Correction: Glory LG12 preventives loperamide-induced constipation in mice by modulating intestinal flora and metabolic pathways.

[This corrects the article DOI: 10.3389/fmicb.2025.

Correction: How digital leadership impacts community resilience: a moderated mediation model.

[This corrects the article DOI: 10.3389/fpubh.2025.

CCN1: A Dermo-Epidermal Crosstalk Mediator and Regulatory Protein in Cutaneous Homeostasis.

Cellular communication network factor 1 (CCN1), also known as cysteine-rich angiogenic inducer 61 (CYR61), is a pivotal member of the CCN family, which comprises six secretory matricellular proteins. CCN1 exhibits multifaceted biological functions, including regulation of cell proliferation, differentiation, senescence, angiogenesis and tissue repair. Current evidence demonstrates that CCN1 activates intracellular signalling cascades by binding to receptors such as integrins and heparan sulphate proteoglycans (HSPGs), thereby mediating its biological effects.

Arabidopsis RabGDIs mediate Rab targeting and are crucial for male gametophytic function.

Rab GTPases are key regulators of vesicular trafficking, not only switching between active and inactive forms but also cycling between donor/resident and target membranes, a process regulated by factors including guanine nucleotide dissociation inhibitors (RabGDIs), whose function is largely unknown in plants. By reverse genetic approaches, we demonstrate that Arabidopsis RabGDIs redundantly mediate male fertility such that the functional loss of RabGDIs compromises pollen development, germination, and directional growth of pollen tubes. By combining cellular and pharmacological approaches, we demonstrate that RabGDIs are critical for the targeting of Rab GTPases not only in secretory but also in vacuolar pathways.

Corydalis rhizoma attenuates primary dysmenorrhea in rats by inhibiting the FAK/PI3K-AKT/NF-κB signaling pathway.

Ethnopharmacological Relevance: Primary dysmenorrhea (PD) is a prevalent condition affecting women globally. Corydalis rhizoma (known as Yanhusuo in Chinese, YHS) is commonly used to treat PD. However, the mechanisms by which raw-YHS (YHS-R) and vinegar-processed YHS (YHS-V) exert the therapeutic effects on PD remain unclear.

Age- and time-dependent waning vaccine effectiveness of PPV23 against community-acquired pneumonia among adults aged 60 and older: A cohort study.

The 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for adults to prevent pneumococcal diseases, while its effectiveness over time remains unclear. This study aimed to assess the age- and time-dependent effectiveness of PPV23 in reducing community-acquired pneumonia (CAP) incidence among adults aged 60 and older in China. We conducted a prospective cohort study in Shanghai, China, identifying CAP cases via inpatient and outpatient medical records.

A synbiotic combination of mixed probiotics and oligofructose restores intestinal microbiota disturbance in DSS-induced colitis in mice.

Both probiotics and prebiotics can regulate gut microbiota and produce metabolites that are beneficial to the host, showing potential therapeutic prospects for ulcerative colitis (UC). This study aimed to investigate the therapeutic effects and mechanisms of low-, medium-, and high-dose probiotic mixtures ( subsp. XLTG11: Glory LP16: CCFM8661) combined with oligofructose (FOS) on DSS-induced colitis mice.

Efgartigimod following plasma exchange in the treatment of subjects with generalised myasthenia gravis: study protocol for a multicentre, three-arm, open-label study.

Introduction: Myasthenia gravis (MG), an IgG-mediated autoimmune disorder targeting neuromuscular junctions, shows refractory in 12-20% of generalised MG (gMG) patients despite immunotherapies. Plasma exchange (PLEX) transiently depletes pathogenic mediators, while neonatal Fc receptor antagonists (eg, efgartigimod) offer novel therapeutic potential. Both PLEX and efgartigimod require adjunctive non-steroidal immunosuppressive therapy (NSIST) for sustained remission.

Multiscale Synergistic SERS Chiral Detection: Gold Nanoclusters-Mediated Enantioselective Molecular Discrimination on the Self-Assembly of Gold Nanoparticles.

