Platinum/nitrogen-co-doped TiO as photocatalyst and light-free catalytic adsorbent for gaseous formaldehyde.

Platinum and nitrogen co-doped titanium dioxide (Pt/N-TiO, with 1 wt% Pt and an N/Ti molar ratio of 1) has been synthesized. This Pt/N co-doping strategy creates Schottky junctions, reduces the bandgap energy (3.25 to 2.

Metagenomic profiling of gut microbime: associating their role with the advancement of diabetic nephropathy.

Emerging evidence suggests that alterations in the gut microbiome should play a critical role in the development and progression of type 2 diabetes and its complication such as diabetic nephropathy (DN). Nevertheless, a considerable gap remains in our understanding of the interconnection between DN pathogenesis and gut microbiota arrangement. In this context, this review highlights recent research on the connection between the intestinal microbiota and DN risk, with a particular focus on the role of microbial metabolites in disease development.

Anti- Compounds of Hance Branch.

Hance (Viburnaceae), the Korean elderberry, is widely used in herbal medicine and in the food industry. It is known to have various pharmacological effects, including antitumor, antioxidant, anti-inflammatory, and antimicrobial activities. During our search for anti- compounds from natural resources, the methanol extract of the branch significantly inhibited the growth of .

SERS-based aptasensor for culture-free detection of Escherichia coli in urinary tract infection diagnosis.

A surface-enhanced Raman scattering (SERS)-based aptasensor was developed for the rapid and sensitive detection of Escherichia coli (E. coli), a major pathogen in urinary tract infections (UTIs). The sensor utilizes magnetic beads embedded with gold nanoparticles (MB-AuNPs) functionalized with capture DNA (cDNA) as both the SERS-active substrate and magnetic separation tool.

APOE-high myeloid cells are uniquely associated with metastatic intrathoracic lymph nodes obtained by EBUS-TBNA in primary lung cancer.

The draining lymph node (LN) is the most frequent and often first site of cancer metastasis. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is frequently performed as a standard practice in lung cancer diagnosis and staging, its diagnostic accuracy remains modest, primarily due to the minuscule sample size of needle aspirates. With the advent of single-cell technologies, we comprehensively analyzed the immune cell repertoire in a series of EBUS-TBNA samples.

The smoking of heat-not-burn (HNB) cigarette products and its effects on indoor air quality.

In this research, the concentration levels of volatile organic compounds (VOCs) are monitored in a designated smoking booth using heat-not-burn (HNB) cigarettes (in reference to 1R6F cigarette) with controlled variables of number of cigarettes smoked (1, 3, and 6 cigarettes), booth ventilation (closed vs. open), and time after the release of cigarette smoke (T = 0, T = 5, T = 10, and T = 20 min)). The total VOC concentration (TVOC) released from an HNB cigarette is compared as a collective group (TV) and as three individual subgroups (TV: TV for 14 standardized VOCs (G), TV for 17 reference VOCs (G), and TV for 10 carbonyl compounds (CCs: G).

Modification of Belantamab Mafodotin Dosing to Balance Efficacy and Tolerability in the DREAMM-7 and DREAMM-8 Trials.

Belantamab mafodotin (belamaf) combined with standard therapies demonstrated significant progression-free survival (PFS) and overall survival benefits in DREAMM-7 and PFS benefit in DREAMM-8 in relapsed/refractory multiple myeloma. Belamaf dose modifications managed adverse events, including belamaf-related ocular events. Ocular events included ocular adverse reactions (eg, dry eyes, photophobia, eye irritation) and protocol-mandated ophthalmic examination findings.

Real-World Efficacy and Safety of Teclistamab for Patients with Relapsed or Refractory Multiple Myeloma: Nationwide Retrospective Analysis of the Named Patient Program in Korea.

Purpose: The prognosis for heavily pretreated patients with relapsed or refractory multiple myeloma (RRMM) remains poor. Teclistamab, a bispecific antibody targeting B-cell maturation antigen (BCMA) and CD3, has demonstrated deep and durable responses in triple-class exposed RRMM patients in the MajesTEC-1 trial. To further evaluate the efficacy and safety of teclistamab in Korean patients, we conducted a nationwide retrospective analysis.

Ultrathin K-doped g-CN/BiOBr heterojunctions with S-scheme charge transfer for efficient photodegradation of tetracycline.

Residual tetracycline (TC) in aquatic ecosystems poses a significant risk to the health of both flora and fauna. Advanced catalysts with strong photocatalytic capabilities have emerged as a promising solution for not only TC degradation but also water purification. Here, the photocatalytic destruction (PCD) of TC has been investigated using ultrathin potassium-doped g-CN/BiOBr heterojunctions (KCNx/By, where x and y are the percent mass ratio values of KOH/melamine and KCN/BiOBr, respectively).

