Subsequently to the publication of the above paper, the authors contacted the Editor to explain that, concerning the cell invasion assay experiments shown in Fig. 4, and due to an error made in filing the data, the image featured for the OA group / MGC803 cellular experiment in Fig. 4C had been inadvertently duplicated from the invasion image showing the shSET group / SGC7901 cellullar experiment in Fig.
View Article and Find Full Text PDFJ Mol Graph Model
August 2025
The design and fabrication of high-performance anode materials are pivotal in advancing the development of next-generation magnesium-ion batteries (MIBs). Herein, we conducted a comprehensive first-principles calculation to investigate the structure properties and electronic characteristics of the emerging TiB monolayer, and further evaluate its potential as an anode material of MIBs. Our computational results reveal that the TiB anode exhibits intrinsic metallic behavior and demonstrates a strong affinity for Mg ions with a notably low adsorption energy of -1.
View Article and Find Full Text PDFBiological motion (BM) perception is crucial for survival and social interaction. Previous studies have shown that form structure influences the perception of walking direction and body orientation. However, the neural mechanisms underlying how form modulates the processing of these features remain unclear.
View Article and Find Full Text PDFClin Transl Med
August 2025
Chromatin relaxation is a permissiven progress for DNA repair through enabling repair factors to access the damaged DNA. Linker histone H1 is important in maintaining chromatin compaction under physiological state. The recent evidence highlights the importance of H1 modifications in response to cellular stress.
View Article and Find Full Text PDFThe construction of chiral photochromic lanthanide complexes represents a topic of interest in photoresponsive materials for the potential applications of chiroptical photoswitches. Here, the combined employment of chiral hexa-azamacrocycle and photochromic dithienylethene-containing carboxylic ligand, 2,2″,5,5″-tetramethyl-[3,2':3',3″-terthiophene]-5'-carboxylic acid (), results in the assembly of a pair of chiral lanthanide macrocyclic complexes, -[Ln(L)(3ThCOO)](BPh) (, Ln = Eu, Dy, Y; L derived from the condensation of pyridine-2,6-dicarbaldehyde and (1, 2)/(1, 2)-1,2-diphenylethyl-enediamine), which were characterized by single-crystal XRD and CD spectra. The spectroscopic comparisons before and after photoirradiation revealed the occurrence of photochromic behaviors in both solution and solid states arising from the complementary effects of two different photoresponsive mechanisms.
View Article and Find Full Text PDFBackground: The Dietary Index for Gut Microbiota (DI-GM), a newly introduced metric, indicates gut microbiota diversity. However, its correlation with frailty remains unexplored.
Method: A total of 25,320 individuals were included in the 2007-2020 National Health and Nutrition Examination Survey (NHANES).
Nurse Educ Today
November 2025
Background: A learner profile, as a method for presenting students' core characteristics and behaviors, has been widely recognized in personalized education, yet it remains underexplored in the context of diversified nursing teaching modes. Nursing requires the application of theoretical knowledge of the curriculum to clinical practice procedures, demanding that nursing students not only absorb information but also transform, integrate, and critically apply it in dynamic, real-world settings. Investigating nursing students' learning style preferences and behavioral strategies is critical for understanding how to adapt teaching methods to meet varied learning needs, thereby enhancing teaching quality and improving student learning outcomes.
View Article and Find Full Text PDFBackground: Acute-on-chronic liver failure (ACLF) of various aetiologies is a complex syndrome with high short-term mortality and significant global burden.
Objective: To explore easily applicable diagnostic criteria and an accurate prognostic score for ACLF.
Design: Clinical data from 5288 patients (after exclusions from 7388 screened) with acute deterioration of chronic liver disease across various aetiologies were used to evaluate the performance of European Chronic Liver Failure (CLIF) and Chinese Group on the Study of Severe Hepatitis B (COSSH) criteria.
Background: Most studies have investigated the possibility of emulsions as mayonnaise substitutes, but have not paid attention to the bulk rheology and oral processing. The present study investigated the potential of cinnamaldehyde-loaded Pickering emulsions (PEs) and high internal phase PEs (HIPPEs) as mayonnaise substitutes by correlating their rheological and tribological properties.
Results: As the cinnamaldehyde content in the oil phase increased, PEs/HIPPEs exhibited reduced viscoelasticity and viscosity.
Front Mol Biosci
July 2025
Metabolomics is an expanding field dedicated to elucidating metabolic disorders by analyzing endogenous small molecules in biological samples. With the rapid advancement of metabolomics, researchers are investigating the influence of metabolites on metabolic phenotypes. The emergence of functional metabolomics provides a methodological framework to address this issue.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
A highly sensitive and stable fluorescent strategy for detecting alkaline phosphatase (ALP) in complex samples was developed using oxidized single-walled carbon nanohorns (oxSWCNHs) and exonuclease I (Exo I). A ssDNA probe, comprising a fluorophore-labeled aptamer and a 3' phosphate group, was designed and synthesized. In the absence of ALP, the ssDNA probe binds to oxSWCNHs, causing fluorescence quenching.
View Article and Find Full Text PDFPrimary ovarian squamous cell carcinoma (POSCC) represents an exceedingly rare subtype of epithelial ovarian cancer (EOC) characterized by a cryptic etiology and insidious onset. The rarity and high mortality associated with pure primary ovarian squamous cell carcinoma (SCC) make it challenging to conduct large randomized controlled studies. Furthermore, there are currently no commercially available ovarian SCC cell lines for research purposes, necessitating the urgent establishment of novel lines.
