PRMT5 encourages cell migration and metastasis of tongue squamous cell carcinoma through methylating ΔNp63α.

Tongue squamous cell carcinoma (TSCC) is a common oral malignancy prone to metastasis, whose underlying mechanism remains obscure. Here, we report the oncogenic roles of protein arginine methyltransferase 5 (PRMT5) in TSCC via inhibiting transcription factor ΔNp63α. We found that PRMT5 physically interacts with ΔNp63α, resulting in impairment of ΔNp63α-mediated transcriptional regulation.

MSFI: Multi-timescale spatio-temporal features integration in spiking neural networks.

Dynamic vision sensors (DVS) asynchronously encode the polarity of brightness changes with high temporal resolution and a wide dynamic range, making them ideal for capturing temporal information. Spiking neural networks (SNNs) are well-suited for handling such event streams due to their inherent temporal information processing capability. However, existing SNNs only transmit membrane potential across timesteps, neglecting spatial dependencies and failing to extract complex temporal features.

Traditional Chinese Medicinal Herbs for Treating Post-Ischemic Stroke Cognitive Impairment Insights From Frequency and Association Analysis.

Background: This study analyzes medicinal herbs in Traditional Chinese Medicine (TCM) formulations for post-ischemic stroke cognitive impairment, identifying key herbs, their interactions, and potential therapeutic mechanisms through systematic review, frequency analysis, and association rule mining.

Methods: Systematic searches were performed across major databases (CBM, CNKI, VIP, Wanfang Data) to find studies on TCM for post-ischemic stroke cognitive impairment. Inclusion criteria focused on studies reporting TCM formulas and their cognitive effects.

Ultrasound-Mediated Non-Specific Splenic Immunopotentiation to Elicit Broad-Spectrum Anti-Neoplastic Effects.

Background: Splenic immunomodulation triggered by ultrasound shows a significant anti-inflammatory effect against various inflammatory diseases, whose mechanism is mainly attributable to the activation of cholinergic anti-inflammatory pathway (CAP). However, the potential role and underlying mechanism of splenic ultrasound stimulation in cancer management have been rarely reported and superficially defined.

Methods: Following optimization of ultrasonic parameters, this study evaluated the anti-tumor efficacy of splenic sonication across multiple tumor models (eg, orthotopic H22 hepatocellular carcinoma (HCC), orthotopic Hepa1-6 HCC, and subcutaneous 4T1 breast cancer), and applied flow cytometry to quantify dynamic alterations in immune cell populations.

Immunoglobulin G4-related lung disease mistaken for pulmonary tuberculosis: A case report.

Background: Immunoglobulin G4-related disease (IgG4-RD) is a persistent and progressive autoimmune condition marked by inflammation and fibrotic changes in the affected tissues. Cases of IgG4-RD causing pulmonary lesions are relatively rare, and some may be misdiagnosed as pulmonary tuberculosis.

Case Summary: In this report, we present an uncommon instance of IgG4-related lung disease, which was diagnosed through lung tissue biopsy conducted puncture.

Study on the mechanism of Fuzi Lizhong decoction in the treatment of colorectal cancer of spleen kidney deficiency from the perspective of intestinal flora and hypoxia inducible factor-1α signalling pathway.

Objective: To evaluate the effect of Fuzi Lizhong decoction on intestinal flora, serum inflammatory factors, and hypoxia inducible factor-1α (HIF-1α) in patients with colorectal cancer associated with spleen and kidney deficiency.

Methods: A total of 100 patients diagnosed with advanced colorectal cancer were randomly divided into two groups: a control group (CON, 50) and a Traditional Chinese Medicine (TCM) group ( 50). The control group received treatment with the Capecitabine + Oxaliplatin (CAPEOX) regimen, while the TCM group received the same regimen along with Fuzi Lizhong decoction for six weeks.

PRMT1 oligomerization regulates RNA-binding protein cascade to promote pancreatic cancer.

