Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation.

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.

Sex-Dependent Effects of Body Fat on Cardiac Function and Outcomes in Community-Dwelling Older Adults.

Background: Among older adults, sex hormones may exert differential effects on body fat and cardiac health.

Objectives: The authors aimed to study the effects of sex on body fat composition and aging-related diastolic function, as well as their longitudinal changes.

Methods: Community-dwelling older adults without cardiovascular disease underwent prospective baseline same-day anthropometry for body fat mass (BFM), percentage body fat (PBF), and waist hip ratio (WHR) quantification by bioimpedance and transthoracic Doppler echocardiography, with measurements repeated at 5 years.

Effect of Frailty on Cardiovascular Clinical Trials: A Systematic Review and Meta-Analysis.

Background: Patients with cardiovascular (CV) diseases are increasingly frail but rarely represented in trials. Understanding effect modification by frailty on CV trials is critical as it could help define treatment strategies in frail patients.

Objectives: This meta-analysis aims to assess the implications of frailty on CV outcomes in clinical trials.

The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5.

Glutamine reprogramming plays a crucial role in the growth and survival of clear cell renal cell carcinoma (ccRCC), although the mechanisms governing its regulation are still not fully understood. We demonstrate that the RNA demethylase fat mass and obesity-associated gene (FTO) drives glutamine reprogramming to support ccRCC growth and survival. Genetic and pharmacologic inhibition of FTO in ccRCC cells impaired glutamine-derived reductive carboxylation, depleted pyrimidines, and increased reactive oxygen species.

Survival post out-of-hospital cardiac arrest from anomalous right coronary artery: A case report and insight into management.

Unlabelled: Anomalous coronary arteries originating from the opposite sinus of Valsalva are rare causes of sudden cardiac death (SCD), and when present are associated with poor outcomes. We present a rare case of a young man with an anomalous right coronary artery (RCA) presenting with out of hospital cardiac arrest and provide insights into management. A 27-year-old healthy Chinese man presented with out of hospital cardiac arrest during exertion, with initial electrocardiogram and echocardiography unrevealing for an underlying cause of collapse.

Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology.

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by hepatic steatosis, inflammation and fibrosis, is becoming a global epidemic. However, the currently available effective clinical strategies remain limited.

Methods: We conducted the choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) induced MASH mouse model to explore the effects of diphyllin on MASLD mice.

Photosensitized Imino-Sulfamoylation of Alkenes with Oxime Carbamates.

In this study, we have devised a strategy that employs oxime carbamate as a bifunctional diamination reagent in combination with SO to realize imino-sulfamoylation of alkenes. This protocol is characterized by its mild conditions, operational simplicity, and metal-free nature, while demonstrating broad functional group tolerance for alkenes. Furthermore, the application of this method provides an accessible route to a diverse range of β-amino sulfonamide derivatives.

Research progress of silicon-based anode materials for lithium-ion batteries.

In recent years, with the rapid development of fields such as portable electronic devices, electric vehicles, and energy storage systems, the performance requirements for lithium-ion batteries have been continuously rising. Among the numerous key components of lithium-ion batteries, the performance of the anode materials plays a crucial role, as it is directly related to core indicators such as the energy density, cycle life, and safety of the batteries. Among them, silicon-based anode materials have stood out among many anode materials by virtue of their extremely high theoretical specific capacity, becoming one of the hot research directions in the field of lithium-ion battery anode materials at present.

Iron-Cobalt Dual Catalysis for the Synthesis of Alkenyl Amino Acids and Modification of Peptides.

Herein, we report an Fe/Co dual-catalyzed strategy for synthesizing alkenyl unnatural amino acids and peptide modifications. This approach utilizes aspartic acid and glutamic acid derivatives as alkyl radical precursors. It avoids the use of expensive photoredox catalysts and substrate preactivation while preserving the chirality of the amino acids.

The Warburg effect: The hacked mitochondrial-nuclear communication in cancer.

Mitochondrial-nuclear communication is vital for maintaining cellular homeostasis. This communication begins with mitochondria sensing environmental cues and transmitting signals to the nucleus through the retrograde cascade, involving metabolic signals such as substrates for epigenetic modifications, ATP and AMP levels, calcium flux, etc. These signals inform the nucleus about the cell's metabolic state, remodel epigenome and regulate gene expression, and modulate mitochondrial function and dynamics through the anterograde feedback cascade to control cell fate and physiology.

Primary Prevention of Cardiovascular Disease in Asia: Opportunities and Solutions: A Narrative Review.

Importance: Asia faces a rapidly rising burden of cardiovascular disease (CVD). Preventive cardiology efforts may help address the CVD epidemic.

Observations: Solutions to address the CVD burden include a cardiovascular risk assessment framework, improving health screening efforts, better cardiovascular risk factor management, novel innovation strategies encompassing targeted lifestyle measures, and strengthening governmental efforts.

Primary Prevention of Cardiovascular Disease in Asia: Challenges: A Narrative Review.

Importance: Asia is home to 60% of the world's population, including the world's 2 most populous countries, India (1.1B) and China (1.2B).

Biomarkers in clonal haematopoiesis of indeterminate potential (CHIP) linking cardiovascular diseases, myeloid neoplasms and inflammation.

There is increasing evidence that points to ubiquity of clonal haematopoiesis of indeterminate potential (CHIP) especially with rising age. CHIP has been associated with a multitude of inflammatory, cardiovascular and malignant conditions. In this review article, we evaluate the current literature on CHIP and clinical associations with cardiovascular and haematological diseases.

