PRMT5 encourages cell migration and metastasis of tongue squamous cell carcinoma through methylating ΔNp63α.

Tongue squamous cell carcinoma (TSCC) is a common oral malignancy prone to metastasis, whose underlying mechanism remains obscure. Here, we report the oncogenic roles of protein arginine methyltransferase 5 (PRMT5) in TSCC via inhibiting transcription factor ΔNp63α. We found that PRMT5 physically interacts with ΔNp63α, resulting in impairment of ΔNp63α-mediated transcriptional regulation.

Carnosol attenuates Ang II-induced renal injury by p62-KEAP1-NRF2 signaling pathway.

Hypertension engenders numerous complications, including hypertensive renal disease (HRD). Recent studies have underscored the significance of redox homeostasis in hypertension-associated kidney disorders. Carnosol (Car) has been identified as a potent antioxidant in other diseases.

Association between creatinine-to-albumin ratio and mortality in intracerebral hemorrhage: a superior predictive indicator.

Background: Intracerebral hemorrhage is a severe and devastating condition with a high mortality rate worldwide. While creatinine and albumin levels have been studied individually, the prognostic value of the creatinine-to-albumin ratio in predicting mortality in intracerebral hemorrhage patients remains underexplored.

Methods: We performed a retrospective cohort study of intracerebral hemorrhage patients from West China Hospital of Sichuan University (December 2010-July 2019) and The First People's Hospital of Longquanyi District, Chengdu (January 2017-October 2020).

Neutrophil-to-Albumin Ratio Predicts Stroke-Associated Pneumonia in Patients with Intracerebral Hemorrhage.

Background And Aim: Pneumonia is a significant complication that negatively impacts outcomes in patients with intracerebral hemorrhage (ICH). Identifying reliable biomarkers for predicting such infections is crucial for timely intervention and improving patient management. This study aims to evaluate the predictive value of neutrophil-to-albumin Ratio (NAR)for pneumonia in patients undergoing surgical intervention for ICH.

Establishment of a clinically relevant beagle model for periprosthetic joint infection with 3D-printed prostheses and multimodal evaluation.

Objective: Periprosthetic joint infection (PJI) poses significant challenges to arthroplasty outcomes, necessitating translational animal models for pathogenesis studies and therapeutic development. This study aimed to establish a standardized Beagle PJI model by integrating species-specific 3D-printed femoral prostheses with quantitative bacterial inoculation, while evaluating the dose-dependent effects of () on infection progression.

Methods: Two titanium alloy prostheses were designed using CT-based anatomical data: BFP-C (canine-optimized) and BFP-H (human-derived).

A longitudinal metabolomics study on blood mercury and depressive symptoms.

Mercury exposure may increase the risk of depression. This study examined associations between blood mercury, depressive symptoms (PHQ-9), and metabolomic pathways in Chinese young adults. Fasting venous blood samples and questionnaire data (N = 477) were collected from the Chinese undergraduate cohort study in 2019 and 2021.

Association Between Neutrophil Percentage-to-Albumin Ratio and Neutrophil-to-Albumin Ratio with Long-Term Mortality in Patients with Intracerebral Hemorrhage.

Background: The association between the neutrophil percentage-to-albumin ratio (NPAR) and neutrophil-to-albumin ratio (NAR) with long-term mortality in patients with intracerebral hemorrhage (ICH) remains underexplored.

Methods: We conducted a retrospective cohort study, including patients diagnosed with ICH from 2 tertiary care centers. NPAR and NAR levels were calculated from blood samples obtained within 24 hours of admission.

Study on properties of straw fiber steel slag foam concrete.

The objective of this scholarly endeavor is to engineer an innovative, eco-friendly construction material, specifically straw fiber steel slag foam concrete (SFSSFC), with the dual purpose of optimizing resource utilization and mitigating energy expenditure within the construction sector. Through meticulous manipulation of the constituent ratios of steel slag powder, straw fiber, and foam, a series of 15 SFSSFC specimens were fabricated. Subsequent to their preparation, a comprehensive evaluation was conducted to ascertain their fluidity, water absorption, mechanical strength, thermal conductivity, and resistance to freeze-thaw cycling.

