Platelet-rich plasma-contained drug delivery systems to treat orthopedic injuries.

Orthopedic disorders affecting bones, joints, muscles, tendons, and other tissues are prevalent among outpatients, often caused by trauma, sports, or tumor removal. Surgical intervention is common but may yield unsatisfactory results due to limited regenerative capacity and poor blood supply. Platelet-rich plasma (PRP), an autologous biocomponent, has been clinically applied in tissue regeneration and repair, yet it faces challenges such as unclear mechanisms, side effects, and uncontrollable release.

Aberrant activation of the PI3K/AKT/HIF‑1α pathway promotes glycolysis and lenvatinib resistance in liver cancer.

Lenvatinib, a multi‑target tyrosine kinase inhibitor, has been approved as the first‑line treatment for advanced liver cancer (LC). However, its efficacy is markedly hindered by the rapid emergence of drug resistance. The phosphatidylinositol 3 kinase/protein kinase B/hypoxia‑inducible factor‑1 α (PI3K/AKT/HIF‑1α) signaling axis represents a key oncogenic pathway that regulates diverse biological processes, including aerobic glycolysis, and is closely associated with tumor progression and therapeutic resistance.

Identification of histidine decarboxylase and its multi-enzyme cascade system for cost-efficient biosynthesis of carcinine.

Unlabelled: Carcinine, a bioactive compound with antioxidant and anti-glycation properties, holds significant promise for applications in pharmaceuticals and cosmetics. This study demonstrates a novel strategy for the direct biosynthesis of carcinine from low-cost L-histidine and β-alanine using a multi-enzyme cascade system. A highly efficient histidine decarboxylase (PphHDC) was identified.

Ochratoxin A Induces Epithelial Mesenchymal Transition of Human Gastric Epithelium GES-1 Cells via the PKM2-Dependent Glycolytic Metabolism.

Ochratoxin A (OTA), a potent mycotoxin with well-documented carcinogenic potential, facilitates tumor progression by triggering epithelial-mesenchymal transition (EMT). Nevertheless, the precise molecular pathways governing this phenomenon remain elusive. In this investigation, we sought to delineate OTA's involvement in EMT and explore its association with glycolytic metabolism and pyruvate kinase M2 (PKM2) regulation in human gastric epithelial GES-1 cells.

Electrolyte-mediated Cu/Cu ratio control in Cu/graphene catalysts for divergent CO electroreduction pathways.

The electrochemical CO reduction reaction (CORR) to multi‑carbon products offers a promising route for sustainable fuel production, yet achieving high selectivity remains challenging due to the complex interplay between catalyst structure and reaction pathways. Here, we report a rational design of Cu-CuO/graphene (Cu/G) composites with tunable Cu/Cu ratios via electrolyte-mediated electrochemical synthesis. By varying tetraalkylammonium/phosphonium electrolytes (TBABF, TBAPF, TBACFSO, TBPBF), we precisely control Cu oxidation states, as validated by the results of X-ray absorption fine structure (XAFS), X-ray diffraction (XRD), and high-resolution transmission electron microscope (HRTEM).

Pre-harvest Chitooligosaccharide application enhances phenolic composition, antioxidant capacity, and sensory quality of cabernet Gernischt grapes ( L.) and wine.

This study evaluates the effects of pre-harvest chitooligosaccharide (COS) application on the quality of Cabernet Gernischt grapes and wine. Grapevines were sprayed with 0.37 mM COS and 0.

Evaluation of Concomitant Imaging Dose in 4D-CBCT Guided Thoracic Radiotherapy.

IntroductionThis retrospective study evaluated the imaging dose of 4D-CBCT in patients treated with thoracic radiotherapy.MethodsA geometric model of a 4D-CBCT system was built for Monte Carlo (MC) calculations. Percentage depth dose (PDD) and profiles of the system were measured and compared with MC calculations to verify the model.

Comparative Effectiveness of Ciltacabtagene Autoleucel in CARTITUDE-4 Versus Real-World Physician's Choice of Therapy from the Flatiron Registry in Lenalidomide-Refractory Multiple Myeloma.

Introduction: Ciltacabtagene autoleucel (cilta-cel) is approved for relapsed or refractory multiple myeloma (RRMM). In the CARTITUDE-4 study (NCT04181827), cilta-cel demonstrated superior efficacy versus pomalidomide, bortezomib, and dexamethasone or daratumumab, pomalidomide, and dexamethasone in patients with RRMM after 1-3 prior lines of therapy (LOT). We conducted an indirect treatment comparison to understand the comparative efficacy of cilta-cel versus real-world (RW) physician's choice of treatment for lenalidomide-refractory MM.

