Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation.

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.

Technological evolution and research frontiers of robot-assisted ultrasound examination: a bibliometric exploration.

Technological innovations in robot-assisted ultrasound (RAUS) have remarkably advanced the development of precision and intelligent medical imaging diagnosis. This study aims to use bibliometric methods to systematically analyze the technological evolution and research frontiers in the RAUS field, providing valuable insights for future research. This study used the Web of Science Core Collection database to retrieve English-language research papers and reviews related to RAUS published between 2000 and 2024.

A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAF inhibition in melanoma.

The BRAF pathway and epigenetic machinery are central to melanoma pathogenesis. However, how these processes intersect and their potential for synthetic lethality remains unclear. Here, we identified a BRAF-driven epigenetic mechanism in melanoma that involves a H3K27 methylation-to-acetylation switch, facilitating metabolic adaptation to targeted therapies.

The growth-promoting effect and mechanism of microalgae on plants in PAHs contaminated soil.

Microalgae can effectively degrade polycyclic aromatic hydrocarbons (PAHs) in water. However, the remediation mechanism of microalgae in PAH-contaminated soil remains unclear. In this study, the growth-promoting effects of wheat by Chlorella vulgaris in PAH-contaminated soil were studied.

Phase-interface-anchored cadmium single-atom catalysts for efficient methanol steam reforming.

Employing interface engineering to design innovative single-atom catalysts (SACs) for effective methanol steam reforming (MSR) presents an attractive yet formidable challenge. Here, we report phase-interface confined Cd/P25 SACs, where Cd atoms are stably anchored at the phase interface between anatase (101) and rutile (110) facets. The Cd-O-Ti phase interface sites formed exhibit asymmetric geometric and electronic properties that enable 100% methanol conversion, a low CO concentration (~0.

Organic matter-driven hydroxyl radical generation enhances emerging pollutant removal in plant rhizosphere of constructed wetlands: Coupled direct and indirect effects.

The hydroxyl radical (•OH) plays a key role in the removal of emerging pollutants (EPs) within redox environments. The rhizosphere is known for its pronounced fluctuations in oxygen levels. However, the mechanisms governing •OH generation and its effects on EPs within the rhizosphere of constructed wetlands (CWs) remain insufficiently explored.

SMF-net: semantic-guided multimodal fusion network for precise pancreatic tumor segmentation in medical CT image.

Background: Accurate and automated segmentation of pancreatic tumors from CT images via deep learning is essential for the clinical diagnosis of pancreatic cancer. However, two key challenges persist: (a) complex phenotypic variations in pancreatic morphology cause segmentation models to focus predominantly on healthy tissue over tumors, compromising tumor feature extraction and segmentation accuracy; (b) existing methods often struggle to retain fine-grained local features, leading to performance degradation in pancreas-tumor segmentation.

Methods: To overcome these limitations, we propose SMF-Net (Semantic-Guided Multimodal Fusion Network), a novel multimodal medical image segmentation framework integrating a CNN-Transformer hybrid encoder.

Distinct morphology and self-assembly behavior of Xylan nanoparticles are correlated with arabinose side-chains in Sorghum.

Arabinoxylans (AXs) are complex polysaccharides with varying arabinose substitution patterns that affect their structural properties and self-assembly behaviors. In this study, we selected two sorghum varieties (S2 and S13) from a pool of 18 representative varieties, based on their distinct hemicellulose compositions. Techniques such as arabinoxylan-directed monoclonal antibodies (mAbs), High-Performance Anion-Exchange Chromatography (HPAEC), and 2-D HSQC NMR showed that S13 hemicellulose was of higher Ara/Xyl ratio of 0.

Enantioselective Carbonylative Coupling Reactions: Merging Nickel-Based Selectivity and Photoredox Reactivity.

Transition metal-catalyzed carbonylative coupling reactions play a crucial role in the synthesis of functional molecules of use throughout pharmaceutical development, natural products, and material science. This utility is driven by both the efficiency of carbonylation chemistry and the broad presence of the carbonyl functionality in most synthetic materials. Unfortunately, the development of enantioselective carbonylative coupling reactions of alkyl halides and nucleophiles to access the α-chiral motif found in most drugs is, to date, not viable.

