Dietary supplementation of yeast glycoprotein improves egg quality, immunity, antioxidant capacity, and fecal microbiota in laying hen.

The objective of this study was to investigate the impact of yeast glycoprotein (YG) on the laying performance, egg quality, immune parameters, antioxidant capacity, deodorizing properties, and fecal microbial composition of laying hens. Results demonstrated that dietary YG significantly increased albumen height compared to CON (P < 0.05).

Yeast protein as a fishmeal substitute: impacts on reproductive performance, immune responses, and gut microbiota in two sow hybrids.

Introduction: The persistent African swine fever epidemic has significantly compromised China's swine production. To accelerate production recovery, commercial farms are increasingly adopting retention of two-way backcross sows (Landrace × Yorkshire × Landrace, LLY) for breeding. This study aimed to investigate the effects of yeast protein, an emerging sustainable protein source, on reproductive performance, immune responses, and gut microbiota in two-way crossbred sows (Landrace × Yorkshire, LY) and LLY sows.

17-1 Ameliorates DSS-Induced Colitis by Modulating the Colonic Microbiota Composition and Metabolome in Mice.

: strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). However, the strain specificity and limited stress resistance of restricts its therapeutic effectiveness. The aim of this study was to investigate the effects of dietary supplementation with microencapsulated 17-1 on the intestinal immune responses, gut microbiota composition, and metabolic characteristics in colitis mice.

Gestational Inulin Supplementation in Low-/High-Fat Sow Diets: Effects on Growth Performance, Lipid Metabolism, and Meat Quality of Offspring Pigs.

This study investigated whether the supplementation of prebiotic inulin to gestating sows programmatically affects offspring growth performance and meat quality while exploring its epigenetic effects through histone acetylation modulation. After mating, sixty multiparous sows (Landrace × Yorkshire; parity 2-3) were assigned to a 2 × 2 factorial arrangement with inulin (0% vs. 1.

Mapping Temperate Savanna in Northeastern China Through Integrating UAV and Satellite Imagery.

Temperate savannas are globally distributed ecosystems that play a crucial role in regulating the global carbon cycle and significantly contribute to human livelihoods. This study aims to develop a novel method for identifying temperate savannas and to map their distribution in Northeastern China. To achieve this objective, Unmanned Aerial Vehicle (UAV) imagery was integrated with Sentinel-2 and Sentinel-1 satellite imagery using Random Forest  (RF) regression and Classification and Regression Tree (CART) algorithms.

Indole-3-lactic acid derived from tryptophan metabolism promotes trophoblast migration and invasion by activating the AhR/VCAN pathway.

Background: Preeclampsia (PE) is a life-threatening condition that is unique to human pregnancy, and it is a leading cause of maternal and neonatal morbidity and mortality. Currently, the only definitive treatment for PE is delivery of the placenta. Several studies have suggested that the gut microbiota and its derived metabolites may be associated with PE.

Local Electronic Regulation by Oxygen Coordination with Single- Atomic Iridium on Ultrathin Cobalt Hydroxide Nanosheets for Electrocatalytic Oxygen Evolution.

Rationally optimizing the atomic and electronic structure of electrocatalysts is an effective strategy to improve the activity of the electrocatalytic oxygen evolution reaction (OER), yet it remains challenging. In this work, atomic heterointerface engineering is developed to accelerate OER by decorating iridium atoms on low-crystalline cobalt hydroxide nanosheets (Ir-Co(OH)) via oxygen-coordinated bonds to modulate the local electronic structure. Leveraging detailed spectroscopic characterizations, the Ir species were proved to promote charge transfer through Ir-O-Co coordination between the Ir atom and the Co(OH) support.

Efficacy of late cervical cerclage for preventing preterm birth in pregnancies complicated by cervical incompetence: retrospective cohort study.

Objectives: To compare different periods of cerclage placement in preventing preterm birth in singleton pregnancies complicated by cervical incompetence.

Methods: This retrospective cohort study was conducted at a tertiary hospital in Shanghai, China. A total of 499 singleton pregnancies undergoing prophylactic cervical cerclage between January 1, 2021, and June 30, 2023, at Shanghai East Hospital were included in the study.

