Real-World Evidence on Low-Dose Olanzapine (≤1.25 mg) for Personalized Antipsychotic Dosing.

: This cohort study aimed to elucidate the real-world treatment course of patients receiving low-dose olanzapine (<2.5 mg), to assess its efficacy, and to examine its metabolic side effects. This study was a cohort study using a clinical registry.

Boosting Physical Activity Among Individuals With Low Engagement Through Double-Point Incentives in a Community-Based mHealth Intervention: Retrospective Observational Study.

Background: The administration of incentives to promote physical activity, such as the amount or timing, can vary depending on target health behaviors, research settings, intervention delivery channels, and participants' preferences. Interventions implemented at scale necessitate the consideration of potential fiscal constraints for public health promotion. Since limited funding is a barrier to implementing community-based interventions, examining both immediate and sustained effects of temporary incentive increases on physical activity is important.

Understanding Inequalities in Mobile Health Utilization Across Phases: Systematic Review and Meta-Analysis.

Background: Mobile health (mHealth) holds promise for enhancing patient care, yet attrition in its use remains a major barrier. Low retention rates limit its potential impact, while barriers to accessing or adopting mHealth vary across populations and countries. These differences in utilization of mHealth may exacerbate health inequalities, contributing to the digital health divide.

Hearing changes and trajectories during the menopausal transition and their association with metabolic factors.

Background: Hearing loss is an emerging public health concern, with women typically experiencing deterioration during menopause; however, longitudinal studies across this transition are limited. This study examined hearing changes across the menopausal transition in order to identify distinct patterns of hearing decline from 11 years before to 9 years after the final menstrual period, with the goal of informing strategies for early detection and intervention.

Materials And Methods: We followed 4448 women aged 42-52 years who underwent regular health exams at the Kangbuk Samsung Hospital Total Healthcare Centers (2014-2018) through 2023.

A trial-ready cohort for finding unmet needs and improving quality of life among patients with esophageal cancer: a multicenter prospective cohort study.

Although esophageal cancer survivors experience lower health-related quality of life (HRQoL), it is hard to provide proper supportive care due to difficulties to find potential target population. This study aims to develop a trial-ready cohort (TRC) to assess the unmet needs and HRQoL of survivors of esophageal cancer. This prospective, multicenter TRC study will include 600 patients diagnosed with primary esophageal cancer who have undergone curative treatment.

Menopausal stage transitions and associations with overall and domain-specific perceived stress in middle-aged Korean women.

Background: The menopausal transition, closely linked to later-life health, involves substantial physiological and psychological changes, potentially increasing perceived stress. However, longitudinal studies have reported inconsistent results, with limited data for Asian women, despite the potential for perceived stress to vary with both race and socioeconomic status. Therefore, this study investigated the longitudinal association between menopausal transition and perceived stress among middle-aged Korean women.

Association between loneliness and depression, anxiety and anger during the COVID-19 pandemic: a nationwide population-based survey.

Objectives: This study aims to determine the association between loneliness and depression, anxiety and anger with a representative sample of the general population in Korea, which are the most prevalent mental health problems during the pandemic.

Design: Cross-sectional study.

Setting: National survey across all 17 provinces in South Korea between December 2021 and January 2022.

Breast Cancer Information Grand Round for Survivorship (BIG-S) prospective cohort.

Existing evidence indicates that long-term effects of breast cancer treatment can significantly impact survivors' ability to fulfill their personal, familial, and social roles. However, few studies comprehensively integrate patient-reported outcomes (PROs) and real-world healthcare utilization data, particularly in Asian populations. Thus, we established a prospective cohort, the Breast Cancer Information Grand Round for Survivorship (BIG-S), to address these gaps and introduce this resource.

Short- and Long-Term Neonatal Outcomes According to Cerclage in Nulliparous Singleton Women: A National Cohort Study Over 15 Years.

Background: This study assessed short- and long-term neonatal outcomes in nulliparous women with singleton pregnancies who underwent cerclage compared with those who did not.

