Plasmonic Fiber Optic Sensing Platform for Point-of-Care Pharmacokinetic Monitoring of Platinum Chemotherapeutics: Toward Ultratrace Multi-omics Precision Chemotherapy Management.

Precision chemotherapy management requires efficient and ultrasensitive dynamic monitoring of drug pharmacokinetics alongside real-time tracking of critical biomarker responses, yet existing clinical diagnostic systems neither achieve real-time integration of these critical parameters nor provide point-of-care testing (POCT) capabilities within a unified analytical framework. Here, we develop a plasmonic fiber-optic sensing platform based on tilted fiber Bragg grating surface plasmon resonance (TFBG-SPR) for point-of-care pharmacokinetic monitoring of platinum chemotherapeutics. By utilizing programmable DNA-based biosensors, our system achieves femtomolar-level detection limits for platinum drugs in minimal sample volumes (10 μL, 100-fold dilution).

Incidence, Outcomes and Risk Factors for Atrial Fibrillation in Patients With JAK2-Positive Myeloproliferative Neoplasms.

Background: The incidence, outcomes and risk factors for AF in the JAK2-positive MPN patients are still unknown.

Methods: The clinical profiles of patients with JAK2-positive MPN were retrospectively analyzed. Multivariable Cox regression analysis was performed to identify risk factors of AF, thereby developing a risk prediction model.

XthA phospholipase contributes the cell-wall functionality of pathogenic mycobacteria by increasing the synthesis of mycolic acid.

The mycobacterial cell wall is a complex structure that plays a critical role in resisting external environmental stress and contributing to pathogenesis, with mycolic acid being a key component in maintaining cell wall integrity. Moreover, the enzymes involved in cell wall synthesis are frequently targeted in antimycobacterial drug research. In this study, we demonstrate that the conserved extracellular DNase XthA from mycobacteria exhibits phospholipase A (PLA) activity, whereas this activity is absent in non-pathogenic mycobacteria.

[Comparison between food frequency questionnaire and 24-hour dietary recall or weighing methods in evaluating dietary nutrient intakes of pregnant women].

Objective: This study aimed to compare the similarities and differences among Food Frequency Questionnaire(FFQ), 24-hour dietary recall method, and weighing method in assessing the intakes of foods, energy, and nutrients in pregnant women, and to evaluate the validity of the FFQ.

Methods: From June to September in 2017, a total of 82 pregnant women were recruited across the entire Wuqiang County in Hebei Province. The subjects were surveyed using the FFQ for the most recent week, 24-hour dietary recall for 3 consecutive days, and in-home weighing for 3 consecutive days.

[Relationship between maternal pre-pregnancy obesity and infant development: the Taicang and Wuqiang mother-child cohort study in China].

Objective: To explore the effects of maternal pre-pregnancy obesity on infant development.

Methods: Pre-pregnancy obese pregnant women who gave birth in Wuqiang County Hospital from October 2017 to October 2021 were selected, and pregnant women with normal weight before pregnancy were matched by propensity score. A total of 206 pregnant women were included, including 103 in the pre-pregnancy obesity group and 103 in the pre-pregnancy normal weight group.

[Association between feeding patterns within 4 months of age and physical growth, overweight and obesity in children aged 0-3 years old].

Objective: To investigate the association between feeding patterns within 4 months of age and both physical growth and the risk of overweight and obesity in young children aged 0-3 years.

Methods: Based on the TAWS prospective cohort study in China, children aged 0-3 years were followed up in Taicang cohort from 2013 to 2019. A structured questionnaire was used to collect and evaluate the feeding patterns of children within the first 4 months, weight and height/length were measured at birth and at 1, 3, 6, 8, 12, 18, 24, 30 and 36 months of age, weight for age Z-score(WAZ), length for age Z-score(LAZ) and weight for length Z-score(WLZ) were calculated for each measurement.

[Relationship between human milk oligosaccharides concentrations and physical growth of infants within the first six months of life].

Objective: To investigate the relationship between human milk oligosaccharides(HMOs) levels in healthy mothers and infant physical growth.