The E3 ligase TRIM21 promotes progression of pancreatic ductal adenocarcinoma by down-regulating TAp63α and derepressing .

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor and frequently has mutations in the transcription factor p53. TAp63α is a member of the p53 protein family that is generally tumor suppressive in various other p53-mutant or p53-deficient cancers. Here, we found that TAp63α inhibited cell proliferation, epithelial-mesenchymal transition (EMT), and migration in several p53-mutant PDAC cell lines.

Associations between long-term PM exposure and metabolomic signatures: A retrospective cohort study.

Background: Long-term exposure to fine particulate matter (PM) has been reported to be associated with inflammation and oxidative stress. However, the underlying metabolic mechanisms remain poorly understood.

Objective: To identify the blood metabolome and metabolic pathways associated with long-term PM exposure.

Alleviating Effect and Potential Mechanisms of Selenium Supplementation on Chronic Liver Injury Induced by Oxidized Soybean Oil.

Lipid oxidation can induce liver oxidative stress and lipotoxic damage, while selenium (Se) possesses detoxification, antioxidation, immunity, and liver protection functions. However, the effects of Se and oxidized lipids on liver oxidative stress and lipid metabolism, along with the underlying mechanisms, remain underexplored. This study aimed to investigate the protective effects of Se against liver injury induced by oxidized soybean oil (OSO) in mice.

Family environment and prosocial behavior tendency of college students: The chain mediating role of empathy and moral sensitivity.

Objectives: In order to explore the influence mechanism of family environment on the prosocial behavior tendency of college students and the chain mediating role of empathy and moral sensitivity in this relationship.

Methods: A survey was conducted on 451 college students using the Family Adaptability and Cohesion scales, the Dispositional Moral Sensitivity Questionnaire, the Prosocial Tendencies Measure and the Chinese Version of the Interpersonal Reactivity Index-C.

Results: The results showed that empathy and moral sensitivity significantly mediate the effect of family environment on college students' prosocial behavior tendency.

17-1 Ameliorates DSS-Induced Colitis by Modulating the Colonic Microbiota Composition and Metabolome in Mice.

: strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). However, the strain specificity and limited stress resistance of restricts its therapeutic effectiveness. The aim of this study was to investigate the effects of dietary supplementation with microencapsulated 17-1 on the intestinal immune responses, gut microbiota composition, and metabolic characteristics in colitis mice.

JOSD2 alleviates acute kidney injury through deubiquitinating SIRT7 and negativity regulating SIRT7-NF-κB inflammatory pathway in renal tubular epithelial cells.

Acute kidney injury (AKI), triggered by various stimuli including ischemia-reperfusion, nephrotoxic insult, and sepsis, is characterized by an abrupt deterioration in kidney function. Ubiquitination is a post-translational modification of proteins that plays a critical role in the pathogenesis and progression of AKI. In this study, we aimed to investigate the role and underlying mechanism of the deubiquitinating enzyme Josephin Domain-containing protein 2 (JOSD2) in AKI.

Global research landscape and trends in Toxoplasma gondii from 2003 to 2022: A bibliometric analysis.

Toxoplasmosis is a globally prevalent zoonotic disease with significant public health impact, yet effective prevention and control measures remain lacking. This study analyzed 10,737 publications from 2003 to 2022 in the Web of Science and Scopus databases using bibliometric methods. Key metrics, including annual publication trends, journals, core authors, contributing countries, citations, and keywords, were examined.

Efficacy of restrictive versus liberal transfusion strategies in patients with traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials.