Exploring the associations between intraoperative electroencephalographic depression mediated by different anaesthetic drugs and negative postoperative behavioural changes in children undergoing day surgery: a protocol for a two-centre randomised clinical trial.

Background: Negative postoperative behavioural changes (NPOBCs) are among the most common complications of paediatric anaesthesia. The association between electroencephalogram (EEG) suppression and postoperative outcomes in previous clinical studies has been limited to delirium occurring early in the anaesthesia recovery room, and there are no reports of associations with negative postoperative behavioural changes in the distant postoperative period. However, this has important implications for children undergoing day surgery who are discharged on the same day after surgery.

Research on farmers' willingness to grow high-quality rice based on the TAM-TPB model: evidence from China.

Introduction: Professional grain farmers play a key role in China's food production, and growing high-quality rice is essential to secure their income. Existing studies have analyzed the willingness of farmers to adopt new rice varieties from a number of perspectives, such as farm characteristics and external factors, and have focused on the overall category of farmers. There are few studies to explore how professional grain farmers induce the planting intention of high-quality rice from the level of subjective psychological mechanism.

Development, hotspots, and trend directions of research on green production behavior of farmers based on CiteSpace and VOSviewer visual analysis.

Introduction: Promoting the popularization of green production behavior among farmers is the key to achieving sustainable agricultural development, guaranteeing food security and protecting the ecological environment.

Methods: Based on the Web of Science core database, this study used CiteSpace and VOSviewer to conduct a bibliometric analysis of 697 literatures on green production behaviors of farmers from 2000 to 2024, aiming to sort out the development history and characteristics of this research field.

Results And Discussion: The results show that the number of literature in this field continues to grow, and the studies are concentrated in the field of environmental sciences, and most of them are published in Sustainability journals; China is the largest contributor to the literature in this field, and it cooperates closely with the United States, and the research institutes and authors are mainly from the Chinese institutions of higher education; the studies are mainly focused on the three dimensions of the behavioral drivers, the development of the theoretical models, and the evaluation of the benefits of the implementation.

An integrated all-fiber-based sensing system for monitoring humidity physiological signals.

With the advancement of wearable electronics, flexible sensors have attracted significant attention in health monitoring and personalized medical services. While these sensors exhibit excellent responsiveness for health tracking, they often overlook the importance of skin surface humidity. All-fiber-based sensors exhibit exceptional flexibility, breathability and lightweight nature.

Vancomycin-Loaded Isogenous Membrane Vesicles for Macrophage Activation and Intracellular Methicillin-Resistant Elimination.

Introduction: Methicillin-resistant (MRSA), a notorious multidrug-resistant (MDR) pathogen, frequently resides and proliferates within macrophages, contributing to refractory and recurrent infections. Conventional antibiotics exhibit limited efficacy against intracellular MRSA due to poor cellular penetration.

Methods: Vancomycin (VAN) was encapsulated into membrane vesicles (MVs) derived from the attenuated strain RN4220Δ, generating VAN-loaded nanoparticles (MV-VAN).

Evaluation of individual and combined effects of microplastics and naphthalene on aquatic sediment: Disturbance of carbon and microbial dynamics.

Microplastics (MPs) can absorb contaminants, enhancing their distribution and toxicity in the environment. While few data are available on the co-effect of MPs and polycyclic aromatic hydrocarbons (PAHs) on aquatic sediment. In this study, the effects of different contents (0.

First Measurement of the Muon Neutrino Interaction Cross Section and Flux as a Function of Energy at the LHC with FASER.

This Letter presents the measurement of the energy-dependent neutrino-nucleon cross section in tungsten and the differential flux of muon neutrinos and antineutrinos. The analysis is performed using proton-proton collision data at a center-of-mass energy of 13.6 TeV and corresponding to an integrated luminosity of (65.

Thioredoxin-mediated sulfur cycling and biogenic sulfur encapsulation synergistically enhance co-removal of nitrogen, sulfamethoxazole, and resistance genes in constructed wetlands.

