Discovery of as a New Gene Predisposing to Dilated Cardiomyopathy.

Dilated cardiomyopathy (DCM), defined as dilation and contractile dysfunction of the left or both cardiac ventricles, remains the most common category of primary myocardial disease worldwide. It is the most prevalent cause of chronic heart failure and the most common indication for cardiac transplantation in young subjects. Accumulating evidence increasingly highlights the substantial genetic defects underlying DCM.

Non-Direct Contact ECG Signal Classification Using a Hybrid Deep Learning Framework with Validation in Bedside Heart Rate Variability Analysis.

In recent years, the demand for smart healthcare solutions have heightened the need for accuracy, reliability, and comfort in bedside ECG recording and analysis. This study presents a bedside non-direct contact ECG recording system based on capacitive coupling electrocardiography (cECG) and verifies its performance in accurately capturing Heart Rate Variability (HRV) during the night. Firstly, cECG collects ECG data through clothing, avoiding skin irritation from conventional wet electrodes.

Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection.

The outbreak of mpox since 2022 has driven the development of mpox virus (MPXV)-specific, subunit-based, next-generation vaccines, instead of the currently used live-attenuated vaccinia virus (VACV) vaccines. Here, we describe a self-assembling protein nanoparticle against MPXV using lumazine synthase to present viral surface proteins. Multivalent nanoparticles elicited broader and stronger immune responses against MPXV and provided superior heterologous protection in rodent models against lethal VACV challenges compared to monovalent formulations.

Effects of wavelength and spinal cord injury segment on photobiomodulation efficacy: Monte Carlo simulation in a rat model.

Significance: Spinal cord injury (SCI) is a severe condition characterized by complex pathophysiology and challenges in neural regeneration within the central nervous system, presenting substantial difficulties for repair. Although surgery and medication are employed for early rehabilitation and complications prevention, biomaterial transplantation, stem cell therapy, and neuromodulation techniques have been extensively investigated to promote axon regeneration and neural circuit remodeling in SCI, though results remain suboptimal.

Aim: Photobiomodulation (PBM), with its strong anti-inflammatory and tissue repair effects, is gaining increasing attention as a noninvasive physical therapy.

miR146a/circKMT2c regulates inflammation in fracture-induced acute lung injury via p65 nuclear translocation.

Surgical intervention for fractures in elderly patients may lead to severe complications, notably acute lung injury (ALI). miR146a, a microRNA regulating cellular physiological activities, plays a crucial role in maintaining immune homeostasis and modulating inflammatory responses. circKMT2c, a non-coding circular RNA that functions as a competitive endogenous RNA by binding to miRNA response elements, regulates mRNA expression.

The Effects of Azithromycin Modified Triple Antibiotic Paste in Resolving Periapical Inflammation.

Objective: This study aimed to assess the anti-inflammatory and antibacterial properties of traditional and modified triple antibiotic paste. The 16S rDNA was employed to analyse the root canal microbial community's characteristics pre- and post-treatment.

Methods: Rabbits with periapical inflammation (AP) were treated with both pastes.

Effect of family-centred perioperative care for anaesthesia on the incidence of emergence delirium in children after surgery: a protocol for a randomised controlled trial in China.

Introduction: Emergence delirium (ED) stands out as a prevalent postoperative complication among paediatric patients, correlating with extended hospitalisation periods, escalated healthcare expenses and increased incidence of postoperative maladaptive behaviours (POMBs). Well-established pharmacological or non-pharmacological interventions demonstrating efficacy in reducing the occurrence of ED are notably absent. Therefore, this study aimed to assess the potential of family-centred perioperative care for anaesthesia (FPCA) in mitigating the incidence of ED in children compared with routine anaesthesia.

Association between profiles of psychopathy and externalizing problems in Chinese children: A longitudinal moderated mediation analysis.

Background: Psychopathy is often significantly associated with serious externalizing problems, and childhood is a critical period in the development of psychopathy. However, the associations between profiles of psychopathy and children's externalizing problems remain unclear.