Emerging MOFs, COFs, and their derivatives for energy and environmental applications.

Traditional fossil fuels significantly contribute to energy supply, economic development, and advancements in science and technology. However, prolonged and extensive use of fossil fuels has resulted in increasingly severe environmental pollution. Consequently, it is imperative to develop new, clean, and pollution-free energy sources with high energy density and versatility as substitutes for conventional fossil fuels, although this remains a considerable challenge.

Efficient degradation of neomycin by and isolated from mangrove soil and pharmaceutical wastewater.

Neomycin, an aminoglycoside antibiotic, is widely utilized for veterinary medicine in disease prevention. Biodegradation is a key pathway for the removal of neomycin from the environment. To date, only the white-rot fungus and the ericoid mycorrhizal fungus have been documented to efficiently degrade neomycin.

Rapid Electrochemical Uranium Extraction from Real Seawater via the Intermediate of Vacancy-Trapped Isolated Uranyl.

Electrochemical uranium extraction from seawater is a vital project for the sustainable development of the nuclear industry, which requires selective intrinsic binding sites for uranyl. In this work, oxygen vacancies (O vacancies) were developed as an atomically identified confinement for uranyl, and thus, rapid uranium extraction from seawater was achieved. In a short period of 700 s, InO nanosheets with rich O vacancies (V-rich InO nanosheets) exhibited a high extraction efficiency of 88.

Indole-3-lactic acid derived from tryptophan metabolism alleviates the sFlt-1-induced preeclampsia-like phenotype via the activation of aryl hydrocarbon receptor.

Aims: Preeclampsia (PE) is an unusual multisystem condition that occurs during pregnancy and is characterized by maternal endothelial dysfunction and damage to various organs. The catabolism of L-tryptophan (Trp) is involved in various biological activities, including healthy pregnancy. Our previous work revealed that PE significantly elevated the concentration of indole-3-lactic acid (ILA), a Trp derivative, during the third trimester of pregnancy.

Imidazole Encapsulation Enabled by Confinement for I and CHI Coremoval.

Nitrogen-rich small molecules are frequently doped into porous materials to enhance their iodine adsorption properties. To explore how imidazole confinement in metal-organic frameworks (MOFs) affects iodine adsorption, we obtained a UiO-66-based composite by embedding imidazole in UiO-66 pores via solid-phase adsorption (Im@UiO-66). Characterization confirmed that imidazole was successfully confined within the UiO-66 pores, with each unit of UiO-66 accommodating up to 27 imidazole molecules.

Sex differences in brain functional specialization and interhemispheric cooperation among children with autism spectrum disorders.

The prevalence of autism spectrum disorders (ASDs) differs substantially between males and females, suggesting that sex-related neurodevelopmental factors are central to ASD pathogenesis. Numerous studies have suggested that abnormal brain specialization patterns and poor regional cooperation contribute to ASD pathogenesis, but relatively little is known about the related sex differences. Therefore, this study examined sex differences in brain functional specialization and cooperation among children with ASD.

Constructing the Electron-Rich Microenvironment of an All-Polymer-Based S-Scheme Homostructure for Accelerating Uranium Capture from Nuclear Wastewater.

Large quantities of uranium-containing radioactive wastewater are typically generated during nuclear fuel cycle processes. Despite significant efforts, efficient capture of migratable hexavalent uranium U(VI) is still a huge challenge due to its acidity, radioactivity, coexisting organics, and high impurity cation abundance in wastewater. Herein, we have fabricated all-polymer-based 0D/2D CN/CN homostructure hybrids with an S-scheme electronic configuration by coordinating the band engineering of semiconductors to enrich uranium species from the complex wastewater environment.

Phase 1 dose escalation study of the MDM2 inhibitor milademetan as monotherapy and in combination with azacitidine in patients with myeloid malignancies.

Background: Mouse double minute-2 homolog (MDM2) plays a key role in downregulating p53 activity in hematologic malignancies, and its overexpression is associated with poor outcomes.

Methods: This phase 1 study assessed the safety and efficacy of different dosing regimens of the MDM2 inhibitor milademetan as monotherapy and in combination with azacitidine (AZA) in patients with relapsed or refractory acute myeloid leukemia or high-risk myelodysplastic syndromes.

