Optimising hatchery release strategies: Size-dependent training effects on the swimming performance of juvenile Schizothorax wangchiachii.

The success of fish stock enhancement programmes is often limited by the high mortality of hatchery-reared individuals after their release. Poor swimming performance, a critical factor for survival, is a key reason for this low success rate. While exercise training can improve the physical fitness of fish, it is unclear whether these benefits are consistent across different sizes and developmental stages.

Sleep quality mediates the association between tea consumption and duration of COVID-19-related symptoms in middle-aged and elderly adults (aged 50 and above).

Objectives: The association between tea consumption and the duration of COVID-19-related symptoms remains inconclusive. This cross-sectional study investigates the potential mediating role of sleep quality in this association. The association between tea consumption and the duration of COVID-19-related symptoms remains inconclusive.

sp. nov., a novel species isolated from black soil applied with herbicide atrazine in Northeast China.

The strain tm was isolated from black soil applied with the herbicide atrazine in Northeast China. Phylogenetic analyses based on 16S rRNA gene sequences and phylogenomic analysis revealed that the strain tm is classified to the genus . The DNA G+C content of strain tm was 67.

From gut to joint: the protective impact of on rheumatoid arthritis.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex and diverse etiology. The onset of RA is closely associated with intestinal flora, which is essential for immune regulation.

Methods: Fecal samples of 22 healthy controls and 38 patients with newly diagnosed RA were used for performing 16S rRNA sequencing, microbiota diversity assessment, and functional enrichment analysis.

Mesenchymal Stem Cells Reduce Inflammation in a Mouse Model of Lyme Arthritis.

Lyme disease (LD), a zoonotic infectious disease caused by (), can affect various organs, including the skin, heart, nervous system, and joints. Lyme arthritis (LA) is the most common and severe late-stage presentation of LD, often presenting with intermittent joint swelling and pain. Although antibiotics are effective in most patients with LA, some patients may continue to experience arthritis symptoms for months or years after standard treatment, which poses a serious threat to their quality of life.

Artificial intelligence and machine learning in acute respiratory distress syndrome management: recent advances.

Acute Respiratory Distress Syndrome (ARDS) remains a critical challenge in intensive care, marked by high mortality and significant patient heterogeneity, which limits the effectiveness of conventional supportive therapies. This review highlights the transformative potential of Artificial Intelligence (AI) and Machine Learning (ML) in revolutionizing ARDS management. We explore diverse AI/ML applications, including early prediction and diagnosis using multi-modal data (electronic health records [EHR], imaging, ventilator waveforms), advanced prognostic assessment and risk stratification that outperform traditional scoring systems, and precise identification of ARDS subtypes to guide personalized treatment.

Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis.

Objective: Lifestyle factors play a critical role in osteoporosis management and are closely linked to the development and progression of comorbid depression. This study examines lifestyle patterns and their association with depression in individuals with osteopenia or osteoporosis, while assessing the mediating role of the Dietary Inflammatory Index (DII).

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2009-2020 were analyzed using latent class analysis (LCA) to classify 3,384 adults based on their lifestyle behaviors.

Executive Functioning as Mediator in the Longitudinal Relationship Between Media Multitasking and Divergent Thinking in Adolescents.

Junior high school students frequently multitask with media because of the rapid development of media tools. It is vital to investigate the relationship between junior high school students' individual cognitive abilities and media multitasking to better support their educational and developmental needs. Using a longitudinal design, this study investigated the relationship between media multitasking and divergent thinking, and the mediating role of executive function.

KFLC-index distinguishes multiple sclerosis from anti-myelin oligodendrocyte glycoprotein and aquaporin 4 diseases in a Chinese cohort.

Background: Kappa free light chain (KFLC) index has emerged as a diagnostic biomarker for multiple sclerosis (MS). This study aims to evaluate the diagnostic accuracy of the KFLC-index in Chinese patients with MS, and its capacity to discriminate MS from myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorders with aquaporin-4 antibody (AQP4+NMOSD).

Methods: 428 patients tested for KFLC-index were enrolled in the study, including 130 patients with MS, 41 with MOGAD, 25 with AQP4+NMOSD, 123 with other inflammatory or infectious neurological disorders (OIND) and 109 with non-inflammatory neurological disorders (NIND).