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL.

Relapse continues to limit survival for patients with B-cell acute lymphoblastic leukemia (B-ALL). Previous studies have independently implicated activation of B-cell developmental signaling pathways and increased glucose consumption with chemo-resistance and relapse risk. Here, we connect these observations, demonstrating that B-ALL cells with active signaling, defined by high expression of phosphorylated ribosomal protein S6 ("pS6+ cells"), are metabolically unique and glucose dependent.

Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK.

Obesity is regarded as a chronic inflammatory disease involving adipose tissue macrophages (ATM), but whether immunometabolic reprogramming of ATM affects obesity remains unclarified. Here we show that in ATM glutaminolysis is the fundamental metabolic flux providing energy and substrate, bridging with AMP-activated protein kinase (AMPK) activity, succinate-induced interleukin-1β (IL-1β) production, and obesity. Abrogation of AMPKα in myeloid cells promotes proinflammatory ATM, impairs thermogenesis and energy expenditure, and aggravates obesity in mice fed with high-fat diet (HFD).

Photocatalytic [3 + 2]-annulation sodium tetraarylborate: a fundamental approach for synthesizing 1,4,2-diazaborole analogs.

Substantial advancements have been achieved in the field of photocatalytic borylation utilizing 4c-7e Lewis base-boryl radicals. However, the utilization of 3c-5e neutral boryl radicals for C-B bond formation remains relatively underexplored due to their inherent instability. In this study, we successfully demonstrated the direct construction of C-B bonds using sodium tetraarylborate as a key reagent.

Performance of Risk-Stratification Scores for Patients With Pulmonary Arterial Hypertension in a Multi-Ethnic Asian Population.

Guidelines recommend risk stratification of pulmonary arterial hypertension (PAH) patients to guide management. There are currently several risk stratification scores available, which have largely been validated in various pulmonary hypertension registries in the West but not in Asia. We aim to study the performance of these different risk scores in PAH patients from a multi-ethnic Asian population.

Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation.

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.

USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1.

Yes-associated protein 1 (YAP1) has attracted attention for its potential in the treatment of various types of malignancies. The Hippo-YAP1 axis is inhibited in bladder cancer (BC), which is a major driver of BC progression and oncogenesis. Hippo pathway activity is controlled by the phosphorylation cascade in the MST1/2-LATS1/2-YAP1 axis, in addition to other modifications such as ubiquitination of the Hippo pathway proteins through the co-regulation of E3 ligases and deubiquitinases.

Single-cell RNA sequencing analysis reveals the dynamic changes in the tumor microenvironment during NMIBC recurrence.

Background: Due to the clinical characteristic of frequent recurrence in urothelial bladder cancer (UBC), patients face significant health impacts and economic burdens. Therefore, understanding the molecular mechanisms involved in UBC recurrence is crucial for reducing its recurrence rate. The aim of our study is to help urologists and clinical researchers gain a deeper understanding of the changes in the tumor microenvironment (TME) during UBC recurrence.

Photocatalytic Borylation of Imines and Alkenes via Decarboxylation of Trimethylamine Carboxyborane: A New Approach for Generating Boryl Radicals.

In this study, we investigated the photocatalytic decarboxylation of trimethylamine carboxyborane under mild conditions, successfully generating boryl radicals for subsequent borylation reactions with imines and various alkenes. This method exhibited broad substrate compatibility, including the functionalization of biologically relevant molecules. Our findings expand the utility of trimethylamine carboxyborane beyond its role as a carbon-monoxide- and drug-releasing agent, highlighting its potential in radical chemistry through decarboxylation.

Photosensitized Three-Component Carboimination of Alkenes Based on the Relay of Oxy Radicals to Carbon Radicals.

Here, we present a metal-free photosensitized three-component reaction for the carboimination of alkenes based on oxime carbonates. Homolysis of oxime carbonates via light-mediated energy transfer enables the simultaneous generation of iminyl radicals and alkoxycarbonyloxyl radicals. The alkoxycarbonyloxyl and alkoxy radicals can act as an effective hydrogen atom transfer reagent, abstracting hydrogen atoms from alkanes and aldehydes, silanes, and phosphine oxide.

Bio-Inspired Self-Healing Silicon Anodes: Harnessing Tea Polyphenols to Enhance Lithium-Ion Battery Performance.

This study introduces an anode material for lithium-ion batteries, achieved by integrating tea polyphenols (TP) with the widely utilized polyacrylic acid (PAA) binder. The composite material capitalizes on the intrinsic self-healing properties of TP, enhancing the anode's durability and adhesiveness without the need for additional organic synthesis. The incorporation of TP has been demonstrated to significantly elevate ionic conductivity and expedite lithium ion diffusion, thereby reducing interfacial resistance and decelerating the rate of capacity fade due to electrolyte decomposition and silicon particle expansion.

Tunable photoelectric properties of monolayer Mo W Te alloys: a first-principles study.

Monolayer MoTe and WTe within the two-dimensional transition metal dichalcogenides (TMDCs) material family exhibit broad potential for application in optoelectronic devices owing to their direct band gap characteristics. In this work, upon alloying these materials into a monolayer system denoted as Mo W Te, intriguing alterations are observed in the electronic and optoelectronic properties. The photoelectric attributes of these alloys can be tailored by manipulating the respective ratios of molybdenum to tungsten (Mo/W).