Results: Seventy-four patients (monotherapy, n = 57; milademetan-AZA combination, n = 17) were treated.

Natural Products of Licorice for Uranium Decorporation with Low Toxicity and High Efficiency.

The development and exploration of uranium decorporation agents with straightforward synthesis, high removal ability, and low toxicity are crucial guarantees for the safety of workers in the nuclear industry and the public. Herein, we report the use of traditional Chinese medicine licorice for uranium decorporation. Licorice has good adsorption performance and excellent selectivity for uranium in the simulated human environment.

Efficient removal of perrhenate/pertechnetate by a pyridinium-based porous polymer.

The extraction of TcO from radioactive effluents is extremely crucial for the purposes of nuclear disposal and environmental remediation. Herein, utilizing a facile and low-cost synthesis method, we report a pyridinium-based cationic polymer network, CPP-Cl, with impressive adsorption performance and ultrafast adsorption kinetics towards ReO. The structure featuring highly density of charged pyridinium units was synthesized, making it an effective adsorbent for capturing ReO.

Sulfur-Vacancy Engineering Accelerates Rapid Surface Reconstruction in Ni-Co Bimetal Sulfide Nanosheet for Urea Oxidation Electrocatalysis.

Developing a highly efficient catalyst for electrocatalytic urea oxidation reaction (UOR) is not only beneficial for the degradation of urea pollutants in wastewater but also provides a benign route for hydrogen production. Herein, a sulfur-vacancy (S) engineering is proposed to accelerate the formation of metal (oxy)hydroxide on the surface of Ni-Co bimetal sulfide nanosheet arrays on nickel foam (S-CoNiS@NF) for boosting the urea oxidation electrocatalysis. As a result, the obtained S-CoNiS@NF demonstrates an outstanding electrocatalytic UOR performance, which requires a low potential of only 1.

Hydrophobic nanosheet silicalite-1 zeolite for iodine and methyl iodide capture.

Effective capture of radioactive iodine from nuclear fuel reprocessing is of great importance for public safety as well as the secure utility of nuclear energy. In this work, a hydrophobic nanosheet silicalite-1 (NSL-1) zeolite with an adjustable size was developed for efficient iodine (I) and methyl iodide (CHI) adsorption. The optimized all-silica zeolite NSL-1 exhibits an excellent I uptake capacity of 553 mg/g within 45 min and a CHI uptake capacity of 262 mg/g within 1 h.

Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation.

Uranium accumulation in the kidneys and bones following internal contamination results in severe damage, emphasizing the pressing need for the discovery of actinide decorporation agents with efficient removal of uranium and low toxicity. In this work, cinnamic acid (3-phenyl-2-propenoic acid, CD), a natural aromatic carboxylic acid, is investigated as a potential uranium decorporation ligand. CD demonstrates markedly lower cytotoxicity than that of diethylenetriaminepentaacetic acid (DTPA), an actinide decorporation agent approved by the FDA, and effectively removes approximately 44.

Co-adsorption performance of iodine and NO in iodine exhaust gas by NH-MIL-125.

Ti-based MOFs exhibit ultra-high stability in radioactive waste gases containing nitrogen oxides (NO) and are effective in capturing radioactive iodine. In this study, NH-MIL-125 was synthesized via a one-pot solvothermal method and its adsorption performance for iodine was investigated using batch adsorption experiments, the stability of materials was tested by simulating post-processing conditions. The results indicated that NH-MIL-125 had a maximum iodine adsorption capacity of 1.

Entanglement Generation of Polar Molecules via Deep Reinforcement Learning.

Polar molecules are a promising platform for achieving scalable quantum information processing because of their long-range electric dipole-dipole interactions. Here, we take the coupled ultracold CaF molecules in an external electric field with gradient as qubits and concentrate on the creation of intermolecular entanglement with the method of deep reinforcement learning (RL). After sufficient training episodes, the educated RL agents can discover optimal time-dependent control fields that steer the molecular systems from separate states to two-qubit and three-qubit entangled states with high fidelities.