The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and network meta-analysis.

Background: Nutritional supplements are known to ameliorate polycystic ovary syndrome (PCOS) and have been shown to modulate endocrine and metabolic markers, oxidative stress markers and inflammatory biomarkers in patients with PCOS. A variety of nutritional supplements have been applied in clinics, but a more comprehensive ranking of their efficacy has not yet been investigated.

Objectives: To assess the comparative effectiveness of nutritional supplements in women with PCOS.

Sustainable Upcycling of Spent Graphite Anodes via Concentrated Sulfuric Acid.

As the application of lithium-ion batteries (LIBs) becomes increasingly widespread, the amounts of spent batteries are rising year by year. The recycling of LIBs is essential for environmental protection, battery safety and resource sustainability. However, the recycling of graphite anodes is overlooked due to its relatively lower economic value compared to the valuable metal resources of cathodes.

Characteristics of Amino Acid and Glucose Digestion and Metabolism in Energy and Protein Feedstuffs for Pigs.

The objective of this study is to investigate the digestion and metabolism characteristics of amino acids and glucose in energy and protein feeds, and to establish regression equations to accurately predict their release rates in vivo based on the in vitro digestion characteristics of the feedstuffs. A total of 9 energy feedstuffs and 19 protein feedstuffs were selected for in vitro digestion simulation experiments. Additionally, four representative energy and protein feeds were then chosen for the portal vein, femoral artery, and femoral vein blood cannulation experiments in growing pigs.

Preparation and resolution performances of chiral stationary phases based on spherical covalent organic frameworks with various zeta potentials.

The development of novel chiral stationary phases (CSPs) based on spherical covalent organic frameworks (SCOFs) holds great importance in the field of chiral chromatographic separation. Herein, SCOF-1∼SCOF-4 were synthesized using 1,3,5-tris(4-aminophenyl)benzene (TAPB) as the connecting node and 2,5-dihydroxyterephthalaldehyde (DHTA) with 2,5-dimethoxyterephthalaldehyde (DMTA) as linkers, while controlling the ratio of two linkers. Subsequently, SCOF-3 containing phenolic hydroxyl groups was post-modified by 10-camphorsulfonyl chloride, yielding a derivative SCOF-5 with camphorsulfonyl groups.

Seroprevalence of Lyme Disease in Asian Human Populations: A Systematic Review and Meta-Analysis.

Lyme disease (LD, also known as Lyme borreliosis) is the most frequent tick-transmitted disease caused by the spirochete in Europe and the United States. LD is distributed in the Northern Hemisphere, but the seroprevalence of LD in Asian human populations is unclear. To investigate the seroprevalence of LD in Asian human populations.

Unconscious stereotypes: An investigation into public attitudes toward disabled groups.

Background: China has a large population of individuals with physical disabilities and mental disorders. The public's implicit stereotypes of these groups are significant factors influencing their daily lives, social integration, and mental health. The intergroup contact theory implies that the public may have positive implicit stereotypes of physically disabled groups and negative implicit stereotypes of individuals with mental disorders.

Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis.

Defects in the early events of insulin biosynthesis, including inefficient preproinsulin (PPI) translocation across the membrane of the ER and proinsulin (PI) misfolding in the ER, can cause diabetes. Cellular machineries involved in these events remain poorly defined. Genes encoding translocon-associated protein α (TRAPα) show linkage to glycemic control in humans, though their pathophysiological role remains unknown.

Clinical and genetic variant re-analysis among pediatric probands undergoing genetic testing for arrhythmia syndromes.

Background: Despite increases in genetic testing, longitudinal data regarding changes in diagnostic yield and variant reclassification for inherited arrhythmia syndromes are limited.

Objective: Determine longitudinal changes in diagnostic yield and variant classification.

Methods: Single-center retrospective study of probands <18 years undergoing genetic testing for suspected inherited cardiac conditions associated with arrhythmias, 2007 to 2018.

Fluctuations in serum aquaporin-4 antibody titers: the clinical significance in neuromyelitis optica spectrum disorder.

Objectives: To evaluate the relationship between aquaporin-4 immunoglobulin G (AQP4-IgG) titer dynamics and relapse in neuromyelitis optica spectrum disorder (NMOSD), compare AQP4-IgG dynamics across different maintenance therapy strategies, and identify factors associated with AQP4-IgG titer seroreversion to negativity.