PRMT1 is the predominant type I protein arginine methyltransferase responsible for generating monomethylarginine and asymmetric dimethylarginine (MMA and ADMA) in various protein substrates. It regulates numerous biological processes, including RNA metabolism, mRNA splicing, DNA damage repair, and chromatin dynamics. The crystal structure of rat PRMT1 has been previously reported as a homodimer; however, higher-order oligomeric species of human PRMT1 have been observed in vivo, and their structural basis remains elusive.

Diagnostic value of serum human chorionic gonadotropin and uterine artery Doppler indices in missed abortion.

Objective: To evaluate the combined diagnostic value of serum human chorionic gonadotropin (HCG) levels and uterine artery Doppler indices - including pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) - for identifying missed abortion.

Methods: This retrospective cohort study included 160 patients diagnosed with missed abortion and 200 women with normal pregnancies between January 2019 and December 2023. Serum HCG levels were measured using electrochemical immunoassay, and uterine artery Doppler indices were obtained by transvaginal ultrasound.

The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and network meta-analysis.

Background: Nutritional supplements are known to ameliorate polycystic ovary syndrome (PCOS) and have been shown to modulate endocrine and metabolic markers, oxidative stress markers and inflammatory biomarkers in patients with PCOS. A variety of nutritional supplements have been applied in clinics, but a more comprehensive ranking of their efficacy has not yet been investigated.

Objectives: To assess the comparative effectiveness of nutritional supplements in women with PCOS.

Pelvic floor muscle function differs between postmenopausal women with and without stress urinary incontinence: An experimental parallel-controlled study.

Electromyography (EMG) is a well-established method for the quantification of pelvic floor muscle (PFM) activity. The aim of the present study was to evaluate the strength and activity of the urethral sphincter (US) and levator ani muscles (LAMs) by analyzing EMG variables for these PFMs separately using an airbag-type stretchable/inflatable electrode array (ASEA) device. In addition, the study assessed the predictive value of surface EMG (sEMG) signals obtained via ASEA in postmenopausal women with stress urinary incontinence (SUI).

Effect of foliar spray selenium on antioxidant defense system, yields, fatty acid composition, and mineral concentrations in flax ( L.).

Introduction: Flax is an important multipurpose oil crop with high-quality seed, oil, and fibre.

Methods: This study aims to investigate the effect of selenium (Se) fertilization on the flax antioxidant defense system, yields, fatty acid composition, and mineral concentrations. A field experiment was conducted in Gansu, Northwest China in 2022, 2023, and 2024, by foliar application of Se at early budding, early flowering, and early seed-filling using a low-pressure hand sprayer.

Martensitic Transformation Mechanism In Situ Observation for the Simulated Coarse-Grained Heat-Affected Zone of DP1180 Steel.

The martensitic transformation mechanism in the heat-affected zone of DP1180 steel plays a decisive role in the strength of welded joints. In this work, the nucleation and growth kinetics of martensite laths in the coarse grain heat-affected zone (CGHAZ) are analyzed by a high-temperature laser scanning confocal microscope (LSCM). The grain distribution and stress distribution of the samples after in situ observation are analyzed by electron backscatter diffraction (EBSD).

Immune Dysregulation at the Maternal-Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model.

Inflammatory arthritis (IA) has been linked to a number of adverse pregnancy outcomes (APOs), but the mechanisms linking IA-related immune dysregulation to compromised reproductive success remain poorly understood. This project will examine how IA affects pregnancy outcomes and alters the associated immune microenvironment using SKG (ZAP70) mice, a mouse model that suffers from arthritis resembling human IA. IA was induced in SKG mice on a C57BL/6J background via mannan exposure.

The mechanism of IGF-AKT pathway promoting mantle biomineralization in Hyriopsis cumingii.

The formation of shells and pearls in bivalves, such as Hyriopsis cumingii, is a complex biomineralization process regulated by mantle tissue, yet the role of the insulin-like growth factor (IGF)-AKT signaling pathway in these processes remains poorly understood. This study investigated the IGF-AKT pathway's involvement in shell repair and pearl sac formation using a shell damage and pearl-nucleus insertion model, combined with gene and protein-level interventions targeting IGF and IGF2BP. Results showed that HcIGF2BP expression peaked in the pearl sac (P < 0.