Optimization of high-accuracy FBG wavelength demodulation based on spectral correction and algorithm compensation.

Despite the widespread use of array waveguide gratings in fiber Bragg grating demodulation systems, its practical implementations are limited by nanoscale size control and processing accuracy, leading to spectral inconsistencies that affect wavelength demodulation. We propose a spectral correction and compensation algorithm combining bandwidth matching and Gaussian fitting to improve demodulation accuracy. Simulation results show a 74.

Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects.

Inhibition of autophagy has been considered as a promising strategy for tumor therapy, discovery of small-molecule autophagy inhibitors suitable for clinical use would be of great significance. Since cysteine protease ATG4B plays a key role in the autophagy machinery by processing pro-LC3 and lipidated LC3 to drive the autophagy progress, inhibition of ATG4B may serve as a potential therapeutic strategy. We previously found that copper ions instead of other ions efficiently inhibited ATG4B activity, which was more potent than other ATG4B inhibitors reported.

Increase in insecticide susceptibility after sublethal exposure to deltamethrin in the German cockroach (Blattodea: Ectobiidae).

The German cockroach, Blattella germanica (L.), is a major urban insect pest primarily controlled by insecticides, including pyrethroid sprays, fipronil baits, and indoxacarb baits. However, widespread pyrethroid resistance increases the probability that cockroaches will survive treatments in the field.

A wide-range flexible pressure sensor based on MWCNTs/TPU composite conductive fibers.

In this study, a flexible piezoresistive pressure sensor with a wide pressure detection range, high sensitivity, and excellent robustness was designed and proposed based on micro/nano manufacturing technology and electrospinning. The pressure-sensitive film is composed of multi-walled carbon nanotubes/thermoplastic polyurethane elastomer composite conductive fibers. The flexible pressure sensor exhibited a high pressure-detection limit of 1200 kPa.

Multi-Source Data-Driven Terrestrial Multi-Algorithm Fusion Path Planning Technology.

This paper presents a multi-source data-driven hybrid path planning framework that integrates global A* search with local Deep Q-Network (DQN) optimization to address complex terrestrial routing challenges. By fusing ASTER GDEM terrain data with OpenStreetMap (OSM) road networks, we construct a standardized geospatial database encompassing elevation, traffic, and road attributes. A dynamic-heuristic A* algorithm is proposed, incorporating traffic signals and congestion penalties, and is enhanced by a DQN-based local decision module to improve adaptability to dynamic environments.

Effects of chlorogenic acid and its isomers on growth performance and antioxidant function of broilers: a meta-analysis.

Current evidence suggests that chlorogenic acid (CGA) and its isomers may positively influence the growth performance and antioxidant capacity of broilers. Nevertheless, the growth-promoting and antioxidant activities of CGA and its isomers have not yet been comprehensively evaluated. Therefore, this study aimed to systematically review and conduct a meta-analysis of the effects of CGA and its isomers on broilers.

The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5.

Glutamine reprogramming plays a crucial role in the growth and survival of clear cell renal cell carcinoma (ccRCC), although the mechanisms governing its regulation are still not fully understood. We demonstrate that the RNA demethylase fat mass and obesity-associated gene (FTO) drives glutamine reprogramming to support ccRCC growth and survival. Genetic and pharmacologic inhibition of FTO in ccRCC cells impaired glutamine-derived reductive carboxylation, depleted pyrimidines, and increased reactive oxygen species.

Ursolic Acid Alleviates DSS-Induced Colitis and Associated Liver Damage by Restoring Treg/Th17 Balance and Modulating Gut Microbiota and Its Histidine Metabolism.

Ursolic acid (UA), a natural compound abundant in fruits and vegetables, exhibits established anti-inflammatory and hepatoprotective properties. This study investigated the therapeutic potential of UA as a dietary supplement for DSS-induced colitis and secondary liver injury using both an DSS-induced colitis mouse model and an intestinal epithelial cell model. Colitis model mice were administered UA at doses of 5, 25, 100, and 250 mg/kg.

Two Mycopolysaccharides from Hirsutella sinensis mycelia: Structural characterization and dual antioxidant-cardioprotective functions.

Cordyceps sinensis, a precious traditional Chinese herb, exhibits diverse polysaccharide structures and functions across strains. This study screened Hirsutella sinensis 02-3 and successfully extracted two mycopolysaccharides (fungal polysaccharides): ISP-AII (MW = 4.70 kDa) and ISP-BII (MW = 75.

Application of dual-frequency resonant RFID gas sensor based on ZnO/MoS₂/WO₃/rGO for indoor formaldehyde and ammonia detection.