Surface-enhanced Raman scattering (SERS), despite its high sensitivity in molecular fingerprint detection, typically lacks chiral specificity. Chiral metal nanoclusters (CMNCs) with sub-3 nm cores hold promise for chiral molecular sensing, yet their application in SERS-based chiral recognition remains largely unexplored. In this study, two-dimensional self-assembly of Au nanoparticles (NPs, 30 ∼ 50 nm) functionalized with D- or L-penicillamine (Pen) stabilized sub-3 nm Au nanoclusters (NCs) were constructed as SERS-active substrates.

Overcoming the blood-brain barrier challenge: nanotechnology-enhanced photodynamic therapy for glioblastoma treatment.

Glioblastoma (GBM), one of the most aggressive malignant tumors of the central nervous system, exhibits high recurrence rates and multiple pathological mechanisms, leading to an extremely poor prognosis for patients. Photodynamic therapy (PDT) has emerged as a significant research focus in solid tumor therapy due to its high efficacy and safety, inducing tumor cell-specific damage through a series of reactions mediated by photosensitizers. However, the blood-brain barrier (BBB) impedes drug delivery, and enhancing the penetration of photosensitizers across the BBB and targeting the lesion has become a critical challenge in the application of PDT for GBM.

Aptamer-Functionalized Granzyme B-Responsive Nanoprobe for Immunotherapy Assessment: Real-Time Monitoring of Cytotoxic T Lymphocyte Activation Cleavage.

Real-time visualization of immune effector functions remains pivotal for advancing cancer immunotherapy. However, most existing molecular probes are hindered by limited sensitivity and specificity due to their "always on" signals and the absence of targeted characteristics. To address this limitation, we engineered an activatable nanoprobe (A-GNP) through the integration of granzyme B-cleavable peptide substrates with CD63-targeting aptamers on gold nanoparticles.

Glory LG12 preventives loperamide-induced constipation in mice by modulating intestinal flora and metabolic pathways.

Introduction: Constipation is a common gastrointestinal disease, the incidence of which has been increasing year by year in recent years, and prolonged constipation seriously affects the physical and mental health of patients. Constipation often leads to dysbiosis of the intestinal flora, which in turn exacerbates intestinal dysfunction, and this may be an important mechanism for the development of constipation. Studies have shown that probiotics may be effective in relieving constipation by regulating intestinal flora.

A DCT-UNet-based framework for pulmonary airway segmentation integrating label self-updating and terminal region growing.

Intrathoracic airway segmentation in computed tomography is important for quantitative and qualitative analysis of various chronic respiratory diseases and bronchial surgery navigation. However, the airway tree's morphological complexity, incomplete labels resulting from annotation difficulty, and intra-class imbalance between main and terminal airways limit the segmentation performance.Three methodological improvements are proposed to deal with the challenges.

Overcoming microbial antagonism: strategic enhancements for dibenzofuran bioremediation.

The ecological interaction networks governing microbiome dynamics during bioremediation of recalcitrant organic pollutants have garnered increasing attention; however, the molecular mechanisms underpinning negative interspecies interactions remain poorly characterized. This study investigates the antagonistic interplay between Rhodococcus sp. strain p52 (a dibenzofuran degrader) and Pseudomonas sp.

An mRNA Vaccine Targeting the C-Terminal Region of P1 Protein Induces an Immune Response and Protects Against .

, a cell wall-deficient pathogen, primarily affects children and adolescents, causing (MPP). Following the relaxation of non-pharmaceutical interventions (NPIs) post COVID-19, there has been a global increase in MPP cases and macrolide-resistant strains. Vaccination against is being explored as a promising approach to reduce infections, limit antibiotic misuse, and prevent the emergence of drug-resistant variants.

The Effect of Non-Thermal Processing on the Fate of Pathogenic Bacteria and Hidden Hazardous Risks.

