Knowledge, Attitude, and Practice on Atrial Fibrillation and Atrial Fibrillation Screening in High-Risk Population: A Cross-Sectional Study.

Objectives: Atrial fibrillation (AF) is a common clinical arrhythmia. Failure to identify AF leaves patients at a considerably higher risk of disability and death, making its early screening and prevention extremely important. This study aimed to investigate knowledge, attitude, and practice (KAP) towards AF prevention and screening among the high-risk population.

Plasma non-targeted metabolomics unravels the metabolic features of normal trans-right heart.

Introduction: Right heart (RH), as a junction between the venous system and pulmonary circulation, gains great emphasis on exploring the relevant pathological mechanism of many cardiopulmonary diseases. Although these pathogensis researches centering on RH-related diseases advance, the physiological mechanism research of the RH is scarce.

Objectives: This study aimed to accurately unravel the metabolic features of normal trans-RH through non-targeted metabolomics.

Multimodality treatment approach in a patient with EGFR-mutated NSCLC and leptomeningeal metastases: A case report and literature review.

Rationale: Leptomeningeal metastases in pulmonary adenocarcinoma patients carrying epidermal growth factor receptor mutations present a critical therapeutic dilemma. However, there is no established standard therapy following drug resistance. Novel treatment modalities are urgently needed.

Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial.

Background: More efficacious, noninvasive screening methods are needed for advanced colorectal neoplasia. miR-92a is a reliable and reproducible biomarker for early colorectal cancer detection in stool samples. We compared the diagnostic efficacies of miR-92a, immunochemical fecal occult blood testing (FIT), and their combination (FIT + miR-92a) in a prospective multicenter screening trial.

Carbonate-Bearing Ionizable Lipids for mRNA Delivery to Splenic NK Cells.

mRNA immunotherapies targeting natural killer (NK) cells hold substantial potential for treating cancer and viral diseases. However, achieving functional delivery of mRNA to splenic NK cell subsets remains a formidable challenge. Herein, we rationally design a library of 161 carbonate-bearing ionizable lipids (CAILs) and formulate lipid nanoparticles (LNPs) for functional mRNA delivery to the spleen and NK cells following intravenous administration.

A potential therapeutic target at Connexin 43 serine phosphorylation against ischaemia/reperfusion arrhythmia.

Background And Purpose: Dephosphorylation of several phosphor residues in connexin 43 (Cx43) is critically involved in ischaemia/reperfusion (I/R) arrhythmias. Here, we sought to identify constitutive Cx43-serine 282 (S282) dephosphorylation as an independent and targetable substrate to delineate reperfusion arrhythmogenesis.

Experimental Approach: Reperfusion arrhythmias were induced by rat I/R (15/45 min), identified in heterozygous knock-in mice with S282 to alanine (Cx43-S282A/+) and rescued by LB100, a specific protein phosphatase 2A (PP2A) inhibitor, via surface electrocardiogram and epicardial mapping detections.

Association between family history and onset age of cancer in China.

Background: Family history (FH) of cancer is an established risk factor for early onset of cancer. However, reliable estimates on the difference in onset age between familial and sporadic cancers remain scarce in the Chinese population.

Methods: This multicenter, hospital-based, cross-sectional study included 23 hospitals across 12 provinces.

Recurrent thrombotic events in a patient with endometrial cancer: A case report of Trousseau syndrome.

Rationale: Trousseau syndrome is a well-recognized paraneoplastic syndrome that manifests as thrombosis in patients with malignancies. It is particularly associated with mucin-producing adenocarcinomas and is known to lead to significant morbidity and mortality due to its thrombotic complications. The underlying mechanisms involve a hypercoagulable state induced by cancer-related factors, which necessitates vigilant monitoring and management.

Targeted molecular rapid SERS diagnosis in clinical human serum through aptamer origami-collapsed nanofingers chip.

Surface-Enhanced Raman Scattering (SERS) offers great potential for label-free molecular diagnosis, especially in detecting disease biomarkers. However, the complexity of the biological environment in clinical human serum often significantly impairs detection accuracy. In this study, we present a highly effective SERS strategy utilizing aptamer origami-collapsed nanofingers for the precise qualitative and quantitative detection of specific targeted biomarkers in clinical serum.

Cholesteric Contact Lenses for Diabetics-Related Noninvasive Glucose Monitoring and Eye Healthcare.

Blood sugar monitoring has crucial significance for diabetes mellitus diagnosis, and noninvasive continuous detection methods are the future development trend. Among various noninvasive detection methods, glucose detection in tears has the advantages of a high level of subject compliance, minimal pollution, and accuracy. However, sensors used for detecting glucose concentration in tears usually embed noble microelectrical components into contact lenses, making the process complicated and costly, and easily cause environmental pollution and resource wastage.

Disability-adjusted life years for colorectal cancer in China, 2017-2030: A prevalence-based analysis focusing on the impact of screening coverage and the application of local weights.

Background: Most studies have evaluated disability-adjusted life years (DALYs) of colorectal cancer (CRC) patients based on a set of generic disability weights (DWs). This study aimed to apply local CRC-stage-specific DWs to estimate the burden of DALYs for CRC (CRC-DALYs) in populations in China and consider the influence of local screening coverage of CRC.

Methods: A prevalence-based model was constructed using data from various sources.

Novel therapeutic insights into pathological cardiac hypertrophy: tRF-16-R29P4PE regulates PACE4 and metabolic pathways.

