Real-World Evidence on Low-Dose Olanzapine (≤1.25 mg) for Personalized Antipsychotic Dosing.

: This cohort study aimed to elucidate the real-world treatment course of patients receiving low-dose olanzapine (<2.5 mg), to assess its efficacy, and to examine its metabolic side effects. This study was a cohort study using a clinical registry.

Understanding Inequalities in Mobile Health Utilization Across Phases: Systematic Review and Meta-Analysis.

Background: Mobile health (mHealth) holds promise for enhancing patient care, yet attrition in its use remains a major barrier. Low retention rates limit its potential impact, while barriers to accessing or adopting mHealth vary across populations and countries. These differences in utilization of mHealth may exacerbate health inequalities, contributing to the digital health divide.

A trial-ready cohort for finding unmet needs and improving quality of life among patients with esophageal cancer: a multicenter prospective cohort study.

Although esophageal cancer survivors experience lower health-related quality of life (HRQoL), it is hard to provide proper supportive care due to difficulties to find potential target population. This study aims to develop a trial-ready cohort (TRC) to assess the unmet needs and HRQoL of survivors of esophageal cancer. This prospective, multicenter TRC study will include 600 patients diagnosed with primary esophageal cancer who have undergone curative treatment.

Impact of Serious Infection on Mortality of Patients With Chronic Liver Disease: A Nationwide Population-based Cohort Study.

Background & Aims: This study aimed to investigate the impact of serious infection on mortality of patients with chronic liver disease (CLD).

Methods: This study was conducted on 1,699,159 patients with CLD from the Korean National Health Insurance Service between 2009 and 2021. Serious infection was defined as acute meningitis, acute osteomyelitis, bacteremia, pneumonia, pyelonephritis, serious gastrointestinal infection, skin and soft tissue infections, spontaneous bacterial peritonitis, or COVID-19 infection.

Association between loneliness and depression, anxiety and anger during the COVID-19 pandemic: a nationwide population-based survey.

Objectives: This study aims to determine the association between loneliness and depression, anxiety and anger with a representative sample of the general population in Korea, which are the most prevalent mental health problems during the pandemic.

Design: Cross-sectional study.

Setting: National survey across all 17 provinces in South Korea between December 2021 and January 2022.

Breast Cancer Information Grand Round for Survivorship (BIG-S) prospective cohort.

Existing evidence indicates that long-term effects of breast cancer treatment can significantly impact survivors' ability to fulfill their personal, familial, and social roles. However, few studies comprehensively integrate patient-reported outcomes (PROs) and real-world healthcare utilization data, particularly in Asian populations. Thus, we established a prospective cohort, the Breast Cancer Information Grand Round for Survivorship (BIG-S), to address these gaps and introduce this resource.

Short- and Long-Term Neonatal Outcomes According to Cerclage in Nulliparous Singleton Women: A National Cohort Study Over 15 Years.

Background: This study assessed short- and long-term neonatal outcomes in nulliparous women with singleton pregnancies who underwent cerclage compared with those who did not.

Methods: This nationwide retrospective cohort study included all singleton nulliparous women from the Korean National Health Insurance Service database with live births between January 2006 and December 2019. Women were categorized into three groups based on gestational age at cerclage placement: < 16 weeks, 16-24 weeks, and > 24 weeks.

Increased risk of lung cancer in individuals with preserved ratio impaired spirometry: a nationwide cohort study.

Accumulating data showed that individuals with preserved ratio impaired spirometry (PRISm) have an increased risk for all-cause mortality and respiratory-related mortality compared with normal spirometry. However, the association between PRISm and lung cancer development is not known. A retrospective cohort study was conducted using the Korean National Health and Nutrition Examination Survey data between 2007 and 2017, which was linked to the Health Insurance Review and Assessment database from 2007 to 2021.

Changes in Cancer Care for Patients Aged 80 and Above: A Cohort Study from Samsung Comprehensive Cancer Center in South Korea.

With an estimated 70% of new cancer diagnoses expected to be in older adults within the next decade, cancer care for this population has attracted increasing global attention. Additionally, older patients are less likely to receive optimal cancer treatments. This retrospective cohort study utilized data from the Samsung Medical Center Cancer Registry, which includes patients diagnosed with cancer between 2008 and 2022.

Association between maternal chronic hepatitis B virus infection and the neurodevelopment of children: A comprehensive Korean cohort study.

Objective: Previous studies have indicated a potential association between maternal Hepatitis B virus (HBV) infection and impaired neurodevelopment in offspring. This study aimed to evaluate the relationship between maternal HBV infection and neurodevelopmental disorders (NDD) in children.

Methods: A retrospective cohort study was conducted utilizing data from the Korean National Health Insurance Service database, encompassing live births from 2005 to 2019.

Risk of Neurodevelopmental Disorders in the Offspring of Young Female Cancer Survivors.

This study aimed to examine the risk of neurodevelopmental disorders (NDDs) in cJihye Heohildren born to female cancer survivors under 40 years old. Using nationwide retrospective data from the Korean National Health Insurance Service between January 1, 2005, and December 31, 2019, we included 19,474 children born to female cancer survivors under 40 years old. Propensity-score matching (1:3) with 58,422 controls born to women without cancer was conducted.

Trends and Outcomes of Lung Cancer Surgery in South Korea.

Purpose: This study analyzed nationwide trends in lung cancer surgery in South Korea over 14 years, focusing on surgical volume, patient demographics, surgical approaches, and outcomes.

Materials And Methods: We performed a retrospective cohort study using nationwide health insurance claims data (124,334 cases) and robotic surgery data (1,740 cases) provided by the manufacturer. Patients who underwent lung cancer surgery between 2010 and 2023 were included.