Non-thermal processing encompasses a range of emerging food technologies, including high-pressure processing (HPP), pulsed electric field (PEF), cold atmospheric plasma (CAP), high-pressure carbon dioxide (HPCD), and ultrasound (US). Unlike traditional thermal processing or chemical preservatives, these methods offer advantages such as lower energy consumption, enhanced environmental sustainability, and effective microbial inactivation, thereby extending food shelf life. Moreover, they can better preserve the nutritional integrity, color, flavor, and texture of food products.

Structural and functional disconnections in non-acute post-stroke patients.

Background: Structural alterations and functional reorganizations related to motor dysfunction after stroke remain unclear. This study aims to investigate alterations in structural connectivity (SC) and functional connectivity (FC) in non-acute post-stroke patients, and their associations with motor performance.

Methods: Thirty-six non-acute post-stroke patients and thirty-eight well-matched healthy controls (HCs) were included.

Mutualistic Cross Feeding Mediated by Metabolic Intermediates and Siderophores Enhances Dibenzo--dioxin Removal.

Microbial interactions, such as cross-feeding and competition, are crucial in the bioremediation of recalcitrant organic pollution. However, information regarding the metabolic interactions and associated mechanisms during bioremediation remains scarce. This study used a bottom-up approach to illustrate how mutually beneficial cross-feeding relationships form and influence the degradation of recalcitrant organic pollutants.

PedSemiSeg: Pedagogy-inspired semi-supervised polyp segmentation.

Recent advancements in deep learning techniques have contributed to developing improved polyp segmentation methods, thereby aiding in the diagnosis of colorectal cancer and facilitating automated surgery like endoscopic submucosal dissection (ESD). However, the scarcity of well-annotated data poses challenges by increasing the annotation burden and diminishing the performance of fully-supervised learning approaches. Additionally, distribution shifts due to variations among patients and medical centers require the model to generalize well during testing.

Study on the risk factors for colorectal polyp recurrence: a cross-sectional retrospective cohort study.

Objective: To investigate the factors associated with the recurrence of colorectal polyps.

Methods: Data on polyp recurrence and related factors, including gender, age, BMI, family history, smoking history, alcohol consumption history, gallbladder disease history, food allergy, polyp size, number, and pathological classification, (Hp) infection, parathyroid hormone, gastrin, and blood lipid levels, were collected as exposure factors. Polyp recurrence was used as the outcome measure.

Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial.

Background: Postoperative sleep disturbance (PSD) is a common surgical complication. In this study, we investigated the effect of intraoperative esketamine infusion on the incidence of PSD in patients who underwent laparoscopic cholecystectomy.

Methods: A single-center, double-blinded, placebo-controlled randomized clinical trial was perfomed from May to August 2024 at the People's Hospital of Ningxia Hui Autonomous Region.

4-HIAA Blocks Methamphetamine-Induced Conditioned Place Preference in Mice Through Modulation of the 5-HT Pathway in the Nucleus Accumbens.

4-hydroxyindole-3-acetic acid (4-HIAA) is a metabolite of psilocin. Here, we explored the ability of 4-HIAA to cross the blood-brain barrier and its potential effects on methamphetamine (METH)-induced conditioned place preference (CPP) in mice. Treatment with 1-mg/kg 4-HIAA inhibited CPP formation during the acquisition phase, promoted METH extinction and inhibited METH relapse.

How digital leadership impacts community resilience: a moderated mediation model.

Introduction: Community resilience is crucial for communities to effectively respond to disasters such as public health emergencies. Digital technology and leadership are integral to building community resilience; however, the impact of digital leadership on community resilience has been underexplored.

Methods: This study administered a questionnaire survey to 306 participants to examine the impact of digital leadership on community resilience.

A Study on the Aggregation and Dehydration Behavior of Aqueous Boric Acid Solutions Confined in Carbon Nanotubes.

The properties and structure of boric acid aqueous solutions confined in different carbon nanotubes (CNTs) with pore sizes are investigated using multiscale simulations. The study shows that a CNT pore size of 2.56 nm is a critical value for the properties and structure of confined boric acid solutions.