Mussel inspired carboxymethyl cellulose/pectin composite hydrogel with photothermal enhanced antibacterial property for burn wound healing.

The burn wounds are particularly susceptible to bacterial infection, while the hydrogel wound dressings with antibacterial property are expected to promote burn wound repairing progress. In this research, carboxymethyl cellulose bearing hydrazide groups and hemostatic polyphosphate moiety (CHP) was synthesized and cross-linked with dopamine grafted oxidized pectin (OPD) to prepare hemostatic self-healing hydrogel for burn wound repairing. Polydopamine coated graphene oxide (PGO) was loaded into the hydrogel to endow it with photothermal stimulated antibacterial property and enhanced the ROS scavenging ability, which can inhibit bacterial infection and promote tissue regeneration.

Radiomics classification of fresh and old vertebral compression fractures: Impact of compression grade and morphology on diagnostic performance.

Objectives: To develop a radiomics model for identifying fresh or old vertebral compression fractures (VCFs) from CT images, thereby assisting physicians in making more effective decisions.

Methods: Patients with VCFs who underwent both CT and MRI within one week were retrospectively enrolled from June 2018 to February 2023. VCFs were categorized as subgroups according to compression grades (mild, moderate or severe) or morphology types (wedge-shaped, biconcave or crush).

Effects of social support on cognitive frailty among the older adults in China: mediation of psychological resilience and moderated mediation of education.

Objectives: Previous research has revealed a relationship between social support and cognitive frailty. However, the underlying mechanisms of this connection have still not been well explored. The study aimed to investigate the effect of social support on cognitive frailty, mediated by psychological resilience and to examine the moderated mediation effect of education.

Conformal hexagonal boron nitride encapsulation of graphene-skinned glass fiber fabric for enhanced electrical stability.

Encapsulation is crucial for protecting graphene devices, but traditional whole-package encapsulations usually add bulky structures and reduce their flexibility. Hexagonal boron nitride (h-BN) holds potential for graphene encapsulation, but faces challenges in large-area acquisition and conformal coverage due to limitations in exfoliation and transfer techniques. Graphene-skinned glass fiber fabric (GGFF), made via graphene CVD growth on each fiber of a glass fiber fabric, consists of a hierarchical conductive network, but pressure/deformation-induced inter-fiber contact resistance fluctuations destabilize its electrical conduction.

Prophage transduction promotes the transmission of phage resistance interfering with adsorption among Chinese foodborne Staphylococcus aureus.

Although bacteriophages have proven to be efficient biocontrol agents for foodborne Staphylococcus aureus, the transmission of phage resistance resulting in the reduced efficacy of phage therapy remains to be explored. In this study, phage resistance and adsorption of 91 Chinese foodborne S. aureus isolates by 18 phages were estimated, and the distribution and transmission of phage resistance genes were investigated.

LLM-Based Unknown Function Automated Modeling in Sensor-Driven Systems for Multi-Language Software Security Verification.

The rapid expansion of the Internet of Things (IoT) has made software security and reliability a critical concern. With multi-language programs running on edge computing, embedded systems, and sensors, each connected device represents a potential attack vector, threatening data integrity and privacy. Symbolic execution is a key technique for automated vulnerability detection.

Deletion of a novel upstream promoter of p53 impairs cold tolerance capacity in zebrafish.

P53 is a tumor suppressor that plays a crucial role in stress responses. We previously identified a novel upstream p53 promoter in cold acclimated zebrafish cells, however the functional significance of this upstream promoter under cold stress in zebrafish remains unclear. We generated novel p53 promoter zebrafish using CRISPR/Cas9 and characterized their responses to cold stress.

Graphene-skinned Alumina fiber Fabric for Diverse Electrothermal and Electromagnetic Compatibility and Its Mass Production.

As electronics and instrumentation grow increasingly complex, multifunctional materials are essential for simplifying designs. Electrothermal and electromagnetic functions are commonly used, typically supplied by separate materials. Integrating them into a single material can reduce components and miniaturize systems.