Methods: Based on a nationally representative, multi-stage stratified sampling cross-sectional survey on human milk composition, 195 lactating women within 6 months postpartum and their infants were enrolled. Human milk oligosaccharide(HMOs) concentrations were quantified using ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS).

Research Progress of CLE and Its Prospects in Woody Plants.

The peptide ligands of the CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) family have been previously identified as essential signals for both short- and long-distance communication in plants, particularly during stem cell homeostasis, cell fate determination, and growth and development. To date, most studies on the CLE family have focused on model plants and especially those involving stem and apical meristems. Relatively little is known about the role of CLE peptides in tall trees and other plant meristems.

Evaluating the environmental impact of polylactic acid plastics in agriculture: Microbial degradation and plant interaction insights.

In the last decade, non-degradable plastics have been increasingly replaced by biodegradable alternatives like polylactic acid (PLA), particularly in agriculture. However, the feasibility of microbial degradation of PLA plastics in agricultural soils still needs to be confirmed. In addition, it remains unclear whether the degradation process of PLA affects plant growth.

Longitudinal changes in human milk lactoferrin during the first year: a prospective cohort study.

Background: Lactoferrin (Lf) is an important bioactive protein in human milk involved in diverse biological functions. Concentrations of milk Lf are tightly regulated during lactation. This study aims to investigate the longitudinal changes in human milk Lf concentrations during the first year postpartum and identify the factors associated with these changes.

Effectiveness of Managing Cancer and Living Meaningfully Therapy on Health-Related Outcomes for Patients With Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Managing cancer and living meaningfully (CALM) therapy is a psychosocial intervention designed to enhance the well-being of cancer patients; however, its impact on health-related outcomes in cancer patients remains unclear.

Aims: This study aimed to systematically synthesize current evidence to assess the impact of CALM therapy on health-related health outcomes and identify key features for optimizing the intervention.

Methods: An exhaustive search was conducted across seven databases from inception to July 5, 2024.

Music Aggravates Catechol-Induced Behavioural Abnormality and Redox Imbalance in Zebrafish.

Catechol, also known as pyrocatechol, is a widespread antioxidant carcinogen that has been shown to cause central nervous system damage and metabolic abnormalities, and in zebrafish, it has been shown that exposure to aqueous solutions of catechol results in reduced pigmentation and decreased basal locomotor rate in juvenile zebrafish. However, the effects of catechol on zebrafish redox and behaviour are unknown. The aim of this study was to investigate the effects of catechol on oxidative stress levels in early zebrafish development and on behaviour in later stages of zebrafish development and to attempt to intervene in this effect with music therapy.

WP-MOD: A multi-omics and taxonomy database for woody plants.

Woody plants, including trees, shrubs, and woody vines, are vital components of terrestrial ecosystems and are critical for maintaining biodiversity, regulating climate, and supporting human livelihoods. Over the past decade, the accumulation of high-throughput sequencing data, multi-omics data, and taxonomic information on woody plants has increased significantly, highlighting the need for an integrative database. Here, we present the Woody Plant Multi-Omics Database (WP-MOD, https://www.

Prussian Blue Nanozyme Featuring Enhanced Superoxide Dismutase-like Activity for Myocardial Ischemia Reperfusion Injury Treatment.

The blood flow, when restored clinically following a myocardial infarction (MI), disrupts the physiological and metabolic equilibrium of the ischemic myocardial area, resulting in secondary damage termed myocardial ischemia-reperfusion injury (MIRI). Reactive oxygen species (ROS) generation and inflammatory reactions stand as primary culprits behind MIRI. Current strategies focusing on ROS-scavenging and anti-inflammatory actions have limited remission of MIRI.

Correction: Duan, Y.; Li, S. Effects of Plant Communities on Human Physiological Recovery and Emotional Reactions: A Comparative Onsite Survey and Photo Elicitation Study. 2022, , 721.

In the original publication [...

Antibacterial activity of the biogenic volatile organic compounds from three species of bamboo.