Pathological cardiac hypertrophy (PCH) is a complex condition with an incompletely understood pathogenesis. Emerging evidence suggests that transfer RNA-derived small RNAs (tsRNAs) may play a significant role in various cellular processes, yet their impact on PCH remains unexplored. In this study, we performed tsRNA sequencing on plasma samples from PCH patients and identified a marked decrease in the expression of tRNA-related fragment 16-R29P4PE (tRF-16-R29P4PE), a specific tsRNA fragment, with a diagnostic area under the curve value of 0.

Connexin 43 dephosphorylation mediates the Dchs1/YAP/TEAD signaling pathway to induce cardiac fibrosis.

Background: The gap junction protein connexin 43 (Cx43) has been implicated in the development of cardiac fibrosis. Our previous findings revealed that Cx43 dephosphorylation at serine 282 (S282) is related to cardiomyocyte apoptosis and arrhythmias in hearts damaged by ischemia/reperfusion. In this study, we investigated the role of Cx43 S282 phosphorylation in cardiac fibrosis.

A Versatile Strategy to Transform Cationic Polymers for Efficient and Organ-Selective mRNA Delivery.

The progress of mRNA therapeutics underscores the imperative demand for the development of targeted delivery systems. While cationic polymers hold promise as genetic vectors, their poor in vivo efficacy and numerous variants highlight the urgent need for a universal functionalization strategy to bolster their delivery capabilities. Here, we present a versatile strategy to transform low-cost commercial cationic polymers into phospholipidated and alkylated polymers (PAPs), enabling efficient and organ-selective mRNA delivery in vivo.

A comb-shaped microfluidic aptasensor for rapid and sensitive on-site simultaneous detection of aflatoxin B1 and deoxynivalenol.

Mycotoxins are widely found as co-contaminants in agricultural products and their derivatives. However, on-site monitoring of multiple mycotoxins remains a significant challenge. We developed an electrochemical aptasensor integrating microelectrodes and microfluidics for simultaneous aflatoxin B1 (AFB1) and deoxynivalenol (DON) detection.

An Improved Method for Extracting Rat Cerebrospinal Fluid with Repeatable Large-Scale Collection.

The aim of this study was to explore an improved method for extracting rat cerebrospinal fluid (CSF), observing the impact on animal health under conditions of large-scale CSF collection and evaluating the feasibility of repeated collections. A total of 20 rats were anesthetized and fixed in a stereotactic frame. A 26G scalp needle, combined with a 1 mL syringe, was used to puncture the atlanto-occipital membrane and collect approximately 170 μL of CSF.

Unveiling Doping Kinetics in Cu(I) Metal Halides for Customized Luminescent Performance.

Intentional doping plays a pivotal role in customizing metal halides' electronic and optical features. This work manipulates the incorporation and distribution of Mn in Cu(I) halide by controlling the elemental steps involved in the growth-doping kinetics as well as investigates the localized lattice and electronic structures in different doping configurations. Complementary experimental and theoretical results demonstrate that a uniform and relatively high Mn doping level can be achieved by a step-tailored strategy that encompasses reducing the growth rate of the halide matrix, enhancing the surface adsorption of Mn, and facilitating the incorporation of the dopants.

Extending breast cancer screening beyond age 45-64 years in China: A cost-effectiveness analysis.

The optimal breast cancer (BC) screening age in China remains uncertain. In this study, we evaluated the benefits, harms, and cost-effectiveness of lowering the screening starting age from 45 to 35 years and extending the stopping age from 64 to 79 years in Chinese women at an average risk of progressing BC. Biennial screening showed a lower incremental cost-effectiveness ratio (ICER) compared to annual screening.

Prognostic Value of Systemic Inflammatory Markers in Elderly Patients with Tumor-associated Venous Thromboembolism.

Background: Elderly tumor patients are more prone to venous thrombotic events than nontumor patients. To investigate the relationship between systemic inflammatory markers and overall survival (OS) in elderly patients with tumorassociated venous thromboembolism (TAVTE). And to evaluate the prognostic value of combined lymphocyte platelettolymphocyte ratio (PLR) with neoplasm metastasis in elderly patients.

Acceptance status and influencing factors of advance care planning among elderly patients with chronic disease.

The aging population has become a severe public health issue both in China and globally. Over 180 million elderly people in China have chronic diseases, with 75% of them suffering from 2 or more chronic diseases, posing significant threats to their independence and quality of life, and imposing immense mental and disease burdens on patients and their families. So our research analyzes the influencing factors based on the current acceptance status of advance care planning (ACP) among elderly patients with chronic diseases.

Impact of New-Onset Atrial Fibrillation on Mortality in Critically Ill Patients.

Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in critically ill patients and significantly impacts mortality. This study sought to evaluate the impact of new-onset AF on mortality in a critically ill population.

Methods: This study identified 48018 adult patients admitted to the ICU from the Medical Information Mart for Intensive Care (MIMIC)-IV database.

Impact of bone metastasis on prognosis in non-small cell lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis.

Background: Lung cancer is a leading cause of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. While immune checkpoint inhibitors (ICIs) have transformed treatment for advanced NSCLC, the role of bone metastasis in modulating ICI efficacy remains unclear. Bone metastasis, occurring in 30-40% of advanced NSCLC cases, is associated with worse outcomes.

A multi-center big-data approach for precise PICC-RVT prognosis and identification of major risk factors in clinical practice.

Background: The Peripherally Inserted Central Catheter (PICC) is a widely used technique for delivering intravenous fluids and medications, especially in critical care units. PICC may induce venous thrombosis (PICC-RVT), which is a frequent and serious complication. In clinical practice, Color Doppler Flow Imaging (CDFI) is regarded as the gold standard for diagnosing PICC-RVT.