Methods: Altogether 171 patients with ≥ 2 serum AQP4-IgG tests by fixed cell-based assay 30 days apart and at least once positive were included. Their clinical and treatment data were reviewed.

Federated Machine Learning Enables Risk Management and Privacy Protection in Water Quality.

Real-time water quality risk management in wastewater treatment plants (WWTPs) requires extensive data, and data sharing is still just a slogan due to data privacy issues. Here we show an adaptive water system federated averaging (AWSFA) framework based on federated learning (FL), where the model does not access the data but uses parameters trained by the raw data. The study collected data from six WWTPs between 2018 and 2024, and developed 10 machine learning models for each effluent indicator, with the best performance bidirectional long-term memory network (BM) as Baseline.

makino alleviates ulcerative colitis in mice by modulating the Nrf2/Keap1 pathway.

Background: Ulcerative colitis (UC) is a prevalent immune-mediated inflammatory bowel disease characterized by mucus secretion, hematochezia, and diarrhea. This study compared the therapeutic effects of three Siegesbeckiae Herba (SH) species used in traditional Chinese medicine- L (SO), Makino (SP), and Makino (SG) - in dextran sulfate sodium (DSS)-induced UC mice.

Methods: UC was induced in C57BL/6 mice with 3% DSS for 7 days.

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Administration of a Novel Anti-NGF Monoclonal Antibody (AK115) in Healthy Participants: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase I Clinical Trial.

Objective: This study aimed to investigate the safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of a novel anti-nerve growth factor (NGF) monoclonal antibody (mAb) (AK115) in healthy Chinese participants.

Methods: A randomized, double-blind, placebo-controlled, dose-escalation phase I clinical study was conducted as follows: eligible participants were divided into 6 dose groups, among which 0.5 mg group was administrated with AK115 injection and the remaining 5 groups were randomly assigned to AK115 injection or accompanying placebo at a ratio of 3:1.

High Partial Molar Volume Polymer Electrolyte for Upgraded Lithium Metal Batteries.

Lithium (Li) metal batteries combined with solid electrolytes represent a highly promising technology for high-energy-density storage systems. However, their cycling performance encounters inferior stability due to the continuous growth of Li-dendrites. The initial motivation for Li-dendrite growth theoretically arises from the high chemical potential difference (∆µ) at the electrolyte/Li metal interface, yet the effectiveness of ∆µ regulation lacks experimental validation.

Engineered hybrid cell membrane nanovesicles for potentiated cancer immunotherapy through dual immune checkpoint inhibition.

Immune checkpoint inhibitors (ICIs) have demonstrated remarkable success in treating various types of solid tumors; however, only a limited number of patients currently benefit from these therapeutic agents. Developing novel ICIs that elicit systemic and durable antitumor immune responses remains a significant challenge in improving immunotherapy outcomes. In this study, we engineered PD-1/LAG-3 receptors onto cell membrane nanovesicles to simultaneously block two immune checkpoints for the treatment of colorectal cancer.

Insights into the roles of Al in improving the H-SCR performance of Pt/ZrTiO catalyst.

Thermally induced nitrogen oxides (NO) in Hydrogen Internal Combustion Engine (H-ICE) are inevitable. Selective catalytic reduction of NO by H (H-SCR) is a prospective technology for eliminating NO in H-ICE, thanks to the availability of H in exhaust. Herein, we report an Al-modified Pt/ZrTiO catalyst that significantly enhances the H-SCR activity of Pt/ZrTiO (Pt/ZT) at low-temperature and its stability.

Clinical Characteristics and Outcomes of Takotsubo Syndrome Patients with Gastrointestinal Diseases: A Systematic Review.

Background: Takotsubo syndrome (TTS) is identified by its acute and transient impairment of left ventricular systolic function. Although recent research has highlighted occurrences of TTS among individuals with gastrointestinal diseases (GI diseases), comprehensive and systematic investigations focusing on this patient demographic are still scarce.

Methods: This retrospective study analyzed case reports and series that documented an association between gastrointestinal diseases (GI diseases) and Takotsubo syndrome (TTS).