Plant biogenic volatile organic compounds (BVOCs) possess ecological functions in antimicrobial benefits and air purification. The objectives of the study were to determine the differences in antimicrobial capacity of bamboo forests at different sampling sites. Three common bamboo species-, and -were selected to determinate the antimicrobial activity of bamboo forests as well as under conditions.

SWATH-MS based proteomics reveals the role of photosynthesis related proteins and secondary metabolic pathways in the colored leaves of sweet olive (Osmanthus fragrans).

Colored leaves, a notable horticultural trait, have high research and ornamental value. The evergreen sweet olive (Osmanthus fragrans), one of the top ten traditional flowers in China, has been cultivated for more than two thousand years. However, in recent years, an increasing number of O.

Toward Better Semantic Interoperability of Data Element Repositories in Medicine: Analysis Study.

Background: Data element repositories facilitate high-quality medical data sharing by standardizing data and enhancing semantic interoperability. However, the application of repositories is confined to specific projects and institutions.

Objective: This study aims to explore potential issues and promote broader application of data element repositories within the medical field by evaluating and analyzing typical repositories.

ANAgdb: a multi-omics and taxonomy database for ANA-grade.

Background: The ANA-grade, encompassing early-diverging angiosperm lineages, Amborellales, Nymphaeales, and Austrobaileyales, represents a fundamental phase in the evolutionary history of flowering plants. Since the completion of key assembly of the Amborella genome, the continuous influx of omics data from the lineage underscores the need for a specialized database.

Results: Here, we introduce the ANA-grade Genome Database (ANAgdb, https://anagenome.

The association between macrosomia and glucose, lipids and hormones levels in maternal and cord serum: a case-control study.

Background: The formation of macrosomia is associated with excessive nutrition and/or unable to regulate effectively. This case-control study aims to explore the relationship between macrosomia and glucose, lipids and hormones levels in maternal and cord serum.

Methods: In the case-control study, 78 pairs of mothers and newborns were recruited who received care at one hospital of Hebei, China between 2016 and 2019.

The jacktree genome and population genomics provides insights for the mechanisms of the germination obstacle and the conservation of endangered ornamental plants.

Hu represents the first woody genus described by Chinese botanists, with all species classified as endangered ornamental plants endemic to China. Their characteristic spindle-shaped fruits confer high ornamental value to the plants, making them favored in gardens and parks. Nevertheless, the fruits likely pose a germination obstacle, contributing to the endangered status of this lineage.

A spermine-responsive supramolecular chemotherapy system constructed from a water-soluble pillar[5]arene and a diphenylanthracene-containing amphiphile for precise chemotherapy.

Stimuli-responsive supramolecular chemotherapy, particularly in response to cancer biomarkers, has emerged as a promising strategy to overcome the limitations associated with traditional chemotherapy. Spermine (SPM) is known to be overexpressed in certain cancers. In this study, we introduced a novel supramolecular chemotherapy system triggered by SPM.

Impact of seasonal changes in urban green spaces with diverse vegetation structures on college students' physical and mental health.

Based on the perceptions of college student participants in winter and summer, the effects of different vegetation structures within landscapes (single-layer woodland, tree-shrub-grass composite woodlands, tree-grass composite woodland, and single-layer grassland) and concrete squares without plants were investigated, and the skin conductivity level (SCL) and environmental perception recovery score (PRS) associated with landscape types were calculated. The results indicated that seasonal differences in landscape perception significantly affected college student participants' PRS but not their SCL scores, both in winter and summer. Viewing single-layer and tree-shrub-grass composite woodlands in summer, as well as single-layer woodland in winter, enhanced the environmental perception of the college student participants.

An Insulin-Modified pH-Responsive Nanopipette Based on Ion Current Rectification.

The properties of nanopipettes largely rely on the materials introduced onto their inner walls, which allow for a vast extension of their sensing capabilities. The challenge of simultaneously enhancing the sensitivity and selectivity of nanopipettes for pH sensing remains, hindering their practical applications. Herein, we report insulin-modified nanopipettes with excellent pH response performances, which were prepared by introducing insulin onto their inner walls via a two-step reaction involving silanization and amidation.