Belantamab mafodotin plus bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma (DREAMM-7): updated overall survival analysis from a global, randomised, open-label, phase 3 trial.

Background: In the primary (first interim) analysis of the DREAMM-7 trial (median follow-up 28·2 months), belantamab mafodotin, bortezomib, and dexamethasone (BVd) showed a statistically significant and clinically meaningful progression-free survival benefit versus daratumumab, bortezomib, and dexamethasone (DVd) in patients with relapsed or refractory multiple myeloma (RRMM) after at least one line of therapy. The aim of this study is to report overall survival from the second interim analysis, with extended follow-up.

Methods: In the ongoing global, open-label, randomised, phase 3 DREAMM-7 trial done at 142 study centres (research facilities, hospitals, and institutions) in 20 countries across North America, South America, Europe, and the Asia-Pacific region, eligible patients were aged at least 18 years and had confirmed multiple myeloma (according to International Myeloma Working Group criteria), an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, and progression on or after at least one previous line of therapy.

Real-World Comparison of Carfilzomib, Lenalidomide, and Dexamethasone Versus Ixazomib, Lenalidomide, and Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma: KMM2004 Study.

Background: Lenalidomide-based triplet regimens, specifically carfilzomib, lenalidomide, and dexamethasone (KRd) and ixazomib, lenalidomide, and dexamethasone (IRd), are recognized as effective treatments for relapsed/refractory multiple myeloma (RRMM). Since 2020, South Korea's National Health Insurance Service has covered these combinations, prompting a need for real-world comparisons of their efficacy and safety.

Methods: A retrospective analysis of 182 RRMM patients treated with KRd (112) or IRd (70) at 17 South Korean centers from May 2020 to April 2021 was conducted.

A Phase II Study of Daratumumab in Combination with Bortezomib and Dexamethasone in Patients with Multiple Myeloma Who Received One Prior Line of Therapy (KMM1906).

Purpose: Daratumumab combined with bortezomib and dexamethasone (DVd) has been established as the standard treatment for relapsed/refractory multiple myeloma (MM) based on pivotal phase 3 trials. A subgroup analysis demonstrated enhanced efficacy in the second-line setting, although the fixed duration of bortezomib administration remained a limitation. Therefore, we conducted a phase II trial evaluating continuous bortezomib as maintenance in a DVd regimen for second-line treatment.

Changes in Cancer Care for Patients Aged 80 and Above: A Cohort Study from Samsung Comprehensive Cancer Center in South Korea.

With an estimated 70% of new cancer diagnoses expected to be in older adults within the next decade, cancer care for this population has attracted increasing global attention. Additionally, older patients are less likely to receive optimal cancer treatments. This retrospective cohort study utilized data from the Samsung Medical Center Cancer Registry, which includes patients diagnosed with cancer between 2008 and 2022.

Nanomaterials-mediated electrochemical detection of neutrophil gelatinase-associated lipocalin for chronic kidney disease: Advances, challenges, and future prospects.

Chronic kidney disease (CKD) is characterized by a gradual and permanent deterioration in kidney function, resulting in disruption of the body's internal balance. Traditional diagnostic methods based on serum metabolites often suffer from inaccuracy for CKD diagnosis due to interference from factors such as age, gender, and comorbidities. Neutrophil gelatinase-associated lipocalin (NGAL) is considered an effective clinical marker for early and reliable CKD diagnosis due to its rapid elevation in both serum and urine following renal tubular injury.

Imaging in plasma cell disorders-consensus recommendations of the Asian myeloma network bone imaging workgroup.

The role of imaging in accurate classification and management of plasma cell disorders is substantial with the increasing evidence in the ability of cross-sectional imaging to identify disease related manifestations. International myeloma working group and nation-wide guidelines provide recommendations for guiding practice. However, there are remarkable variations in practice globally and in particular, adoption of incorrect imaging techniques due to lack of awareness/education, lack of equipment or personnel and resource constraints.

Identification of Metabolic Changes and Comparison of Antioxidant Activities in Two Pimpinella Species.

Pimpinella species are commonly consumed as favored edible herbs and accumulate diverse metabolites. To date, the identification and comparison of metabolites have not been studied well in Pimpinella brachycarpa and Pimpinella koreana. This study aimed to analyze the primary and secondary metabolites present in these two Pimpinella species.

The viability of mildly oxidized microporous carbons for adsorptive removal of gaseous aromatic hydrocarbons in humid air.