Cardiovascular disease in adolescent and young adult survivors of non-Hodgkin lymphoma in Korea.

Purpose: Long-term cardiovascular risk in adolescent and young adult (AYA) survivors of non-Hodgkin lymphoma (NHL) remains insufficiently characterized. This retrospective cohort study investigated the incidence of cardiovascular disease (CVD) among AYA survivors of NHL.

Methods: We identified 4553 individuals aged 15-39 years diagnosed with NHL between 2006 and 2019 using the Korean National Health Insurance System database.

Different Level and Difficulties with Financial Burden in Multiple Myeloma Patients and Caregivers: A Dyadic Qualitative Study.

Objectives: This study aimed to explore the multifaceted financial burden experienced by patients with multiple myeloma (MM) and their caregivers, focusing on direct and indirect costs, as well as variability and discordance in perceived financial burdens.

Methods: A dyadic qualitative study was conducted with 40 patient-caregiver pairs recruited from a tertiary hospital in Seoul, Korea. Semistructured interviews were used to explore participants' experiences with financial burden, and thematic analysis was performed to identify key themes.

Clinical significance of low-density lipoprotein cholesterol percentage reduction and attained levels after percutaneous coronary intervention.

Background: Differences exist between European and American guideline recommendations regarding targets for low-density lipoprotein cholesterol (LDL-C) levels after percutaneous coronary intervention (PCI), with European guidance advocating for more aggressive reduction to less than 1.4 mmol/L compared with the American guideline, which recommends an LDL-C level of 1.8 mmol/L or greater as the threshold for treatment intensification.

Association Between Time From Percutaneous Coronary Intervention to Cancer Surgery and Cardiovascular and Oncological Outcomes.

Background: Patients who undergo noncardiac surgery shortly after percutaneous coronary intervention (PCI) experience higher rates of perioperative ischemic events, but delaying surgery may affect disease staging and influence cancer recurrence. We aimed to evaluate the association between time from PCI to cancer surgery and cardiovascular and oncologic outcomes in patients with early-stage cancer.

Methods And Results: We included patients with early-stage cancer with a history of PCI who underwent cancer surgery (N=3621).

Dynamics in distress and quality of life in patients undergoing radiation therapy: a prospective cohort study.

Purpose: This study used a mobile-based assessment tool to evaluate the dynamics of distress and quality of life (QoL) in patients with esophageal, head and neck, and rectal cancers undergoing radiation therapy (RT).

Methods: A prospective cohort study was conducted between November 2022 and July 2023 and included 100 patients who had completed assessments at pre-RT, weeks 2, 4, and 6 of RT, and 1 month post-treatment. The National Comprehensive Cancer Network Distress Thermometer and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire were used.

Efficacy and safety of clopidogrel versus aspirin monotherapy in patients at high risk of subsequent cardiovascular event after percutaneous coronary intervention (SMART-CHOICE 3): a randomised, open-label, multicentre trial.

Background: The optimal strategy for long-term antiplatelet maintenance for patients who underwent percutaneous coronary intervention (PCI) remains uncertain. This study aimed to compare the efficacy and safety of clopidogrel versus aspirin monotherapy in patients who completed a standard duration of dual antiplatelet therapy (DAPT) following PCI with drug-eluting stents.

Methods: In this multicentre, randomised, open-label trial, patients aged 19 years or older at high risk of recurrent ischaemic events (previous myocardial infarction at any time before enrolment, medication-treated diabetes, or complex coronary lesions) who completed a standard duration of DAPT after PCI were randomly assigned (1:1) to receive clopidogrel (75 mg once a day) or aspirin (100 mg once a day) oral monotherapy at 26 sites in South Korea.

Clinical N Staging Subclassification for Stage III-N2 NSCLC Patients Undergoing Trimodality Therapy: A Good Beginning Is Half the Battle.

Background: Lung cancer patients with stage III-N2 disease may benefit from the subclassification of nodal involvement before decision-making. We aimed to evaluate whether the clinical N descriptor subclassification predicts prognosis in patients undergoing trimodality therapy for stage III-N2 non-small cell lung cancer.

Methods: Using our institutional registry between 2003 and 2019, we analyzed 899 consecutive patients with stage III-N2 non-small cell lung cancer undergoing neoadjuvant concurrent chemoradiotherapy followed by surgery.

Increased cardiovascular disease risk among adolescent and young adult survivors of cervical cancer.

Objective: To investigate the incidence and risk factors of cardiovascular disease (CVD) in adolescent and young adult survivors of cervical cancer.

Methods: This retrospective cohort study used data from the Korean National Health Insurance Service. Adolescent and young adult (AYA) cervical cancer survivors (n=7,803) were matched with non-cancer controls (n=23,327) using 1:3 propensity score matching, and hazard ratios (HRs) for CVD were determined using Cox regression models.

Impact of coronary artery calcium on progression of diastolic dysfunction: a cohort study.

Background: The relationship between coronary artery calcium (CAC) and progression of diastolic dysfunction (DD) during longitudinal follow-up is uncertain. This study aimed to investigate the prevalence and progression of DD according to severity of CAC and understand their synergistic effect on mortality.

Methods: This was a population-based cohort study.

Development and Validation of Facial Line Distress Scale-Glabellar Lines (FINE-GL).

Purpose: We developed and validated facial line distress scale-glabellar lines (FINE-GL) to evaluate the severity and psychosocial distress associated with GL.

Patients And Methods: In Phase I, a preliminary item pool for the FINE-GL was developed through a literature review and expert consultation. This was followed by cognitive interviews to ensure comprehensibility of the items.