Background: The effects of restrictive versus liberal transfusion strategies in critically ill patients with traumatic brain injury (TBI) and anemia, particularly in adult patients with moderate to severe TBI, remain inconclusive. Therefore, this systematic review and meta-analysis aim to evaluate the comparative impact of restrictive and liberal red blood cell transfusion strategies among critically ill adult patients with moderate to severe TBI.

Methods: We conducted a search of PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from their inception through October 20, 2024, to identify randomized controlled trials that compared restrictive (transfusions at a hemoglobin level of ≤ 7 g/dL) and liberal (transfusions at a hemoglobin level of ≤ 9-10 g/dL) transfusion strategies in adult patients with TBI.

Isoliquiritigenin induced hepatotoxicity and endoplasmic reticulum stress in zebrafish embryos.

Isoliquiritigenin (ISL), a naturally occurring flavonoid derived from licorice root, exhibits antioxidant, anticancer, anti-inflammatory, and anti-allergic properties, and is frequently detected in both environmental and human samples. Previous studies from our lab have demonstrated that ISL exposure can lead to developmental deformities and aberrant immune responses. However, the molecular mechanisms underlying ISL toxicity in zebrafish embryos remain incompletely elucidated.

Pharmacological restoration of GTP hydrolysis by mutant RAS.

Approximately 3.4 million patients worldwide are diagnosed each year with cancers that have pathogenic mutations in one of three RAS proto-oncogenes (KRAS, NRAS and HRAS). These mutations impair the GTPase activity of RAS, leading to activation of downstream signalling and proliferation.

Associations between soft drinks intake and primary dysmenorrhea among Chinese undergraduate female students.

Primary dysmenorrhea (PD) is a common global health concern. However, limited studies explored the association between soft drinks intake and PD among female undergraduates in China. To determine the association between soft drinks (carbonated soft drinks, etc.

Comprehensive foodomics analysis reveals key lipids affect aroma generation in beef.

Lipids are vital precursors to beef aroma compounds, but the exact lipid molecules influencing aroma generation remain unconfirmed. This study employs gas chromatography-olfactometry-mass spectrometry and absolute quantitative lipidomics to identify beef's aroma and lipid profiles and to examine lipid alterations post-thermal processing. The aim is to understand the role of lipids in aroma generation during beef's raw-to-cooked transition.

Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury.

Recent studies have shown the crucial role of podocyte injury in the development of diabetic kidney disease (DKD). Deubiquitinating modification of proteins is widely involved in the occurrence and development of diseases. Here, we explore the role and regulating mechanism of a deubiquitinating enzyme, OTUD5, in podocyte injury and DKD.

3D-Printed Biomimetic Hydroxyapatite Composite Scaffold Loaded with Curculigoside for Rat Cranial Defect Repair.

The treatment of various large bone defects has remained a challenge for orthopedic surgeons for a long time. Recent research indicates that curculigoside (CUR) extracted from the curculigo plant exerts a positive influence on bone formation, contributing to fracture healing. In this study, we employed emulsification/solvent evaporation techniques to successfully fabricate poly(ε-caprolactone) nanoparticles loaded with curculigoside (CUR@PM).

Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury.

Selenium (Se) is indispensable in alleviating various types of intestinal injuries. Here, we thoroughly investigated the protective effect of Se on the regulation of the epithelial cell-M2 macrophages pathway in deoxynivalenol (DON)-induced intestinal damage. In the present study, Se has positive impacts on gut health by improving gut barrier function and reducing the levels of serum DON in vivo.

Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.

Osteogenesis is caused by multiple factors, and the inflammatory response, osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), regeneration of blood vessels, and other factors must be considered in bone tissue engineering. To effectively repair bone defect, it is important to decrease excessive inflammation, enhance the differentiation of mesenchymal stem cells into osteoblasts, and stimulate angiogenesis. Herein, nano-attapulgite (ATP), polyvinyl alcohol (PVA), and gelatin (GEL) scaffolds were produced using 3D printing technology and pioglitazone (PIO)-containing polylactic acid-glycolic acid (PLGA) nanospheres were added.