Methods: This nationwide retrospective cohort study included all singleton nulliparous women from the Korean National Health Insurance Service database with live births between January 2006 and December 2019. Women were categorized into three groups based on gestational age at cerclage placement: < 16 weeks, 16-24 weeks, and > 24 weeks.

Changes in Cancer Care for Patients Aged 80 and Above: A Cohort Study from Samsung Comprehensive Cancer Center in South Korea.

With an estimated 70% of new cancer diagnoses expected to be in older adults within the next decade, cancer care for this population has attracted increasing global attention. Additionally, older patients are less likely to receive optimal cancer treatments. This retrospective cohort study utilized data from the Samsung Medical Center Cancer Registry, which includes patients diagnosed with cancer between 2008 and 2022.

Analysis of Phase I Clinical Trial Design of Anti-Cancer Agents.

Since 2000, there have been cancer research and regulatory changes in the development of anti-cancer therapies. The broadening understanding of cancer biology, coupled with advances in molecular biology and technology, has led to the development of new cancer drugs with diverse mechanisms of action. This study aims to analyze the trends and major features of Phase 1 clinical trial designs for anti-cancer agents approved by the U.

Impact of tumor size by clinical N subclassification and histology in trimodality-treated N2 non-small cell lung cancer.

The evolving TNM classification has emphasized the tumor size's role in NSCLC prognosis, reclassifying stage IIIA patients from the previous edition as stage IIIB (T3-4N2M0, 8th edition). However, the prognostic implications of tumor size and survival in stage III NSCLC patients undergoing neoadjuvant therapy remain unexplored. Therefore, we investigated the association between tumor size and mortality in N2 non-small cell lung cancer (NSCLC) patients undergoing neoadjuvant concurrent chemoradiotherapy followed by surgery (trimodality therapy), considering the number of metastatic N2 stations and histology.

Cardiovascular disease in adolescent and young adult survivors of non-Hodgkin lymphoma in Korea.

Purpose: Long-term cardiovascular risk in adolescent and young adult (AYA) survivors of non-Hodgkin lymphoma (NHL) remains insufficiently characterized. This retrospective cohort study investigated the incidence of cardiovascular disease (CVD) among AYA survivors of NHL.

Methods: We identified 4553 individuals aged 15-39 years diagnosed with NHL between 2006 and 2019 using the Korean National Health Insurance System database.

Early Onset Red Breast Syndrome: The Incidence, Risk Factors, and Clinical Outcomes in Prepectoral Direct-to-Implant Breast Reconstruction.

Background: Red breast syndrome (RBS) is a concerning condition often mistaken for infection following acellular dermal matrix (ADM)-assisted breast reconstruction. Although various factors have been suggested as possible causes, the timing of onset has not been considered in diagnosing RBS.

Objectives: This study aims to investigate the incidence, risk factors, and clinical outcomes of RBS occurring within the first week after immediate ADM-assisted prepectoral direct-to-implant (DTI) breast reconstruction.

Different Level and Difficulties with Financial Burden in Multiple Myeloma Patients and Caregivers: A Dyadic Qualitative Study.

Objectives: This study aimed to explore the multifaceted financial burden experienced by patients with multiple myeloma (MM) and their caregivers, focusing on direct and indirect costs, as well as variability and discordance in perceived financial burdens.

Methods: A dyadic qualitative study was conducted with 40 patient-caregiver pairs recruited from a tertiary hospital in Seoul, Korea. Semistructured interviews were used to explore participants' experiences with financial burden, and thematic analysis was performed to identify key themes.

Clinical significance of low-density lipoprotein cholesterol percentage reduction and attained levels after percutaneous coronary intervention.

Background: Differences exist between European and American guideline recommendations regarding targets for low-density lipoprotein cholesterol (LDL-C) levels after percutaneous coronary intervention (PCI), with European guidance advocating for more aggressive reduction to less than 1.4 mmol/L compared with the American guideline, which recommends an LDL-C level of 1.8 mmol/L or greater as the threshold for treatment intensification.

