[Research on hybrid brain-computer interface based on imperceptible visual and auditory stimulation responses].

In recent years, hybrid brain-computer interfaces (BCIs) have gained significant attention due to their demonstrated advantages in increasing the number of targets and enhancing robustness of the systems. However, Existing studies usually construct BCI systems using intense auditory stimulation and strong central visual stimulation, which lead to poor user experience and indicate a need for improving system comfort. Studies have proved that the use of peripheral visual stimulation and lower intensity of auditory stimulation can effectively boost the user's comfort.

Direct Intramolecular Chemiexcitation Strategy Enables Sensitive Chemiluminescence Imaging of HOCl in Rheumatoid Arthritis.

As a pivotal pathophysiological biomarker, hypochlorous acid (HOCl) necessitates sensitive detection technologies to resolve its spatiotemporal dynamics in biological systems. Excitation-free chemiluminescent probes circumvent tissue autofluorescence interference intrinsic to fluorescence imaging, thereby enabling high-contrast deep-tissue monitoring. However, current chemiluminescent probes often demand intricate modifications for HOCl recognition, resulting in compromised stability and sensitivity.

Human retinal organoids for modelling dry age-related macular degeneration and screening drugs.

Age-related macular degeneration (AMD) poses a significant threat to the vision of the elderly population globally. Unfortunately, there is no effective treatment available for dry AMD. In this study, we utilized human retinal organoids (ROs) stimulated with sodium iodate to establish a model for dry AMD.

Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells.

Aim: To explore the changes in early retinal development after the occurrence of ischemia.

Methods: Human retinal organoids (hROs) of day 18 or day 30 were treated with oxygen-glucose deprivation and reperfusion (OGD/R) to simulate the retinal ischemia. All hROs were maintained normally until day 60 to evaluate changes in ischemic injuries during retinal development.

The impact of ketamine on cognitive outcomes in geriatric anesthesia: a comprehensive review.

Background: Ketamine, a dissociative anesthetic with N-methyl-D-aspartate (NMDA) receptor blockade, has become increasingly popular in geriatric anesthesia because of its hemodynamic stability, lack of respiratory depression, and possible neuroprotective properties. Yet, its effect on cognitive function in elderly surgical patients is unknown. Postoperative cognitive dysfunction (POCD) and postoperative delirium (POD) are frequent complications in elderly surgical patients, resulting in longer hospital stays, higher healthcare costs, and long-term cognitive impairment.

Design and Implementation of a Sun Outage Simulation System with High Uniformity and Stray Light Suppression Capability.

To enable accurate evaluation of satellite laser communication terminals under solar outage interference, this paper presents the design and implementation of a solar radiation simulation system targeting the 1540-1560 nm communication band. The system reconstructs co-propagating interference conditions through standardized and continuously tunable output, based on high irradiance and spectral uniformity. A compound beam homogenization structure-combining a multimode fiber and an apodizator-achieves 85.

Cost-effective Φ-OTDR with laser phase noise mitigation using self-mixing interferometry.

The performances and cost of the phase-sensitive optical time-domain reflectometry (Φ-OTDR) systems are heavily influenced by the lasers used. Traditionally, Φ-OTDR systems rely on highly coherent ultra-narrow linewidth lasers (NLL). This paper proposes a Φ-OTDR system that utilizes self-mixing interferometry to mitigate the impact of laser phase noise and a triple-frequency scheme to achieve fading-free detection over 40 km.

Hybrid Raman and phase-sensitive amplifier for ultra-low-noise few-mode amplification and modal crosstalk mitigation in MDM systems.

Ultra-low-noise amplification and modal crosstalk mitigation are critical for advancing mode division multiplexing (MDM) systems. We propose and experimentally demonstrate a few-mode hybrid optical amplifier that combines a few-mode distributed Raman amplifier (FM-DRA) with a single-mode phase-sensitive amplifier (PSA). The FM-DRA implemented in a 100-km few-mode fiber provides preliminary low-noise amplification, while the subsequent PSA leverages its unique phase-sensitive gain property to further enhance signal gain, improve optical signal-to-noise ratio, and suppress modal crosstalk.

High-precision UAV-borne single-photon LiDAR by adaptive averaging.