The interplay between sulfur-driven denitrification and antibiotic resistance genes (ARGs) proliferation remains unresolved in constructed wetlands (CWs), where sulfide accumulation and reactive oxygen species generation paradoxically enhance nitrogen removal while compromising microbial integrity. To resolve this conflict, this study engineered a FeS@S° composite filler that synergized thioredoxin (Trx)-mediated sulfur cycling and biogenic sulfur (bio-S) encapsulation. Upregulation of trxA/B genes (2.

Enhancing working memory in MCI: Modulating alpha-gamma coupling and gamma oscillations via rTMS.

Cross-frequency coupling (CFC), particularly the interaction between alpha and gamma oscillations, is a pivotal mechanism implicated in cognitive function, with potential for modulation by repetitive transcranial magnetic stimulation (rTMS). This study aimed to investigate the impact of high-frequency rTMS (HF rTMS) on CFC and visual working memory (VWM) in individuals with mild cognitive impairment (MCI). Twenty MCI patients and twenty healthy controls were administered 10Hz rTMS targeting the left dorsolateral prefrontal cortex (DLPFC).

How does livelihood capital influence the green production behaviors among professional grain farmers cultivating high-quality rice?

Introduction: As a vital food crop in China, the sustainable production of high-quality rice is essential for ensuring food security and facilitating the green transformation of agriculture. However, the limited adoption of green production technologies for high-quality rice among farmers poses a significant obstacle to the sustainable development of the grain sector. While previous studies have primarily focused on the adoption of green technologies by traditional farmers, there has been a lack of attention on professional grain farmers as a distinct category of agricultural operators.

Effect of construction work conditions on safety outcomes: Construction safety resilience as a mediator.

BackgroundWork conditions are critical for construction workers' personal health and project safety performance. However, few studies have explored the effect of construction work conditions on safety outcomes from a systematic perspective.ObjectiveThis study examined the relationship between construction work conditions (CWCs, including high temperature, rainy day, nighttime, and low temperature) and safety outcomes (including physical symptom, psychological symptom, and unsafe event), while construction safety resilience (CSR) performing as a mediator.

Outcomes of arthroscopic one-stage repair and reconstruction of Schenck II-IV knee dislocations with multiple ligament injuries: a single-center study.

Objective: To evaluate the outcomes of arthroscopic one-stage repair and reconstruction of Schenck II-IV knee dislocations with multiple ligament injuries.

Methods: We retrospectively reviewed the data of patients with Schenck II-IV knee dislocations and multiple ligament injuries treated in our hospital during 2019-2022. Patients underwent single-bundle reconstruction of the cruciate ligaments via an arthroscopic all-inside technique, along with repair/reconstruction of the collateral ligaments if necessary, and management of concomitant injuries.

Three-dimensional cell culture models in respiratory virus research: technological advances and current applications.

From the Spanish flu to the COVID-19 pandemic, respiratory viruses have inflicted significant damage on the global population. As research into these viruses progresses, so too does the methodology employed. Although traditional two-dimensional (2D) cell culture techniques and animal models have played crucial roles in our understanding of respiratory viruses and have made significant contributions to research on viral infection mechanisms, as well as the development of drugs and vaccines, they have limitations.

Reconfigurable terahertz optoelectronic logic through charge-density-wave phase engineering.

Charge density waves, manifestations of strongly correlated electronic states in low-dimensional materials, exhibit collective quantum phenomena that enable phase-coherent electronic manipulation. Conventional approaches face limitations in integrating sensing and computing functions, particularly at terahertz frequencies where traditional semiconductors struggle. We achieve deterministic switching between resistive and dissipationless states in 1T-TaS through synergistic thermal, electrical, and optical modulation of metastable charge-density-wave configurations.

Lithography-Free Chalcogenide Canvas for Photonic Integrated Circuits.

Chalcogenide integrated photonic devices have garnered widespread attention due to their excellent wideband transparency. However, current fabrication methods primarily rely on mature silicon-based CMOS processes, which are not readily adaptable to chalcogenides, significantly hindering their development. Here, we present a flexible fabrication approach that judiciously leverages the intrinsic oxidation susceptibility of chalcogenide materials, transforming chalcogenide thin films into a lithography-free canvas for versatile integrated photonic devices.