A digital workflow for full-arch implant fixed prosthesis: Clinical application of a 3D-printed polychromatic flangeless trial denture, anatomic bone reduction guide, and intraoral scanning for definitive prosthesis fabrication.

This clinical report presents a comprehensive digital workflow for rehabilitating a patient with maxillary terminal dentition using a full-arch, implant-supported fixed dental prosthesis (FP-1). It highlights the integration of a 3D-printed polychromatic flangeless trial denture and a customized anatomic bone reduction template, enabling prosthetically driven implant planning and optimal bone architecture modification. The workflow incorporated fully guided implant surgery using sequential templates and immediate loading with a closed-mouth pickup system.

Effects of non-volatility of memristor on the synchronizability of memristor-coupled heterogeneous neurons.

Synaptic plasticity is of great significance for understanding the leaning and memory processes in different brain regions since it determines the synchronized firing activities of neurons. A volatility-switchable memristor-coupled heterogeneous neuron model is proposed to explore the effects of the synaptic plasticity on the synchronous dynamics of coupled neurons in different brain regions. With the increment of the non-volatility, the critical coupling strength of synchronization between two heterogeneous neurons decreases in a power-law relationship with the character parameter of the memristor.

Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays.

Single-cell sequencing technologies have advanced our understanding of cellular heterogeneity and biological complexity. However, existing methods face limitations in throughput, capture uniformity, cell size flexibility, and technical extensibility. We present Stereo-cell, a spatial enhanced-resolution single-cell sequencing platform based on high-density DNA nanoball (DNB)-patterned arrays, which enables scalable and unbiased cell capture at a wide input range and supports high-fidelity transcriptome profiling.

A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations.

Schizophrenia is a complex neuropsychiatric disorder, and the abnormalities in brain networks during its early stages remain incompletely understood. Previously, we identified a stable high-intensity functional network, termed the "Frame Network," in healthy individuals and observed its aberrations in schizophrenia patients. This study aimed to utilize this network to explore disconnection abnormalities in early-stage schizophrenia.

Technique for retrieving a locked implant-supported bar overdenture following direct attachment pick-up procedure.

Implant-assisted complete dentures, particularly those utilizing implant-supported bar systems (RP-4), offer significant advantages in patient satisfaction and prosthetic function compared to conventional dentures. However, complications can arise during the direct intraoral pick-up procedure, such as inadvertent resin polymerization in undercut areas, which may lock the overdenture in place. This report introduces a predictable, digitally guided technique to retrieve a locked implant-supported bar overdenture using the original digital design to locate screw access channels and guide targeted occlusal drilling.

Low Cholinesterase Is a Potential Poor Prognostic Factor in Colorectal Cancer Presenting With Tumor Markers Negative.

Background: Colorectal cancer (CRC) is the third most common malignant tumor in the world and has the second highest mortality rate. Tumor markers are proteins used to diagnose and monitor cancer. Serum cholinesterase (CHE) is a nutritional indicator indicating the liver''s ability to synthesize proteins and is a predictor of CRC.

Distinct morphology and self-assembly behavior of Xylan nanoparticles are correlated with arabinose side-chains in Sorghum.

Arabinoxylans (AXs) are complex polysaccharides with varying arabinose substitution patterns that affect their structural properties and self-assembly behaviors. In this study, we selected two sorghum varieties (S2 and S13) from a pool of 18 representative varieties, based on their distinct hemicellulose compositions. Techniques such as arabinoxylan-directed monoclonal antibodies (mAbs), High-Performance Anion-Exchange Chromatography (HPAEC), and 2-D HSQC NMR showed that S13 hemicellulose was of higher Ara/Xyl ratio of 0.

Predictive value of an early comprehensive assessment model for refractory mycoplasma pneumoniae pneumonia and internal validation.

Background: Refractory mycoplasma pneumoniae pneumonia (RMPP) can result in severe complications and long-term effects. Early identification of RMPP and appropriate treatments can effectively alleviate complications and restrict the progression of sequelae. There is currently a dearth of a comprehensive and efficient model for predicting and evaluating RMPP.

Cholesteric Contact Lenses for Diabetics-Related Noninvasive Glucose Monitoring and Eye Healthcare.

Blood sugar monitoring has crucial significance for diabetes mellitus diagnosis, and noninvasive continuous detection methods are the future development trend. Among various noninvasive detection methods, glucose detection in tears has the advantages of a high level of subject compliance, minimal pollution, and accuracy. However, sensors used for detecting glucose concentration in tears usually embed noble microelectrical components into contact lenses, making the process complicated and costly, and easily cause environmental pollution and resource wastage.

The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder.

Background: Major depressive disorder (MDD) is significantly influenced by genetic factors. The present study aims to examine the potential correlation between the 4977 bp deletion of mitochondrial DNA (mtDNA) and MDD.

Methods: The 4977 bp deletion of mtDNA was detected in the peripheral blood of 253 MDD patients and 257 healthy controls, with depression assessed by the Hamilton Depression Rating scale and functioning by the Global Assessment of Function Scale.

Myeloma cell-intrinsic ANXA1 elevation and T cell dysfunction contribute to BCMA-negative relapse after CAR-T therapy.

Multiple myeloma (MM) relapse still occurs after a durable response to anti-B cell maturation antigen (BCMA) chimeric antigen receptor-engineered T (CAR-T) cell therapy with less-defined factors. Herein, we investigated a CAR-T-exposed MM patient who relapsed after 12 months of remission by single-cell transcriptome sequencing. The bone marrow CAR-T population at relapse exhibited exhaustion and proliferation attenuation.

