Angiographic assessment of lenticulostriate artery sign to predict clinical outcomes after thrombectomy in patients with stroke.

Objective: Lenticulostriate artery (LSA) reperfusion is critical for basal ganglia blood supply. Basal ganglia infarction (BGI) inconveniencing patients with large artery occlusion and occluded perforators may influence clinical outcomes. This study aims to investigate the association between LSA recanalization, BGI, and long-term outcome after thrombectomy in the ischemic hemisphere.

An Investigation on Workplace Violence in an Infectious Disease Hospital: A Mixed-Methods Study from the Perspectives of Healthcare Workers and Patients.

Workplace violence (WPV) against healthcare workers (HCWs) in infectious disease hospitals, particularly in high-risk settings, remains a critical yet understudied occupational hazard. A mixed-methods study was conducted at a Chinese infectious disease hospital, combining quantitative surveys (N = 675) and semi-structured interviews (28 HCWs, 17 patients/families). Logistic regression was used to analyze WPV incidence and predictors, while a thematic analysis of interview data identified contextual drivers.

Application of transthoracic echocardiography to assess the dynamic evolution of early cardiac damage induced by abdominal aorta-inferior vena cava fistula in female rats with chronic renal failure.

Objective: Left ventricular dysfunction (LVD) frequently occurs in patients with chronic renal failure (CRF) who have an arteriovenous fistula (AVF). In a rat model of CRF with AVF, we assessed the utility of transthoracic echocardiography for the early detection of LVD and examined the associated pathological damage.

Methods: Forty female rats that had successfully established a CRF model were divided into three groups: the CRF group (n = 13), the sham group (n = 13), and the AVF group (n = 14).

Enhancing Efficiency and Stability of Tin-Based Perovskite Solar Cells through A-Site Compositional Engineering.

Tin-based perovskite solar cells (TPSCs) have attracted significant attention due to their relatively competitive performance and environmentally benign characteristics. Small-molecule additive strategies have been extensively employed to enhance TPSCs' performance through crystallization modulation and defect passivation. However, most small-molecule additives exhibit lattice deformation or spontaneous desorption from perovskite, leading to accelerated device degradation under operational thermal/electrical stresses.

From material hardship to harsh parenting: Testing the Family Stress Model in dyadic family context.

Objectives: This study investigates the association between material hardship and harsh parenting behaviors within the framework of the Family Stress Model (FSM) using a dyadic family systems perspective.

Study Design: This is a longitudinal study.

Methods: Utilizing data from the Future of Families and Child Wellbeing Study, the analysis examines both maternal and paternal pathways, focusing on the mediating role of parental depression.

METTL9 as a protein biomarker predicts the prognosis and immunotherapy response of skin-cutaneous melanoma.

The role of methyltransferase-like proteins (METTLs) in skin cutaneous melanoma (SKCM) remains unclear. This study investigates the expression of METTLs, particularly METTL9, in SKCM and its clinical significance. Through multiple database analyses and immunohistochemical experiments, we found that METTL9 is significantly upregulated in SKCM tissues, and its expression level is closely associated with tumor-node-metastasis stage, N stage, and ulceration status.

Size-dependent cellular association of cubosomes as nanocarriers.

Cubosomes feature in the growing arsenal of lipid nanocarriers for drug delivery applications. Particle size has been shown to significantly influence the performance of vaccines and chemotherapeutics using other types of nanoparticles. However, elucidating size-property relationship with cubosomes has been challenging.

USP13 Suppresses Colorectal Cancer Angiogenesis by Downregulating VEGFA Expression through Inhibition of the PTEN-AKT Pathway.

Background: Tumor angiogenesis is related to solid tumor occurrence. Ubiquitin-specific peptidase 13 (USP13) is a deubiquitinating enzyme with a pivotal effect on tumor proliferation, metastasis, and tumorigenesis. Nonetheless, its effect on colorectal cancer (CRC) angiogenesis remains poorly understood.

MambaCpG: an accurate model for single-cell DNA methylation status imputation using mamba.

DNA methylation is a key epigenetic modification involved in biological processes and disease development. The accurate analysis of DNA methylation site information is of significant biological importance. Despite advances in single-cell sequencing, data sparsity due to low cytosine-phosphate-guanine (CpG) coverage remains a challenge.

Early feature study of Yunnan pine pinewood nematode disease based on hyperspectral remote sensing of ground objects.

Pine Wilt Disease (PWD), caused by the pine wood nematode, is a major global forest pathology characterized by the rapid death of pine trees within a span of three months. Forestry management policy requires the eradication of all infected trees during the initial outbreak phase of a disease to contain its spread. This measure substantially relies on the timely identification of diseased trees.

Deep Mining of Novel Acylated Polyamines by Integrated Prior-Knowledge-Guided Prediction and Chemical Isotope Labeling-Based Metabolomics.

Acylated polyamines (acyl-PAs) are gaining significant attention due to their involvement in various diseases. However, their annotation and quantification remain challenging, as robust analytical methods are lacking, with only a few acyl-PAs characterized to date. In this study, we integrated prior-knowledge-guided prediction with chemical isotope labeling-based metabolomics to identify novel acyl-PAs.

Mitochondrial Quality Control in Bovine Oocyte Maturation: Mechanisms, Challenges, and Prospects for Enhancing Reproductive Efficiency.

Oocyte maturation represents a fundamental biological process in bovine reproduction, establishing the physiological basis for fertilization and early embryonic development while critically determining the propagation of improved varieties and breeding efficiency. The roles of MQC in reproduction have gained substantial scientific attention. The proper maturation of oocytes fundamentally depends on adequate mitochondrial functionality.

The facilitation of gut barrier function by infant formula mimicking breast milk protein in piglets.