Unmanned aerial vehicles (UAVs) equipped with light detection and ranging (LiDAR) represent a flexible and low-cost approach to remote sensing. However, UAVs have limited payload capacity and power consumption, constraining the measurement precision and point cloud acquisition rate of onboard LiDAR systems. In this paper, we developed a single-photon LiDAR using a low-power, high-repetition-rate pulsed laser to achieve a high point cloud rate.

Sensitive micro UAV detection based on a high-repetition-rate single-photon LiDAR.

High sensitivity detection of micro unmanned aerial vehicles (UAVs) is a key technology for defending against UAV threats. This paper proposes a single-photon light detection and ranging (SPL) that multiplexes wavelength and repetition rate, and incorporates parallel line scanning to achieve an efficient and uniform distribution of 8.1 million laser pulses emitted per second, thereby enhancing the SPL's detection capability for small targets.

FPGA-based automatic laser frequency stabilization system using the dynamic time warping algorithm.

Achieving laser frequency stabilization is essential for high-precision applications in unmanned environments. This paper presents an FPGA-based automatic laser frequency stabilization system using the dynamic time warping (DTW) algorithm. We utilize DTW's pattern recognition capability to directly identify spectrum signals during the locking process.

Ultrasensitive Digital Immunoassay in Homogenous Format by Singlet-Oxygen Activated Up-conversion Luminescence.

New diagnostic tools for accurately detecting extremely low levels of protein biomarkers in the bloodstream are essential for a wide range of clinical applications. We develop a singlet-oxygen activated up-conversion luminescence assay (SOLA) that enables ultrasensitive digital immunometric detection of protein biomarkers in homogenous format with no wash steps. This approach designs a pair of labeled antibodies, one labeled with a singlet-oxygen (O) nanogenerator of porphyrin-metal organic framework (pMOF) and the other tagged using an upconversion nanoparticle (UCNP) nanoreporter with luminescence caged by O-cleavable quenchers.

Quantification and Evolution of Online Public Opinion Heat Considering Interactive Behavior and Emotional Conflict.

With the rapid development of the Internet, the speed and scope of sudden public events disseminating in cyberspace have grown significantly. Current methods of quantifying public opinion heat often neglect emotion-driven factors and user interaction behaviors, making it difficult to accurately capture fluctuations during dissemination. To address these issues, first, this study addressed the complexity of interaction behaviors by introducing an approach that employs the information gain ratio as a weighting indicator to measure the "interaction heat" contributed by different interaction attributes during event evolution.

Aptamer-Functionalized Granzyme B-Responsive Nanoprobe for Immunotherapy Assessment: Real-Time Monitoring of Cytotoxic T Lymphocyte Activation Cleavage.

Real-time visualization of immune effector functions remains pivotal for advancing cancer immunotherapy. However, most existing molecular probes are hindered by limited sensitivity and specificity due to their "always on" signals and the absence of targeted characteristics. To address this limitation, we engineered an activatable nanoprobe (A-GNP) through the integration of granzyme B-cleavable peptide substrates with CD63-targeting aptamers on gold nanoparticles.

High-capacity phase-sensitively amplified transmission in a field-deployed fiber cable.

Phase-sensitive amplifiers (PSAs) outperform conventional phase-insensitive amplifiers by enhancing signal-to-noise ratio (SNR) through distinct gains for deterministic signal and stochastic noise depending on their phase features. Yet despite this potential, the practical implementation of PSAs in deployed fiber transmission systems remains under-explored. Here we present the field trial of high-capacity phase-sensitively amplified transmission in a field-deployed optical fiber cable.

Hybrid BCI for upper limb rehabilitation: integrating MI with peripheral field SSVEP stimulation.

Background: Rehabilitation systems based on brain-computer interfaces (BCIs) hold significant potential for stroke patients. Existing systems, predominantly relying on motor imagery (MI), have room for improvement in both performance and user comfort. This study aims to enhance these aspects by developing a hybrid BCI system integrating MI with steady-state visual evoked potentials (SSVEPs) elicited by peripheral visual field stimulation.

Technology anxiety in elderly patients with chronic co-morbidities: a latent profile analysis.

