MPTN: A video-based multi-point tracking network for atrioventricular junction detection and tracking in cardiovascular magnetic resonance imaging.

Background And Objective: To develop an end-to-end artificial intelligence solution-video-based Multi-Point Tracking Network (MPTN), for detecting and tracking atrioventricular junction (AVJ) points from cardiovascular magnetic resonance and deriving AVJ motion parameters.

Methods: The MPTN model consists of two modules: AVJ point detection and AVJ motion tracking. The detection module utilizes convolutional-based feature extraction and elastic regression to detect all candidate AVJ points.

LncRNA SNHG5 modulates cell proliferation and migration through the miR-92a-3p/BTG2 axis in gastric cancer by the PI3K/AKT pathway.

Background: Gastric cancer (GC) is a widespread malignancy and associated with high rates of morbidity and mortality worldwide.

Aim: To examine the functional role of long non-coding RNAs small nucleolar RNA host gene 5 (SNHG5) and its regulation of miR-92a-3p and B-cell translocation gene 2 (BTG2) in GC progression.

Methods: Quantitative reverse transcription PCR and western blot analysis determined the expression of SNHG5, miR-92a-3p, and BTG2 in GC and adjacent non-neoplastic mucosa.

Rare earth valve manipulates dual regulation of electronic states and adsorption geometry in the selective hydrogenation of ethynylbenzene.

The semi-hydrogenation of ethynylbenzene is a fundamental reaction in the synthesis of polymer precursors. However, achieving a balance between catalytic activity and styrene selectivity remains a significant challenge due to the risk of over-hydrogenation. Herein, we design ternary PtCoCe rare earth alloys to synergistically regulate electronic states and adsorption geometries, thereby enhancing selective hydrogenation.

Haemodynamic implications of cardiovascular magnetic resonance pulmonary capillary wedge pressure in acute myocardial infarction.

Aims: Cardiovascular magnetic resonance (CMR)-derived pulmonary capillary wedge pressure (PCWP) has demonstrated diagnostic and prognostic utility in heart failure patients. However, its clinical value in acute myocardial infarction (AMI) remains undetermined. This study investigates the relationship between CMR-derived PCWP, myocardial injury, and left ventricular (LV) remodelling in re-perfused acute ST-elevation myocardial infarction (STEMI).

Polysaccharides and proteins as natural polymers for electrospun wound dressings: A review of healing potential, challenges, and crosslinking strategies.

Electrospinning nanofibers possesses several properties that enhance wound healing and are widely utilized in wound dressings. Most natural polymers, including a variety of polysaccharides and proteins such as chitosan, hyaluronic acid, silk fibroin, collagen, alginate, and zein, have good biocompatibility and abundant bioactivity and are considered beneficial materials for promoting wound healing. However, natural polymers' stability and mechanical properties are poor, affecting their application in electrospinning to a certain extent.

Circulating tumor DNA in cholangiocarcinoma: current clinical applications and future perspectives.

Cholangiocarcinoma is a highly heterogeneous malignant tumor, including intrahepatic cholangiocarcinoma, hepatoportal cholangiocarcinoma and distal cholangiocarcinoma. Its incidence is increasing worldwide and currently accounts for approximately 15% of all primary liver cancers and 3% of all gastrointestinal malignancies. There is a lack of early diagnostic methods for cholangiocarcinoma, and the overall treatment effect is poor, with a 5-year survival rate of less than 25%.

Development and external validation of a nomogram prediction model based on quantitative coronary angiography for predicting ischemic lesions: a multi-centre study.

Objectives: Quantitative coronary angiography (QCA) has significantly contributed to the diagnosis of coronary artery disease. This study aimed to construct and validate a QCA-based prediction model, represented as a nomogram, for predicting ischemic lesions defined by invasive fractional flow reserve (FFR) ≤ 0.80.

Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery.