Breast milk is the best source of nutrition for infants. Simulating breast milk, which maximizes the restoration of composition and proportion in breast milk protein, is the ultimate goal of upgrading powdered infant milk products. Although products upgraded with protein, including lactoferrin and osteopontin, have been sold on the market, their effect on intestinal health is not yet well-defined.

GA-TongueNet: tongue image segmentation network using innovative DiFP and MDi for stable generalization ability.

Tongue is directly or indirectly connected to many internal organs in Traditional Chinese Medicine (TCM). In computer-aided diagnosis, tongue image segmentation is the first step in tongue diagnosis, and the precision of this segmentation is decisive in determining the accuracy of the tongue diagnosis results. Due to challenges such as insufficient available sample size and complex background, the generalization and robustness of current tongue segmentation algorithms are usually poor, which seriously hinders the practicality of tongue diagnosis.

Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis.

Background: An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges.

Methods: In this phase II trial, patients received Gamma Knife SBRT combined with Tislelizumab. Biomarker analysis was performed pre- and post-treatment.

Multifunctional Hydrogel with Synergistic Reactive Oxygen Species Scavenging and Macrophage Polarization-Induced Osteo-immunomodulation for Enhanced Bone Regeneration.

The regeneration of bone defects remains an enormous clinical challenge owing to locally abnormal reactive oxygen species (ROS) levels and the inability to timely regulate the osteoimmune microenvironment. Herein, polydopamine (PDA) modified black phosphorus nanosheets (BP) with small palladium nanoparticles (Pd NPs) immobilized in situ were prepared (BP@PDA-Pd) and incorporated into a gelatin methacryloyl/methacrylated poly-γ-glutamate hybrid hydrogel to fabricate a composite photocurable therapeutic platform (BPPP/GP) with excellent antioxidant and osteo-immunomodulatory activity for enhanced high-quality endogenous bone regeneration. The BPPP with optical absorbance in the near-infrared (NIR) region endows the composite hydrogel with excellent NIR-responsive characteristics, resulting in mild photothermal-enhanced antioxidant enzyme-like activity to scavenge ROS and the induction of endogenous cell recruitment.

Cerebral venous thrombosis during pregnancy and postpartum: A systematic review and meta-analysis.

Background: Cerebral venous thrombosis (CVT) is a rare but life-threatening condition, particularly among pregnant and postpartum women. However, estimates of its incidence, recurrence, and associated adverse outcomes remain inconsistent. Moreover, the role of antithrombotic prophylaxis in mitigating these risks has not been fully established.

Harnessing magnetic cross-linked cell aggregates (CLCAs) for cost-effective preparation of Konjac mannan-oligosaccharide.

Konjac mannan oligosaccharides (KMOS) are currently popular in food additives for their health benefits. However, the simple and efficient preparation of KMOS is still a challenge. In this study, A novel gene encoding β-mannanase (CsMan134) from Cellvibrio sp.

Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention.

Background: High-risk percutaneous coronary intervention (HRPCI) procedures supported by percutaneous left ventricular assist devices (pLVAD) are increasingly common, but existing PCI risk scores were developed in patients across the risk spectrum, including few pLVAD-assisted patients.

Objectives: Assess the performance of existing PCI risk scores in patients receiving pLVAD-assisted HRPCI and create a novel risk score specific to this group.

Methods: Patients in the PROTECT III multicenter, observational (46 US centers) study undergoing pLVAD-assisted HRPCI were assessed.

Carbonate-Bearing Ionizable Lipids for mRNA Delivery to Splenic NK Cells.

mRNA immunotherapies targeting natural killer (NK) cells hold substantial potential for treating cancer and viral diseases. However, achieving functional delivery of mRNA to splenic NK cell subsets remains a formidable challenge. Herein, we rationally design a library of 161 carbonate-bearing ionizable lipids (CAILs) and formulate lipid nanoparticles (LNPs) for functional mRNA delivery to the spleen and NK cells following intravenous administration.

Revealing the Spatial Shielding Effect of Interfacial Water Molecules in Photocatalytic CO Reduction from Overall Water Splitting.

In this context, a AlO doped SrTiO (Al:SrTiO) was synthesized via the molten salt method. The spatial separation active sites of the hydrogen evolution and the CO reduction in photocatalysis were revealed by using absorbed H as a probe, which indicated that CoOOH could be the photocatalytic CO reduction active site while RhCrO could serve as the main site for hydrogen species activation and generation. The photocatalytic CO reduction could be determined by the spatial-temporal transfer of active hydrogen species coupled with carriers, from the interface of RhCrO-Al:SrTiO to CoOOH-Al:SrTiO probably.

Deciphering meiotic chromatin organization by SYCP3.

Chromatin structure during meiosis is different from somatic cells due to the assembly of the synaptonemal complex between homologous chromosome axes. However, genome-wide organizing principles of this meiosis-specific multiprotein complex remain mysterious despite intensive super-resolution imaging analysis. Here, we profiled chromatin occupancy of SYCP3, the key chromatin organizer of synaptonemal complex, in mouse spermatocytes, and showed its enrichment at open chromatin regions.

Recurrent Stroke Prevention Strategies in Patients Receiving Acute Stroke Reperfusion Therapies (CoPrime Study Survey).

Introduction: Patients who have undergone reperfusion treatments, like all ischemic stroke patients, are at risk of recurrent ischemic strokes in the first 90 days. Current guidelines recommend single antiplatelet therapy for secondary prevention at variable time points after the procedure. This study assessed the practices and perspectives of healthcare professionals on the use of dual antiplatelet therapy in patients with non-cardioembolic ischemic stroke who have undergone reperfusion therapy.