Background: Technological anxiety has a multidimensional negative effect on the medical process of elderly patients with chronic co-morbidities, which is mainly reflected in the increase of cognitive load and the decrease of doctor-patient interaction efficiency. The challenge of how elderly patients can more effectively use digital health technologies is a critical issue that both healthcare providers and patients must address. We aimed to explore technology anxiety in elderly patients with chronic co-morbidities by identifying and characterising distinct technology anxiety profiles using latent profile analysis.

Amorphous MnO nanoflower with high laccase-like activity for colorimetric detection of pheochromocytoma biomarker.

Manganese dioxide (MnO), a classical catalyst, plays a pivotal role in modern chemistry and industrial production. However, its laccase-like activity has been underexplored, and particularly the intriguing relationship between its diverse structures and laccase-like properties remains an unresolved question. In this study, five types of MnO, including crystalline α-MnO, β-MnO, γ-MnO, δ-MnO and amorphous MnO nanoflower (NF), were successfully synthesized.

Ultrasonic-assisted molecular probe for turn-on electrochemical and fluorescence dual-mode detection of GSH in human serum.

A molecular probe, 3-oxo-3H-phenoxazin-7-yl thiophene-2-carboxylate (RD), was synthesized using resorufin (Re) as the substrate for the specific recognition of glutathione (GSH). Ultrasonic waves were employed to enhance the reaction efficiency between the molecular probe and GSH. The molecular probe was designed to exhibit specific recognition ability for GSH.

Adsorption efficiency of alizarin red and 2,4-dichlorphenoxyacetic acid from wastewater onto chitosan and iron oxide-coated peanut husk-activated carbon: Isothermal, kinetic, and antibacterial analyses.

In this study, a magnetic biocomposite (CS/FeO-NPs@PHAC) was developed by depositing chitosan (CS) onto peanut husk-activated carbon (PHAC) using acid digestion and pyrolysis. This composite was used to remove the water contaminants (including alizarin red (AR) and 2,4-dichlorophenoxyacetic acid (2,4-D)) and for antibacterial applications. Adsorption studies showed that presence of salts reduced the efficiency, while the acidic conditions enhanced adsorptive process.

Transferring the released component of Z-scheme heterojunction onto opposite photoelectrode: A dual-electrode-cooperating signal amplification strategy in photo fuel cell for self-powered biosensing.

Exploration of signal amplification strategy is an important link during the development of self-powered photoelectrochemical biosensors (SPECs). Herein, we develop a dual-electrode-cooperating signal amplification mode by transferring the released component of Z-scheme heterojunction onto opposite photoelectrode, and integrate it with DNA entropy-driven amplification design for ultrasensitive SPECs bioanalysis. Specifically, microRNA-155, the model analyte triggers the entropy-driven DNA circuit to release large amounts of output DNAs, which can competitively hybridize with the partial complementary DNA double strand between TiO nanospheres and SbS/Au photoanode for initiating the release of TiO nanospheres.

Cataract Aggravates Alzheimer-Like Pathologies and Cognitive Deficits in an APP/PS1 Mouse Model.

Clinical investigations have suggested a potential link between cataracts and Alzheimer's disease (AD). However, whether cataract has an impact on the progression of AD remains unclear. The objective of this research was to determine the relationship between cataracts and AD.

The Power of Vision on Speech Recognition Among Older People.

Objective: This study aimed to explore the relationship between visual acuity and speech recognition.

Method: The study subjects finally included 30 patients aged over 60 years who were treated in our hospital (20 cases in the observation group and 10 cases in the control group). The general information, vision, pure-tone average (PTA), and speech recognition percentage (SRP) were recorded for analysis.

Tin-Lead-Selenide Nanocrystals for Sensitive Uncooled Mid-Infrared Focal Plane Array Imager with Monolithic Readout Integration.

The mid-infrared focal plane array (FPA) imager has developed over recent decades to become multifunctional, powerful, reliable, miniaturized, and cost-effective. However, the complexity of the refrigerated packaging process (such as dewar flask) and traditional fabrication technology (such as flip-chip) continues to contribute significantly to the high cost of industrial production. Here, a simple, low-cost, and effective type of uncooled mid-infrared FPA imager is reported through the monolithic integration of mid-infrared PbSnSe nanocrystals (NCs) PIN heterojunction (PbS/PbSnSe/ZnO) photodetectors and glass-based readout integrated circuits (ROICs).