Background: Hysteroscopy, a minimally invasive gynecological procedure, requires effective sedation for patient comfort and surgical success. Remimazolam Besylate, a new ultra-short-acting benzodiazepine, offers potential for safe sedation, but the optimal dose for postoperative outcomes is unclear. This study evaluated the effects of different doses of Remimazolam Besylate on postoperative sedation, pain, and adverse reactions in hysteroscopic surgery patients.

Study on multi-dimensional dynamic changes and quality control of Aurantii Fructus during the stir-frying with bran process.

Aurantii Fructus (AF), a medicine-food homology substance, is valued for its distinctive aroma and health-promoting properties, and has been widely used in food, condiments, and traditional Chinese medicine. However, the raw form's irritating properties limit its direct application, and stir-frying with bran mitigates this drawback, enhancing its suitability for food applications. This study investigated the dynamic changes in AF's multi-dimensional parameters (including physical, chemical, and biological) during the stir-frying with bran process, aiming to elucidate the underlying processing mechanisms.

Evaluating the generalizability of an automated coronary artery calcium segmentation and scoring algorithm using multi-vendor dataset.

Coronary artery calcification score (CACS), also known as the Agatston score, is a significant prognostic tool for cardiovascular disease (CVD) that utilizes computed tomography (CT). We expand our previously proposed algorithm, Residual-block Inspired Coordinate Attention U-Net (RICAU-Net), to evaluate its generalizability on CT data from previously unseen scanners for lesion-specific CAC segmentation. The multi-vendor datasets were 1,108 CT scans acquired by Siemens, GE, Philips, and Toshiba.

AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts.

A number of cardioprotective pharmacological agents are not effective in diabetic hearts. The role of AGGF1-EPCs therapy in diabetic ischaemia-reperfusion(I/R) injury and the underlying mechanism by which AGGF1 regulates EPCs under hyperglycemia (HG) + hypoxia/reoxygenation (H/R) stress are still unclear. We observed that the damaging effects of HG + H/R on EPCs were abolished by AGGF1.

Research on the evaluation of canal route schemes based on multiattribute decisionmaking methods.

The scientific evaluation of canal route schemes is a crucial aspect of canal engineering design, directly affecting construction costs and overall benefits. Addressing this multi-attribute decision-making problem, this study establishes a comprehensive evaluation system: Initially, a multi-level evaluation system comprising four criteria layers and 20 specific indicators is constructed from the dimensions of technical feasibility, economic benefits, social impact, and environmental protection. In terms of indicator processing, qualitative indicators are quantified using triangular fuzzy numbers combined with the Delphi expert survey method, while quantitative indicators are normalized.

Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk.

Aims: Traditional risk factors do not fully characterize cardiovascular aging and are less helpful in assessing sex differences in cardiovascular risk. Using a novel cardiovascular magnetic resonance (CMR) method, we determined sex differences in aortic global longitudinal strain (AOGLS) and ventriculoarterial coupling (VAC) with correlations to Framingham risk scores.

Methods And Results: Community older adults without cardiovascular disease underwent CMR.

Cultivation of Auxenochlorella protothecoides using tofu whey wastewater for aquaculture feed production: Integrating resource recovery and microalgal biomass valorization strategy.

This study investigates the potential of utilizing tofu whey wastewater (TWW) for Auxenochlorella protothecoides cultivation and aquatic protein feed production. Results demonstrate that A. protothecoides cultured in TWW (AP-C-TWW) achieves biomass and protein yield of 16.

Prognostic Value of the Global Left Ventricular Contractility Index in Patients with Severe Mitral Regurgitation and Preserved Left Ventricular Ejection Fraction.

Introduction: Assessment of left ventricular (LV) systolic function is important in valvular heart disease. The global LV contractility index, , is load-independent and has been reported to be associated with clinical outcomes in heart failure and aortic stenosis. We aim to assess if could predict adverse outcomes in patients with severe mitral regurgitation (MR).

Cardiac MRI-derived mean right atrial pressure and its prognostic importance.

Background: Right atrial pressure (RAP) is a key variable that cardiac MRI (CMR) cannot currently measure. We aimed to develop a model to estimate mean RAP (mRAP) using CMR and assess the prognostic value of CMR-derived mRAP in an independent patient cohort.