The adsorption efficacy of commercial activated carbon (AC) toward volatile organic compounds (VOCs) is generally impeded by the presence of moisture under real environmental conditions. To address this limitation, surface modification strategies such as oxidative treatments are employed to enhance the hydrophilicity of AC. In this study, coconut shell-based AC (CSAC) is subjected to mild hydrogen peroxide (HO) oxidation at 100 and 125 °C, producing samples labeled as CSAC100 and CSAC125, respectively.

Real-World Use of carfilzomib-lenalidomide-dexamethasone (KRd) and carfilzomib-dexamethasone (Kd) in Relapsed/Refractory Multiple Myeloma in the Asia Pacific Region: A Prospective Multicenter Observational Study.

Background: Carfilzomib has demonstrated enhanced efficacy and tolerability in head-to-head clinical trials in patients with relapsed/refractory multiple myeloma (RRMM). However, real-world data on its use and outcomes in the Asia Pacific region remains limited.

Methods: This prospective, observational, real-world study included 300 RRMM patients from 29 sites in the Asia Pacific region, who received carfilzomib between July 2019 and June 2023.

Health-related quality of life with daratumumab, bortezomib, melphalan, and prednisone versus bortezomib, melphalan, and prednisone alone in transplant-ineligible patients with newly diagnosed multiple myeloma: analysis of the phase 3 OCTANS study.

In the phase 3 OCTANS study, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) significantly improved response rates and progression-free survival versus VMP alone in transplant-ineligible Asian patients with newly diagnosed multiple myeloma (NDMM). Understanding the impact of treatment on patient-reported outcomes (PROs) is of increasing interest. Here, we report on the impact of D-VMP and VMP on PROs in OCTANS.

Sexual Victimization and Psychological and Behavioral Outcomes Among Children and Adolescents in South Korea.

Objective: By focusing on a person-centered approach using latent class analyses (LCA), this study examined the patterns of sexual victimization among children and adolescents in South Korea and compared the psycho-behavioral outcomes of these classes.

Methods: Participants were 546 females aged 6-17, including 117 sexual victimization survivors and 429 non-victims in South Korea. LCA, an analysis of covariance, and Bonferroni post-hoc tests were conducted.

A review of deoxyribonucleic acid-based single-nucleotide polymorphisms in diabetic kidney disease among Asian populations: Challenges and future directions.

Diabetic kidney disease (DKD) is a persistent disorder that occurs as a result of long-term diabetes mellitus with genetic and environmental risk factors. The identification of DKD associated single-nucleotide polymorphisms (SNPs) is pivotal for patient screening. This manuscript briefly outlines the pathophysiology and the role of genetic factors in DKD expansion.

Recent advances in nanomaterial-based adsorbents for removal of pharmaceutical pollutants from wastewater.

To cope with the environmental risks posed by pharmaceutical waste, adsorption is considered a viable option due to its simplicity, cost-effectiveness, and reliability. This review explores the opportunities and challenges involved in applying nanomaterial-based adsorbents in their metallic, non-metallic, and hybrid forms for removal of common pharmaceuticals (, antibiotics, beta-blockers, analgesics, non-steroidal anti-inflammatory drugs, endocrine disrupters, and anticancer drugs) from water. To improve the selectivity and scalability of diverse adsorbents against such targets, the adsorption capacity and partition coefficient (PC) of each adsorbent are evaluated.

Titanium carbide MXene/anatase titanium dioxide-supported gold catalysts for the low-temperature oxidation of benzene in indoor air.

In the present study, the oxidative removal of benzene (model carcinogenic aromatic volatile organic compound (VOC)) from indoor air is investigated using titanium carbide (TiC) MXene/anatase titanium dioxide (TiO)-supported gold (Au) catalysts under dark and low-temperature (DLT: 30-90 °C) conditions. The reduction pre-treatment (catalyst labelled with the 'R' suffix) has been used to form metallic Au (Au) nanoparticles and anatase TiO in the MXene structure. The relative ordering in the Au catalysts, if assessed in terms of room-temperature (RT) benzene (5 ppm) conversion (X (%)) at 10,191 h gas hourly space velocity, is found as: 0.

Circulation characteristics of bat coronaviruses linked to bat ecological factors in Korea, 2021-2022.

Considering that bat ecology alterations may be linked with pathogen spillover, research on bat coronaviruses, particularly on the infection and transmission pattern among bats in relation with their ecology, is essential. We captured bats distributed in Korea from 2021 to 2022, examined coronaviruses in oral swabs, feces, urine, and ectoparasites, and were able to detect alphacoronavirus. We investigated coronaviruses, but noted no substantial differences in the body condition index in the coronavirus-positive bats.