Synthesis of transition metal-sensitized lanthanide near-infrared luminescent nanoparticles.

The versatility of lanthanide-doped near-infrared (NIR, 700-1,700 nm) luminescent nanoparticles makes them valuable tools in various scientific and technological fields, from bioimaging to information security. However, the luminescence intensity of typical lanthanide-doped nanoparticles is significantly influenced by the efficiency of the sensitizer. The introduction of transition metal ions (such as Cr, Mn and Ni) can greatly enrich the library of lanthanide NIR luminescence nanoparticles.

Beyond single perspective bias: Fusing personalized and common preferences for comprehensive personal preference learning.

In recommendation systems, Graph Convolutional Network (GCN)-based models are generally influenced by popular items. Over-emphasizing these items can lead to a single-perspective bias that overshadows the learning of the user's personalized preferences. Therefore, existing GCN-based models usually suppress information from popular items.

DSTANet: A Lightweight and High-Precision Network for Fine-Grained and Early Identification of Maize Leaf Diseases in Field Environments.

Early and accurate identification of maize diseases is crucial for ensuring sustainable agricultural development. However, existing maize disease identification models face challenges including high inter-class similarity, intra-class variability, and limited capability in identifying early-stage symptoms. To address these limitations, we proposed DSTANet (decomposed spatial token aggregation network), a lightweight and high-performance model for maize leaf disease identification.

Whole exome sequencing analysis of susceptibility loci in transgender individuals.

Background: Genetic factors contributing to sex-associated dimorphic brain development may also underlie gender identity-related anxiety disorders.

Aim: To establish a high-throughput whole-exome sequencing (WES) and bioinformatics pipeline for identifying rare variants in sex-dimorphic neural pathways and explore their association with gender identity-related anxiety.

Methods: Peripheral genomic DNA was collected from 23 patients (13 Assigned male at birth (AMAB), 10 Assigned female at birth (AFAB)) presenting with gender identity-related anxiety at Shanghai Mental Health Centre between March 2020 and February 2022.

Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment via Anti-Inflammation, Antioxidation, and Microbiota Modulation.

Inflammatory bowel disease (IBD) management remains challenging due to the inadequate efficacy and systemic toxicity of conventional therapies. Herein, we developed an inulin hydrogel loaded with self-assembled nanoparticles of curcumin and glycyrrhizic acid (CURG@IN) for IBD treatment. CURG@IN exhibited remarkable gel characteristics and enzyme-responsive drug release behavior.

High-precision space camera self-calibration via structural priors and intelligent optimization.

During long-term on-orbit operation, space cameras are subjected to extreme thermal cycles, high vacuum, intense radiation, and complex mechanical loads, which cause drift in the geometric parameters of the imaging system. To improve the on-orbit camera's imaging quality without altering the optical system, existing calibration methods are insufficient. Therefore, this study proposes, to our knowledge, a novel on-orbit autonomous calibration method based on the structural features of the spacecraft.

The complete chloroplast genome sequence and phylogenetic analysis of Linnaeus 1753 (Lamiaceae), a tropical and subtropical coastal shrub.

The complete chloroplast genome of Linnaeus 1753 (Lamiaceae) was sequenced and characterized for the first time. The chloroplast genome of is 151,066 bp in length and comprises a large single-copy region (82,508 bp), a small single-copy region (17,302 bp), and a pair of inverted repeat regions each 25,628 bp. The genome encodes 87 protein-coding genes, 37 transfer RNA (tRNA) genes, and 8 ribosomal RNA (rRNA) genes.

Mogroside V restores glycolytic function via LDHA promoter demethylation independent of alternative splicing in PCOS granulosa cells.

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder characterized by metabolic dysfunction. This study investigated whether Mogroside V (MV) ameliorates hyperandrogenism-induced glycolytic dysfunction in testosterone (TES)-treated KGN cells. KGN cells treated with 150 µM TES exhibited significantly reduced viability, decreased lactate production, and increased pyruvate levels, which were reversed by 60 µM MV.

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury.