A dual-frequency passive radio frequency identification (RFID) gas sensor based on zinc oxide (ZnO)/molybdenum disulfide (MoS)/tungsten trioxide (WO)/reduced graphene (rGO) is proposed for indoor detection of formaldehyde and ammonia concentrations. The antenna model is designed on the antenna simulation software, and then, the antenna is made by the engraving mechanism. Nano-sensitive materials are prepared by the hydrothermal method to characterize the materials, and then, different combinations of materials are coated on both sides of the antenna to produce gas-sensitive sensors.

To share or hide under performance pressure: the role of supervisor support in shaping subordinate knowledge management behaviors.

Introduction: While knowledge sharing is widely acknowledged as a critical driver of organizational learning and development, employees may engage in knowledge hiding-particularly under performance-related pressure. This behavior can impede organizational growth, underscoring the need to understand the boundary conditions that determine whether performance pressure leads to knowledge sharing or knowledge hiding. Grounded in conservation of resources theory, this study proposes a dual-path model that examines how perceived supervisor support moderates the effects of employee performance pressure on knowledge management behaviors.

Plaque biomarkers from high-frame rate vector flow imaging and shear wave elastography in mild carotid stenosis.

Purpose: This study aimed to investigate the association of carotid plaque biomechanical parameters and elasticity-measured using high-frame rate vector flow imaging (VFI) and shear wave elastography (SWE)-with the occurrence of ipsilateral ischemic stroke in patients with mild stenosis.

Methods: The study included 122 patients with mild carotid stenosis involving a single plaque between September 2023 and April 2024 who underwent B-mode ultrasound, high-frame rate VFI, and SWE examinations. Based on head computed tomography or magnetic resonance imaging findings, participants were classified as symptomatic (with ipsilateral ischemic lesions) or asymptomatic.

Changes in Metabolomics Profiles of in Response to Acute Heat Stress.

The ladybird beetle, Thunberg (Coleoptera: Coccinellidae), is a widely distributed natural predator that is crucial in controlling various agricultural pests in China. Despite frequent references to its remarkable thermotolerance, the molecular mechanisms underlying its thermotolerance remain poorly understood. Here, we investigated metabolomic changes in following exposure to acute heat stress (AHS) lasting 1 h at 39 °C and 43 °C in populations from Zhengzhou (ZZ, warm temperate climate zone) and Shenzhen (SZ, subtropical climate zone), representing distinct northern and southern Chinese ecosystems.

Health-related quality of life with daratumumab, bortezomib, melphalan, and prednisone versus bortezomib, melphalan, and prednisone alone in transplant-ineligible patients with newly diagnosed multiple myeloma: analysis of the phase 3 OCTANS study.

In the phase 3 OCTANS study, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) significantly improved response rates and progression-free survival versus VMP alone in transplant-ineligible Asian patients with newly diagnosed multiple myeloma (NDMM). Understanding the impact of treatment on patient-reported outcomes (PROs) is of increasing interest. Here, we report on the impact of D-VMP and VMP on PROs in OCTANS.

Organic-Inorganic PTB7-Th:ITIC/ZnO Heterojunction Based Self-Powered Photodetectors with Tunable Dual Detection Windows.

In this work, we demonstrate a filter-free self-powered photodetector based on PTB7-Th:ITIC/ZnO heterojunction that exhibits remarkable selective spectral response characteristics. The device achieves band-selective detection through innovative manipulation of incident light direction, enabling multiple spectral detection capabilities within a single architecture. Under 0 V bias voltage operation, the device exhibits dual-mode detection capability depending on the illumination direction.

Tofacitinib Versus Methotrexate in Treating Mucocutaneous and Musculoskeletal Lesions of Systemic Lupus Erythematosus: Real-World Results From the CSTAR Cohort XXXII.

Objectives: This study aimed to evaluate and compare the efficacy and safety of tofacitinib versus methotrexate in the management of systemic lupus erythematosus (SLE) within a real-world cohort, with a particular focus on mucocutaneous and musculoskeletal involvement.

Methods: We conducted a retrospective analysis based on the Chinese SLE Treatment and Research Group (CSTAR) cohort. Patients with SLE presenting with active mucocutaneous or musculoskeletal involvement who initiated treatment with tofacitinib or methotrexate were included.

Streamlining Thoracic Radiotherapy Quality assurance: One-Class Classification for Automated OAR Contour Assessment.

PurposeAutomating quality assurance (QA) for contours generated by automatic algorithms is critical in radiotherapy treatment planning. Manual QA is tedious, time-consuming, and prone to subjective experiences. Automatic segmentation reduces physician workload and improves consistency.