Methods: The derivation cohort consisted of patients investigated for heart failure symptoms with right heart catheterisation and CMR.

USF1-activated hsa_circ_0076691 induces oxaliplatin resistance via facilitating FGF9 expression in miR-589-3p-dependent manners.

Chemotherapeutic efficacy in colorectal cancer (CRC) is significantly hindered by the development of drug resistance. Emerging evidence indicates that circular RNAs (circRNAs) play pivotal roles in various cancer-related biological processes. Nonetheless, the specific role of circRNAs in oxaliplatin resistance in CRC remains largely unexplored.

Safety and efficacy of the neuroform EZ stent for treating intracranial atherosclerotic stenosis in the posterior circulation: a comparative study of pre-procedure and post-procedure outcomes.

Background: Treatment options for intracranial atherosclerotic stenosis (ICAS) are limited, but endovascular intervention has gained increasing attention in recent years.

Aim: To evaluate the safety and efficacy of the Neuroform EZ stent for treating ICAS in the posterior circulation.

Material & Methods: Patients' (n = 50) eligibility depended on ICAS with severe stenosis (≥ 70%) in the intracranial segment of the vertebral artery or basilar artery shown by cerebral angiography.

NRF2 modulates WNT signaling pathway to enhance photodynamic therapy resistance in oral leukoplakia.

Oral leukoplakia (OLK) is a common potentially malignant oral disorder with high risk of malignant transformation. While photodynamic therapy (PDT) offers a minimally invasive treatment for OLK, some patients show resistance to PDT and the mechanisms remain unclear. This study aims to identify key regulatory pathways driving PDT resistance in OLK.

Erratum: Author correction to "SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade" [Acta Pharm Sin B 9 (2019) 304-315].

[This corrects the article DOI: 10.1016/j.apsb.

IRF2-driven upregulation of OAS3 promotes AML cell proliferation by modulating the JAK-STAT signaling pathway.

Acute myeloid leukemia (AML) presents significant treatment challenges due to its heterogeneity and resistance to conventional therapies. This study explored the role of 2'-5'-oligoadenylate synthetase 3 (OAS3) in AML progression and its potential as a prognostic and therapeutic biomarker. Through bioinformatics analysis, OAS3 was found to be significantly upregulated in AML patients and associated with poor clinical outcomes.

Cardiovascular magnetic resonance imaging markers of ageing: a multi-centre, cross-sectional cohort study.

Aims: Cardiac ageing involves a series of anatomical and physiological changes contributing to a decline in overall performance. Cardiac magnetic resonance (CMR) provides comprehensive structural and functional assessment for detecting age-related cardiovascular remodelling. We aimed to develop a fully automated CMR model to predict functional heart age.

A Dendrobium chrysotoxum extract erianin induce AML cells death by activating PPARɑ and downregulating PI3K/AKT signaling pathways.

Erianin is a biphenyl compound with low toxicity and a single structure that is extracted from Dendrobium officinale. The wide spectrum of pharmacological properties and excellent toxicity of erianin have been comprehensively proven in multiple tumors. However, less is known about the toxicity of erianin in acute myeloid leukemia (acute myeloid leukemia AML).

High-Entropy Rare Earth Oxides Anchoring Tunable Cu Nanochimneys for Self-Tandem C-C Coupling Catalysis.

Copper (Cu)-based materials are promising for carbon-carbon bond (C─C) coupling catalysis, but they are limited to poor structural stability, high activation energy, and low selectivity toward C products. Here a customized synthetic protocol is defined for the fabrication of 2D ultrathin high-entropy rare earth (RE) oxides (HE-REOs) with rich lattice distortions and oxygen vacancies, which act as robust supports for anchoring Cu serial domains with tunable oxidation states. The rationally integrated HE-REOs-Cu heterostructures feature largely exposed synergistic multi-site driving rapid *CO spillover, and multiple stabilized Cu chimneys promoting cascade *CO coupling, together with intrinsic electron activation channels enabling RE 4f electron delocalization to lower the energy barrier.