Decoding coal-induced pulmonary endothelial injury using single-cell omics.

Pulmonary endothelial injury is a critical factor in the pathogenesis and progression of coal pneumoconiosis. However, the precise mechanisms underlying this injury remain poorly understood. To address this, we established a coal pneumoconiosis mouse model by chronic intranasal coal dust exposure over 9 months.

Technological evolution and research frontiers of robot-assisted ultrasound examination: a bibliometric exploration.

Technological innovations in robot-assisted ultrasound (RAUS) have remarkably advanced the development of precision and intelligent medical imaging diagnosis. This study aims to use bibliometric methods to systematically analyze the technological evolution and research frontiers in the RAUS field, providing valuable insights for future research. This study used the Web of Science Core Collection database to retrieve English-language research papers and reviews related to RAUS published between 2000 and 2024.

Optimization of biocatalytic production of sodium gluconate using a dual-enzyme system.

Sodium gluconate has a wide range of applications, including in the fields of construction, textiles, medicine, the chemical industry, and food, so the industrialized production of sodium gluconate is particularly important. However, the preparation process of sodium gluconate is not mature enough, and the production cost is high, which restricts the development of the industry. In this study, the optimization of process conditions for the catalytic production of sodium gluconate from glucose via a dual-enzyme system of glucose oxidase (GOD) and catalase (CAT) was investigated in detail.

Profiles of resilience and patient activation among patients with colorectal cancer and an enterostomy: A latent profile analysis.

Objective: This study aims to identify the latent profiles of resilience among patients with colorectal cancer and an enterostomy, analyze potential influencing factors, and explore the differences in patient activation across different profiles.

Methods: This cross-sectional study recruited a total of 375 patients with colorectal cancer and an enterostomy from three large public hospitals in Chongqing, China, between August 2024 and January 2025 using convenience sampling. Questionnaires used include sociodemographic information, a 10-item Connor-Davidson Resilience Scale, and a Patient Activation Measure.

Harmine suppresses pancreatic cancer through DYRK1A-mediated hyper-activated RAS/MAPK inhibition.

KRAS is the most frequent RAS mutation in pancreatic cancer (PC). Recently, small molecule inhibitors like MRTX1133, which target KRAS , have shown efficacy in inhibiting PC growth. However, the development of intrinsic and acquired resistance to these inhibitors has been observed, necessitating the identification of novel therapeutic targets.

Sea cucumber polypeptide ameliorates aging properties via the brain-gut axis in naturally aging mice.

Background: Sea cucumber has been recognized as a traditional nutraceutical in Chinese medicine for millennia, with its derived polypeptide (SCP) demonstrating diverse bioactive properties. Nevertheless, the molecular mechanisms underlying SCP's potential geroprotective effects remain insufficiently characterized.

Methods: We systematically evaluated SCP's impact on neuromotor function and cognitive performance in physiologically aged C57BL/6 J mice models using a behavioral test battery comprising open field, Y-maze, and Barnes maze paradigms.

The synergistic administration of sanguinarine and curcumin ameliorates indomethacin-induced small intestinal injury in rats through the modulation of Nrf2 and NF-κB signaling pathways.

The synergistic effects of natural compounds provide "multi-component, multi-target" advantages by optimizing efficacy-toxicity profiles. This study elucidates the protective mechanisms and optimal combination of sanguinarine (SA) and curcumin (Cur) in mitigating indomethacin-induced small intestinal injury. A rat model of indomethacin-induced intestinal injury was utilized to assess the therapeutic efficacy of various SA/Cur combinations, with the SA1+Cur40 mg/kg combination identified as optimal, using berberine (Ber) as a positive control.

Elevated Cutaneous Interleukin-21 Links Eczematous Eruption to Interleukin-17A Inhibitor Treatment in Psoriasis.

Background: Eczematous eruption (EE) is an adverse effect observed in psoriasis patients undergoing interleukin (IL)-17A inhibitor therapy, with reported incidence rates ranging from 2.2% to 12.1%.

A Rare Case of Coinfection of and in an Immunocompetent Human Host.

Background: and are aerobic, gram-positive bacteria distributed extensively in the sediment of various environments globally. They usually manifest as opportunistic infections in immunocompromised hosts. Here, we report a coinfection case of and in a patient with normal immune system.

Multinational cost-effectiveness analysis of pembrolizumab combined with chemotherapy as first-line treatment for advanced biliary tract cancer.

Background: Immunotherapy is a promising treatment for advanced biliary tract cancer. However, the cost-effectiveness of pembrolizumab combined with gemcitabine and cisplatin remains unclear across different healthcare systems. This study evaluates its international cost-effectiveness in four countries.

Predictive value of serum myeloperoxidase (MPO) concentration combined with triglyceride-glucose index (TyG) for major adverse cardiaovascular events (MACE) in patients with coronary heart disease.

Background: Coronary heart disease (CHD) remains a leading cause of mortality globally. The prognostic value of myeloperoxidase (MPO) and the triglyceride-glucose (TyG) index in predicting adverse cardiovascular events among individuals with CHD remains uncertain. This study aimed to investigate the predictive value of MPO in combination with the TyG index for major adverse cardiovascular events (MACE) in patients with CHD.

Extracting rubber tree parameters and estimating carbon storage using airborne LiDAR.

Facing the dual challenges of global warming and carbon neutrality, forestry carbon sinks play a vital role in achieving carbon neutrality. Rubber plantations, in particular, offer significant ecological and economic co-benefits. However, the efficient and rapid acquisition of data on rubber plantations and the calculation of carbon stock remain key challenges in forestry carbon sink studies.