Unlocking the Power of Photothermal Agents: A Universal Platform for Smart Immune NIR-Agonists for Precise Cancer Therapy.

Selective ablation of tumor cells allows safe eradication, thereby minimizing off-target damage, while specifically inducing immunogenic cell death (ICD) rather than commonly non-immunogenic apoptosis of tumor cells enables activation of anti-tumor immune response against residual cancer cells, including metastatic lesions. Herein, we present a general strategy leveraging a novel photothermal agent (PTA) that concomitantly enables precise tumor killing and activation of anti-tumor immunity. The unique PTA scaffold exhibits unexpected inherent endoplasmic reticulum (ER)-targeting capability and potent near-infrared (NIR) photothermal activity, inducing NIR-controlled immunogenic pyroptosis in various tumor cell lines via targeting ER stress in an oxygen-independent manner.

The effects of anodization and instrumentation on titanium abutment surface characteristics and biofilm formation.

Purpose: To assess the impact of anodization and instrumentation on titanium abutment surface characteristics (surface roughness and wettability) and biofilm formation (viability and mass).

Materials And Methods: Titanium discs were obtained from pre-milled abutment blanks made of titanium-6aluminum-7niobium alloy. Polished samples were divided into three groups: un-anodized, gold-anodized, and pink-anodized.

Effects of integrated blood purification on haemodynamics and oxygen metabolism in children with severe sepsis.

Objective: To investigate the effects of integrated blood purification on haemodynamics and oxygen metabolism in children with severe sepsis.

Methods: Clinical data of 12 children with severe sepsis admitted to the pediatric intensive care unit of our hospital between October 2021 and June 2022 were retrospectively analyzed. All patients were treated with integrated blood purification, and changes in haemodynamic parameters, including heart rate, blood pressure, mean arterial pressure and cardiac output, and oxygen metabolism parameters (blood lactic acid, oxygen delivery, oxygen consumption and oxygen extraction rate) were observed before and after treatment.

Intraoral scanning for implant-supported complete-arch fixed dental prostheses (ISCFDPs): Four clinical reports.

Although there are difficulties with using intraoral scans for implant-supported complete-arch fixed dental prostheses (ISCFDPs), several commercially available systems have become helpful in simplifying the treatment process in the prosthetic phase. These systems help patients move from interim ISCFDPs to receiving definitive prostheses in just three clinical visits. This clinical report summarizes the indications, benefits, and limitations of the four systems.

Devising Biocompatible, NIR-Activated Helical Pyroptosis Agents via 𝛑-Twisting Strategy for Promoting Antitumor Immunity.

Specifically controlling cell pyroptosis is advantageous for oncotherapy as it allows simultaneous ablation of primary tumors and activation of immunogenicity of tumor environment. Herein, a facile and robust strategy is presented to construct efficient NIR-activated helical pyroptosis agents (PyroAs) with negligible dark cytotoxicity. It is demonstrated that the construction of four intramolecular B-X bonds (X = O or N) within the BODIPY chromophore enforces a significant twisting of its π-conjugation, yielding a variety of helical BD molecules with desired high photosensitivity and negligible dark toxicity.

Reduction of intracortical inhibition (ICI) correlates with cognitive performance and psychopathology symptoms in schizophrenia.

Cognitive impairment is a core symptom of schizophrenia (SZ), with GABAergic dysfunction in the brain potentially serving as a critical pathological mechanism underlying this condition. Intracortical inhibition (ICI), which includes short-interval intracortical inhibition (SICI) and long-interval intracortical inhibition (LICI), can be used to assess the inhibitory function of cortical GABAergic neurons. The aim of this study was to investigate the relationship between ICI and cognitive function, as well as psychopathological symptoms, in SZ patients.

Controlled Crystallization and Enhanced Performance of γ-CsPbI Perovskite Through Methylammonium Iodide-Assisted Coevaporation.

Cesium lead triiodide (CsPbI) perovskites have garnered significant attention owing to their suitable bandgap for tandem silicon substrates and excellent chemical stability. However, γ-CsPbI prepared via low-temperature co-evaporation is limited by a narrow black phase processing window and random crystal orientation, hindering its optoelectronic performance and industrial applications. This study introduced trace amounts of methylammonium iodide (MAI) into the co-evaporation system, enhancing the crystallization process, promoting columnar grain growth, and stabilizing the γ-phase perovskite, resulting in films with improved structural integrity and reduced defect density.

Bottom Contact Engineering for Ambient Fabrication of >25% Durable Perovskite Solar Cells.

The bottom contact in perovskite solar cells (PSCs) is easy to cause deep trap states and severe instability issues, especially under maximum power point tracking (MPPT). In this study, sodium gluconate (SG) is employed to disperse tin oxide (SnO) nanoparticles (NPs) and regulate the interface contact at the buried interface. The SG-SnO electron transfer layer (ETL) enabled the deposition of pinhole-free perovskite films in ambient air and improved interface contact by bridging effect.

Effect of CO-HO Interaction with High-Rank Coal on Mechanical Properties and Acoustic Emission Characteristics under Confining Pressure.

The adsorption of CO by coal leads to changes in its mechanical properties, particularly when considering supercritical CO and water with supercritical CO adsorption. This is strongly linked to the efficiency of CO-enhanced coalbed methane (CO-ECBM) extraction and the safety of CO geological storage. This study focuses on 3 coal from the Datong Mine in Gaoping City, Shanxi Province.