Association Between Time From Percutaneous Coronary Intervention to Cancer Surgery and Cardiovascular and Oncological Outcomes.

Background: Patients who undergo noncardiac surgery shortly after percutaneous coronary intervention (PCI) experience higher rates of perioperative ischemic events, but delaying surgery may affect disease staging and influence cancer recurrence. We aimed to evaluate the association between time from PCI to cancer surgery and cardiovascular and oncologic outcomes in patients with early-stage cancer.

Methods And Results: We included patients with early-stage cancer with a history of PCI who underwent cancer surgery (N=3621).

Clinical N Staging Subclassification for Stage III-N2 NSCLC Patients Undergoing Trimodality Therapy: A Good Beginning Is Half the Battle.

Background: Lung cancer patients with stage III-N2 disease may benefit from the subclassification of nodal involvement before decision-making. We aimed to evaluate whether the clinical N descriptor subclassification predicts prognosis in patients undergoing trimodality therapy for stage III-N2 non-small cell lung cancer.

Methods: Using our institutional registry between 2003 and 2019, we analyzed 899 consecutive patients with stage III-N2 non-small cell lung cancer undergoing neoadjuvant concurrent chemoradiotherapy followed by surgery.

Increased cardiovascular disease risk among adolescent and young adult survivors of cervical cancer.

Objective: To investigate the incidence and risk factors of cardiovascular disease (CVD) in adolescent and young adult survivors of cervical cancer.

Methods: This retrospective cohort study used data from the Korean National Health Insurance Service. Adolescent and young adult (AYA) cervical cancer survivors (n=7,803) were matched with non-cancer controls (n=23,327) using 1:3 propensity score matching, and hazard ratios (HRs) for CVD were determined using Cox regression models.

Regulation of keratinocyte proliferation and differentiation by secoiridoid oleacein in monoculture and fibroblast co-culture models.

Aberrant differentiation of keratinocytes is closely associated with both pathological skin disorders and non-pathological skin conditions, making the maintenance of normal differentiation process essential for skin integrity and homeostasis. This study investigated the effect of olive-derived secoiridoid oleacein (OC) on keratinocyte proliferation and differentiation in vitro and further validated it in a co-culture model with fibroblasts mimicking a skin-like environment. OC was compared with oleuropein (OP) as a reference compound having similar chemical structure and reported effects on skin barrier formation and wound healing.

Development and Validation of Facial Line Distress Scale-Glabellar Lines (FINE-GL).

Purpose: We developed and validated facial line distress scale-glabellar lines (FINE-GL) to evaluate the severity and psychosocial distress associated with GL.

Patients And Methods: In Phase I, a preliminary item pool for the FINE-GL was developed through a literature review and expert consultation. This was followed by cognitive interviews to ensure comprehensibility of the items.

Efficacy of contrast versus non-contrast CT surveillance among patients surviving two years without recurrence after surgery for stage I lung cancer.

Contrast-enhanced chest CT (CECT) is more sensitive than non-contrast-enhanced chest CT (NCECT), but NCECT may have comparable efficacy in detecting new primary lung cancer among stage I NSCLC survivors after two years of surveillance. This study aimed to evaluate the efficacy of NCECT versus CECT for surveillance among stage I NSCLC patients surviving two years after curative resection without disease recurrence. We conducted a retrospective cohort study of patients with stage I NSCLC who underwent curative-intent lung resection between January 2009 and December 2017 using the Registry for Thoracic Cancer Surgery at the Samsung Medical Center, Seoul, Korea.

Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform.

Brain diseases complexity have necessitated advanced research platforms for better understanding, treatment, and prevention strategies. However, existing brain disease registries face limitations such as incomplete variable sets, lack of standardization, insufficient linkage to external databases, absence of integrated platforms for comprehensive data collection, and lack of continuity. To address these challenges, the Korea National Institute of Health initiated the Brain disease Research Infrastructure for Data Gathering and Exploration (BRIDGE), a national prospective platform designed to overcome the shortcomings of current registries.