Isolation and Identification of Lactic Acid Bacteria from Traditional Fermented Shredded Potato and Research on Their Prebiotic, Antioxidant, and Fermentative Properties.

The aim of this study was to screen lactic acid bacteria (LAB) suitable for starch-based fermentation from traditional fermented shredded potatoes (TFSP). Analysis of the microbial diversity by 16S rDNA sequencing in TFSP revealed that LAB were a genus with high relative abundance of the bacteria population. Thirty LAB strains were isolated and purified from TFSP.

Effect of Cartilage Lesions on the Metabolic Profiles of Synovial Fluid in Patients With Anterior Cruciate Ligament Tears.

Background: Anterior cruciate ligament (ACL) tears often coincide with variable extents of cartilage lesions, which typically worsen clinical symptoms and increase osteoarthritis risk. Alterations in the metabolic profile may be informative for the response of the ACL-injured knee to cartilage lesions.

Purpose: To determine the effect of the severity of cartilage lesions on synovial fluid metabolism of patients with ACL tears by (1) identifying characteristic metabolites and key metabolic pathways and (2) analyzing the associations between these biomarkers and patient-reported outcome measures (PROMs).

Real-world effectiveness of rope-ladder in situ cannulation in reducing pain and complications for hemodialysis patients with autogenous arteriovenous fistula.

Purpose: To evaluate the real-world effectiveness of the rope-ladder in situ puncture technique in autogenous arteriovenous fistulas (AVF) for hemodialysis patients.

Methods: A retrospective analysis was conducted on 88 AVF patients from the Hemodialysis Center of Cangzhou Central Hospital. The observation group ( = 40) received the Rope Ladder-in-Situ Cannulation Technique (RLiSCT), while the control group ( = 48) underwent conventional rope-ladder or area puncture.

Cost-Effectiveness of Perioperative Nivolumab for Stage III Non-Small-Cell Lung Cancer: A Perspective From The United States.

Purpose: The NADIM II trial demonstrated that combining perioperative nivolumab, an immune checkpoint inhibitor, with intensified chemotherapy significantly enhanced pathological complete response rates and overall survival in patients with surgically resectable stage III non-small-cell lung cancer (NSCLC) compared to those receiving chemotherapy alone. However, concerns persist regarding the substantial cost of immunotherapy. Our study aims to evaluate the cost-effectiveness of neoadjuvant treatment combining nivolumab with chemotherapy versus standard neoadjuvant chemotherapy alone in resectable stage III NSCLC patients within the U.

Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation.

As the global population ages, there is an increasing prevalence of spinal cord injury (SCI) among elderly individuals, accompanied by significant challenges in treatment and recovery. Age-related conditions, such as osteoporosis, muscle atrophy, and impaired balance, predispose older adults to falls and traumatic injuries, leading to worse neurological outcomes compared to younger patients. SCI pathophysiology consists of two phases: the initial mechanical injury and the secondary injury that involves a cascade of pathological events, including ischemia, apoptosis, and neuronal cell death.

The Effect of Mild Residual Rotational Laxity on Performance After Anterior Cruciate Ligament Reconstruction.

Background: Some patients still experience mild residual rotational laxity of the knee after anterior cruciate ligament reconstruction (ACLR). The clinical symptoms of this residual rotational laxity are controversial, and methods for evaluating the symptoms have become a focus of academic interest in recent years. It is unclear whether there is a correlation between mild residual rotational laxity after ACLR and performance.

Advances in the Clinical Use of Clopidogrel: A Review of Individualized Treatment Strategies and Monitoring Optimization Based on Genetic Polymorphisms.

This paper systematically reviews recent advances in clopidogrel clinical applications to optimize therapeutic precision and medication safety. Using a literature review methodology, we elucidate clopidogrel's pharmacokinetic properties and pharmacodynamic mechanisms, while evaluating its clinical efficacy and adverse reactions in disease management. Recent studies have emphasized the key role of genetic polymorphisms in regulating the efficacy and safety of clopidogrel.

Pulmonary function and motoric cognitive risk syndrome in older adults.

Poor pulmonary function (PF) has been linked to neurodegenerative disorders. However, the association of PF with motoric cognitive risk syndrome (MCR) which is a prodromal stage of dementia remains unclear. This study aimed to examine the PF-MCR association in older adults.

Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair.

Spinal cord injury (SCI) is a devastating condition with limited self-repair capacity, resulting in long-term disabilities. Endogenous neural stem cells (eNSCs), which are present in the adult central nervous system (CNS), hold significant potential for repairing neural damage following SCI. These cells can proliferate, migrate to the injury site, and differentiate into various neural cell types, including neurons and glial cells.

Cinnamaldehyde mitigates spinal cord injury in rats through anti-inflammatory and anti-apoptotic pathways.

Background: Spinal cord injury (SCI) is a destructive neuropathological condition. Cinnamaldehyde (CA), a major bioactive component in Cinnamon essential oil, is known for its neuroprotective effects by inhibiting neuroinflammation, oxidative stress, and apoptosis. However, CA specific role in SCI remains unclear.

To Explore the Efficacy and Safety of Neoadjuvant Chemoradiation Therapy in Locally Advanced Colon Cancer: A Systematic Review and Meta-analysis.

Purpose: The aim of this study was to systematically evaluate the efficacy and safety of neoadjuvant chemoradiation therapy (NCRT) in locally advanced colon cancer (LACC).

Methods And Materials: PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched to review relevant studies on NCRT for LACC published publicly from January 1, 2000 to October 31, 2024.

Subtypes I and II of O.F. Müller: Dominant Green Tide Species in the Southern Yellow Sea and Their Responses to Natural Light and Temperature Conditions.

This study systematically investigated two ecotypes of , the dominant species responsible for green tides in the Yellow Sea, classified as Subtype I (strain ) and Subtype II (strain ). Both subtypes produce positively phototactic biflagellate gametes with oval/pear-shaped morphology but exhibit distinct cellular dimensions. Subtype I gametes demonstrated significantly larger cell sizes, with long and short axes measuring 6.

Pericyte Biomarkers for Ischemic Stroke: Potential and Prospects.

Ischemic stroke (IS) has a high mortality rate. Multiplexed detection of IS core biomarkers is of great significance to early diagnosis and personalized treatment of IS patients. Whether pericytes, a key component of the neurovascular unit and blood-brain barrier located on the capillary wall, could serve as a promising biomarker for IS is to be explored.

Targeted molecular rapid SERS diagnosis in clinical human serum through aptamer origami-collapsed nanofingers chip.

Surface-Enhanced Raman Scattering (SERS) offers great potential for label-free molecular diagnosis, especially in detecting disease biomarkers. However, the complexity of the biological environment in clinical human serum often significantly impairs detection accuracy. In this study, we present a highly effective SERS strategy utilizing aptamer origami-collapsed nanofingers for the precise qualitative and quantitative detection of specific targeted biomarkers in clinical serum.

Constructing a neural network model based on tumor-infiltrating lymphocytes (TILs) to predict the survival of hepatocellular carcinoma patients.

Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide, and early pathological diagnosis is crucial for formulating treatment plans. Despite the widespread attention to pathology in the treatment of HCC patients, a large amount of information contained in pathological images is often overlooked.

Methods: We retrospectively collected clinical data and pathological slide images from (a) 331 HCC patients at Qingdao University Affiliated Hospital between January 2013 and December 2016 and (b) 180 HCC patients from The Cancer Genome Atlas (TCGA).

Pesticide poisoning in Zhejiang Province, China: a retrospective analysis from 2008 to 2022.

Background: Pesticide poisoning has emerged as a significant public health concern on a global scale. China has a diverse range of agricultural practices and varying pesticide usage across its regions. Nevertheless, there is a paucity of research on the epidemiology of pesticide poisoning in China.

Construction of a heterojunction between Ni/Al layered double oxides and CdS quantum dots for efficient photocatalytic hydrogen production.

The Ni/Al layered double oxide (Ni/Al-LDO) is a promising photocatalyst because of the high surface area and abundant active sites. However, the application of Ni/Al-LDO for photocatalytic hydrogen evolution is hindered by the unclarity of the optimized microstructure and limited light absorption. In this work we report the structural evolution from Ni/Al layered double hydroxides (Ni/Al-LDH) to Ni/Al-LDO, which is able to achieve a precise regulation of the layered structure with abundant acid sites for photocatalysis.