Stroke represents a significant threat to public health, with insufficient understanding of its pathological mechanisms hindering therapeutic advancements. Exosomes are implicated in both the injury and recovery processes of ischemic stroke. While enhanced glycolysis is linked to exosome biogenesis, its regulatory mechanisms remain largely unexplored.

Design, synthesis and biological activity of tubulin inhibitors based on the structure of deoxypodophyllotoxin.

As the key components and elements of the cytoskeleton, tubulin play a fundamental and essential role in multiple biological processes. In this work, we designed and synthesized a series of deoxypodophyllotoxin derivatives by strategy of introducing nitrogen into the C-4 position of deoxypodophyllotoxin. Among them, compounds A7 and A8 exhibited the potent antiproliferative activity against five cancer cell lines and paclitaxel-resistant A549 cells.

ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.

T lymphocytes, which are essential for cell-mediated immunity in vertebrates, rely on thymic seeding of lymphoid progenitors for commitment, differentiation and maturation. However, the epigenetic programming of lymphoid-primed progenitor migration and differentiation is incompletely understood. Here, we show that zebrafish embryos lacking the epigenetic modulator Atf7ip or Setdb1 methyltransferase exhibit decreased thymic homing and differentiation of lymphoid progenitor cells.

Antibacterial mechanism of ultrasound combined with oregano essential oil nano-emulsion on Escherichia coli O157:H7 and application in cherry tomatoes storage.

Escherichia coli (E. coli) O157:H7 on the surfaces of fruits and vegetables poses significant risks to human health. This study assessed the bactericidal mechanisms of ultrasound (US) and oregano essential oil nanoemulsion (OEON) against E.

Comparative study on the redox-responsive properties and antitumor efficacy of polyurethane nanocarriers with mono-, Di-, and trisulfide bonds.

Polyurethane (PU) is considered an ideal nanocarrier for drug delivery due to its excellent biocompatibility and efficient drug-loading capacity. Sulfur bonds (such as monosulfide, disulfide, and trisulfide bonds), have attracted considerable attention in drug delivery systems due to their redox-responsive properties. However, current research primarily focuses on the application of sulfur bonds in prodrug nanoassemblies, where designs rely on specific chemical conjugation groups, limiting their applicability to a narrow range of drug molecules and thus restricting broader utility.

CMCS/PEGDA-based photoresponsive hydrogel with high efficiency for gingival retraction and rapid hemostasis.

Prosthodontics is a dental specialty with a long history of providing patients with prostheses to restore or replace damaged or missing teeth and dentition. Gingival retraction is a vital step after tooth preparation to obtain aesthetic and functional restorations. Gingival retraction materials have been used in clinics and are among the most prospective alternatives to gingival retraction cords.

[Fast determination of per- and polyfluoroalkyl substances in human serum by cold-induced phase separation coupled with liquid chromatography-tandem mass spectrometry].

Per- and polyfluoroalkyl substances （PFASs） are a large group of synthetic chemicals that have been widely used in various industrial and commercial products owing to their unique physicochemical properties. However， accumulating evidence suggests that PFASs are persistent， transmissive over long distances， bioaccumulative， and toxic； consequently， their adverse effects on ecosystems and humans is of widespread concern. Serum is the most commonly used human matrix for assessing internal exposure to environmental pollutants， and several analytical methods have been developed to measure PFASs in sera.

Mogroside-rich extract alleviates the inflammation state in polycystic ovary syndrome rats through modulating intestinal microbiota-metabolic axis and suppressing the NF-κB/NLRP3 pathway.

Polycystic ovary syndrome (PCOS), a complex endocrine-metabolic disorder characterized by hyperandrogenism, polycystic ovarian morphology, and ovulatory dysfunction, is often associated with insulin resistance. Mogroside-rich extract (MGE) from Siraitia grosvenorii possesses significant anti-inflammatory and antioxidant properties. However, its potential to restore intestinal microbial homeostasis and metabolic balance in PCOS and the underlying mechanisms remain unexplored.

Martensitic Transformation Mechanism In Situ Observation for the Simulated Coarse-Grained Heat-Affected Zone of DP1180 Steel.