Methods: A total of 2141 Chinese children from a mid-sized city in South China participated in assessments at three time points, using six-month assessment intervals.

Immune Dysregulation at the Maternal-Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model.

Inflammatory arthritis (IA) has been linked to a number of adverse pregnancy outcomes (APOs), but the mechanisms linking IA-related immune dysregulation to compromised reproductive success remain poorly understood. This project will examine how IA affects pregnancy outcomes and alters the associated immune microenvironment using SKG (ZAP70) mice, a mouse model that suffers from arthritis resembling human IA. IA was induced in SKG mice on a C57BL/6J background via mannan exposure.

Erratum: Author correction to "SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade" [Acta Pharm Sin B 9 (2019) 304-315].

[This corrects the article DOI: 10.1016/j.apsb.

Intermediate knowledge enhanced the performance of the amide coupling yield prediction model.

Amide coupling is an important reaction widely applied in medicinal chemistry. However, condition recommendation remains a challenging issue due to the broad condition space. Recently, accurate condition recommendation machine learning has emerged as a novel and efficient method to find suitable conditions to achieve the desired transformations.

Structural characteristics and biological activities of six polysaccharides purified from the rhizomes of Alisma plantago-aquatica.

Alisma Rhizome (AR) is widely used in China to treat hyperlipidaemia and diabetes, with polysaccharides being the main components of AR aqueous extract. However, their detailed structural characterisation remains unclear. In this study, six purified polysaccharides (AP-1a, AP-1b, AP-1c, AP-2a, AP-3a, and AP-4a) were isolated from AR.

Identification and Functional Characterization of a Novel Mutation Predisposing to Coffin-Siris Syndromic Congenital Heart Disease.

Congenital heart disease (CHD) occurs in ~1% of all live neonates globally, rendering it the most prevalent developmental anomaly affecting humans; this condition confers substantial infant morbidity and mortality worldwide. Although there is ample evidence to suggest a paramount genetic basis for CHD, the genetic etiologies underpinning the majority of CHD remain elusive. In the present study, was selected as a significant candidate gene for human CHD, mainly because SOX4 is abundantly expressed in both human and murine hearts during embryogenesis, and the knockout of in mice causes embryonic demise predominantly attributable to cardiovascular developmental defects.

Changes in microbiome composition after fecal microbiota transplantation via oral gavage and magnetic navigation technology-assisted proximal colon/cecum enema in antibiotic knock-down rats: a comparative experimental study.

Background: Fecal microbiota transplantation (FMT) transfers fecal matter from a donor into the gastrointestinal tract of a recipient to induce changes to the gut microbiota for therapeutic benefit; however, differences in the composition of gut microbiota after FMT via different donor material delivery routes are poorly understood. In this study, we first developed a novel technique for FMT, magnetic navigation technology(MAT)-assisted proximal colon enemas, in healthy Sprague-Dawley rats. Besides, the difference in fecal microbiota composition after FMT via oral gavage and proximal colon/cecum enemas was determined in antibiotic knock-down rats, in addition to the impact on intestinal barrier function.

Association between dyslipidemia and vitamin D deficiency: a cross-sectional study in Chinese healthy population.

Background: Given the global prevalence of vitamin D deficiency, this study examines the association between serum 25-hydroxyvitamin D (25(OH)D) levels and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG).

Methods: In a cross-sectional analysis at the Yuhuan People's Hospital Physical Examination Center, 1535 asymptomatic individuals underwent anthropometric assessment and blood sampling. Serum 25(OH)D levels were quantified by a chemiluminescent immunoassay, while lipid parameters were evaluated by an enzymatic method on a fully automated analyzer.

The Effectiveness of Acupressure on Sleep Quality in Cancer Patients: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Aims: To examine the effectiveness of acupressure on sleep quality in cancer patients and to identify the population-level and intervention-level characteristics associated with the intervention outcome of sleep quality.