Seasonal Fluctuations and Stability of Adenosine in Dried Blood Spots for Neonatal Screening.

Seasonal and environmental factors, including temperature, humidity, and storage conditions, significantly impact the stability of biochemical markers in dried blood spot (DBS) samples. This study investigates these influences specifically for adenosine (ADO) levels, a critical biomarker for neonatal screening of adenosine deaminase (ADA) deficiency. This study analyzed seasonal fluctuations in ADO concentrations across three regions in China (Ningbo, Nanjing, and Changsha) over 11 months, and evaluated ADO stability under different storage conditions (4 °C, 20 °C, and 40 °C).

Differential risk and clinical characteristics of placenta accreta spectrum in twin and singleton pregnancies: implications for perinatal outcomes.

Background: This study compares the prevalence of placenta accreta in singleton and twin pregnancies and examines its impact on adverse perinatal outcomes, exploring whether twin gestation increases the risk of poor outcomes in placenta accreta cases.

Methods: A multivariate logistic regression analysis assessed the link between twin pregnancy and placenta accreta, comparing associated adverse perinatal outcomes in twin vs. singleton pregnancies.

Fed-batch fermentation of Phaffia rhodozyma D3 for enhanced astaxanthin production and nutritional components analysis.

Background: Astaxanthin is a high-value ketocarotenoid with excellent antioxidant properties, anti-tumor and immune-enhancing properties, which has a broad development prospect in the food, feed, medical and nutraceutical industries. Currently, Phaffia rhodozyma is a promising source for natural astaxanthin. The study adopted a fed-batch fermentation strategy to improve the astaxanthin production and determine the nutrient composition of the P.

circFOXK2 inhibits vascular permeability and angiogenesis in advanced lung adenocarcinoma via the miR-1275/CLDN1 axis.

CircRNAs are crucial regulators of angiogenesis, but their role in advanced lung adenocarcinoma (LUAD) angiogenesis remains unclear. In this study, we found that circFOXK2 expression was significantly reduced in advanced LUAD tissues with high angiogenic activity, which correlated with poor clinical outcomes. Reduced circFOXK2 expression upregulates the oncogenic miR-1275 in tumor cells, which is then encapsulated into exosomes.

A multicenter, real-world study analysis: pembrolizumab changes treatment strategy for the patient with recurrent/metastatic head and neck squamous cell carcinoma.

Anti-PD-1/PD-L1 has made breakthrough progress in the treatment of recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, the Asian population in KEYNOTE-048 only accounts for 13.2% of the total population, and there is a lack of data on the mainland Chinese population.

Knockdown of MiD49 and MiD51 alleviates collagen-induced arthritis and suppresses mitophagy and fatty acid oxidation (FAO) in rheumatoid arthritis fibroblast-like synoviocytes.

Increasing evidence confirms that imbalances in mitochondrial dynamics can impair mitochondrial function, thereby disrupting cellular homeostasis and potentially contributing to a variety of diseases. This study investigated whether mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51, MiDs) contribute to the maintenance of the abnormal functions of fibroblast-like synoviocytes (FLS), thereby participating in the pathological process of rheumatoid arthritis (RA), and to elucidate the specific mechanisms. We found that MiDs were significantly upregulated in the FLS of synovial tissues from RA patients and collagen-induced arthritis (CIA) models, as well as in the serum of RA patients.

Luminescence modulation via solvent-triggered single-crystal-to-single-crystal transformation in a non-porous molecular crystal.

Stimuli-responsive crystalline materials have demonstrated significant potential for developing multifunctional systems. Achieving precise structural modulation in non-porous crystalline phases remains a critical challenge, particularly in correlating molecular-level conformational changes with macroscopic properties. Here, we report a solvatomorphic crystalline system, (1-azabicyclo[2.

A review of anti-aging mechanisms of proteins, macropeptides, and related prenylated derivatives.

The process of aging is understood to be associated with the presence of oxidative damage to cells. The development of synthetic prenylated proteins for therapeutic purposes has been a subject of research and development for several decades. The present review encompasses information regarding natural and synthetic prenylated proteins and macropeptides, in addition to the anti-aging effects of these isoprenoids and their underlying mechanisms.

Gaussian primitives for deformable image registration.

Background And Purpose: Deformable image registration (DIR) plays a critical role in radiotherapy by compensating for anatomical deformations. However, existing iterative and data-driven methods are often hindered by computational inefficiency or limited generalization. In response, our objective was to develop a novel optimization-based DIR method that reduces computational overhead and preserves the robust generalization of iterative methods while enhancing interpretability.

Multi-omics analysis reveals distinct responses to light stress in photosynthesis and primary metabolism between maize and rice.

High light (HL) stress is a significant environmental factor limiting crop productivity. Maize (Zea mays) and rice (Oryza sativa), two key global crops, can both grow under high light intensities, but differ in photosynthetic metabolism, with maize being a C species and rice a C species. However, the molecular mechanisms underlying their responses to HL stress remain poorly understood.

Long-range cholinergic input promotes glioblastoma progression.

Glioblastoma (GBM), the most aggressive primary brain tumor, is shaped by its integration into neural networks. While glutamatergic input is linked to tumor progression, the broader architecture and function of neuron-glioma connectomes remain unclear. Using monosynaptic rabies tracing, we map brain-wide neural input to patient-derived xenografts and reveal a consistent organizational logic: local inputs are primarily glutamatergic, while long-range connections exhibit diverse neurotransmitter profiles, with basal forebrain cholinergic projections emerging as a conserved input across sites.