exosomes of patients with calcium oxalate.

Methods: Ultrahigh-speed centrifugation and Illumina high-throughput sequencing were used to isolate and detect the expression levels of exocrine miRNAs in urine samples from 10 patients with calcium oxalate stones and 10 matched normal persons, and construct their differential expression profiles.