View Article and Find Full Text PDFThe response mechanisms of rice to submergence stress during the tillering stage remain unclear, and different seedling cultivation and transplanting methods may influence submergence tolerance. This study aimed to investigate the differential responses of rice to submergence stress under diverse combinations of seedling cultivation and transplanting methods, providing a theoretical basis for evaluating rice submergence tolerance. The japonica rice cultivar 'Nanjing 46' was used as the test material.
View Article and Find Full Text PDFAurantii Fructus (AF), a medicine-food homology substance, is valued for its distinctive aroma and health-promoting properties, and has been widely used in food, condiments, and traditional Chinese medicine. However, the raw form's irritating properties limit its direct application, and stir-frying with bran mitigates this drawback, enhancing its suitability for food applications. This study investigated the dynamic changes in AF's multi-dimensional parameters (including physical, chemical, and biological) during the stir-frying with bran process, aiming to elucidate the underlying processing mechanisms.
View Article and Find Full Text PDFThe mycobacterial cell wall is a complex structure that plays a critical role in resisting external environmental stress and contributing to pathogenesis, with mycolic acid being a key component in maintaining cell wall integrity. Moreover, the enzymes involved in cell wall synthesis are frequently targeted in antimycobacterial drug research. In this study, we demonstrate that the conserved extracellular DNase XthA from mycobacteria exhibits phospholipase A (PLA) activity, whereas this activity is absent in non-pathogenic mycobacteria.
View Article and Find Full Text PDFBackground: Uterine cancer poses a growing global health threat, with rising incidence among women aged ≥ 50 years. This study aimed to evaluate its disease burden across regions and nations.
Methods: Using Global Burden of Disease 2021 data, we analyzed the incidence, mortality, disability-adjusted life years (DALYs), and trends via estimated annual percentage change (EAPC), decomposition, inequality analyses, and Bayesian Age-Period-Cohort modeling for 2022-2040 projections.
Goji berries (Lycium), recognized globally as nutraceutical supplements, have traditionally been investigated for their polysaccharide and anthocyanin profiles, yet emerging phytochemical evidence reveals critical knowledge gaps in novel bioactive constituents. This review addresses such limitations by systematically evaluating hydroxycinnamic acid amides (HCAAs), a novel class of phenolic acid derivatives (phenolamides) recently identified in Lycium species. Through critical synthesis of the peer-reviewed studies related to goji berry HCAAs or phenolamides from 2010 to 2024, 114 structurally characterized amides have been cataloged across four taxonomically validated species (L.
View Article and Find Full Text PDFInflammation is a widespread physiological response that occurs when the body is stimulated by pathogens or endogenous signals [...
View Article and Find Full Text PDFInt J Biol Macromol
June 2025
Persistent intraoperative hemorrhage is the major cause of trauma-related mortality, emphasizing the need for hemostatic dressings with improved efficacy. In this study, we designed a PLGA-CTS-TXA composite sponge, which was fabricated by grafting of poly (lactic-co-glycol acid) (PLGA) and hemostatic small molecule tranexamic acid (TXA) onto chitosan (CTS), for rapid hemostasis. The sponge integrates the advantages of CTS, PLGA and TXA, showcasing superior porosity (nearly 85 %) and water absorption capacity (3197 ± 105 % within 30 s).
View Article and Find Full Text PDFAllenyl silanes and boronates are pivotal building blocks in organic synthesis. Nevertheless, their synthesis requires the manipulation of transition metal or highly reactive species. Hence, the development of more sustainable protocol is highly sought after.
View Article and Find Full Text PDFChiral lanthanide complexes hold great potential in developing advanced circularly polarized luminescence (CPL) materials in the near-infrared (NIR) wavelength range. While various ligands, such as β-diketonates and biphenols, have been successfully used to sensitize NIR emission of lanthanide ions, little attention has been paid to regulating CPL behaviors via ligand modification. In this study, we report the synthesis, structure, luminescence, and chiroptical properties of a pair of novel air-stable Shibasaki-type Yb(III) enantiomers supported by 3,3'-fluorinated binaphthol (FBINOL).
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
Photothermo-chemotherapy has shown a synergistic anti-cancer efficiency and can enhance the therapeutic effect of simple chemotherapy. The photothermal conversion characteristics of carriers are vital in photothermal chemotherapy. In this study, we developed functional carbon dots (CDs) as a photothermal agent and carrier to load bergenin (Ber) for simultaneous biological imaging and photo-chemothermal synergistic therapy.
View Article and Find Full Text PDFBackground: The intersection of aging and digitalization is a distinctive feature of this new era. While digitalization brings convenience, it also forces older people to use tools that did not exist during their formative or working years. Understanding digital exclusion in older adults, the primary demographic affected, is essential to better support integration into the digital society, particularly in enhancing digital healthcare services' usability, continuity, and precision.
View Article and Find Full Text PDFCell Death Dis
April 2025
The aggressive phenotype of prostate cancer (PCa) requires adaptation to androgen deprivation (AD) to progress into castration-resistant PCa (CRPC), including adaptation to AD-induced oxidative stress. However, our understanding of the oncogenes that maintain the redox balance during CRPC progression is limited. Here, we identified Bromodomain-containing protein 9 (BRD9) as a metabolic checkpoint for reprogramming cell metabolism to support tumor growth and impart a castration-resistant phenotype under metabolic and oxidative stress.
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