Expression of SARS-CoV-2 entry receptor ACE2 in human brain and its association with Alzheimer's disease and COVID-19.

It is known that infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause coronavirus disease 2019 (COVID-19). It is widely reported that Alzheimer's disease (AD) is associated with the highest risk of COVID-19 infection, hospitalization and mortality. However, it remains largely unclear about the link between AD and COVID-19.

Combining network pharmacology and transcriptomics to validate and explore the efficacy and mechanism of Huayu Wan in treating non-small cell lung cancer.

Ethnopharmacological Relevance: Huayu Wan (HYW), a traditional Chinese medicine prescription widely used in the clinical treatment of advanced lung cancer, has been clinically proven to effectively inhibit the progression of pulmonary tumors and improve patients' quality of life. However, its specific components and potential anti-cancer molecular mechanisms remain unclear.

Aim Of The Study: To explore the active ingredients of HYW and predict its effective targets and pathways against non-small cell lung cancer (NSCLC) using a combination of network pharmacology and transcriptomics.

Inflammatory Bridges: Interconnections Between Alzheimer's Disease and Bone Health.

Alzheimer's disease is a neurodegenerative disorder that predominantly affects the elderly and is characterized by complex pathogenesis. Within the unified framework of the ANT, the introduction of B (the disruption of the blood-brain barrier) facilitates communication between the brain and the periphery through the blood-brain barrier. In this context, inflammatory factors act as a bridge, and the neuroinflammation hypothesis is gaining increasing acceptance.

Unveiling the Therapeutic Potential of Banxia Xiexin Decoction in Alzheimer's Disease: Insights From Network Pharmacology and Experimental Validation.

Background: Alzheimer's disease (AD) is associated with various pathological states for which there is no effective treatment. First documented in the Eastern Han Dynasty's medical classic, "Treatise on Febrile and Miscellaneous Diseases" (200-210 Anno Domini), Banxia Xiexin Decoction (BXD) stands as a quintessential approach to treating spleen ailments. Recent studies have shown BXD's effectiveness in mitigating memory impairment associated with AD.

Mechanistic insights and optimization strategies for perovskite single-crystal thin film growth.

Perovskite materials, with their tunable band gaps, high optical absorption, and excellent carrier mobility, are key candidates for lasers, LEDs, photodetectors, and solar cells. Polycrystalline thin films dominate current applications but suffer from efficiency and stability losses largely due to grain boundaries. Perovskite single-crystal thin films (SCTFs) offer optimized carrier diffusion and reduced recombination losses, though challenges in achieving high-quality SCTFs remain.

La Doping LiNiO Cathode to Immobilize the Lattice Oxygen for Highly Stable Lithium-Ion Batteries.

LiNiO (LNO) with a high theoretical capacity and entirely free of cobalt has aroused much attention as a promising cathode material for lithium-ion batteries (LIBs). The rapid capacity decay, however, obstructs its commercialization. We first propose a strategy of La lattice-doping in the LNO (La-LNO) as a high-stability cathode for LIBs.

Aerosolized nicotine-free e-liquid base constituents exacerbates mitochondrial dysfunction and endothelial glycocalyx shedding via the AKT/GSK3β-mPTP pathway in lung injury models.

Smoking has been recognized as a risk factor of cancer, heart disease, stroke, diabetes, and lung diseases such as chronic obstructive pulmonary disease, and nicotine appears to be the responsible component of tobacco smoke that affects lung development. While nicotine-free electronic cigarettes (e-cigarettes) are often promoted as a safer alternative to traditional smoking, recent evidence suggests that they might pose significant health risks. This study investigates the effects of nicotine-free e-cigarette vapor (ECV) on lung tissue and endothelial function.

Identification of a missing Pictet-Spenglerase in the Gloriosa superba L. colchicine biosynthesis pathway.

Background: Colchicine is a natural medicinal alkaloid from Gloriosa superba L. The biosynthetic pathway of colchicine has been nearly completely revealed, but the Pictet-Spenglerase that catalyses the formation of the crucial intermediate 1-phenethylisoquinoline scaffold has not been identified. Identification and characterization of the missing Pictet-Spenglerase will provide the last piece of the puzzle of colchicine biosynthesis in G.