Design: Systematic review and meta-analysis.

Data Sources: PubMed, EMBASE, APA PsycInfo, Web of Science, CINAHL, Cochrane Library, China National Knowledge Infrastructure and WanFang were searched for eligible randomised controlled trials from inception to April 2024.

Comparison of the start-up of rotating biofilm contactor reactor with HN-AD bacteria inoculation under high and low influent ammonia conditions.

Biofilm formation is critical for the engineering application of pure biofilm RBC processes inoculated with HN-AD bacteria. This study focused on comparing the startup of pure biofilm RBC systems inoculated with HN-AD bacteria under high ammonia nitrogen (NH-N = 500 mg/L, H-RBC) and low ammonia nitrogen (NH-N = 120 mg/L, L-RBC) influent conditions. The results showed that H-RBC shortened the biofilm formation time by 6 days.

Novel fabrication of biodegradable superabsorbent polymer from wheat stalk for water holding and sustained fertilizer release.

Water-retaining agents have been shown to significantly improve the efficiency of irrigation water use in long-term agricultural activities, outperforming traditional irrigation methods. However, existing water-retaining agents still face challenges related to cost-effectiveness and degradability. To address these issues, we developed a superabsorbent material composed of wheat stalk (WS) and polyacrylic acid (PAA)-polyacrylamide (PAM), fabricated versatile polymerization techniques.

Chromosomal Location and Identification of as a New Gene Responsible for Familial Bicuspid Aortic Valve.

Congenital bicuspid aortic valve (BAV) signifies the most frequent category of congenital cardiovascular anomaly globally, occurring in approximately 0.5-2% of the general population worldwide. BAV is a major cause of thoracic aortopathy, encompassing aortic stenosis, aortic root dilation with regurgitation, aortic dissection, and aortic aneurysms, consequently leading to substantial late-onset morbidity and mortality.

Interfacing with the Brain: How Nanotechnology Can Contribute.

Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along with the available technology.

Shortening the recipient warm ischemia time could be a strategy for expanding the liver donor pool.

Background: Shortening the recipient warm ischemia time (rWIT) has been proven to be effective for improving the short- and long-term outcomes after liver transplantation (LT) and offsets the negative impact of an extended cold ischemia time. However, few studies have been conducted to explore the prognostic effects of shortening the rWIT in transplantations using a liver graft from an extended-criteria donor (ECD).

Aim: To investigate whether shortening the rWIT could improve the outcomes of ECD LT.

Serum Olink Targeted Proteomics Identifies IL-17A as a Prospective Inflammatory Marker for the Prediction and Diagnosis of Kawasaki Disease.

Purpose: Kawasaki disease (KD) is an acute febrile vasculitis and the leading cause of acquired heart disease in children. However, early diagnosis of KD remains challenging, and its pathogenic mechanisms are yet to be fully elucidated. This study utilized Olink Targeted Proteomics to analyze serum protein profiles and identify potential early diagnostic biomarkers for patients with KD.

Effectiveness of Acupressure on Sleep Quality Among Inpatients: A Systematic Review and Meta-Analysis.

Sleep quality in adult inpatients is frequently and severely disturbed by various factors such as noise, pain, and unfamiliar surroundings, which can impair disease recovery. Acupressure is widely used to improve sleep quality in hospitalized patients, but its overall effectiveness is unclear. This meta-analysis aims to analyze the efficacy of acupressure therapy on sleep quality and sleep parameters in adult inpatients.

Unlocking the role of wound microbiome in diabetic, burn, and germ-free wound repair treated by natural and synthetic scaffolds.

In current clinical practice, various dermal templates and skin substitutes are used to enhance wound healing. However, the role of wound commensal microbiome in regulating scaffold performance and the healing process remains unclear. In this study, we investigated the influence of both natural and synthetic scaffolds on the wound commensal microbiome and wound repair in three distinct models including diabetic wounds, burn injuries, and germ-free (GF) wounds.