The martensitic transformation mechanism in the heat-affected zone of DP1180 steel plays a decisive role in the strength of welded joints. In this work, the nucleation and growth kinetics of martensite laths in the coarse grain heat-affected zone (CGHAZ) are analyzed by a high-temperature laser scanning confocal microscope (LSCM). The grain distribution and stress distribution of the samples after in situ observation are analyzed by electron backscatter diffraction (EBSD).

Overlooked role of aged cationic natural organic matter in aquatic microplastics aggregation-sedimentation.

Environmental behavior of microplastics (MPs) is critically modulated by natural organic matter (NOM), yet the role of aged cationic biopolymers like chitosan (CTS) remains less understood. Herein, we demonstrate the unparalleled ability of aged-CTS to drive aggregation-sedimentation of two types of MPs: conventional polystyrene (PS) and biodegradable polymethyl methacrylate (PMMA), challenging the paradigm of NOM as omnipresent stabilizers. CTS exhibited strong aggregation-sedimentation for both MPs while metal cations failed to induce PMMA aggregation.

Comprehensive Genome-Wide Investigation and Transcriptional Regulation of the bZIP Gene Family in Litchi Fruit Development.

, a crucial tropical and subtropical fruit tree in southern China, is widely appreciated for its distinctive flavor, high nutritional value, and significant economic impact. The bZIP (basic leucine zipper) gene family plays an essential role in regulating key biological functions during plant growth and development. In this study, we performed a comprehensive bioinformatics analysis of the bZIP gene family in litchi to systematically elucidate its molecular characteristics and functional properties.

Sn-Doped Beta Zeolite with Rich Lewis Acidic Sites Enhances Lithium-Ion Dissociation and Transport in PEO-Based Solid Polymer Electrolytes.

Poly(ethylene oxide) (PEO)-based solid polymer electrolytes (SPEs) demonstrate strong electrode adhesion and facile processability, making them promising candidates in all-solid-state lithium metal batteries (ASSLMBs). However, poor ionic conductivity, low Li transference number, and insufficient mechanical strength greatly limit their practical application. Zeolite, a porous ceramic material rich in active sites, shows significant potential as a filler in the PEO-based SPEs.

Sediment-based biochar enhances growth, physiological and phytochemical properties of submerged plant Vallisneria spiralis via improving rhizosphere micro-ecological environment.

In-situ remediation of eutrophic waters using submerged plants is a widely applied strategy. However, harsh sediment conditions impair the physiological and phytochemical functions of submerged plants, which diminishes their water purification capabilities. Herein, sediment-based biochar (SBC) was introduced to enhance the growth, physiological and phytochemical properties of submerged plant Vallisneria spiralis (V.

Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies.

Background: T-cell malignancies are highly aggressive hematological tumors with limited effective treatment options. CAR-NK cell therapy targeting CD7 has emerged as a promising approach for treating T-cell malignancies. However, conventional CAR-NK cell therapy faces the challenges of cell fratricide due to CD7 expression on both malignant cells and normal NK cells.

Physicochemical properties and cosmetic benefits of polysaccharide fractions from Zizania latifolia precipitated by different ethanol concentrations.

Four polysaccharide fractions (designated as ZLPF-60, ZLPF-70, ZLPF-80, and ZLPF-90), extracted from the swollen culms of Zizania latifolia, were obtained by precipitation with varying ethanol concentrations (60, 70, 80, and 90 %, v/v). Their physicochemical properties and in vitro cosmetic benefits, including antioxidant activity, moisture absorption capacity, moisturizing efficacy, and whitening effect, were investigated. The results demonstrated that, with increasing ethanol concentration, the combined content of uronic acids and sulfates, zeta potential, and average molecular weight (Mw) decreased, while the particle size initially increased and then decreased.

Dual trajectory of insomnia and depressive symptoms in women from early pregnancy to 6 months postpartum: a prospective cohort study.

Background: Perinatal insomnia and depression significantly impact maternal-infant health, but their co-developing trajectories are poorly understood. This study examines their heterogeneous progression, interrelationships, and predictive factors across the perinatal period.

Methods: This was part of a mother-infant cohort study conducted in the obstetrics outpatient clinic of a tertiary hospital in Wuhan, Hubei Province.